Molecular basis for islet development, growth, and regeneration

Current Opinion in Endocrinology and Diabetes

Volumn 5, Issue 2, 1998, Pages 97-107

  Nielsen, Jens Høiriis ^a   Serup, Palle ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CELL GROWTH; GENE EXPRESSION REGULATION; HUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031798819     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199804000-00005     Document Type: Review

References (116)

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78. Stout LE, Svensson AM, Sorenson RL: Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation. Endocrinology 1997, 138:1592-1603.
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86. Carlsson C, Tornehave D, Lindberg K, Galante P, Billestrup N, Michelsen B, Larsson LI, Nielsen JH: Growth-hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic-islets-molecular-cloning and expression pattern during development and growth of the endocrine pancreas. Endocrinology 1997, 138:3940-3948. Identifies Pref-1 as a GH- and prolactin-stimulated islet gene.
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88. Freemark M, Driscoll P, Maaskant R, Petryk A, Kelly PA: Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development. J Clin Invest 1997, 99:1107-1117.
89. Shafrir E: Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. Diabetes Metab 1996, 22:122-131.
90. Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR: Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997, 88:561-572. Shows islet cell hyperplasia with combined insulin receptor and IRS-1 mutations.
91. Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 1997, 99:861-866. Discusses islet cell hyperplasia in mice with combined glucokinase and IRS-1 mutations.
92. Moran A, Zhang HJ, Olson LK, Harmon JS, Poitout V, Robertson RP: Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15. J Clin Invest 1997, 99:534-9. Discusses the downregulation of Pdx-1 with high glucose in HIT cells.
93. Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 1997, 272:30261-30269.
94. Leahy JL: Impaired beta-cell function with chronic hyperglycemia: "overworked beta-cell" hypothesis. Diabetes Rev 1996, 4:298-319. Reviews the evidence for overstimulation of β cells in the development of type 2 diabetes.
95. Gumbiner B, Van Cauter E, Beltz WF, Ditzler TM, Griver K, Polonsky KS, Henry RR: Abnormalities of insulin pulsatility and glucose oscillations during meals in obese noninsulin-dependent diabetic patients: effects of weight reduction. J Clin Endocrinol Metab 1996, 81:2061-2068.
96. Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF: Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 1997, 46:1087-1093. Discusses the inhibition of insulin release by leptin.
97. Pallett AL, Morton NM, Cawthorne MA, Emilsson V: Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem Biophys Res Commun 1997, 238:267-270. Discusses the inhibition of insulin release and transcription by leptin.
98. Vinik A, Pittenger G, Rafaeloff R, Rosenberg L, Duguid W: Determinants of pancreatic islet cell mass: a balance between neogenesis and senescence/apoptosis. Diabetes Rev 1996, 4:235-263. Comprehensively reviews islet cell destruction and regeneration.
99. Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, Duguid WP, Vinik AI: Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 1997, 99:2100-2109. Discusses the identification and possible role of INGAP in islet regeneration.
100. Zenilman ME, Magnuson TH, Swinson K, Egan J, Perfetti R, Shuldiner AR: Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. Gastroenterology 1996, 110:1208-1214.
101. Baeza N, Moriscot C, Figarella C, Guy-Crotte O, Vialettes B: Reg protein: a potential beta-cell-specific growth factor? Diabetes Metab 1996, 22:229-234.
102. Moriscot C, Renaud W, Bouvier R, Figarella-Branger D, Figarella C, Guy-Crotte O: Absence of correlation between reg and insulin gene expression in pancreas during fetal development. Pediatr Res 1996, 39:349-353.
103. Perfetti R, Raygada M, Wang Y, Zenilman ME, Egan JM, Denno KM, Sadler TW, Shuldiner AR: Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos. J Mol Endocrinol 1996, 17:79-88.
104. Zhu M, Noma Y, Mizuno A, Sano T, Shima K: Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM. Diabetes 1996, 45:941-946.
105. Rooman I, Schuit F, Bouwens L: Effect of vascular endothellal growth factor on growth and differentiation of pancreatic ductal epithelium. Lab Invest 1997, 76:225-232.
106. Wang RN, Rehfeld JF, Nielsen FC, Kloppel G: Expression of gastrin and transforming growth factor-alpha during duct to Islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 1997, 40:887-893.
107. Amush M, Gu D, Baugh C, Sawyer SP, Mroczkowski B, Krahl T, Sarvetnick N: Growth factors in the regenerating pancreas of gamma-interferon transgenic mice. Lab Invest 1996, 74:985-990.
108. O'Reilly LA, Gu D, Sarvetnick N, Edlund H, Phillips JM, Fulford T, Cooke A: alpha-Cell neogenesis in an animal model of IDDM. Diabetes 1997, 46:599-606. Evidence for recapitulation of islet development in response to β-cell damage.
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110. Movassat J, Saulnier C, Portha B: Insulin administration enhances growth of the beta-cell mass in streptozotocin-treated newborn rats. Diabetes 1997, 46:1445-1452.
111. Nacher V, Raurell M, Merino JF, Aranda O, Soler J, Montana E: Beta-cell growth and mass are preserved in long-term syngeneic islet transplantation in streptozocin-induced diabetic Lewis rats. Diabetes 1996, 45:1541-1546. Demonstrates β-cell replication in long-term islet grafts.
112. Fernandas A, King LC, Guz Y, Stein R, Wright CV, Teitelman G: Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 1997, 138:1750-1762.
113. Cornelius JG, Tchernev V, Kao KJ, Peck AB: In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas. Horm Metab Res 1997, 29:271-277. Presents evidence for the presence of islet precursor cells in cultured mouse islets.
114. Kerr-Conte J, Pattou F, Lecomte-Houcke M, Xia Y, Boilly B, Prove C, Lefebvre J: Ductal cyst formation in collagen-embedded adult human Islet preparations. A means to the reproduction of nesidioblastosis in vitro. Diabetes 1996, 45:1108-1114. Presents evidence for the presence of islet precursor cells in cultured human islets.
115. Yuan SY, Rosenberg L, Paraskevas S, Agapitos D, Duguid WP: Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture. Differentiation 1996, 61:67-75.
116. Wolfe-Coote S, Louw J, Woodroof C, Toit DFD: The non-human primate pancreas: development, regeneration potential and metaplasia. Cell Biol Int 1996, 20:95-101. Discusses the possible role of transdifferentiation of pancreatic cells after partial duct ligation in monkeys.