메뉴 건너뛰기




Volumn 121, Issue , 2014, Pages 321-349

Regulation of pancreatic islet beta-cell mass by growth factor and hormone signaling

Author keywords

Apoptosis; Growth factor; Growth hormone; Insulin like growth factor; Islet beta cell mass; Proliferation; Protein complex formation; Signaling crosstalk

Indexed keywords

GROWTH FACTOR; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HORMONE; INSULIN; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STAT5 PROTEIN;

EID: 84896712033     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800101-1.00010-7     Document Type: Chapter
Times cited : (41)

References (160)
  • 1
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • R.A. DeFronzo Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes Diabetes Rev 5 1997 177 269
    • (1997) Diabetes Rev , vol.5 , pp. 177-269
    • Defronzo, R.A.1
  • 2
    • 4143151942 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • R.A. DeFronzo Pathogenesis of type 2 diabetes mellitus Med Clin North Am 88 2004 787 835
    • (2004) Med Clin North Am , vol.88 , pp. 787-835
    • Defronzo, R.A.1
  • 3
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • M. Prentki, and C. Nolan Islet beta cell failure in type 2 diabetes J Clin Invest 116 2006 1802 1812
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.2
  • 4
    • 0036319371 scopus 로고    scopus 로고
    • Pancreatic cell growth and survival - A role in obesity-linked type 2 diabetes?
    • M.K. Lingohr, R. Buettner, and C.J. Rhodes Pancreatic cell growth and survival - a role in obesity-linked type 2 diabetes? Trends Mol Med 8 2002 375 384
    • (2002) Trends Mol Med , vol.8 , pp. 375-384
    • Lingohr, M.K.1    Buettner, R.2    Rhodes, C.J.3
  • 5
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • P. Zimmet, K. Alberti, and J. Shaw Global and societal implications of the diabetes epidemic Nature 414 2001 782 787
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.2    Shaw, J.3
  • 6
    • 33845984333 scopus 로고    scopus 로고
    • Epidemic obesity and type 2 diabetes in Asia
    • K. Yoon, J. Lee, and J. Kim et al. Epidemic obesity and type 2 diabetes in Asia Lancet 368 2006 1681 1688
    • (2006) Lancet , vol.368 , pp. 1681-1688
    • Yoon, K.1    Lee, J.2    Kim, J.3
  • 7
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • S. Kahn, R. Hull, and K. Utzschneider Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 2006 840 846
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.1    Hull, R.2    Utzschneider, K.3
  • 8
    • 0035850402 scopus 로고    scopus 로고
    • The continuing epidemics of obesity and diabetes in the United States
    • A. Mokdad, B. Bowman, E. Ford, F. Vinicor, J. Marks, and J. Koplan The continuing epidemics of obesity and diabetes in the United States JAMA 286 2001 1195 1200
    • (2001) JAMA , vol.286 , pp. 1195-1200
    • Mokdad, A.1    Bowman, B.2    Ford, E.3    Vinicor, F.4    Marks, J.5    Koplan, J.6
  • 9
    • 0035122304 scopus 로고    scopus 로고
    • Regulation of cell mass by hormones and growth factors
    • J.H. Nielsen, E.D. Galsgaard, and A. Moldrup et al. Regulation of cell mass by hormones and growth factors Diabetes 50 2001 S25 S29
    • (2001) Diabetes , vol.50
    • Nielsen, J.H.1    Galsgaard, E.D.2    Moldrup, A.3
  • 10
    • 0031798819 scopus 로고    scopus 로고
    • Molecular basis for islet development, growth, and regeneration
    • J.H. Nielsen, and P. Serup Molecular basis for islet development, growth, and regeneration Curr Opin Endocrinol Diabetes 5 1998 97 107
    • (1998) Curr Opin Endocrinol Diabetes , vol.5 , pp. 97-107
    • Nielsen, J.H.1    Serup, P.2
  • 12
    • 3242656480 scopus 로고    scopus 로고
    • Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt?
    • L.M. Dickson, and C.J. Rhodes Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab 287 2004 E192 E198
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Dickson, L.M.1    Rhodes, C.J.2
  • 13
    • 0034853485 scopus 로고    scopus 로고
    • Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes
    • S.E. Kahn Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes J Clin Endocrinol Metab 86 2001 4047 4058
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4047-4058
    • Kahn, S.E.1
  • 14
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes - A matter of cell life and death?
    • C. Rhodes Type 2 diabetes - a matter of cell life and death? Science 307 2005 380 384
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.1
  • 15
    • 64149130125 scopus 로고    scopus 로고
    • Functional pancreatic beta-cell mass: Involvement in type 2 diabetes and therapeutic intervention
    • M. Karaca, C. Magnan, and C. Kargar Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention Diabetes Metab 35 2009 77 84
    • (2009) Diabetes Metab , vol.35 , pp. 77-84
    • Karaca, M.1    Magnan, C.2    Kargar, C.3
  • 16
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Y. Dor, J. Brown, O.I. Martinez, and D.A. Melton Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation Nature 429 2004 41 46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 17
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • M. Teta, M.M. Rankin, S.Y. Long, G.M. Stein, and J.A. Kushner Growth and regeneration of adult beta cells does not involve specialized progenitors Dev Cell 12 2007 817 826
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 18
    • 0034042959 scopus 로고    scopus 로고
    • Islet growth and development in the adult
    • S. Bonner-Weir Islet growth and development in the adult J Mol Endocrinol 24 2000 297 302
    • (2000) J Mol Endocrinol , vol.24 , pp. 297-302
    • Bonner-Weir, S.1
  • 19
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic beta-cell signal transduction
    • C.B. Newgard, and J.D. McGarry Metabolic coupling factors in pancreatic beta-cell signal transduction Annu Rev Biochem 64 1995 689 719
    • (1995) Annu Rev Biochem , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 20
    • 0029932643 scopus 로고    scopus 로고
    • New insights into pancreatic beta-cell metabolic signaling in insulin secretion
    • M. Prentki New insights into pancreatic beta-cell metabolic signaling in insulin secretion Eur J Endocrinol 134 1996 272 286
    • (1996) Eur J Endocrinol , vol.134 , pp. 272-286
    • Prentki, M.1
  • 21
    • 33750865703 scopus 로고    scopus 로고
    • STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes
    • M. Jackerott, A. Møldrup, and P. Thams et al. STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes Diabetes 55 2006 2705 2712
    • (2006) Diabetes , vol.55 , pp. 2705-2712
    • Jackerott, M.1    Møldrup, A.2    Thams, P.3
  • 23
    • 0028845665 scopus 로고
    • Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas
    • L. Scaglia, F.E. Smith, and S. Bonner-Weir Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas Endocrinology 136 1995 5461 5468
