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Volumn 25, Issue 12, 2011, Pages 2119-2133

Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-cells

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; JANUS KINASE 2; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STAT5 PROTEIN;

EID: 82055194416     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1052     Document Type: Article
Times cited : (29)

References (65)
  • 2
    • 4143151942 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • DeFronzo RA 2004 Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 88:787-835
    • (2004) Med Clin North Am , vol.88 , pp. 787-835
    • Defronzo, R.A.1
  • 3
    • 33745863033 scopus 로고    scopus 로고
    • Islet β cell failure in type 2 diabetes
    • Prentki M, Nolan CJ 2006 Islet β cell failure in type 2 diabetes. J Clin Invest 116:1802-1812
    • (2006) J Clin Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 4
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes-a matter of cell life and death?
    • Rhodes CJ 2005 Type 2 diabetes-a matter of cell life and death? Science 307:380-384
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 5
    • 64149130125 scopus 로고    scopus 로고
    • Functional pancreatic β-cell mass: Involvement in type 2 diabetes and therapeutic intervention
    • Karaca M, Magnan C, Kargar C 2009 Functional pancreatic β-cell mass: involvement in type 2 diabetes and therapeutic intervention. Diabetes Metab 35:77-84
    • (2009) Diabetes Metab , vol.35 , pp. 77-84
    • Karaca, M.1    Magnan, C.2    Kargar, C.3
  • 6
    • 0034130454 scopus 로고    scopus 로고
    • IGF-I and GH post-receptor signaling mechanisms for pancreatic β-cell replication
    • Rhodes CJ 2000 IGF-I and GH post-receptor signaling mechanisms for pancreatic β-cell replication. J Mol Endocrinol 24:303-311
    • (2000) J Mol Endocrinol , vol.24 , pp. 303-311
    • Rhodes, C.J.1
  • 7
    • 0031798819 scopus 로고    scopus 로고
    • Molecular basis for islet development, growth, and regeneration
    • Nielsen JH, Serup P 1998 Molecular basis for islet development, growth, and regeneration. Curr Opin Endocrinol Diabetes 5:97-107
    • (1998) Curr Opin Endocrinol Diabetes , vol.5 , pp. 97-107
    • Nielsen, J.H.1    Serup, P.2
  • 10
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    • Favelyukis S, Till JH, Hubbard SR, Miller WT 2001 Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol 8:1058-1063
    • (2001) Nat Struct Biol , vol.8 , pp. 1058-1063
    • Favelyukis, S.1    Till, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 12
    • 56549091431 scopus 로고    scopus 로고
    • The complexity of mitogen-activated protein kinases (MAPKs) made simple
    • Krishna M, Narang H 2008 The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell Mol Life Sci 65:3525-3544
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3525-3544
    • Krishna, M.1    Narang, H.2
  • 13
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC 2007 AKT/PKB signaling: navigating downstream. Cell 129:1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 14
    • 0035125526 scopus 로고    scopus 로고
    • β-Cell mass and function in type 2 diabetes: IRS proteins and β-cell function
    • Burks DJ, White MF 2001 β-Cell mass and function in type 2 diabetes: IRS proteins and β-cell function. Diabetes 50:S140-S145
    • (2001) Diabetes , vol.50
    • Burks, D.J.1    White, M.F.2
  • 15
  • 16
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent
    • Hügl SR, White MF, Rhodes CJ 1998 Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent. J Biol Chem 273:17771-17779
    • (1998) J Biol Chem , vol.273 , pp. 17771-17779
    • Hügl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 18
    • 0021894457 scopus 로고
    • Mode of action of pituitary growth hormone on target cells
