Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagenllin in colonic inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 38, 2005, Pages 13610-13615

  Rhee, Sang Hoon ^a   Im, Eunok ^b   Riegler, Martin ^c   Kokkotou, Efi ^a   O'Brien, Michael ^d   Pothoulakis, Charalabos ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Colitis; Commensal bacteria; Innate immunity

Indexed keywords

CHEMOKINE; DEXTRAN SULFATE; FLAGELLIN; INTERLEUKIN 6; LIPOTEICHOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; APOPTOSIS; ARTICLE; BASOLATERAL MEMBRANE; COLITIS; COLON INJURY; COLON MUCOSA; CONTROLLED STUDY; DIGESTIVE SYSTEM INFLAMMATION; DISEASE COURSE; DISEASE MODEL; ENZYME ACTIVATION; EVALUATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; MORTALITY; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; CHEMOKINES; COLITIS; COLON; FLAGELLIN; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTESTINAL MUCOSA; KERATINOCYTES; LIPOPOLYSACCHARIDES; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MEMBRANE GLYCOPROTEINS; MICE; PEPTIDOGLYCAN; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TEICHOIC ACIDS; TISSUE CULTURE TECHNIQUES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 26444440067     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502174102     Document Type: Article

References (32)

1. Underbill, D. M. & Ozinsky, A. (2002) Curr. Opin. Immunol. 14, 103-110.
2. Kopp, E. & Medzhitov, R. (2003) Curr. Opin. Immunol. 15, 396-401.
3. Akira, S. (2003) Curr. Opin. Immunol. 15, 5-11.
4. Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G. & Gordon, I. I. (2001) Science 291, 881-884.
5. Swidsinski, A., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V., Ortner, M., Weber, I., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) Gastroenterology 122, 44-54.
6. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. (2004) Cell 118, 229-241.
7. Strober, W. (2004) Nat. Med. 10, 898-900.
8. Stagg, A. J., Hart, A. L., Knight, S. C. & Kamm, M. A. (2003) Gut 52, 1522-1529.
9. Hart, A. L., Stagg, A. J. & Kamm, M. A. (2003) J. Clin. Gastroenterol. 36, 111-119.
10. Cummings, J. H., Macfarlane, G. T. & Macfarlane, S. (2003) Curr. Issues Intest. Microbiol. 4, 9-20.
11. Beutler, B. (2001) Immunity 15, 5-14.
12. Rhee, S. H., Keates, A. C., Moyer, M. P. & Pothoulakis, C. (2004) J. Biol. Chem. 279, 25179-25188.
13. Kwon, J. H., Keates, S., Bassani, L., Mayer, L. F. & Keates, A. C. (2002) Gut 51, 818-826.
14. Banks, C., Bateman, A., Payne, R., Johnson, P. & Sheron, N. (2003) J. Pathol. 199, 28-35.
15. Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M. & Hershberg, R. M. (2004) J. Clin. Invest. 113, 1296-1306.
16. Riegler, M., Castagliuolo, I., Wang, C, Wlk, M., Sogukoglu, T., Wenzl, E., Matthews, J. B. & Pothoulakis, C. (2000) Gastroenterology 119, 348-357.
17. Mall, M., Kreda, S. M., Mengos, A., Jensen, T. J., Hirtz, S., Seydewitz, H. H., Yankaskas, J., Kunzelmann, K., Riordan, J. R, & Boucher, R. C. (2004) Gastroenterology 126, 32-41.
18. Siegmund, B., Lehr, H. A. & Fantuzzi, G. (2002) Gastroenterology 122, 2011-2025.
19. Rhee, S. H., Jones, B. W., Toshchakov, V., Vogel, S. N. & Fenton, M. J. (2003) J. Biol. Chem. 278, 22506-22512.
20. Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J. & Madara, J. L. (2001) J. Immunol. 167, 1882-1885.
21. Reed, K. A., Hubert, M. E., Kolenda, C. E., Sands, K. A., Rathman, M., O'Connor, M., Lyons, S., Gewirtz, A. T., Sansonetti, P. J. & Madara, J. L. (2002) J. Biol. Chem. 277, 13346-13353.
22. Bambou, J. C., Giraud, A., Menard, S., Begue, B., Rakotobe, S., Heyman, M., Taddei, F., Cerf-Bensussan, N. & Gaboriau-Routhiau, V. (2004) J. Biol. Chem. 279, 42984-42992.
23. Kitajima, S., Takuma, S. & Morimoto, M. (1999) Exp. Anim. 48, 137-143.
24. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) Science 282, 2085-2088.
25. Rhee, S. H. & Hwang, D. (2000) J. Biol. Chem. 275, 34035-34040.
26. Visser, L., Jan de Heer, H., Boven, L. A., van Riel, D., van Meurs, M., Melief, M. J., Zahringer, U., van Strijp, J., Lambrecht, B. N., Nieuwenhuis, E. E., et al. (2005) J. Immunol. 174, 808-816.
27. Murthy, K. G., Deb, A., Goonesekera, S., Szabo, C. & Salzman, A. L. (2004) J. Biol. Chem. 279, 5667-5675.
28. Cario, E. & Podolsky, D. K. (2000) Infect. Immun. 68, 7010-7017.
29. Otte, J. M., Cario, E. & Podolsky, D. K. (2004) Gastroenterology 126, 1054-1070.
30. Didierlaurent, A., Ferrero, I., Otten, L. A., Dubois, B., Reinhardt, M., Carlsen, H., Blomhoff, R., Akira, S., Kraehenbuhl, J. P. & Sirard, J. C. (2004) J. Immunol. 172, 6922-6930.
31. Smythies, L. E., Sellers, M., Clements, R. H., Mosteller-Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M. & Smith, P. D. (2005) J. Clin. Invest. 115, 66-75.
32. West, A. P., Dancho, B. A. & Mizel, S. B. (2005) J. Biol. Chem. 280, 9482-9488.