Stimulation of pancreatic β-cell proliferation by growth hormone is glucose dependent: Signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling

Biochemical Journal

Volumn 344, Issue 3, 1999, Pages 649-658

  Cousin, Sharon P ^a   Hügl, Sigrun R ^a   Myers Jr , Martin G ^b   White, Morris F ^b   Reifel Miller, Anne ^c   Rhodes, Christopher J ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

MAP kinase; Nutrient stimulus response coupling; Phosphatidylinositol 3' kinase; Tyrosine phosphorylation

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C; STAT5 PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; ENZYME ACTIVATION; GLUCOSE METABOLISM; MITOGENESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; GLUCOSE; GRB2 ADAPTOR PROTEIN; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; JANUS KINASE 2; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEIN, DROSOPHILA; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

ANIMALIA; JANUS; MURINAE;

EID: 1642618179     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3440649     Document Type: Article

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