    • (1995) Endocrinology , vol.136 , pp. 5461-5468
    • Scaglia, L.1    Smith, F.E.2    Bonner-Weir, S.3
  • 24
    • 84869838512 scopus 로고    scopus 로고
    • Progression to type 2 diabetes in women with former gestational diabetes: Time trajectories of metabolic parameters
    • A. Tura, A. Grassi, and Y. Winhofer et al. Progression to type 2 diabetes in women with former gestational diabetes: time trajectories of metabolic parameters PLoS One 7 2012 e50419
    • (2012) PLoS One , vol.7 , pp. 50419
    • Tura, A.1    Grassi, A.2    Winhofer, Y.3
  • 25
    • 0023635603 scopus 로고
    • Growth hormone receptor and serum binding protein: Purification, cloning and expression
    • D.W. Leung, S.A. Spencer, and G. Cachianes et al. Growth hormone receptor and serum binding protein: purification, cloning and expression Nature 330 1987 537 543
    • (1987) Nature , vol.330 , pp. 537-543
    • Leung, D.W.1    Spencer, S.A.2    Cachianes, G.3
  • 26
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • J.F. Bazan Structural design and molecular evolution of a cytokine receptor superfamily Proc Natl Acad Sci U S A 87 1990 6934 6938
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6934-6938
    • Bazan, J.F.1
  • 27
    • 0027179365 scopus 로고
    • Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
    • L.S. Argetsinger, G.S. Campbell, and X. Yang et al. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase Cell 74 1993 237 244
    • (1993) Cell , vol.74 , pp. 237-244
    • Argetsinger, L.S.1    Campbell, G.S.2    Yang, X.3
  • 28
    • 0028786276 scopus 로고
    • The Janus protein tyrosine kinase family and its role in cytokine signaling
    • J.N. Ihle The Janus protein tyrosine kinase family and its role in cytokine signaling Adv Immunol 60 1995 1 35
    • (1995) Adv Immunol , vol.60 , pp. 1-35
    • Ihle, J.N.1
  • 29
    • 0011718801 scopus 로고    scopus 로고
    • Growth hormone receptor
    • J.J. Oppenheim, M. Feldman, Academic Press Harcourt, London
    • S.J. Frank, and J.L. Messina Growth hormone receptor J.J. Oppenheim, M. Feldman, Cytokine Reference On-Line 2002 Academic Press Harcourt, London 1 21
    • (2002) Cytokine Reference On-Line , pp. 1-21
    • Frank, S.J.1    Messina, J.L.2
  • 30
    • 0029912878 scopus 로고    scopus 로고
    • Molecular mechanism of growth hormone action
    • C. Carter-Su, J. Schwartz, and L.S. Smit Molecular mechanism of growth hormone action Annu Rev Physiol 58 1996 187 207
    • (1996) Annu Rev Physiol , vol.58 , pp. 187-207
    • Carter-Su, C.1    Schwartz, J.2    Smit, L.S.3
  • 31
    • 0002440739 scopus 로고    scopus 로고
    • Growth hormone action: Signaling via a JAK/STAT-coupled receptor
    • P.M. Conn, A. Means, Humana Press Totowa, NJ
    • D.J. Waxman, and S.J. Frank Growth hormone action: signaling via a JAK/STAT-coupled receptor P.M. Conn, A. Means, Principles of Molecular Regulation 2000 Humana Press Totowa, NJ 55 83
    • (2000) Principles of Molecular Regulation , pp. 55-83
    • Waxman, D.J.1    Frank, S.J.2
  • 32
    • 0029968831 scopus 로고    scopus 로고
    • The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH
    • L.S. Smit, D.J. Meyer, N. Billestrup, G. Norstedt, J. Schwartz, and C. Carter-Su The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH Mol Endocrinol 10 1996 519 533
    • (1996) Mol Endocrinol , vol.10 , pp. 519-533
    • Smit, L.S.1    Meyer, D.J.2    Billestrup, N.3    Norstedt, G.4    Schwartz, J.5    Carter-Su, C.6
  • 33
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • G.B. Udy, R.P. Towers, and R.G. Snell et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression Proc Natl Acad Sci U S A 94 1997 7239 7244
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 7239-7244
    • Udy, G.B.1    Towers, R.P.2    Snell, R.G.3
  • 34
    • 0037590103 scopus 로고    scopus 로고
    • Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    • J. Woelfle, J. Billiard, and P. Rotwein Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b J Biol Chem 278 2003 22696 22702
    • (2003) J Biol Chem , vol.278 , pp. 22696-22702
    • Woelfle, J.1    Billiard, J.2    Rotwein, P.3
  • 37
    • 0028829590 scopus 로고
    • Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites
    • P.L. Bergad, H.M. Shih, H.C. Towle, S.J. Schwarzenberg, and S.A. Berry Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites J Biol Chem 270 1995 24903 24910
    • (1995) J Biol Chem , vol.270 , pp. 24903-24910
    • Bergad, P.L.1    Shih, H.M.2    Towle, H.C.3    Schwarzenberg, S.J.4    Berry, S.A.5
  • 38
    • 2542420725 scopus 로고    scopus 로고
    • Physical and functional interaction of growth hormone and insulin-like growth factor-1 signaling elements
    • Y. Huang, S.O. Kim, N. Yang, J. Jiang, and S.J. Frank Physical and functional interaction of growth hormone and insulin-like growth factor-1 signaling elements Mol Endocrinol 18 2004 1471 1485
    • (2004) Mol Endocrinol , vol.18 , pp. 1471-1485
    • Huang, Y.1    Kim, S.O.2    Yang, N.3    Jiang, J.4    Frank, S.J.5
  • 39
    • 0037805620 scopus 로고    scopus 로고
    • Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling
    • Y. Huang, S.O. Kim, J. Jiang, and S.J. Frank Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling J Biol Chem 278 2003 18902 18913
    • (2003) J Biol Chem , vol.278 , pp. 18902-18913
    • Huang, Y.1    Kim, S.O.2    Jiang, J.3    Frank, S.J.4
  • 40
    • 3042596821 scopus 로고    scopus 로고
    • Growth hormone alters epidermal growth factor receptor binding affinity via activation of ERKs in 3T3-F442A cells
    • Y. Huang, Y. Chang, X. Wang, J. Jiang, and S.J. Frank Growth hormone alters epidermal growth factor receptor binding affinity via activation of ERKs in 3T3-F442A cells Endocrinology 145 2004 3297 3306
    • (2004) Endocrinology , vol.145 , pp. 3297-3306
    • Huang, Y.1    Chang, Y.2    Wang, X.3    Jiang, J.4    Frank, S.J.5
  • 41
    • 0029825056 scopus 로고    scopus 로고
    • Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
    • V. Goffin, K. Shiverick, P. Kelly, and J. Martial Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals Endocr Rev 17 1996 385 410
    • (1996) Endocr Rev , vol.17 , pp. 385-410
    • Goffin, V.1    Shiverick, K.2    Kelly, P.3    Martial, J.4
  • 42
    • 0030451788 scopus 로고    scopus 로고
    • Extrapituitary prolactin: Distribution, regulation, functions, and clinical aspects
    • N. Ben-Jonathan, J.L. Mershon, D.L. Allen, and R.W. Steinmetz Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects Endocr Rev 17 1996 639 669
    • (1996) Endocr Rev , vol.17 , pp. 639-669
    • Ben-Jonathan, N.1    Mershon, J.L.2    Allen, D.L.3    Steinmetz, R.W.4
  • 43
    • 0033771336 scopus 로고    scopus 로고
    • Prolactin: Structure, function, and regulation of secretion
    • M.E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy Prolactin: structure, function, and regulation of secretion Physiol Rev 80 2000 1523 1631
