-
1
-
-
2342496712
-
Foxos at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili, D. and Arden, K. C. (2004). Foxos at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
2
-
-
0034708832
-
The c-Jun NH2- terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
-
Aguirre, V., Uchida, T., Yenush, L., Davis, R. and White, M. F. (2000). The c-Jun NH2- terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J. Biol. Chem. 275, 9047-9054
-
(2000)
J. Biol. Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
3
-
-
58049218983
-
Tissue damage-induced intestinal stem cell division in Drosophila
-
Amcheslavsky, A., Jiang, J. and Ip, Y. T. (2009). Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4, 49-61
-
(2009)
Cell Stem Cell
, vol.4
, pp. 49-61
-
-
Amcheslavsky, A.1
Jiang, J.2
Ip, Y.T.3
-
4
-
-
79958207849
-
Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
-
Amcheslavsky, A., Ito, N., Jiang, J. and Ip, Y. T. (2011). Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J. Cell Biol. 193, 695-710
-
(2011)
J. Cell Biol
, vol.193
, pp. 695-710
-
-
Amcheslavsky, A.1
Ito, N.2
Jiang, J.3
Ip, Y.T.4
-
5
-
-
73949145172
-
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
-
Apidianakis, Y., Pitsouli, C., Perrimon, N. and Rahme, L. (2009). Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc. Natl. Acad. Sci. USA 106, 20883-20888
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20883-20888
-
-
Apidianakis, Y.1
Pitsouli, C.2
Perrimon, N.3
Rahme, L.4
-
6
-
-
79959387473
-
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
-
Badin, P. M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D. and Moro, C. (2011). Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans. Diabetes 60, 1734-1742
-
(2011)
Diabetes
, vol.60
, pp. 1734-1742
-
-
Badin, P.M.1
Louche, K.2
Mairal, A.3
Liebisch, G.4
Schmitz, G.5
Rustan, A.C.6
Smith, S.R.7
Langin, D.8
Moro, C.9
-
7
-
-
84869209803
-
Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide- 2 from the brain
-
Bai, H., Kang, P. and Tatar, M. (2012). Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide- 2 from the brain. Aging Cell 11, 978-985
-
(2012)
Aging Cell
, vol.11
, pp. 978-985
-
-
Bai, H.1
Kang, P.2
Tatar, M.3
-
8
-
-
0026419552
-
Control of larval development by chemosensory neurons in Caenorhabditis elegans
-
Bargmann, C. I. and Horvitz, H. R. (1991). Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 251, 1243-1246
-
(1991)
Science
, vol.251
, pp. 1243-1246
-
-
Bargmann, C.I.1
Horvitz, H.R.2
-
9
-
-
84861885929
-
The critical role of metabolic pathways in aging
-
Barzilai, N., Huffman, D. M., Muzumdar, R. H. and Bartke, A. (2012). The critical role of metabolic pathways in aging. Diabetes 61, 1315-1322
-
(2012)
Diabetes
, vol.61
, pp. 1315-1322
-
-
Barzilai, N.1
Huffman, D.M.2
Muzumdar, R.H.3
Bartke, A.4
-
10
-
-
79955133184
-
GF signaling regulates the proliferation of intestinal stem cells in Drosophila Development 138
-
Barzilai, N., Huffman, D. M., Muzumdar, R. H. and Bartke, A. (2012). The critical role of metabolic pathways in aging. Diabetes 61, 1315-1322. Biteau, B. and Jasper, H. (2011). GF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138, 1045-1055
-
(2011)
Development
, pp. 1045-1055
-
-
Biteau B.Jasper, H.1
-
11
-
-
52949093944
-
JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
-
Biteau, B., Hochmuth, C. E. and Jasper, H. (2008). JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3, 442-455
-
(2008)
Cell Stem Cell
, vol.3
, pp. 442-455
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
12
-
-
78449240115
-
Lifespan extension by preserving proliferative homeostasis in Drosophila
-
Biteau, B., Karpac, J., Supoyo, S., Degennaro, M., Lehmann, R. and Jasper, H. (2010). Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 6, e1001159
-
(2010)
PLoS Genet
, vol.6
-
-
Biteau, B.1
Karpac, J.2
Supoyo, S.3
Degennaro, M.4
Lehmann, R.5
Jasper, H.6
-
13
-
-
80755174406
-
Maintaining tissue homeostasis: Dynamic control of somatic stem cell activity
-
Biteau, B., Hochmuth, C. E. and Jasper, H. (2011a). Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell 9, 402-411
-
(2011)
Cell Stem Cell
, vol.9
, pp. 402-411
-
-
Biteau, B.1
Hochmuth, C.E.2
Jasper, H.3
-
14
-
-
79954630776
-
Regulation of Drosophila lifespan by JNK signaling
-
Biteau, B., Karpac, J., Hwangbo, D. and Jasper, H. (2011b). Regulation of Drosophila lifespan by JNK signaling. Exp. Gerontol. 46, 349-354
-
(2011)
Exp. Gerontol
, vol.46
, pp. 349-354
-
-
Biteau, B.1
Karpac, J.2
Hwangbo, D.3
Jasper, H.4
-
15
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Blüher, M., Kahn, B. B. and Kahn, C. R. (2003). Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Blüher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
16
-
-
34247253249
-
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance
-
Bouzakri, K. and Zierath, J. R. (2007). MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. J. Biol. Chem. 282, 7783-7789
-
(2007)
J. Biol. Chem
, vol.282
, pp. 7783-7789
-
-
Bouzakri, K.1
Zierath, J.R.2
-
17
-
-
59849091257
-
Insulin/IGF-like signalling, the central nervous system and aging
-
Broughton, S. and Partridge, L. (2009). Insulin/IGF-like signalling, the central nervous system and aging. Biochem. J. 418, 1-12
-
(2009)
Biochem. J.
