Circulating levels of IGF-1 directly regulate bone growth and density

Journal of Clinical Investigation

Volumn 110, Issue 6, 2002, Pages 771-781

  Yakar, Shoshana ^a   Rosen, Clifford J ^b   Beamer, Wesley G ^b   Ackert Bicknell, Cheryl L ^b   Wu, Yiping ^a   Liu, Jun Li ^c   Ooi, Guck T ^d   Setser, Jennifer ^a   Frystyk, Jan ^e   Boisclair, Yves R ^f   LeRoith, Derek ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b JACKSON LABORATORY   (United States)

^c ROYAL VICTORIA HOSPITAL   (Canada)

^d HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

^f Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY HEIGHT; BONE DENSITY; BONE GROWTH; BONE MINERAL; CARTILAGE CELL; CONTROLLED STUDY; CORTICAL BONE; FEMALE; GENE DISRUPTION; GROWTH PLATE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OSTEOPOROSIS; PATHOPHYSIOLOGY; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THICKNESS; TIBIA;

EID: 0036740049     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215463     Document Type: Article

References (33)

1. Insulin-like growth factors and their binding proteins: Biological actions
2. Insulin-like growth factor(IGF) and IGF-binding proteins: Comparison of human serum and lymph
3. Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart
4. The somatomedin hypothesis: 2001
5. Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice
6. Normal growth and development in the absence of hepatic insulin-like growth factor I
7. Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system
8. Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity
9. Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats
10. Genetic variability in adult bone density among inbred strains of mice
11. Direct three-dimensional morphometric analysis of human cancellous bone: Microstructural data from spine, femur, iliac crest, and calcaneus
12. The serum half-life of somatomedin activity: Evidence for growth hormone dependence
13. Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy
14. The 16-kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a targeted disruption of the type 1 IGF receptor gene
15. Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation
16. Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy
17. Insulin-like growth factor I (IGF-I)-binding protein complex is a better mitogen than free IGF-I
18. Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity
19. Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-1-stimulated DNA synthesis in human skin fibroblasts
20. Increased clearance and degradation of [3H]insulin in streptozotocin diabetic rats
21. Differential effects of growth hormone and insulin-like growth factor I on colony formation of epiphyseal chondrocytes in suspension culture in rats of different ages
22. Growth hormone potentiates colony formation of epiphyseal chondrocytes in suspension culture
23. Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation
24. Effect of growth hormone and insulin-like growth factor-I on DNA synthesis and matrix production in rat epiphyseal chondrocytes in monolayer culture
25. Insulin-like growth factors and bone: The osteoporosis connection
26. Serum insulin-like growth factors and insulin-like growth factor-binding proteins: Clinical implications
27. Clinical review 123: Anabolic therapy for osteoporosis
28. Igf1 promotes longitudinal bone growth by insulin-like actions augmenting chondrocyte hypertrophy
29. Roles of growth hormone and insulin-like growth factor I in mouse postnatal growth
30. Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities
31. Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
32. Association between insulin-like growth factor I and bone mineral density in older women and men: The Framingham Heart Study
33. Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women