Pancreatic β-cell growth and survival - A role in obesity-linked type 2 diabetes?

Trends in Molecular Medicine

Volumn 8, Issue 8, 2002, Pages 375-384

  Lingohr, Melissa K ^a   Buettner, Roland ^b   Rhodes, Christopher J ^c  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN;

ADAPTATION; ADULT; ANIMAL EXPERIMENT; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DISEASE SEVERITY; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RESISTANCE; KNOCKOUT MOUSE; MITOGENESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PATHOGENESIS; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CELL SURVIVAL; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; GROWTH HORMONE; HUMANS; HYPERGLYCEMIA; HYPERLIPIDEMIAS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; OBESITY; PHOSPHOPROTEINS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; MUS MUSCULUS;

EID: 0036319371     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02377-8     Document Type: Review

References (116)

1. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
2. Disruption of IRS-2 causes type 2 diabetes in mice
3. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
4. Islet growth and development in the adult
5. Clinical review 135: The importance of β-cell failure in the development and progression of type 2 diabetes
6. β-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion
7. Molecular insights into insulin action and secretion
8. The continuing epidemics of obesity and diabetes in the United States
9. Global and societal implications of the diabetes epidemic
10. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
11. Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones
12. Type 2 diabetes in children and adolescents: An emerging disease
13. The β cell transcription factors and development of the pancreas
14. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
15. Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia
16. Diseases of liporegulation: New perspective on obesity and related disorders
17. Decreased insulin secretion in type 2 diabetes: A problem of cellular mass or function?
18. Islet amyloid: A long-recognized but underappreciated pathological feature of type 2 diabetes
19. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide
20. β-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes
21. Minireview: Secondary β-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity
22. Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
23. Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: Signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling
24. Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
25. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas
26. Prevention of β cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I
27. Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice
28. Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia
29. Transgenic mice overexpressing insulin-like growth factor-II in β cells develop type 2 diabetes
30. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
31. A model to explore the interaction between muscle insulin resistance and β-cell dysfunction in the development of type 2 diabetes
32. Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to β-cell hyperplasia in mutant mice lacking insulin
33. Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)
34. Growth hormone is a growth factor for the differentiated pancreatic β-cell
35. Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: Effect of lactogenic hormones
36. Regulation of islet β-cell proliferation by prolactin in rat islets
37. Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones
38. Targeted expression of placental lactogen in the β cells of transgenic mice results in β cell proliferation, islet mass augmentation, and hypoglycemia
39. Targeted deletion of the PRL receptor: Effects on islet development, insulin production, and glucose tolerance
40. Protein kinase Cζ activation mediates glucagon-like peptide-1-induced pancreatic β-cell proliferation
41. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
42. Glucose-dependent insulinotropic polypeptide is a growth factor for β-(INS-1) cells by pleiotropic signaling
43. Hepatocyte growth factor overexpression in the islet of transgenic mice increases β cell proliferation, enhances islet mass, and induces mild hypoglycemia
44. Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact
45. Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells
46. Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia
47. Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse
48. Promotion of β-cell regeneration by betacellulin in ninety percent-pancreatectomized rats
49. A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth
50. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: Identification of betacellulin as a novel β-cell mitogen
51. Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting β-cell line, INS-1
52. NGF-withdrawal induces apoptosis in pancreatic β cells in vitro
53. Mechanisms of pancreatic β-cell growth and regeneration: Studies on rat insulinoma cells
54. Effects of platelet-derived growth factor and somatomedin-C/insulin-like growth factor I on the deoxyribonucleic acid replication of fetal rat islets of Langerhans in tissue culture
55. Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF β receptor in isolated pancreatic islet cells stimulates DNA synthesis
56. Leptin induces proliferation of pancreatic β cell line MIN6 through activation of mitogen-activated protein kinase
57. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes
58. Glucose-stimulated DNA replication of the pancreatic islets during the development of the rat fetus. Effects of nutrients, growth hormone, and triiodothyronine
59. Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion
60. Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program
61. + concentration
62. Effect of nutrients, hormones and serum on survival of rat islet β cells in culture
63. Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1
64. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic β-cells. A possible role in protein translation and mitogenic signaling
65. Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
66. Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover
67. Pancreatic β-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids
68. Attenuation of FGF signalling in mouse β-cells leads to diabetes
69. Factors controlling pancreatic cell differentiation and function
70. Transgenie expression of epidermal growth factor and keratinocyte growth factor in β-cells results in substantial morphological changes
71. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α
72. Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro
73. Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium
74. Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor
75. Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells
76. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
77. Laminin-1 promotes differentiation of fetal mouse pancreatic β-cells
78. Expression and function of α(v) β(3) and α(v) β(5) integrins in the developing pancreas: Roles in the adhesion and migration of putative endocrine progenitor cells
79. Importance of cell-matrix interactions in rat islet β-cell secretion in vitro: Role of α6β1 integrin
80. Circulating levels of free insulin-like growth factors in obese subjects: The impact of type 2 diabetes
81. Growth hormone in obesity
82. Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
83. Regulation of β-cell mass by hormones and growth factors
84. Mechanism of signaling by growth hormone receptor
85. IGF-I: A mitogen also involved in differentiation processes in mammalian cells
86. The IRS-signalling system: A network of docking proteins that mediate insulin action
87. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
88. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
89. IRS-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signalling
90. Activation of IRS-2 mediated signal transduction by IGF-1, but not TGF-α or EGF, augments pancreatic β-cell proliferation
91. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
92. Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic β-cells (INS-1)
93. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
94. Signal transduction mechanisms in nutrient-induced insulin secretion
95. Mammalian TOR: A homeostatic ATP sensor
96. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
97. β-cell specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
98. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
99. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
100. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 α subunit of phosphoinositide 3-kinase
101. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 α
102. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β)
103. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
104. New drug targets for type 2 diabetes and the metabolic syndrome
105. Defective fatty acid mediated β-cell-compensation in Zucker diabetic fatty rats
106. Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
107. Pathogenesis of insulin resistance: Modulation of the insulin signal at receptor level
108. Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612
109. Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade
110. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
111. Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation
112. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
113. β-cell apoptosis: Stimuli and signaling
114. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation
115. Modulation of insulin secretion by cyclic AMP and prostaglandin E: The effects of theophylline, sodium salicylate and tolbutamide
116. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