, vol.418
, pp. 1-12
-
-
Broughton, S.1
Partridge, L.2
-
18
-
-
20044393471
-
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
-
Broughton, S. J., Piper, M. D., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J. et al. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA 102, 3105-3110
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3105-3110
-
-
Broughton, S.J.1
Piper, M.D.2
Ikeya, T.3
Bass, T.M.4
Jacobson, J.5
Driege, Y.6
Martinez, P.7
Hafen, E.8
Withers, D.J.9
Leevers, S.J.10
-
19
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
20
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y. et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
21
-
-
70349617469
-
Invasive and ndigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
-
Buchon, N., Broderick, N. A., Chakrabarti, S. and Lemaitre, B. (2009a). Invasive and ndigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 23, 2333-2344
-
(2009)
Genes Dev
, vol.23
, pp. 2333-2344
-
-
Buchon, N.1
Broderick, N.A.2
Chakrabarti, S.3
Lemaitre, B.4
-
22
-
-
60649091298
-
Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
-
Buchon, N., Broderick, N. A., Poidevin, M., Pradervand, S. and Lemaitre, B. (2009b). Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 5, 200-211
-
(2009)
Cell Host Microbe
, vol.5
, pp. 200-211
-
-
Buchon, N.1
Broderick, N.A.2
Poidevin, M.3
Pradervand, S.4
Lemaitre, B.5
-
23
-
-
78650397479
-
Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
-
Buchon, N., Broderick, N. A., Kuraishi, T. and Lemaitre, B. (2010). Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 8, 152
-
(2010)
BMC Biol
, vol.8
, pp. 152
-
-
Buchon, N.1
Broderick, N.A.2
Kuraishi, T.3
Lemaitre, B.4
-
24
-
-
64949182754
-
How does proliferative homeostasis change with age? What causes it and how does it contribute to aging?
-
Campisi, J. and Sedivy, J. (2009). How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? J. Gerontol. A Biol. Sci. Med. Sci. 64A, 164-166
-
(2009)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.64 A
, pp. 164-166
-
-
Campisi, J.1
Sedivy, J.2
-
25
-
-
67649403606
-
Foxo1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
-
Chakrabarti, P. and Kandror, K. V. (2009). Foxo1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J. Biol. Chem. 284, 13296-133z
-
(2009)
J. Biol. Chem
, vol.284
, pp. 13296-13300
-
-
Chakrabarti, P.1
Kandror, K.V.2
-
26
-
-
67650388208
-
Pathogenic stimulation of intestinal stem cell response in Drosophila
-
Chatterjee, M. and Ip, Y. T. (2009). Pathogenic stimulation of intestinal stem cell response in Drosophila. J. Cell. Physiol. 220, 664-671
-
(2009)
J. Cell. Physiol
, vol.220
, pp. 664-671
-
-
Chatterjee, M.1
Ip, Y.T.2
-
27
-
-
78650503295
-
Nutrition-responsive glia control exit of neural stem cells from quiescence
-
Chell, J. M. and Brand, A. H. (2010). Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell 143, 1161-1173.