    • Isaksson OG, Edén S, Jansson JO 1985 Mode of action of pituitary growth hormone on target cells. Annu Rev Physiol 47:483-499
    • (1985) Annu Rev Physiol , vol.47 , pp. 483-499
    • Isaksson, O.G.1    Edén, S.2    Jansson, J.O.3
  • 19
    • 0011718801 scopus 로고    scopus 로고
    • Growth hormone receptor
    • Oppenheim JJ, Feldman M, eds, London, UK: Academic Press, Harcourt
    • Frank SJ, Messina JL 2002 Growth hormone receptor. In: Oppenheim JJ, Feldman M, eds. Cytokine reference on-line. London, UK: Academic Press, Harcourt; 1-21
    • (2002) Cytokine Reference On-line , pp. 1-21
    • Frank, S.J.1    Messina, J.L.2
  • 21
    • 0344960402 scopus 로고
    • Enhanced IGF-I expression in regenerating rat pancreas is localized to capillaries and proliferating duct cells
    • Smith F, Rosen K, Villa-Komarof L, Weir GC, Bonner-Weir S 1990 Enhanced IGF-I expression in regenerating rat pancreas is localized to capillaries and proliferating duct cells. Diabetes 39(Suppl 1):66A
    • (1990) Diabetes , vol.39 , Issue.SUPPL. 1
    • Smith, F.1    Rosen, K.2    Villa-Komarof, L.3    Weir, G.C.4    Bonner-Weir, S.5
  • 22
    • 0027250196 scopus 로고
    • Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones
    • Maake C, Reinecke M 1993 Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones. Cell Tissue Res 273:249-259
    • (1993) Cell Tissue Res , vol.273 , pp. 249-259
    • Maake, C.1    Reinecke, M.2
  • 23
    • 4444318488 scopus 로고    scopus 로고
    • Effects of insulin-like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats: Comparison with growth hormone replacement
    • Jevdjovic T, Maake C, Eppler E, Zoidis E, Reinecke M, Zapf J 2004 Effects of insulin-like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats: comparison with growth hormone replacement. Eur J Endocrinol 151:223-231
    • (2004) Eur J Endocrinol , vol.151 , pp. 223-231
    • Jevdjovic, T.1    Maake, C.2    Eppler, E.3    Zoidis, E.4    Reinecke, M.5    Zapf, J.6
  • 24
    • 18744382772 scopus 로고    scopus 로고
    • The effect of hypophysectomy on pancreatic islet hormone and insulin-like growth factor I content and mRNA expression in rat
    • Jevdjovic T, Maake C, Zwimpfer C, Krey G, Eppler E, Zapf J, Reinecke M 2005 The effect of hypophysectomy on pancreatic islet hormone and insulin-like growth factor I content and mRNA expression in rat. Histochem Cell Biol 123:179-188
    • (2005) Histochem Cell Biol , vol.123 , pp. 179-188
    • Jevdjovic, T.1    Maake, C.2    Zwimpfer, C.3    Krey, G.4    Eppler, E.5    Zapf, J.6    Reinecke, M.7
  • 25
    • 0025954951 scopus 로고
    • The stimulatory effect of growth hormone, prolactin, and placental lactogen onβ-cell proliferation is not mediated by insulin-like growth factor-I
    • Billestrup N, Nielsen JH 1991 The stimulatory effect of growth hormone, prolactin, and placental lactogen onβ-cell proliferation is not mediated by insulin-like growth factor-I. Endocrinology 129: 883-888
    • (1991) Endocrinology , vol.129 , pp. 883-888
    • Billestrup, N.1    Nielsen, J.H.2
  • 26
    • 1642618179 scopus 로고    scopus 로고
    • Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: Signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediate mitogenic signalling
    • Cousin SP, Hügl SR, Myers Jr MG, White MF, Reifel-Miller A, Rhodes CJ 1999 Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediate mitogenic signalling. Biochem J 344:649-658
    • (1999) Biochem J , vol.344 , pp. 649-658
    • Cousin, S.P.1    Hügl, S.R.2    Myers, M.G.3    White, M.F.4    Reifel-Miller, A.5    Rhodes, C.J.6
  • 27
    • 0026705631 scopus 로고
    • Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells
    • Ashcom G, Gurland G, Schwartz J 1992 Growth hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells. Endocrinology 131:1915-1921