    • (2000) Physiol Rev , vol.80 , pp. 1523-1631
    • Freeman, M.E.1    Kanyicska, B.2    Lerant, A.3    Nagy, G.4
  • 44
    • 0027941433 scopus 로고
    • Activation of receptor-associated tyrosine kinase JAK2 by prolactin
    • H. Rui, R.A. Kirken, and W.L. Farrar Activation of receptor-associated tyrosine kinase JAK2 by prolactin J Biol Chem 269 1994 5364 5368
    • (1994) J Biol Chem , vol.269 , pp. 5364-5368
    • Rui, H.1    Kirken, R.A.2    Farrar, W.L.3
  • 45
    • 0032460226 scopus 로고    scopus 로고
    • Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    • C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P.A. Kelly Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice Endocr Rev 19 1998 225 268
    • (1998) Endocr Rev , vol.19 , pp. 225-268
    • Bole-Feysot, C.1    Goffin, V.2    Edery, M.3    Binart, N.4    Kelly, P.A.5
  • 47
    • 0033537939 scopus 로고    scopus 로고
    • Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules
    • R.C. Lee, J.A. Walters, M.E. Reyland, and S.M. Anderson Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules J Biol Chem 274 1999 10024 10034
    • (1999) J Biol Chem , vol.274 , pp. 10024-10034
    • Lee, R.C.1    Walters, J.A.2    Reyland, M.E.3    Anderson, S.M.4
  • 48
    • 80051473568 scopus 로고    scopus 로고
    • Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
    • E. Aksamitiene, S. Achanta, W. Kolch, B.N. Kholodenko, J.B. Hoek, and A. Kiyatkin Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells Cell Signal 23 2011 1794 1805
    • (2011) Cell Signal , vol.23 , pp. 1794-1805
    • Aksamitiene, E.1    Achanta, S.2    Kolch, W.3    Kholodenko, B.N.4    Hoek, J.B.5    Kiyatkin, A.6
  • 49
    • 33845528355 scopus 로고    scopus 로고
    • Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells
    • Y. Huang, X. Li, J. Jiang, and S.J. Frank Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells Oncogene 25 2006 7565 7576
    • (2006) Oncogene , vol.25 , pp. 7565-7576
    • Huang, Y.1    Li, X.2    Jiang, J.3    Frank, S.J.4
  • 50
    • 0021894458 scopus 로고
    • The nature and regulation of the receptors for pituitary growth hormone
    • J.P. Hughes, and H.G. Friesen The nature and regulation of the receptors for pituitary growth hormone Annu Rev Physiol 47 1985 469 482
    • (1985) Annu Rev Physiol , vol.47 , pp. 469-482
    • Hughes, J.P.1    Friesen, H.G.2
  • 51
    • 0025615418 scopus 로고
    • Zinc mediation of the binding of human growth hormone to the human prolactin receptor
    • B.C. Cunningham, S. Bass, G. Fuh, and J.A. Wells Zinc mediation of the binding of human growth hormone to the human prolactin receptor Science 250 1990 1709 1712
    • (1990) Science , vol.250 , pp. 1709-1712
    • Cunningham, B.C.1    Bass, S.2    Fuh, G.3    Wells, J.A.4
  • 52
    • 0028032203 scopus 로고
    • The X-ray structure of a growth hormone-prolactin receptor complex
    • W. Somers, M. Ultsch, A.M. De Vos, and A.A. Kossiakoff The X-ray structure of a growth hormone-prolactin receptor complex Nature 372 1994 478 481
    • (1994) Nature , vol.372 , pp. 478-481
    • Somers, W.1    Ultsch, M.2    De Vos, A.M.3    Kossiakoff, A.A.4
  • 54
    • 0020055353 scopus 로고
    • Effects of growth hormone, prolactin, and placental lactogen on insulin content and release, and deoxyribonucleic acid synthesis in cultured pancreatic islets
    • J.H. Nielsen Effects of growth hormone, prolactin, and placental lactogen on insulin content and release, and deoxyribonucleic acid synthesis in cultured pancreatic islets Endocrinology 110 1982 600 606
    • (1982) Endocrinology , vol.110 , pp. 600-606
    • Nielsen, J.H.1
  • 55
    • 0015449036 scopus 로고
    • Studies on the effects of growth hormone and thyroxine on proinsulin synthesis and insulin formation in the isolated islets of Langerhans of the rat
    • A.M. Sun, B.J. Lin, and R.E. Haist Studies on the effects of growth hormone and thyroxine on proinsulin synthesis and insulin formation in the isolated islets of Langerhans of the rat Can J Physiol Pharmacol 50 1972 1147 1151
    • (1972) Can J Physiol Pharmacol , vol.50 , pp. 1147-1151
    • Sun, A.M.1    Lin, B.J.2    Haist, R.E.3
  • 56
    • 0018838504 scopus 로고
    • Direct effects of rat growth hormone in rat islets of Langerhans in tissues culture
    • P.G. Whittaker, and K.W. Taylor Direct effects of rat growth hormone in rat islets of Langerhans in tissues culture Diabetologia 18 1980 323 328
    • (1980) Diabetologia , vol.18 , pp. 323-328
    • Whittaker, P.G.1    Taylor, K.W.2
  • 57
    • 0018962674 scopus 로고
    • Effects of growth hormone on insulin release in the rat
    • J. Pierluissi, R. Pierluissi, and S.J. Ashcroft Effects of growth hormone on insulin release in the rat Diabetologia 19 1980 391 396
    • (1980) Diabetologia , vol.19 , pp. 391-396
    • Pierluissi, J.1    Pierluissi, R.2    Ashcroft, S.J.3
  • 60
    • 0023543627 scopus 로고
    • Growth hormone regulation of somatomedin C/insulin-like growth factor i production and DNA replication in fetal rat islets in tissue culture
    • I. Swenne, D.J. Hill, A.J. Strain, and R.D. Milner Growth hormone regulation of somatomedin C/insulin-like growth factor I production and DNA replication in fetal rat islets in tissue culture Diabetes 36 1987 288 294
    • (1987) Diabetes , vol.36 , pp. 288-294
    • Swenne, I.1    Hill, D.J.2    Strain, A.J.3    Milner, R.D.4
  • 61
    • 0028175949 scopus 로고
    • Regulation of islet beta-cell proliferation by prolactin in rat islets
    • T.C. Brelje, J.A. Parsons, and R.L. Sorenson Regulation of islet beta-cell proliferation by prolactin in rat islets Diabetes 43 1994 263 273
    • (1994) Diabetes , vol.43 , pp. 263-273
    • Brelje, T.C.1    Parsons, J.A.2    Sorenson, R.L.3
  • 62
    • 0025974318 scopus 로고
    • Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: Implications for pregnancy
    • T.C. Brelje, and R.L. Sorenson Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy Endocrinology 128 1991 45 57
    • (1991) Endocrinology , vol.128 , pp. 45-57
    • Brelje, T.C.1    Sorenson, R.L.2
  • 63
    • 0020681082 scopus 로고
    • Growth hormone stimulates islet B-cell replication in neonatal rat pancreatic monolayer cultures
    • A. Rabinovitch, C. Quigley, and M.M. Rechler Growth hormone stimulates islet B-cell replication in neonatal rat pancreatic monolayer cultures Diabetes 32 1983 307 312
    • (1983) Diabetes , vol.32 , pp. 307-312
    • Rabinovitch, A.1    Quigley, C.2    Rechler, M.M.3
  • 64
    • 0027183368 scopus 로고
    • Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells
    • A. Møldrup, E.D. Petersen, and J.H. Nielsen Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells Endocrinology 133 1993 1165 1172
    • (1993) Endocrinology , vol.133 , pp. 1165-1172
    • Møldrup, A.1    Petersen, E.D.2    Nielsen, J.H.3
  • 65