-
(2010)
Cell
, vol.143
, pp. 1161-1173
-
-
Chell, J.M.1
Brand, A.H.2
-
28
-
-
43449097534
-
Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
-
Choi, N. H., Kim, J. G., Yang, D. J., Kim, Y. S. and Yoo, M. A. (2008). Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 7, 318-334
-
(2008)
Aging Cell
, vol.7
, pp. 318-334
-
-
Choi, N.H.1
Kim, J.G.2
Yang, D.J.3
Kim, Y.S.4
Yoo, M.A.5
-
29
-
-
81755187019
-
Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway
-
Choi, N. H., Lucchetta, E. and Ohlstein, B. (2011). Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway. Proc. Natl. Acad. Sci. USA 108, 18702-18707
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18702-18707
-
-
Choi, N.H.1
Lucchetta, E.2
Ohlstein, B.3
-
30
-
-
0035815414
-
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
-
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J. and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
31
-
-
84860491077
-
Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
-
Colombani, J., Andersen, D. S. and Léopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 336, 582- 585
-
(2012)
Science
, vol.336
, pp. 582-585
-
-
Colombani, J.1
Andersen, D.S.2
Léopold, P.3
-
32
-
-
67650151005
-
Cancerrelated inflammation, the seventh hallmark of cancer: Links to genetic instability
-
Colotta, F., Allavena, P., Sica, A., Garlanda, C. and Mantovani, A. (2009). Cancerrelated inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30, 1073-1081
-
(2009)
Carcinogenesis
, vol.30
, pp. 1073-1081
-
-
Colotta, F.1
Allavena, P.2
Sica, A.3
Garlanda, C.4
Mantovani, A.5
-
33
-
-
84862860608
-
Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
-
Conboy, I. M. and Rando, T. A. (2012). Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. Cell Cycle 11, 2260-2267
-
(2012)
Cell Cycle
, vol.11
, pp. 2260-2267
-
-
Conboy, I.M.1
Rando, T.A.2
-
34
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis, R. J. (2000). Signal transduction by the JNK group of MAP kinases. Cell 103, 239- 252
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
35
-
-
78650918920
-
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
-
Demontis, F. and Perrimon, N. (2010). FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 143, 813-825
-
(2010)
Cell
, vol.143
, pp. 813-825
-
-
Demontis, F.1
Perrimon, N.2
-
36
-
-
84862004148
-
Foxo1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c
-
Deng, X., Zhang, W., O-Sullivan, I., Williams, J. B., Dong, Q., Park, E. A., Raghow, R., Unterman, T. G. and Elam, M. B. (2012). Foxo1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J. Biol. Chem. 287, 20132-20143
-
(2012)
J. Biol. Chem
, vol.287
, pp. 20132-20143
-
-
Deng, X.1
Zhang, W.2
O-Sullivan, I.3
Williams, J.B.4
Dong, Q.5
Park, E.A.6
Raghow, R.7
Unterman, T.G.8
Elam, M.B.9
-
37
-
-
84872899284
-
FOXOs: Signalling integrators for homeostasis maintenance
-
Eijkelenboom, A. and Burgering, B. M. (2013). FOXOs: signalling integrators for homeostasis maintenance. Nat. Rev. Mol. Cell Biol. 14, 83-97
-
(2013)
Nat. Rev. Mol. Cell Biol
, vol.14
, pp. 83-97
-
-
Eijkelenboom, A.1
Burgering, B.M.2
-
38
-
-
42149155999
-
Overexpression of the dual- pecificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
-
Emanuelli, B., Eberlé, D., Suzuki, R. and Kahn, C. R. (2008). Overexpression of the dual- pecificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc. Natl. Acad. Sci. USA 105, 3545-3550
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3545-3550
-
-
Emanuelli, B.1
Eberlé, D.2
Suzuki, R.3
Kahn, C.R.4
-
39
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers, M. A., Weijzen, S., de Vries-Smits, A. M., Saarloos, I., de Ruiter, N. D., Bos, J. L. and Burgering, B. M. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802- 4812
-
(2004)
EMBO J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
De Vries-Smits, A.M.3
Saarloos, I.4
De Ruiter, N.D.5
Bos, J.L.6
Burgering, B.M.7
-
40
-
-
0023678537
-
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
-
Friedman, D. B. and Johnson, T. E. (1988). Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J. Gerontol. 43, B102-B109
-
(1988)
J. Gerontol
, vol.43
-
-
Friedman, D.B.1
Johnson, T.E.2
-
41
-
-
84860487216
-
Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation
-
