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Volumn 92, Issue 3, 2007, Pages 481-496

Physiological regulation of the pancreatic β-cell: Functional insights for understanding and therapy of diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; HOMOCYSTEINE; NATEGLINIDE; TOLBUTAMIDE;

EID: 34247259818     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2006.034835     Document Type: Conference Paper
Times cited : (46)

References (56)
  • 1
    • 23844541266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 enhances production of insulin-producing cells derived from mouse embryonic stem cells
    • Bai L, Meredith G & Tuch BE (2005). Glucagon-like peptide-1 enhances production of insulin-producing cells derived from mouse embryonic stem cells. J Endocrinol 186, 343-352.
    • (2005) J Endocrinol , vol.186 , pp. 343-352
    • Bai, L.1    Meredith, G.2    Tuch, B.E.3
  • 2
    • 0034711586 scopus 로고    scopus 로고
    • Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide
    • Ball AJ, Flatt PR & McClenaghan NH (2000a). Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide. Eur J Pharmacol 408, 327-333.
    • (2000) Eur J Pharmacol , vol.408 , pp. 327-333
    • Ball, A.J.1    Flatt, P.R.2    McClenaghan, N.H.3
  • 3
    • 2942520864 scopus 로고    scopus 로고
    • Acute and long-term effects of nateglinide on insulin secretory pathways
    • Ball AJ, Flatt PR & McClenaghan NH (2004a). Acute and long-term effects of nateglinide on insulin secretory pathways. Br J Pharmacol 142, 367-373.
    • (2004) Br J Pharmacol , vol.142 , pp. 367-373
    • Ball, A.J.1    Flatt, P.R.2    McClenaghan, N.H.3
  • 4
    • 9944242768 scopus 로고    scopus 로고
    • Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide
    • Ball AJ, Flatt PR & McClenaghan NH (2005). Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide. Biochem Pharmacol 69, 59-63.
    • (2005) Biochem Pharmacol , vol.69 , pp. 59-63
    • Ball, A.J.1    Flatt, P.R.2    McClenaghan, N.H.3
  • 6
    • 1842736341 scopus 로고    scopus 로고
    • Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not expression of K-ATP channel components
    • Ball AJ, McCluskey JT, Flatt PR & McClenaghan NH (2004b). Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not expression of K-ATP channel components. Pharmac Res 50, 41-46.
    • (2004) Pharmac Res , vol.50 , pp. 41-46
    • Ball, A.J.1    McCluskey, J.T.2    Flatt, P.R.3    McClenaghan, N.H.4
  • 7
    • 24944591025 scopus 로고    scopus 로고
    • New sources of pancreatic β-cells
    • Bonner-Weir S & Weir GC (2005). New sources of pancreatic β-cells. Nat Biotechnol 23, 857-861.
    • (2005) Nat Biotechnol , vol.23 , pp. 857-861
    • Bonner-Weir, S.1    Weir, G.C.2
  • 9
    • 0036263720 scopus 로고    scopus 로고
    • A NMR based demonstration of substantial oxidative L-alanine metabolism and L-alanine enhanced glucose metabolism in a clonal pancreatic β cell line - Metabolism of L-alanine is important to the regulation of insulin secretion
    • Brennan L, Shine A, Hewage C, Malthouse JPG, Brindle KM, McClenaghan NH, Flatt PR & Newsholme P (2002). A NMR based demonstration of substantial oxidative L-alanine metabolism and L-alanine enhanced glucose metabolism in a clonal pancreatic β cell line - Metabolism of L-alanine is important to the regulation of insulin secretion. Diabetes 51, 1714-1721.