    • (1992) Endocrinology , vol.131 , pp. 1915-1921
    • Ashcom, G.1    Gurland, G.2    Schwartz, J.3
  • 28
    • 0033324510 scopus 로고    scopus 로고
    • Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growth
    • Edmondson SR, Russo VC, McFarlane AC, Wraight CJ, Werther GA 1999 Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growth. J Clin Endocrinol Metab 84:1638-1644
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1638-1644
    • Edmondson, S.R.1    Russo, V.C.2    McFarlane, A.C.3    Wraight, C.J.4    Werther, G.A.5
  • 29
    • 2542420725 scopus 로고    scopus 로고
    • Physical and functional interaction of growth hormone and insulin-like growth factor-1 signaling elements
    • Huang Y, Kim SO, Yang N, Jiang J, Frank SJ 2004 Physical and functional interaction of growth hormone and insulin-like growth factor-1 signaling elements. Mol Endocrinol 18:1471-1485
    • (2004) Mol Endocrinol , vol.18 , pp. 1471-1485
    • Huang, Y.1    Kim, S.O.2    Yang, N.3    Jiang, J.4    Frank, S.J.5
  • 32
    • 34247259818 scopus 로고    scopus 로고
    • Physiological regulation of the pancreatic β-cell: Functional insights for understanding and therapy of diabetes
    • McClenaghan NH 2007 Physiological regulation of the pancreatic β-cell: functional insights for understanding and therapy of diabetes. Exp Physiol 92:481-496
    • (2007) Exp Physiol , vol.92 , pp. 481-496
    • McClenaghan, N.H.1
  • 33
    • 8344271936 scopus 로고    scopus 로고
    • Cell lines derived from pancreatic islets
    • Hohmeier HE, Newgard CB 2004 Cell lines derived from pancreatic islets. Mol Cell Endocrinol 228:121-128
    • (2004) Mol Cell Endocrinol , vol.228 , pp. 121-128
    • Hohmeier, H.E.1    Newgard, C.B.2
  • 34
    • 0029825056 scopus 로고    scopus 로고
    • Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
    • Goffin V, Shiverick KT, Kelly PA, Martial JA 1996 Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals. Endocr Rev 17:385-410
    • (1996) Endocr Rev , vol.17 , pp. 385-410
    • Goffin, V.1    Shiverick, K.T.2    Kelly, P.A.3    Martial, J.A.4
  • 35
    • 0242267061 scopus 로고    scopus 로고
    • Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling
    • He K, Wang X, Jiang J, Guan R, Bernstein KE, Sayeski PP, Frank SJ 2003 Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol 17: 2211-2227
    • (2003) Mol Endocrinol , vol.17 , pp. 2211-2227
    • He, K.1    Wang, X.2    Jiang, J.3    Guan, R.4    Bernstein, K.E.5    Sayeski, P.P.6    Frank, S.J.7
  • 36
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • de Vos AM, Ultsch M, Kossiakoff AA 1992 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306-312
    • (1992) Science , vol.255 , pp. 306-312
    • de Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 38
    • 33748309115 scopus 로고    scopus 로고
    • Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding
    • van den Eijnden MJ, Lahaye LL, Strous GJ 2006 Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding. J Cell Sci 119:3078-3086
    • (2006) J Cell Sci , vol.119 , pp. 3078-3086
    • van den Eijnden, M.J.1    Lahaye, L.L.2    Strous, G.J.3
  • 39
    • 56449119800 scopus 로고    scopus 로고
    • Modulation of growth hormone receptor abundance and function: Roles for the ubiquitin-proteasome system
    • Frank SJ, Fuchs SY 2008 Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system. Biochim Biophys Acta 1782:785-794
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 785-794
    • Frank, S.J.1    Fuchs, S.Y.2
  • 41
    • 0036800303 scopus 로고    scopus 로고
    • Growth hormone receptor antagonists: Discovery, development, and use in patients with acromegaly
    • Kopchick JJ, Parkinson C, Stevens EC, Trainer PJ 2002 Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr Rev 23:623-646
