Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

Molecular Endocrinology

Volumn 13, Issue 11, 1999, Pages 1832-1843

  Hansen, Johnny A ^a   Lindberg, Karen ^a   Hilton, Douglas J ^b   Nielsen, Jens H ^a   Billestrup, Nils ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CIS PROTEIN; GLUTATHIONE TRANSFERASE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; JANUS KINASE; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HORMONAL REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0033305402     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.11.0368     Document Type: Article

References (22)

1. Twenty proteins containing a C-terminal SOCS box form five structural classes
2. A family of cytokine inducible inhibitors of signaling
3. Cloning and characterization of novel CIS family genes
4. A novel cytokine inducible gene cis encodes an SH2 containing protein that binds to tyrosine phosphorylated interleukin 3 and erythropoietin receptors
5. A new protein containing an SH2 domain that inhibits Jak kinases
6. Structure and function of a new STAT induced STAT inhibitor
7. Cis, a cytokine inducible SH2 protein, is a target of the Jak Stat5 pathway and modulates Stat5 activation
8. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
9. Identification of SOCS-3 as a potential mediator of central leptin resistance
10. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells
11. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
12. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
13. Three distinct domains of SSI-1/SOCS-1/JAB protein are required fir its suppression of interleukin 6 signaling
14. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to protosomal degradation
15. Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation
16. The role of GH receptor tyrosine phosphorylation in Stat5 activation
17. Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase
18. Intracellular tyrosine residues of the human growth-hormone receptor are not required for the signaling of proliferation or jak-stat activation
19. Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation
20. Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells
21. Mmmary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
22. Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mdiated internalization and down regulation