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • R.L. Sorenson, and T.C. Brelje Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones Horm Metab Res 29 1997 301 307
    • (1997) Horm Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 66
    • 0025362236 scopus 로고
    • Rat insulinoma cells express both a 115-kDa growth hormone receptor and a 95-kDa prolactin receptor structurally related to the hepatic receptors
    • A. Møldrup, N. Billestrup, and J.H. Nielsen Rat insulinoma cells express both a 115-kDa growth hormone receptor and a 95-kDa prolactin receptor structurally related to the hepatic receptors J Biol Chem 265 1990 8686 8690
    • (1990) J Biol Chem , vol.265 , pp. 8686-8690
    • Møldrup, A.1    Billestrup, N.2    Nielsen, J.H.3
  • 67
    • 0028832081 scopus 로고
    • Expression and regulation of growth hormone (GH) and prolactin (PRL) receptors in a rat insulin producing cell line (INS-1)
    • M. Asfari, W. De, M. Postel-Vinay, and P. Czernichow Expression and regulation of growth hormone (GH) and prolactin (PRL) receptors in a rat insulin producing cell line (INS-1) Mol Cell Endocrinol 107 1995 209 214
    • (1995) Mol Cell Endocrinol , vol.107 , pp. 209-214
    • Asfari, M.1    De, W.2    Postel-Vinay, M.3    Czernichow, P.4
  • 68
    • 0023186410 scopus 로고
    • Effects of human placental lactogen and growth hormone on the production of insulin and somatomedin C/insulin-like growth factor i by human fetal pancreas in tissue culture
    • I. Swenne, D.J. Hill, A.J. Strain, and R.D. Milner Effects of human placental lactogen and growth hormone on the production of insulin and somatomedin C/insulin-like growth factor I by human fetal pancreas in tissue culture J Endocrinol 113 1987 297 303
    • (1987) J Endocrinol , vol.113 , pp. 297-303
    • Swenne, I.1    Hill, D.J.2    Strain, A.J.3    Milner, R.D.4
  • 69
    • 17544369037 scopus 로고    scopus 로고
    • Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation
    • L.H. Hansen, X. Wang, and J.J. Kopchick et al. Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation J Biol Chem 271 1996 12669 12673
    • (1996) J Biol Chem , vol.271 , pp. 12669-12673
    • Hansen, L.H.1    Wang, X.2    Kopchick, J.J.3
  • 70
    • 1642618179 scopus 로고    scopus 로고
    • Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: Signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediate mitogenic signalling
    • S.P. Cousin, S.R. Hugl, M.G. Myers, M.F. White, A. Reifel-Miller, and C.J. Rhodes Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediate mitogenic signalling Biochem J 344 1999 649 658
    • (1999) Biochem J , vol.344 , pp. 649-658
    • Cousin, S.P.1    Hugl, S.R.2    Myers, M.G.3    White, M.F.4    Reifel-Miller, A.5    Rhodes, C.J.6
  • 71
    • 0025954951 scopus 로고
    • The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I
    • N. Billestrup, and J. Nielsen The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I Endocrinology 129 1991 883 888
    • (1991) Endocrinology , vol.129 , pp. 883-888
    • Billestrup, N.1    Nielsen, J.2
  • 72
  • 73
    • 0035125344 scopus 로고    scopus 로고
    • Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells
    • E.D. Galsgaard, B.N. Friedrichsen, J.H. Nielsen, and A. Møldrup Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells Diabetes 50 2001 S40 S41
    • (2001) Diabetes , vol.50
    • Galsgaard, E.D.1    Friedrichsen, B.N.2    Nielsen, J.H.3    Møldrup, A.4
  • 75
    • 0035131009 scopus 로고    scopus 로고
    • Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)
    • B.N. Friedrichsen, E.D. Galsgaard, J.H. Nielsen, and A. Møldrup Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5) Mol Endocrinol 15 2001 136 148
    • (2001) Mol Endocrinol , vol.15 , pp. 136-148
    • Friedrichsen, B.N.1    Galsgaard, E.D.2    Nielsen, J.H.3    Møldrup, A.4
  • 76
    • 0037960023 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
    • B.N. Friedrichsen, H.E. Richter, and J.A. Hansen et al. Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells Mol Endocrinol 17 2003 945 958
    • (2003) Mol Endocrinol , vol.17 , pp. 945-958
    • Friedrichsen, B.N.1    Richter, H.E.2    Hansen, J.A.3
  • 77
    • 0030903830 scopus 로고    scopus 로고
    • Prolactin regulation of islet-derived INS-1 cells: Characteristics and immunocytochemical analysis of STAT5 translocation
    • L.E. Stout, A.M. Svensson, and R.L. Sorenson Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation Endocrinology 138 1997 1592 1603
    • (1997) Endocrinology , vol.138 , pp. 1592-1603
    • Stout, L.E.1    Svensson, A.M.2    Sorenson, R.L.3
  • 78
    • 36749052756 scopus 로고    scopus 로고
    • Prolactin stimulates proliferation of the glucose-dependent beta-cell line INS-1 via different IRS-proteins
    • S.R. Hügl, and M. Merger Prolactin stimulates proliferation of the glucose-dependent beta-cell line INS-1 via different IRS-proteins JOP 8 2007 739 752
    • (2007) JOP , vol.8 , pp. 739-752
    • Hügl, S.R.1    Merger, M.2
  • 79
    • 9244232272 scopus 로고    scopus 로고
    • Cytokine induced apoptotic cell-death in a mouse pancreatic beta-cell line: Inhibition by bcl-2
    • H. Iwahashi, T. Hanafusa, and Y. Eguchi et al. Cytokine induced apoptotic cell-death in a mouse pancreatic beta-cell line: inhibition by bcl-2 Diabetologia 39 1996 530 536
    • (1996) Diabetologia , vol.39 , pp. 530-536
    • Iwahashi, H.1    Hanafusa, T.2    Eguchi, Y.3
  • 80
    • 0345161818 scopus 로고    scopus 로고
    • Transfection of human pancreatic islets with anti-apoptotic gene (bcl-2) proteins beta-cells from cytokine-induced destruction
    • A. Rabinovitch, W. Suarez-Pinzon, and K. Strynadka et al. Transfection of human pancreatic islets with anti-apoptotic gene (bcl-2) proteins beta-cells from cytokine-induced destruction Diabetes 48 1999 1223 1229
    • (1999) Diabetes , vol.48 , pp. 1223-1229
    • Rabinovitch, A.1    Suarez-Pinzon, W.2    Strynadka, K.3
  • 81
    • 0006082255 scopus 로고    scopus 로고
    • Effect of growth hormone and prolactin on cytokine induced toxicity in the INS-1 beta cell line (abstract)
    • A.E. Karlsen, E.D. Galsgarrd, J. Nerup, and J.H. Nielsen Effect of growth hormone and prolactin on cytokine induced toxicity in the INS-1 beta cell line (abstract) Eur J Endocrinol 142 2000 10
    • (2000) Eur J Endocrinol , vol.142 , pp. 10
    • Karlsen, A.E.1    Galsgarrd, E.D.2    Nerup, J.3    Nielsen, J.H.4
  • 82
    • 80052522174 scopus 로고    scopus 로고
    • Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways
    • L.F. Terra, M.H. Garay-Malpartida, R.A. Wailemann, M.C. Sogayar, and L. Labriola Recombinant human prolactin promotes human beta cell survival via inhibition of extrinsic and intrinsic apoptosis pathways Diabetologia 54 2011 1388 1397
    • (2011) Diabetologia , vol.54 , pp. 1388-1397
    • Terra, L.F.1    Garay-Malpartida, M.H.2    Wailemann, R.A.3    Sogayar, M.C.4    Labriola, L.5