    • (2002) Diabetes , vol.51 , pp. 1714-1721
    • Brennan, L.1    Shine, A.2    Hewage, C.3    Malthouse, J.P.G.4    Brindle, K.M.5    McClenaghan, N.H.6    Flatt, P.R.7    Newsholme, P.8
  • 13
    • 33749861808 scopus 로고    scopus 로고
    • Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene and protein expression in a clonal pancreatic β cell line
    • Corless M, Kiely A, McClenaghan NH, Flatt PR & Newsholme P (2006). Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene and protein expression in a clonal pancreatic β cell line. J Endocrinol 190, 719-727.
    • (2006) J Endocrinol , vol.190 , pp. 719-727
    • Corless, M.1    Kiely, A.2    McClenaghan, N.H.3    Flatt, P.R.4    Newsholme, P.5
  • 14
    • 27844494151 scopus 로고    scopus 로고
    • Cunningham G, McClenaghan NH, Flatt PR & Newsholme P (2005). L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis. Clin Sci 109, 447-455.
    • Cunningham G, McClenaghan NH, Flatt PR & Newsholme P (2005). L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis. Clin Sci 109, 447-455.
  • 15
    • 0035693530 scopus 로고    scopus 로고
    • Functional enhancement of electrofusion-derived BRIN-BD11 insulin-secreting cells after implantation into diabetic mice
    • Davies EL, Abdel-Wahab YHA, Flatt PR & Bailey CJ (2001). Functional enhancement of electrofusion-derived BRIN-BD11 insulin-secreting cells after implantation into diabetic mice. Int J Exp Diabetes Res 2, 29-36.
    • (2001) Int J Exp Diabetes Res , vol.2 , pp. 29-36
    • Davies, E.L.1    Abdel-Wahab, Y.H.A.2    Flatt, P.R.3    Bailey, C.J.4
  • 16
    • 0347287092 scopus 로고    scopus 로고
    • A comparative study of amino acid consumption by rat islet cells and the clonal β-cell line BRIN BD11 - the functional significance of L-alanine
    • Dixon G, Nolan J, McClenaghan NH, Flatt PR & Newsholme P (2003). A comparative study of amino acid consumption by rat islet cells and the clonal β-cell line BRIN BD11 - the functional significance of L-alanine. J Endocrinol 179, 447-453.
    • (2003) J Endocrinol , vol.179 , pp. 447-453
    • Dixon, G.1    Nolan, J.2    McClenaghan, N.H.3    Flatt, P.R.4    Newsholme, P.5
  • 17
    • 1242284388 scopus 로고    scopus 로고
    • Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal β cell insulin secretion, growth and functional integrity
    • Dixon G, Nolan J, McClenaghan NH, Flatt PR & Newsholme P (2004). Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal β cell insulin secretion, growth and functional integrity. Clin Sci 106, 191-199.
    • (2004) Clin Sci , vol.106 , pp. 191-199
    • Dixon, G.1    Nolan, J.2    McClenaghan, N.H.3    Flatt, P.R.4    Newsholme, P.5
  • 21
    • 0041592594 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    • Gault VA, Flatt PR & O'Harte FPM (2003). Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem Biophys Res Commun 308, 207-213.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 207-213
    • Gault, V.A.1    Flatt, P.R.2    O'Harte, F.P.M.3
  • 22
    • 6344241190 scopus 로고    scopus 로고
    • Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents
    • Green BD, Gault VA, O'Harte FPM & Flatt PR (2004). Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents. Curr Pharm Des 10, 3651-3562.
    • (2004) Curr Pharm Des , vol.10 , pp. 3651-3562
    • Green, B.D.1    Gault, V.A.2    O'Harte, F.P.M.3    Flatt, P.R.4
  • 23
    • 0033756521 scopus 로고    scopus 로고
    • Culture and function of electrofusion-derived clonal insulin-secreting cells immobilised on solid and macroporous microcarrier beads
    • Hamid M, McCluskey JT, McClenaghan NH & Flatt PR (2000). Culture and function of electrofusion-derived clonal insulin-secreting cells immobilised on solid and macroporous microcarrier beads. Biosci Rep 20, 167-176.