Garelli, A., Gontijo, A. M., Miguela, V., Caparros, E. and Dominguez, M. (2012). Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. cience 336, 579-582
-
(2012)
Science
, vol.336
, pp. 579-582
-
-
Garelli, A.1
Gontijo, A.M.2
Miguela, V.3
Caparros, E.4
Dominguez, M.5
-
42
-
-
55549116359
-
DNA damage and ageing: New-age ideas for an age-old problem
-
Garinis, G. A., van der Horst, G. T., Vijg, J. and Hoeijmakers, J. H. (2008). DNA damage and ageing: new-age ideas for an age-old problem. Nat. Cell Biol. 10, 1241- 1247
-
(2008)
Nat. Cell Biol
, vol.10
, pp. 1241-1247
-
-
Garinis, G.A.1
Van Der Horst G, T.2
Vijg, J.3
Hoeijmakers, J.H.4
-
43
-
-
77950353786
-
Homeostasis and inflammation in the intestine
-
Garrett, W. S., Gordon, J. I. and Glimcher, L. H. (2010). Homeostasis and inflammation in the intestine. Cell 140, 859-870
-
(2010)
Cell
, vol.140
, pp. 859-870
-
-
Garrett, W.S.1
Gordon, J.I.2
Glimcher, L.H.3
-
44
-
-
69149110896
-
Remote control of insulin secretion by fat cells in Drosophila
-
Géminard, C., Rulifson, E. J. and Léopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10, 199-207
-
(2009)
Cell Metab
, vol.10
, pp. 199-207
-
-
Géminard, C.1
Rulifson, E.J.2
Léopold, P.3
-
45
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body
-
Giannakou, M. E., Goss, M., Jünger, M. A., Hafen, E., Leevers, S. J. and Partridge, L. (2004). Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305, 361
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Jünger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
46
-
-
67650550499
-
Chronic inflammation, the tumor microenvironment and carcinogenesis
-
Gonda, T. A., Tu, S. and Wang, T. C. (2009). Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle 8, 2005-2013
-
(2009)
Cell Cycle
, vol.8
, pp. 2005-2013
-
-
Gonda, T.A.1
Tu, S.2
Wang, T.C.3
-
47
-
-
84867363816
-
The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells
-
Goulas, S., Conder, R. and Knoblich, J. A. (2012). The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell 11, 529- 540
-
(2012)
Cell Stem Cell
, vol.11
, pp. 529-540
-
-
Goulas, S.1
Conder, R.2
Knoblich, J.A.3
-
48
-
-
40949149823
-
Signaling networks in aging
-
Greer, E. L. and Brunet, A. (2008). Signaling networks in aging. J. Cell Sci. 121, 407- 412
-
(2008)
J. Cell Sci
, vol.121
, pp. 407-412
-
-
Greer, E.L.1
Brunet, A.2
-
49
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov, S. I., Greten, F. R. and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
50
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente, L. and Kenyon, C. (2000). Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
51
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
Han, M. S., Jung, D. Y., Morel, C., Lakhani, S. A., Kim, J. K., Flavell, R. A. and Davis, R. J. 2013). JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339, 218-222
-
(2013)
Science
, vol.339
, pp. 218-222
-
-
Han, M.S.1
Jung, D.Y.2
Morel, C.3
Lakhani, S.A.4
Kim, J.K.5
Flavell, R.A.6
Davis, R.J.7
-
52
-
-
77949559540
-
Nutritional hormesis and aging
-
Hayes, D. P. (2010). Nutritional hormesis and aging. Dose Response 8, 10-15
-
(2010)
Dose Response
, vol.8
, pp. 10-15
-
-
Hayes, D.P.1
-
53
-
-
11144355021
-
C. Elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
-
Hertweck, M., Göbel, C. and Baumeister, R. (2004). C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6, 577-588
-
(2004)
Dev. Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Göbel, C.2
Baumeister, R.3
-
54
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M. and Hotamisligil, G. S. (2002). A central role for JNK in obesity and insulin resistance. Nature 420, 333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
55
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P. and Le Bouc, Y. (2003). IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Géloën, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
56
-
-
0032925340
-
Mechanisms of TNF-alpha-induced insulin resistance
-
Hotamisligil, G. S. (1999). Mechanisms of TNF-alpha-induced insulin resistance. Exp. Clin. Endocrinol. Diabetes 107, 119-125
-
(1999)
Exp. Clin. Endocrinol. Diabetes
, vol.107
, pp. 119-125
-
-
Hotamisligil, G.S.1
-
57
-
-
33644750396
-
Role of endoplasmic reticulum stress and c-Jun NH2- terminal kinase pathways in inflammation and origin of obesity and diabetes
-