    • (2002) Endocr Rev , vol.23 , pp. 623-646
    • Kopchick, J.J.1    Parkinson, C.2    Stevens, E.C.3    Trainer, P.J.4
  • 42
    • 0032755252 scopus 로고    scopus 로고
    • Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization
    • Zhang Y, Jiang J, Kopchick JJ, Frank SJ 1999 Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization. J Biol Chem 274:33072-33084
    • (1999) J Biol Chem , vol.274 , pp. 33072-33084
    • Zhang, Y.1    Jiang, J.2    Kopchick, J.J.3    Frank, S.J.4
  • 43
    • 0037188817 scopus 로고    scopus 로고
    • G120K-PEG, a human GH antagonist, decreases GH signal transduction in the liver of mice
    • Thirone AC, Carvalho CR, Saad MJ 2002 G120K-PEG, a human GH antagonist, decreases GH signal transduction in the liver of mice. Mol Cell Endocrinol 192:65-74
    • (2002) Mol Cell Endocrinol , vol.192 , pp. 65-74
    • Thirone, A.C.1    Carvalho, C.R.2    Saad, M.J.3
  • 44
    • 0037805620 scopus 로고    scopus 로고
    • Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling
    • Huang Y, Kim SO, Jiang J, Frank SJ 2003 Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. J Biol Chem 278:18902-18913
    • (2003) J Biol Chem , vol.278 , pp. 18902-18913
    • Huang, Y.1    Kim, S.O.2    Jiang, J.3    Frank, S.J.4
  • 45
    • 33845528355 scopus 로고    scopus 로고
    • Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells
    • Huang Y, Li X, Jiang J, Frank SJ 2006 Prolactin modulates phosphorylation, signaling and trafficking of epidermal growth factor receptor in human T47D breast cancer cells. Oncogene 25:7565-7576
    • (2006) Oncogene , vol.25 , pp. 7565-7576
    • Huang, Y.1    Li, X.2    Jiang, J.3    Frank, S.J.4
  • 46
    • 78649841561 scopus 로고    scopus 로고
    • Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors
    • Li X, Huang Y, Jiang J, Frank SJ 2011 Synergy in ERK activation by cytokine receptors and tyrosine kinase growth factor receptors. Cell Signal 23:417-424
    • (2011) Cell Signal , vol.23 , pp. 417-424
    • Li, X.1    Huang, Y.2    Jiang, J.3    Frank, S.J.4
  • 48
    • 0029035757 scopus 로고
    • Apoptosis and loss of renal tissue in polycystic kidney diseases
    • Woo D 1995 Apoptosis and loss of renal tissue in polycystic kidney diseases. N Engl J Med 333:18-25
    • (1995) N Engl J Med , vol.333 , pp. 18-25
    • Woo, D.1
  • 49
    • 33645384039 scopus 로고    scopus 로고
    • Synergistic effect of platelet-activating factor and tumor necrosis factor-α on corneal myofibroblast apoptosis
    • He J, Bazan HE 2006 Synergistic effect of platelet-activating factor and tumor necrosis factor-α on corneal myofibroblast apoptosis. Invest Ophthalmol Vis Sci 47:883-891
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 883-891
    • He, J.1    Bazan, H.E.2
  • 50
    • 77952191166 scopus 로고    scopus 로고
    • Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: Involvement of ERK and Akt signaling pathways
    • Maurice JM, Gan Y, Ma FX, Chang YC, Hibner M, Huang Y 2010 Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways. Acta Pharmacol Sin 31:493-500
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 493-500
    • Maurice, J.M.1    Gan, Y.2    Ma, F.X.3    Chang, Y.C.4    Hibner, M.5    Huang, Y.6
  • 52
    • 17544369037 scopus 로고    scopus 로고
    • Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation
    • Hansen LH, Wang X, Kopchick JJ, Bouchelouche P, Nielsen JH, Galsgaard ED, Billestrup N 1996 Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation. J Biol Chem 271:12669-12673
    • (1996) J Biol Chem , vol.271 , pp. 12669-12673
    • Hansen, L.H.1    Wang, X.2    Kopchick, J.J.3    Bouchelouche, P.4    Nielsen, J.H.5    Galsgaard, E.D.6    Billestrup, N.7
  • 53
    • 3242656480 scopus 로고    scopus 로고
    • Pancreatic β-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt?