    • (2000) Biosci Rep , vol.20 , pp. 167-176
    • Hamid, M.1    McCluskey, J.T.2    McClenaghan, N.H.3    Flatt, P.R.4
  • 24
    • 0034954498 scopus 로고    scopus 로고
    • Functional examination of microencapsulated clonal insulin-secreting β cells
    • Hamid M, McCluskey JT, McClenaghan NH & Flatt PR (2001). Functional examination of microencapsulated clonal insulin-secreting β cells. Cell Biol Int 25, 553-556.
    • (2001) Cell Biol Int , vol.25 , pp. 553-556
    • Hamid, M.1    McCluskey, J.T.2    McClenaghan, N.H.3    Flatt, P.R.4
  • 25
    • 0022999213 scopus 로고
    • Selective unresponsiveness of pancreatic B-cells to acute sulphonylurea stimulation during sulphonylurea therapy in NIDDM
    • Karam JH, Sanz E, Solomon E & Nolte MS (1986). Selective unresponsiveness of pancreatic B-cells to acute sulphonylurea stimulation during sulphonylurea therapy in NIDDM. Diabetes 35, 1314-1320.
    • (1986) Diabetes , vol.35 , pp. 1314-1320
    • Karam, J.H.1    Sanz, E.2    Solomon, E.3    Nolte, M.S.4
  • 26
    • 18844396119 scopus 로고    scopus 로고
    • Embryonic stem cell differentiation: Emergence of a new era in biology and medicine
    • Keller G (2005). Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 19, 1129-1155.
    • (2005) Genes Dev , vol.19 , pp. 1129-1155
    • Keller, G.1
  • 27
    • 0842327742 scopus 로고    scopus 로고
    • N-Acetyl-GLP-1: A DPP IV resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic β-cell associated gene expression
    • Liu H-K, Green BD, Gault VA, McClenaghan NH, McCluskey JT & Flatt PR (2004). N-Acetyl-GLP-1: a DPP IV resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic β-cell associated gene expression. Cell Biol Int 28, 69-73.
    • (2004) Cell Biol Int , vol.28 , pp. 69-73
    • Liu, H.-K.1    Green, B.D.2    Gault, V.A.3    McClenaghan, N.H.4    McCluskey, J.T.5    Flatt, P.R.6
  • 28
    • 33745216274 scopus 로고    scopus 로고
    • Deleterious effects of dehydroepiandrosterone sulphate and dexamethasone on rat insulin-secreting cells under in vitro culture condition
    • Liu H-K, Green BD, McClenaghan NH, McCluskey JT & Flatt PR (2006). Deleterious effects of dehydroepiandrosterone sulphate and dexamethasone on rat insulin-secreting cells under in vitro culture condition. Biosci Rep 26, 31-38.
    • (2006) Biosci Rep , vol.26 , pp. 31-38
    • Liu, H.-K.1    Green, B.D.2    McClenaghan, N.H.3    McCluskey, J.T.4    Flatt, P.R.5
  • 29
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R & McKay R (2001). Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5    McKay, R.6
  • 30
    • 31144453418 scopus 로고    scopus 로고
    • Determining the relationship between dietary carbohydrate intake and insulin resistance
    • McClenaghan NH (2005). Determining the relationship between dietary carbohydrate intake and insulin resistance. Nut Res Rev 18, 222-240.
    • (2005) Nut Res Rev , vol.18 , pp. 222-240
    • McClenaghan, N.H.1
  • 31
    • 0034017796 scopus 로고    scopus 로고
    • Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide
    • McClenaghan NH, Ball AJ & Flatt PR (2000). Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide. Br J Pharmacol 130, 478-484.
    • (2000) Br J Pharmacol , vol.130 , pp. 478-484
    • McClenaghan, N.H.1    Ball, A.J.2    Flatt, P.R.3
  • 32
    • 0035282846 scopus 로고    scopus 로고
    • Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure
    • McClenaghan NH, Ball AJ & Flatt PR (2001). Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure. Biochem Pharmacol 61, 527-536.