  • 83
    • 35648994807 scopus 로고    scopus 로고
    • Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation
    • Y. Fujinaka, K. Takane, H. Yamashita, and R.C. Vasavada Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation J Biol Chem 282 2007 30707 30717
    • (2007) J Biol Chem , vol.282 , pp. 30707-30717
    • Fujinaka, Y.1    Takane, K.2    Yamashita, H.3    Vasavada, R.C.4
  • 84
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • T. Naka, M. Narazaki, and M. Hirata et al. Structure and function of a new STAT-induced STAT inhibitor Nature 387 1997 924 929
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1    Narazaki, M.2    Hirata, M.3
  • 85
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • R. Starr, T.A. Willson, and E.M. Viney et al. A family of cytokine-inducible inhibitors of signalling Nature 387 1997 917 921
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1    Willson, T.A.2    Viney, E.M.3
  • 86
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • T.A. Endo, M. Masuhara, and M. Yokouchi et al. A new protein containing an SH2 domain that inhibits JAK kinases Nature 387 1997 921 924
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1    Masuhara, M.2    Yokouchi, M.3
  • 87
    • 35648933970 scopus 로고    scopus 로고
    • Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor
    • I. Uyttendaele, I. Lemmens, and A. Verhee et al. Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor Mol Endocrinol 21 2007 2821 2831
    • (2007) Mol Endocrinol , vol.21 , pp. 2821-2831
    • Uyttendaele, I.1    Lemmens, I.2    Verhee, A.3
  • 88
    • 0031915126 scopus 로고    scopus 로고
    • Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
    • T.E. Adams, J.A. Hansen, R. Starr, N.A. Nicola, D.J. Hilton, and N. Billestrup Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling J Biol Chem 273 1998 1285 1287
    • (1998) J Biol Chem , vol.273 , pp. 1285-1287
    • Adams, T.E.1    Hansen, J.A.2    Starr, R.3    Nicola, N.A.4    Hilton, D.J.5    Billestrup, N.6
  • 89
    • 0033305402 scopus 로고    scopus 로고
    • Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
    • J.A. Hansen, K. Lindberg, D.J. Hilton, J.H. Nielsen, and N. Billestrup Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins Mol Endocrinol 13 1999 1832 1843
    • (1999) Mol Endocrinol , vol.13 , pp. 1832-1843
    • Hansen, J.A.1    Lindberg, K.2    Hilton, D.J.3    Nielsen, J.H.4    Billestrup, N.5
  • 90
    • 0034729710 scopus 로고    scopus 로고
    • Gigantism in mice lacking suppressor of cytokine signalling-2
    • D. Metcalf, C.J. Greenhalgh, and E. Viney et al. Gigantism in mice lacking suppressor of cytokine signalling-2 Nature 405 2000 1069 1073
    • (2000) Nature , vol.405 , pp. 1069-1073
    • Metcalf, D.1    Greenhalgh, C.J.2    Viney, E.3
  • 91
    • 0035862334 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
    • Y. Kawazoe, T. Naka, and M. Fujimoto et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation J Exp Med 193 2001 263 269
    • (2001) J Exp Med , vol.193 , pp. 263-269
    • Kawazoe, Y.1    Naka, T.2    Fujimoto, M.3
  • 92
    • 69449089392 scopus 로고    scopus 로고
    • Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells
    • C. Bruun, P.E. Heding, and S.G. Rønn et al. Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells Mol Cell Endocrinol 311 2009 32 38
    • (2009) Mol Cell Endocrinol , vol.311 , pp. 32-38
    • Bruun, C.1    Heding, P.E.2    Rønn, S.G.3
  • 93
    • 4143085927 scopus 로고    scopus 로고
    • Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice
    • J.L. Liu, K.T. Coschigano, and K. Robertson et al. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice Am J Physiol Endocrinol Metab 287 2004 405 413
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. 405-413
    • Liu, J.L.1    Coschigano, K.T.2    Robertson, K.3
  • 94
    • 18344382724 scopus 로고    scopus 로고
    • Targeted deletion of the PRL receptor: Effects on islet development, insulin production, and glucose tolerance
    • M. Freemark, I. Avril, and D. Fleenor et al. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance Endocrinology 143 2002 1378 1385
    • (2002) Endocrinology , vol.143 , pp. 1378-1385
    • Freemark, M.1    Avril, I.2    Fleenor, D.3
  • 95
    • 34548488987 scopus 로고    scopus 로고
    • The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging
    • J.Y. Lee, O. Gavrilova, B. Davani, R. Na, G.W. Robinson, and L. Hennighausen The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging Biochim Biophys Acta 1773 2007 1455 1461
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1455-1461
    • Lee, J.Y.1    Gavrilova, O.2    Davani, B.3    Na, R.4    Robinson, G.W.5    Hennighausen, L.6
  • 96
    • 79957887666 scopus 로고    scopus 로고
    • Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice
    • Y. Wu, C. Liu, and H. Sun et al. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice J Clin Invest 121 2011 2422 2426
    • (2011) J Clin Invest , vol.121 , pp. 2422-2426
    • Wu, Y.1    Liu, C.2    Sun, H.3
  • 97
    • 0033594893 scopus 로고    scopus 로고
    • Normal growth and development in the absence of hepatic insulin-like growth factor i
    • S. Yakar, J.L. Liu, and B. Stannard et al. Normal growth and development in the absence of hepatic insulin-like growth factor I Proc Natl Acad Sci U S A 96 1999 7324 7329
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7324-7329
    • Yakar, S.1    Liu, J.L.2    Stannard, B.3
  • 98
    • 13044294029 scopus 로고    scopus 로고
    • Liver-derived insulin-like growth factor i (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
    • K. Sjögren, J.L. Liu, and K. Blad et al. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice Proc Natl Acad Sci U S A 96 1999 7088 7092
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7088-7092
    • Sjögren, K.1    Liu, J.L.2    Blad, K.3
  • 99
    • 0346206633 scopus 로고
    • A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro
    • W.D. Salmon, and W.H. Daughaday A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro J Lab Clin Med 49 1957 825 836
    • (1957) J Lab Clin Med , vol.49 , pp. 825-836
    • Salmon, W.D.1    Daughaday, W.H.2
  • 100
    • 0034042726 scopus 로고    scopus 로고
    • Growth hormone axis overview - Somatomedin hypothesis
    • W.H. Daughaday Growth hormone axis overview - somatomedin hypothesis Pediatr Nephrol 14 2000 537 540
    • (2000) Pediatr Nephrol , vol.14 , pp. 537-540
    • Daughaday, W.H.1
  • 101
    • 0033305250 scopus 로고    scopus 로고
    • Effects of Igf1 gene deletion on postnatal growth patterns
    • J. Wang, J. Zhou, L. Powell-Braxton, and C. Bondy Effects of Igf1 gene deletion on postnatal growth patterns Endocrinology 140 1999 3391 3394
    • (1999) Endocrinology , vol.140 , pp. 3391-3394
    • Wang, J.1    Zhou, J.2    Powell-Braxton, L.3    Bondy, C.4
  • 102