    • Dickson LM, Rhodes CJ 2004 Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab 287:E192-E198
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Dickson, L.M.1    Rhodes, C.J.2
  • 54
    • 85047677059 scopus 로고    scopus 로고
    • Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1
    • Sekine N, Ullrich S, Regazzi R, Pralong WF, Wollheim CB 1996 Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology 137:1841-1850
    • (1996) Endocrinology , vol.137 , pp. 1841-1850
    • Sekine, N.1    Ullrich, S.2    Regazzi, R.3    Pralong, W.F.4    Wollheim, C.B.5
  • 56
    • 0032544722 scopus 로고    scopus 로고
    • Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: Role of Fas
    • Harrison M, Dunger AM, Berg S, Mabley J, John N, Green MH, Green IC 1998 Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas. FEBS Lett 435:207-210
    • (1998) FEBS Lett , vol.435 , pp. 207-210
    • Harrison, M.1    Dunger, A.M.2    Berg, S.3    Mabley, J.4    John, N.5    Green, M.H.6    Green, I.C.7
  • 57
    • 0028084965 scopus 로고
    • Effect of nutrients, hormones and serum on survival of rat islet β cells in culture
    • Ling Z, Hannaert JC, Pipeleers D 1994 Effect of nutrients, hormones and serum on survival of rat islet β cells in culture. Diabetologia 37:15-21
    • (1994) Diabetologia , vol.37 , pp. 15-21
    • Ling, Z.1    Hannaert, J.C.2    Pipeleers, D.3
  • 58
    • 0035313701 scopus 로고    scopus 로고
    • The Stat family in cytokine signaling
    • Ihle JN 2001 The Stat family in cytokine signaling. Curr Opin Cell Biol 13:211-217
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 211-217
    • Ihle, J.N.1
  • 59
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell Jr JE 2002 Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651-662
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 60
    • 38549182470 scopus 로고    scopus 로고
    • Protein kinase B: Signalling roles and therapeutic targeting
    • Sale EM, Sale GJ 2008 Protein kinase B: signalling roles and therapeutic targeting. Cell Mol Life Sci 65:113-127
    • (2008) Cell Mol Life Sci , vol.65 , pp. 113-127
    • Sale, E.M.1    Sale, G.J.2
  • 62
    • 68149137267 scopus 로고    scopus 로고
    • Growth hormone increases β-cell proliferation in transplanted human and fetal rat islets
    • Höglund E, Mattsson G, Tyrberg B, Andersson A, Carlsson C 2009 Growth hormone increases β-cell proliferation in transplanted human and fetal rat islets. JOP 10:242-248
    • (2009) JOP , vol.10 , pp. 242-248
    • Höglund, E.1    Mattsson, G.2    Tyrberg, B.3    Andersson, A.4    Carlsson, C.5
  • 63
    • 77956344288 scopus 로고    scopus 로고
    • Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
    • Gan Y, Shi C, Inge L, Hibner M, Balducci J, Huang Y 2010 Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells. Oncogene 29:4947-4958
    • (2010) Oncogene , vol.29 , pp. 4947-4958
    • Gan, Y.1    Shi, C.2    Inge, L.3    Hibner, M.4    Balducci, J.5    Huang, Y.6
  • 65
    • 61349087443 scopus 로고    scopus 로고
    • Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling
    • Ma F, Zhang D, Yang H, Sun H, Wu W, Gan Y, Balducci J, Wei YQ, Zhao X, Huang Y 2009 Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling. Genes Cells 14:281-293
    • (2009) Genes Cells , vol.14 , pp. 281-293
    • Ma, F.1    Zhang, D.2    Yang, H.3    Sun, H.4    Wu, W.5    Gan, Y.6    Balducci, J.7    Wei, Y.Q.8    Zhao, X.9    Huang, Y.10


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