    • (2001) Biochem Pharmacol , vol.61 , pp. 527-536
    • McClenaghan, N.H.1    Ball, A.J.2    Flatt, P.R.3
  • 34
    • 0032547303 scopus 로고    scopus 로고
    • + co-transport by metabolizable and non-metabolizable amino acids stimulates a glucose-regulated insulin-secretory response
    • + co-transport by metabolizable and non-metabolizable amino acids stimulates a glucose-regulated insulin-secretory response. Biochem Biophys Res Comm 249, 299-303.
    • (1998) Biochem Biophys Res Comm , vol.249 , pp. 299-303
    • McClenaghan, N.H.1    Barnett, C.R.2    Flatt, P.R.3
  • 35
    • 0029828189 scopus 로고    scopus 로고
    • Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line
    • McClenaghan NH, Barnett CR, O'Harte FPM & Flatt PR (1996b). Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line. J Endocrinol 151, 349-357.
    • (1996) J Endocrinol , vol.151 , pp. 349-357
    • McClenaghan, N.H.1    Barnett, C.R.2    O'Harte, F.P.M.3    Flatt, P.R.4
  • 36
    • 0029988029 scopus 로고    scopus 로고
    • Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion
    • McClenaghan NH, Barnett CR, O'Harte FPM, Swanston-Flatt SK, Ah-Sing E & Flatt PR (1996c). Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion. J Endocrinol 148, 409-417.
    • (1996) J Endocrinol , vol.148 , pp. 409-417
    • McClenaghan, N.H.1    Barnett, C.R.2    O'Harte, F.P.M.3    Swanston-Flatt, S.K.4    Ah-Sing, E.5    Flatt, P.R.6
  • 38
    • 0032515326 scopus 로고    scopus 로고
    • Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line
    • McClenaghan NH, Elsner M, Tiedge M & Lenzen S (1998b). Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line. Biochem Biophys Res Commun 242, 262-266.
    • (1998) Biochem Biophys Res Commun , vol.242 , pp. 262-266
    • McClenaghan, N.H.1    Elsner, M.2    Tiedge, M.3    Lenzen, S.4
  • 39
    • 0032973065 scopus 로고    scopus 로고
    • Engineering cultured insulin-secreting pancreatic B-cell lines
    • McClenaghan NH & Flatt PR (1999a). Engineering cultured insulin-secreting pancreatic B-cell lines. J Mol Med 77, 235-243.
    • (1999) J Mol Med , vol.77 , pp. 235-243
    • McClenaghan, N.H.1    Flatt, P.R.2
  • 40
    • 0033123538 scopus 로고    scopus 로고
    • Physiological and pharmacological regulation of insulin release: Insights offered through exploitation of insulin-secreting cell lines
    • McClenaghan NH & Flatt PR (1999b). Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines. Diabetes Obes Metab 1, 137-150.
    • (1999) Diabetes Obes Metab , vol.1 , pp. 137-150
    • McClenaghan, N.H.1    Flatt, P.R.2
  • 41
    • 0032904461 scopus 로고    scopus 로고
    • Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic β cell function
    • McClenaghan NH & Flatt PR (1999c). Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic β cell function. Biochim Biophys Acta 426, 110-118.
    • (1999) Biochim Biophys Acta , vol.426 , pp. 110-118
    • McClenaghan, N.H.1    Flatt, P.R.2
  • 42
    • 0033959401 scopus 로고    scopus 로고
    • +-ATP channel independent actions of keto acid initiators of insulin secretion
    • +-ATP channel independent actions of keto acid initiators of insulin secretion. Pancreas 20, 38-46.
