Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation

Journal of Biological Chemistry

Volumn 282, Issue 42, 2007, Pages 30707-30717

  Fujinaka, Yuichi ^a,c   Takane, Karen ^a   Yamashita, Hiroko ^b   Vasavada, Rupangi C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; MEDICAL PROBLEMS; TRANSCRIPTION;

LACTOGENS; STREPTOZOTOCIN (STZ);

PROTEINS;

DEXAMETHASONE; JANUS KINASE 2; PROLACTIN; PROTEIN BCL XL; SMALL INTERFERING RNA; STAT5 PROTEIN; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; FEMALE; GENE ACTIVATION; GENE CONTROL; IN VITRO STUDY; INSULINOMA; MALE; MOUSE; MUTANT; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BCL-X PROTEIN; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPROTECTION; DEXAMETHASONE; DIABETES MELLITUS, EXPERIMENTAL; GENES, DOMINANT; INSULIN; INSULIN-SECRETING CELLS; JANUS KINASE 2; MICE; MICE, TRANSGENIC; MUTATION; PLACENTAL LACTOGEN; PROLACTIN; PROMOTER REGIONS (GENETICS); RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; UP-REGULATION;

MUS MUSCULUS; RATTUS;

EID: 35648994807     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702607200     Document Type: Article

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