    • 0033303497 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 is essential for postnatal growth in response to growth hormone
    • J.L. Liu, and D. LeRoith Insulin-like growth factor 1 is essential for postnatal growth in response to growth hormone Endocrinology 140 1999 5178 5184
    • (1999) Endocrinology , vol.140 , pp. 5178-5184
    • Liu, J.L.1    Leroith, D.2
  • 103
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    • S. Favelyukis, J.H. Till, S.R. Hubbard, and W.T. Miller Structure and autoregulation of the insulin-like growth factor 1 receptor kinase Nat Struct Biol 8 2001 1058 1063
    • (2001) Nat Struct Biol , vol.8 , pp. 1058-1063
    • Favelyukis, S.1    Till, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 105
    • 56549091431 scopus 로고    scopus 로고
    • The complexity of mitogen-activated protein kinases (MAPKs) made simple
    • M. Krishna, and H. Narang The complexity of mitogen-activated protein kinases (MAPKs) made simple Cell Mol Life Sci 65 2008 3525 3544
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3525-3544
    • Krishna, M.1    Narang, H.2
  • 106
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 107
    • 0034685906 scopus 로고    scopus 로고
    • Mechanism of STAT3 activation by insulin-like growth factor i receptor
    • C.S. Zong, J. Chan, D.E. Levy, C. Horvath, H.B. Sadowski, and L.H. Wang Mechanism of STAT3 activation by insulin-like growth factor I receptor J Biol Chem 275 2000 15099 15105
    • (2000) J Biol Chem , vol.275 , pp. 15099-15105
    • Zong, C.S.1    Chan, J.2    Levy, D.E.3    Horvath, C.4    Sadowski, H.B.5    Wang, L.H.6
  • 108
    • 0035816697 scopus 로고    scopus 로고
    • Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase
    • P. Peraldi, C. Filloux, B. Emanuelli, D.J. Hilton, and E. Van Obberghen Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase J Biol Chem 276 2001 24614 24620
    • (2001) J Biol Chem , vol.276 , pp. 24614-24620
    • Peraldi, P.1    Filloux, C.2    Emanuelli, B.3    Hilton, D.J.4    Van Obberghen, E.5
  • 109
    • 0032189323 scopus 로고    scopus 로고
    • Insulin signalling in heart involves insulin receptor substrates-1 and -2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway
    • L.A. Velloso, C.R. Carvalho, F.A. Rojas, F. Folli, and M.J. Saad Insulin signalling in heart involves insulin receptor substrates-1 and -2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway Cardiovasc Res 40 1998 96 102
    • (1998) Cardiovasc Res , vol.40 , pp. 96-102
    • Velloso, L.A.1    Carvalho, C.R.2    Rojas, F.A.3    Folli, F.4    Saad, M.J.5
  • 111
    • 0036549647 scopus 로고    scopus 로고
    • Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function
    • R. Kulkarni Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function Biochem Soc Trans 30 2002 317 322
    • (2002) Biochem Soc Trans , vol.30 , pp. 317-322
    • Kulkarni, R.1
  • 112
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • D.J. Withers, J.S. Gutierrez, and H.H. Towery et al. Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900 904
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1    Gutierrez, J.S.2    Towery, H.H.3
  • 113
    • 0032841435 scopus 로고    scopus 로고
    • IRS-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signaling
    • D.J. Withers, D.J. Burks, H.H. Towery, S.L. Altamuro, C.L. Flint, and M.F. White IRS-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signaling Nat Genet 23 1999 32 40
    • (1999) Nat Genet , vol.23 , pp. 32-40
    • Withers, D.J.1    Burks, D.J.2    Towery, H.H.3    Altamuro, S.L.4    Flint, C.L.5    White, M.F.6
  • 114
    • 0036615436 scopus 로고    scopus 로고
    • Molecular insights into insulin action and secretion
    • C.J. Rhodes, and M.F. White Molecular insights into insulin action and secretion Eur J Clin Invest 32 2002 3 13
    • (2002) Eur J Clin Invest , vol.32 , pp. 3-13
    • Rhodes, C.J.1    White, M.F.2
  • 115
    • 0344960402 scopus 로고
    • Enhanced IGF-1 expression in regenerating rat pancreas is localized to capillaries and proliferating duct cells
    • F. Smith, K. Rosen, L. Villa-Komarof, G.C. Weir, and S. Bonner-Weir Enhanced IGF-1 expression in regenerating rat pancreas is localized to capillaries and proliferating duct cells Diabetes 39 Suppl 1 1990 66A
    • (1990) Diabetes , vol.39 , Issue.SUPPL. 1
    • Smith, F.1    Rosen, K.2    Villa-Komarof, L.3    Weir, G.C.4    Bonner-Weir, S.5
  • 116
    • 0027250196 scopus 로고
    • Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones
    • C. Maake, and M. Reinecke Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones Cell Tissue Res 273 1993 249 259
    • (1993) Cell Tissue Res , vol.273 , pp. 249-259
    • Maake, C.1    Reinecke, M.2
  • 117
    • 4444318488 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats: Comparison with growth hormone replacement
    • T. Jevdjovic, C. Maake, E. Eppler, E. Zoidis, M. Reinecke, and J. Zapf Effects of insulin-like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats: comparison with growth hormone replacement Eur J Endocrinol 151 2004 223 231
    • (2004) Eur J Endocrinol , vol.151 , pp. 223-231
    • Jevdjovic, T.1    Maake, C.2    Eppler, E.3    Zoidis, E.4    Reinecke, M.5    Zapf, J.6
  • 118
    • 18744382772 scopus 로고    scopus 로고
    • The effect of hypophysectomy on pancreatic islet hormone and insulin-like growth factor i content and mRNA expression in rat
    • T. Jevdjovic, C. Maake, and C. Zwimpfer et al. The effect of hypophysectomy on pancreatic islet hormone and insulin-like growth factor I content and mRNA expression in rat Histochem Cell Biol 123 2005 179 188
    • (2005) Histochem Cell Biol , vol.123 , pp. 179-188
    • Jevdjovic, T.1    Maake, C.2    Zwimpfer, C.3
  • 119
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • S.E. Kahn The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 2003 3 19
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 120
    • 0035130272 scopus 로고    scopus 로고
    • Beta-cell adaptation and decompensation during the progression of diabetes
    • G.C. Weir, D.R. Laybutt, H. Kaneto, S. Bonner-Weir, and A. Sharma Beta-cell adaptation and decompensation during the progression of diabetes Diabetes 50 2001 S154 S159
    • (2001) Diabetes , vol.50
    • Weir, G.C.1    Laybutt, D.R.2    Kaneto, H.3    Bonner-Weir, S.4    Sharma, A.5
  • 121
    • 0035125526 scopus 로고    scopus 로고
    • Beta-cell mass and function in type 2 diabetes: IRS proteins and beta-cell function
    • D.J. Burks, and M.F. White Beta-cell mass and function in type 2 diabetes: IRS proteins and beta-cell function Diabetes 50 2001 S140 S145
    • (2001) Diabetes , vol.50
    • Burks, D.J.1    White, M.F.2
  • 122
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
    • E. Araki, M. Lipes, and M. Patti et al. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186 190
