Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor

Molecular Endocrinology

Volumn 21, Issue 11, 2007, Pages 2821-2831

  Uyttendaele, Isabel ^a   Lemmens, Irma ^a   Verhee, Annick ^a   De Smet, Anne Sophie ^a   Vandekerckhove, Joël ^a   Lavens, Delphine ^a   Peelman, Frank ^a   Tavernier, Jan ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RECEPTOR; LEUCINE; PROTEIN SH2; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENETIC VARIABILITY; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

AMINO ACID MOTIFS; CELL LINE; CYTOKINES; DNA PRIMERS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CONFORMATION; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECEPTORS, SOMATOTROPIN; STAT5 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 35648933970     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2006-0541     Document Type: Article

References (45)

1. Flores-Morales A, Greenhalgh CJ, Norstedt G, Rico-Bautista E 2006 Negative regulation of growth hormone receptor signaling. Mol Endocrinol 20:241-253
2. Kopchick JJ, Andry JM 2000 Growth hormone (GH), GH receptor, and signal transduction. Mol Genet Metab 71:293-314
3. Rowland JE, Lichanska AM, Kerr LM, White M, d'Aniello EM, Maher SL, Brown R, Teasdale RD, Noakes PG, Waters MJ 2005 In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol Cell Biol 25:66-77
4. Beyea JA, Sawicki G, Olson DM, List E, Kopchick JJ, Harvey S 2006 Growth hormone (GH) receptor knockout mice reveal actions of GH in lung development. Proteomics 6:341-348
5. Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI 1987 Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330:537-543
6. Zhu T, Goh EL, Graichen R, Ling L, Lobie PE 2001 Signal transduction via the growth hormone receptor. Cell Signal 13:599-616
7. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ 1997 A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921
8. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW 1997 Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 94:7239-7244
9. Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ 2006 Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Mol Endocrinol 20:1333-1351
10. Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG 2003 Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med 349:1139-1147
11. Metcalf D, Greenhalgh CJ, Viney E, Willson TA, Starr R, Nicola NA, Hilton DJ, Alexander WS 2000 Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405:1069-1073
12. Kopchick JJ, Bellush LL, Coschigano KT 1999 Transgenic models of growth hormone action. Annu Rev Nutr 19:437-461
13. Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS 2002 Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Mol Endocrinol 16:1394-1406
14. Greenhalgh CJ, Metcalf D, Thaus AL, Corbin JE, Uren R, Morgan PO, Fabri LJ, Zhang JG, Martin HM, Willson TA, Billestrup N, Nicola NA, Baca M, Alexander WS, Hilton DJ 2002 Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J Biol Chem 277:40181-40184
15. Piessevaux J, Lavens D, Montoye T, Wauman J, Catteeuw D, Vandekerckhove J, Belsham D, Peelman F, Tavernier J 2006 Functional cross-modulation between SOCS proteins can stimulate cytokine signaling. J Biol Chem 281:32953-32966
16. Matsumoto A, Seki Y, Kubo M, Ohtsuka S, Suzuki A, Hayashi I, Tsuji K, Nakahata T, Okabe M, Yamada S, Yoshimura A 1999 Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol Cell Biol 19:6396-6407
17. Ram PA, Waxman DJ 1999 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem 274:35553-35561
18. Ram PA, Waxman DJ 2000 Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone. J Biol Chem 275:39487-39496
19. Greenhalgh CJ, Rico-Bautista E, Lorentzon M, Thaus AL, Morgan PO, Willson TA, Zervoudakis P, Metcalf D, Street I, Nicola NA, Nash AD, Fabri LJ, Norstedt G, Ohlsson C, Flores-Morales A, Alexander WS, Hilton DJ 2005 SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 115:397-406
20. Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M 1999 The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci USA 96:2071-2076
21. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI 2004 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev 18:3055-3065
22. Landsman T, Waxman DJ 2005 Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization. J Biol Chem 280:37471-37480
23. Sotiropoulos A, Moutoussamy S, Renaudie F, Clauss M, Kayser C, Gouilleux F, Kelly PA, Finidori J 1996 Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor. Mol Endocrinol 10:998-1009
24. Hansen LH, Wang X, Kopchick JJ, Bouchelouche P, Nielsen JH, Galsgaard ED, Billestrup N 1996 Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation. J Biol Chem 271:12669-12673
25. Smit LS, Meyer DJ, Billestrup N, Norstedt G, Schwartz J, Carter-Su C 1996 The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. Mol Endocrinol 10:519-533
26. Smit LS, Vanderkuur JA, Stimage A, Han Y, Luo G, Yu-Lee LY, Schwartz J, Carter-Su C 1997 Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B. Endocrinology 138:3426-3434
27. Eyckerman S, Verhee A, Van der Heyden J, Lemmens I, Van Ostade X, Vandekerckhove J, Tavernier J 2001 Design and application of a cytokine-receptor-based interaction trap. Nat Cell Biol 3:1114-1119
28. Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C 1997 Identification of SH2-Bβ as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol Cell Biol 17:6633-6644
29. Bergamin E, Wu J, Hubbard SR 2006 Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure 14:1285-1292
30. Babon JJ, McManus EJ, Yao S, DeSouza DP, Mielke LA, Sprigg NS, Willson TA, Hilton DJ, Nicola NA, Baca M, Nicholson SE, Norton RS 2006 The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell 22:205-216
31. Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton AD, Jove R 2001 Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 276:45443-45455
32. May P, Gerhartz C, Heesel B, Welte T, Doppler W, Graeve L, Horn F, Heinrich PC 1996 Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation. FEBS Lett 394:221-226
33. Narazaki M, Fujimoto M, Matsumoto T, Morita Y, Saito H, Kajita T, Yoshizaki K, Naka T, Kishimoto T 1998 Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc Natl Acad Sci USA 95:13130-13134
34. Nicholson SE, Willson TA, Farley A, Starr R, Zhang JG, Baca M, Alexander WS, Metcalf D, Hilton DJ, Nicola NA 1999 Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J 18:375-385
35. Lavens D, Ulrichts P, Catteeuw D, Gevaert K, Vandekerckhove J, Peelman F, Eyckerman S, Tavernier J 2007 The C-terminus of CIS defines its interaction pattern. Biochem J 401:257-267
36. Montoye T, Lemmens I, Catteeuw D, Eyckerman S, Tavernier J 2005 A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach. Blood 105:4264-4271
37. Lavens D, Montoye T, Piessevaux J, Zabeau L, Vandekerckhove J, Gevaert K, Becker W, Eyckerman S, Tavernier J 2006 A complex interaction pattern of CIS and SOCS2 with the leptin receptor. J Cell Sci 119:2214-2224
38. Endo T, Sasaki A, Minoguchi M, Joo A, Yoshimura A 2003 CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation. J Biochem 133:109-113
39. Bullock AN, Debreczeni JE, Edwards AM, Sundstrom M, Knapp S 2006 Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc Natl Acad Sci USA 103:7637-7642
40. Lemmens I, Eyckerman S, Zabeau L, Catteeuw D, Vertenten E, Verschueren K, Huylebroeck D, Vandekerckhove J, Tavernier J 2003 Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells. Nucleic Acids Res 31:e75
41. Eyckerman S, Broekaert D, Verhee A, Vandekerckhove J, Tavernier J 2000 Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett 486:33-37
42. Scheeren FA, Naspetti M, Diehl S, Schotte R, Nagasawa M, Wijnands E, Gimeno R, Vyth-Dreese FA, Blom B, Spits H 2005 STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol 6:303-313
43. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, and Karplus M 1983 CHARMM: A program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem 4:187-217
44. Neculai D., Neculai AM, Verrier S, Straub K, Klumpp K, Pfitzner E, Becker S 2005 Structure of the unphosphorylated STAT5a dimer. J Biol Chem 280:40782-40787
45. Becker S, Groner B, Muller CW 1998 Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature 394:145-151