    • (2000) Pancreas , vol.20 , pp. 38-46
    • McClenaghan, N.H.1    Flatt, P.R.2
  • 43
    • 34247237046 scopus 로고    scopus 로고
    • Hormones of the endocrine pancreas
    • 2nd edn, ed. Caballero B, Trugo L & Finglas P, pp, Academic Press, London
    • McClenaghan NH & Flatt PR (2003). Hormones of the endocrine pancreas. In Encyclopaedia of Food Science and Nutrition, 2nd edn, ed. Caballero B, Trugo L & Finglas P, pp. 3150-3157. Academic Press, London.
    • (2003) Encyclopaedia of Food Science and Nutrition , pp. 3150-3157
    • McClenaghan, N.H.1    Flatt, P.R.2
  • 45
    • 33645468639 scopus 로고    scopus 로고
    • Stem cells and diabetes treatment
    • Madsen OD (2005). Stem cells and diabetes treatment. APMIS 113, 858-875.
    • (2005) APMIS , vol.113 , pp. 858-875
    • Madsen, O.D.1
  • 47
    • 33646820015 scopus 로고    scopus 로고
    • Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion
    • Patterson S, Flatt PR, Brennan L, Newsholme P & Mc Clenaghan NH (2006). Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. J Endocrinol 189, 301-310.
    • (2006) J Endocrinol , vol.189 , pp. 301-310
    • Patterson, S.1    Flatt, P.R.2    Brennan, L.3    Newsholme, P.4    Mc Clenaghan, N.H.5
  • 49
    • 0036938182 scopus 로고    scopus 로고
    • Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal β cells
    • 3S70-3S77
    • Picton S, McCluskey JT, Flatt PR & McClenaghan NH (2002). Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal β cells. Diabetes Metab 28, 3S70-3S77.
    • (2002) Diabetes Metab , vol.28
    • Picton, S.1    McCluskey, J.T.2    Flatt, P.R.3    McClenaghan, N.H.4
  • 50
    • 0036896505 scopus 로고    scopus 로고
    • Malonyl-CoA signalling, lipid partitioning, and glucolipotoxicity. Role in β-cell adaption and failure in the etiology of diabetes
    • Prentki M, Joly E, El-Assaad W & Roduit R (2002). Malonyl-CoA signalling, lipid partitioning, and glucolipotoxicity. Role in β-cell adaption and failure in the etiology of diabetes. Diabetes 51 (Suppl. 3), S405-S413.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Prentki, M.1    Joly, E.2    El-Assaad, W.3    Roduit, R.4
  • 54
    • 0034628519 scopus 로고    scopus 로고
    • Correction of diabetic hyperglycaemia by transplantation of bioengineered RINm5F cells overexpressing pancreatic β-cell glucokinase
    • Tiedge M, Elsner M, McClenaghan NH, Hedrich HJ, Grube D, Klempnauer J & Lenzen S (2000). Correction of diabetic hyperglycaemia by transplantation of bioengineered RINm5F cells overexpressing pancreatic β-cell glucokinase. Hum Gene Ther 11, 403-414.
    • (2000) Hum Gene Ther , vol.11 , pp. 403-414
    • Tiedge, M.1    Elsner, M.2    McClenaghan, N.H.3    Hedrich, H.J.4    Grube, D.5    Klempnauer, J.6    Lenzen, S.7
  • 55
    • 33646779855 scopus 로고    scopus 로고
    • Minireview: Implication of mitochondria in insulin secretion and action
    • Wiederkehr A & Wollheim CB (2006). Minireview: Implication of mitochondria in insulin secretion and action. Endocrinology 147, 2643-2649.
    • (2006) Endocrinology , vol.147 , pp. 2643-2649
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 56
    • 0022988443 scopus 로고
    • Electrical breakdown, electro-permeabilization and electrofusion
    • Zimmermann U (1986). Electrical breakdown, electro-permeabilization and electrofusion. Rev Physiol Biochem Pharmacol 105, 176-250.
    • (1986) Rev Physiol Biochem Pharmacol , vol.105 , pp. 176-250
    • Zimmermann, U.1


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