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1    Lipes, M.2    Patti, M.3
  • 123
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • H. Tamemoto, T. Kadowaki, and K. Tobe et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 Nature 372 1994 182 186
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1    Kadowaki, T.2    Tobe, K.3
  • 124
    • 0036578921 scopus 로고    scopus 로고
    • Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
    • R. Kulkarni, M. Holzenberger, and D. Shih et al. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass Nat Genet 31 2002 111 115
    • (2002) Nat Genet , vol.31 , pp. 111-115
    • Kulkarni, R.1    Holzenberger, M.2    Shih, D.3
  • 125
    • 0036791398 scopus 로고    scopus 로고
    • Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor
    • S. Xuan, T. Kitamura, and J. Nakae et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor J Clin Invest 110 2002 1011 1019
    • (2002) J Clin Invest , vol.110 , pp. 1011-1019
    • Xuan, S.1    Kitamura, T.2    Nakae, J.3
  • 126
    • 33646351975 scopus 로고    scopus 로고
    • Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
    • K. Ueki, T. Okada, and J. Hu et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes Nat Genet 38 2006 583 588
    • (2006) Nat Genet , vol.38 , pp. 583-588
    • Ueki, K.1    Okada, T.2    Hu, J.3
  • 127
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor i (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent
    • S.R. Hügl, M.F. White, and C.J. Rhodes Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent J Biol Chem 273 1998 17771 17779
    • (1998) J Biol Chem , vol.273 , pp. 17771-17779
    • Hügl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 128
    • 0034511784 scopus 로고    scopus 로고
    • Introduction: The molecular cell biology of insulin production
    • C.J. Rhodes Introduction: the molecular cell biology of insulin production Semin Cell Dev Biol 11 2000 223 225
    • (2000) Semin Cell Dev Biol , vol.11 , pp. 223-225
    • Rhodes, C.J.1
  • 129
    • 0035111325 scopus 로고    scopus 로고
    • Free fatty acid-induced inhibition of glucose and insulin-like growth factor 1-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1
    • S. Cousin, S. Hugl, C. Wrede, H. Kjio, M. Myers, and C. Rhodes Free fatty acid-induced inhibition of glucose and insulin-like growth factor 1-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1 Endocrinology 142 2001 229 240
    • (2001) Endocrinology , vol.142 , pp. 229-240
    • Cousin, S.1    Hugl, S.2    Wrede, C.3    Kjio, H.4    Myers, M.5    Rhodes, C.6
  • 130
    • 0036224165 scopus 로고    scopus 로고
    • Activation of IRS-2 mediated signal transduction by IGF-1, but not by TGF or EGF, augments pancreatic cell proliferation
    • M. Lingohr, L. Dickson, J. McCuaig, S. Hugl, D. Twardzik, and C. Rhodes Activation of IRS-2 mediated signal transduction by IGF-1, but not by TGF or EGF, augments pancreatic cell proliferation Diabetes 51 2002 966 976
    • (2002) Diabetes , vol.51 , pp. 966-976
    • Lingohr, M.1    Dickson, L.2    McCuaig, J.3    Hugl, S.4    Twardzik, D.5    Rhodes, C.6
  • 131
    • 12544252740 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
    • I. Briaud, L.M. Dickson, M.K. Lingohr, J.F. McCuaig, J.C. Lawrence, and C.J. Rhodes Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells J Biol Chem 280 2005 2282 2293
    • (2005) J Biol Chem , vol.280 , pp. 2282-2293
    • Briaud, I.1    Dickson, L.M.2    Lingohr, M.K.3    McCuaig, J.F.4    Lawrence, J.C.5    Rhodes, C.J.6
  • 132
    • 0242329748 scopus 로고    scopus 로고
    • Decreasing IRS-2 expression in pancreatic cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression
    • M.K. Lingohr, L.M. Dickson, and C.E. Wrede et al. Decreasing IRS-2 expression in pancreatic cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression Mol Cell Endocrinol 209 2003 17 31
    • (2003) Mol Cell Endocrinol , vol.209 , pp. 17-31
    • Lingohr, M.K.1    Dickson, L.M.2    Wrede, C.E.3
  • 133
    • 0034781057 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
    • R.L. Tuttle, N.S. Gill, and W. Pugh et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha Nat Med 7 2001 1133 1137
    • (2001) Nat Med , vol.7 , pp. 1133-1137
    • Tuttle, R.L.1    Gill, N.S.2    Pugh, W.3
  • 134
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid induced apoptosis in pancreatic beta-cells (INS-1)
    • C.E. Wrede, L.M. Dickson, M.K. Lingohr, I. Briaud, J.F. McCuaig, and C.J. Rhodes Protein kinase B/Akt prevents fatty acid induced apoptosis in pancreatic beta-cells (INS-1) J Biol Chem 277 2002 49676 49684
    • (2002) J Biol Chem , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    McCuaig, J.F.5    Rhodes, C.J.6
  • 135
    • 1642453553 scopus 로고    scopus 로고
    • Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing
    • G. da Silva Xavier, Q. Qian, P. Cullen, and G. Rutter Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing Biochem J 377 2004 149 158
    • (2004) Biochem J , vol.377 , pp. 149-158
    • Da Silva Xavier, G.1    Qian, Q.2    Cullen, P.3    Rutter, G.4
  • 136
    • 85047677059 scopus 로고    scopus 로고
    • Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1
    • N. Sekine, S. Ullrich, R. Regazzi, W. Pralong, and C. Wollheim Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1 Endocrinology 137 1996 1841 1850
    • (1996) Endocrinology , vol.137 , pp. 1841-1850
    • Sekine, N.1    Ullrich, S.2    Regazzi, R.3    Pralong, W.4    Wollheim, C.5
  • 137
    • 0032544722 scopus 로고    scopus 로고
    • Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: Role of Fas
    • M. Harrison, A. Dunger, and S. Berg et al. Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas FEBS Lett 435 1998 207 210
    • (1998) FEBS Lett , vol.435 , pp. 207-210
    • Harrison, M.1    Dunger, A.2    Berg, S.3
  • 138
    • 0036740049 scopus 로고    scopus 로고
    • Circulating levels of IGF-1 directly regulate bone growth and density
    • S. Yakar, C.J. Rosen, and W.G. Beamer et al. Circulating levels of IGF-1 directly regulate bone growth and density J Clin Invest 110 2002 771 781
    • (2002) J Clin Invest , vol.110 , pp. 771-781
    • Yakar, S.1    Rosen, C.J.2    Beamer, W.G.3
  • 139
    • 0035175162 scopus 로고    scopus 로고
    • Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth
    • F. Lupu, J.D. Terwilliger, K. Lee, G.V. Segre, and A. Efstratiadis Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth Dev Biol 229 2001 141 162
    • (2001) Dev Biol , vol.229 , pp. 141-162
    • Lupu, F.1    Terwilliger, J.D.2    Lee, K.3    Segre, G.V.4    Efstratiadis, A.5
  • 140
    • 82055194416 scopus 로고    scopus 로고
    • Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-Cells
    • F. Ma, Z. Wei, and C. Shi et al. Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-Cells Mol Endocrinol 25 2011 2119 2133
    • (2011) Mol Endocrinol , vol.25 , pp. 2119-2133
    • Ma, F.1    Wei, Z.2    Shi, C.3
  • 141
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • A.M. de Vos, M. Ultsch, and A.A. Kossiakoff Human growth hormone and extracellular domain of its receptor: crystal structure of the complex Science 255 1992 306 312
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 142
    • 26944493862 scopus 로고    scopus 로고
    • Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    • R.J. Brown, J.J. Adams, and R.A. Pelekanos et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer Nat Struct Mol Biol 12 2005 814 821
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 814-821
    • Brown, R.J.1    Adams, J.J.2    Pelekanos, R.A.3
  • 143
    • 33748309115 scopus 로고    scopus 로고
    • Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding
    • M.J. van den Eijnden, L.L. Lahaye, and G.J. Strous Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding J Cell Sci 119 2006 3078 3086
    • (2006) J Cell Sci , vol.119 , pp. 3078-3086
    • Van Den Eijnden, M.J.1    Lahaye, L.L.2    Strous, G.J.3
  • 144
    • 56449119800 scopus 로고    scopus 로고
    • Modulation of growth hormone receptor abundance and function: Roles for the ubiquitin-proteasome system
    • S.J. Frank, and S.Y. Fuchs Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system Biochim Biophys Acta 1782 2008 785 794
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 785-794
    • Frank, S.J.1    Fuchs, S.Y.2
  • 145
    • 0036800303 scopus 로고    scopus 로고
    • Growth hormone receptor antagonists: Discovery, development, and use in patients with acromegaly
    • J.J. Kopchick, C. Parkinson, E.C. Stevens, and P.J. Trainer Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly Endocr Rev 23 2002 623 646
    • (2002) Endocr Rev , vol.23 , pp. 623-646
    • Kopchick, J.J.1    Parkinson, C.2    Stevens, E.C.3    Trainer, P.J.4
  • 146
    • 0031769049 scopus 로고    scopus 로고
    • Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor
    • P. Gual, V. Baron, V. Lequoy, and E. Van Obberghen Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor Endocrinology 139 1998 884 893
    • (1998) Endocrinology , vol.139 , pp. 884-893
    • Gual, P.1    Baron, V.2    Lequoy, V.3    Van Obberghen, E.4
  • 147
    • 0032755252 scopus 로고    scopus 로고
    • Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization
    • Y. Zhang, J. Jiang, J.J. Kopchick, and S.J. Frank Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization J Biol Chem 274 1999 33072 33084
    • (1999) J Biol Chem , vol.274 , pp. 33072-33084
    • Zhang, Y.1    Jiang, J.2    Kopchick, J.J.3    Frank, S.J.4
  • 148
    • 77349121167 scopus 로고    scopus 로고
    • Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling
    • Y. Gan, Y. Zhang, and D.J. Digirolamo et al. Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling Mol Endocrinol 24 2010 644 656
    • (2010) Mol Endocrinol , vol.24 , pp. 644-656
    • Gan, Y.1    Zhang, Y.2    Digirolamo, D.J.3
  • 149
    • 0033324510 scopus 로고    scopus 로고
    • Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growth
    • S.R. Edmondson, V.C. Russo, A.C. McFarlane, C.J. Wraight, and G.A. Werther Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growth J Clin Endocrinol Metab 84 1999 1638 1644
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1638-1644
    • Edmondson, S.R.1    Russo, V.C.2    McFarlane, A.C.3    Wraight, C.J.4    Werther, G.A.5
  • 150
    • 0026705631 scopus 로고
    • Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells
    • G. Ashcom, G. Gurland, and J. Schwartz Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells Endocrinology 131 1992 1915 1921
    • (1992) Endocrinology , vol.131 , pp. 1915-1921
    • Ashcom, G.1    Gurland, G.2    Schwartz, J.3
  • 151
    • 0028084965 scopus 로고
    • Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture
    • Z. Ling, J.C. Hannaert, and D. Pipeleers Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture Diabetologia 37 1994 15 21
    • (1994) Diabetologia , vol.37 , pp. 15-21
    • Ling, Z.1    Hannaert, J.C.2    Pipeleers, D.3
  • 152
    • 34247259818 scopus 로고    scopus 로고
    • Physiological regulation of the pancreatic beta-cell: Functional insights for understanding and therapy of diabetes
    • N.H. McClenaghan Physiological regulation of the pancreatic beta-cell: functional insights for understanding and therapy of diabetes Exp Physiol 92 2007 481 496
    • (2007) Exp Physiol , vol.92 , pp. 481-496
    • McClenaghan, N.H.1
  • 153
    • 8344271936 scopus 로고    scopus 로고
    • Cell lines derived from pancreatic islets
    • H. Hohmeier, and C. Newgard Cell lines derived from pancreatic islets Mol Cell Endocrinol 228 2004 121 128
    • (2004) Mol Cell Endocrinol , vol.228 , pp. 121-128
    • Hohmeier, H.1    Newgard, C.2
  • 154
    • 33646562823 scopus 로고    scopus 로고
    • Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation
    • A. Sotiropoulos, M. Ohanna, and C. Kedzia et al. Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation Proc Natl Acad Sci U S A 103 2006 7315 7320
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7315-7320
    • Sotiropoulos, A.1    Ohanna, M.2    Kedzia, C.3
  • 155
    • 35748958108 scopus 로고    scopus 로고
    • Mode of growth hormone action in osteoblasts
    • D.J. DiGirolamo, A. Mukherjee, and K. Fulzele et al. Mode of growth hormone action in osteoblasts J Biol Chem 282 2007 31666 31674
    • (2007) J Biol Chem , vol.282 , pp. 31666-31674
    • Digirolamo, D.J.1    Mukherjee, A.2    Fulzele, K.3
  • 157
    • 0035313701 scopus 로고    scopus 로고
    • The Stat family in cytokine signaling
    • J.N. Ihle The Stat family in cytokine signaling Curr Opin Cell Biol 13 2001 211 217
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 211-217
    • Ihle, J.N.1
  • 158
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • D.E. Levy, and J.E.J. Darnell Stats: transcriptional control and biological impact Nat Rev Mol Cell Biol 3 2002 651 662
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.J.2
  • 159
    • 38549182470 scopus 로고    scopus 로고
    • Protein kinase B: Signalling roles and therapeutic targeting
    • E.M. Sale, and G.J. Sale Protein kinase B: signalling roles and therapeutic targeting Cell Mol Life Sci 65 2008 113 127
    • (2008) Cell Mol Life Sci , vol.65 , pp. 113-127
    • Sale, E.M.1    Sale, G.J.2
  • 160
    • 68149137267 scopus 로고    scopus 로고
    • Growth hormone increases beta-cell proliferation in transplanted human and fetal rat islets
    • E. Höglund, G. Mattsson, B. Tyrberg, A. Andersson, and C. Carlsson Growth hormone increases beta-cell proliferation in transplanted human and fetal rat islets JOP 10 2009 242 248
    • (2009) JOP , vol.10 , pp. 242-248
    • Höglund, E.1    Mattsson, G.2    Tyrberg, B.3    Andersson, A.4    Carlsson, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.