Hotamisligil, G. S. (2005). Role of endoplasmic reticulum stress and c-Jun NH2- terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 Suppl., S73-S78
-
(2005)
Diabetes
, Issue.SUPPL..54
-
-
Hotamisligil, G.S.1
-
58
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature 444, 860- 867
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
59
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
-
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F. and Spiegelman, B. M. (1996). IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 271, 665-668
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
60
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
-
Hwangbo, D. S., Gershman, B., Tu, M. P., Palmer, M. and Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562-566
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gershman, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
61
-
-
34547219895
-
Metabolic stress signaling mediated by ixedlineage kinases
-
Jaeschke, A. and Davis, R. J. (2007). Metabolic stress signaling mediated by ixedlineage kinases. Mol. Cell 27, 498-508
-
(2007)
Mol. Cell
, vol.27
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
62
-
-
84867410773
-
Skeletal muscle stem cells: Effects of aging and metabolism on muscle regenerative function
-
Jang, Y. C., Sinha, M., Cerletti, M., Dall'Osso, C. and Wagers, A. J. (2011). Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function. Cold Spring Harb. Symp. Quant. Biol. 76, 101-111
-
(2011)
Cold Spring Harb. Symp. Quant. Biol
, vol.76
, pp. 101-111
-
-
Jang, Y.C.1
Sinha, M.2
Cerletti, M.3
Dall'Osso, C.4
Wagers, A.J.5
-
63
-
-
78649519914
-
Metabolic regulation of stem cell behavior and implications for aging
-
Jasper, H. and Jones, D. L. (2010). Metabolic regulation of stem cell behavior and implications for aging. Cell Metab. 12, 561-565
-
(2010)
Cell Metab
, vol.12
, pp. 561-565
-
-
Jasper, H.1
Jones, D.L.2
-
64
-
-
67549133157
-
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
-
Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G. and Edgar, B. A. (2009). Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137, 1343-1355
-
(2009)
Cell
, vol.137
, pp. 1343-1355
-
-
Jiang, H.1
Patel, P.H.2
Kohlmaier, A.3
Grenley, M.O.4
McEwen, D.G.5
Edgar, B.A.6
-
65
-
-
78650977190
-
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
-
Jiang, H., Grenley, M. O., Bravo, M. J., Blumhagen, R. Z. and Edgar, B. A. (2011). EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8, 84-95
-
(2011)
Cell Stem Cell
, vol.8
, pp. 84-95
-
-
Jiang, H.1
Grenley, M.O.2
Bravo, M.J.3
Blumhagen, R.Z.4
Edgar, B.A.5
-
66
-
-
79955511101
-
Emerging models and paradigms for stem cell ageing
-
Jones, D. L. and Rando, T. A. (2011). Emerging models and paradigms for stem cell ageing. Nat. Cell Biol. 13, 506-512
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 506-512
-
-
Jones, D.L.1
Rando, T.A.2
-
67
-
-
77949546072
-
Stress to the rescue: Is hormesis a 'cure' for aging?
-
Kahn, A. and Olsen, A. (2010). Stress to the rescue: is hormesis a 'cure' for aging? Dose Response 8, 48-52
-
(2010)
Dose Response
, vol.8
, pp. 48-52
-
-
Kahn, A.1
Olsen, A.2
-
68
-
-
78049362580
-
Protein synthesis and the antagonistic pleiotropy hypothesis of aging
-
Kapahi, P. (2010). Protein synthesis and the antagonistic pleiotropy hypothesis of aging. Adv. Exp. Med. Biol. 694, 30-37
-
(2010)
Adv. Exp. Med. Biol
, vol.694
, pp. 30-37
-
-
Kapahi, P.1
-
69
-
-
77955747346
-
With TOR, less is more: A key role for the conserved nutrientsensing TOR pathway in aging
-
Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W., Thomas, E. L. and Kockel, L. (2010). With TOR, less is more: a key role for the conserved nutrientsensing TOR pathway in aging. Cell Metab. 11, 453-465
-
(2010)
Cell Metab
, vol.11
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
Kockel, L.7
-
70
-
-
84870700189
-
Notchmediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage
-
Kapuria, S., Karpac, J., Biteau, B., Hwangbo, D. and Jasper, H. (2012). Notchmediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet. 8, e1003045.
-
(2012)
PLoS Genet
, vol.8
-
-
Kapuria, S.1
Karpac, J.2
Biteau, B.3
Hwangbo, D.4
Jasper, H.5
-
71
-
-
21344474327
-
From JNK to pay dirt: Jun kinases, their biochemistry, hysiology and clinical importance
-
Karin, M. and Gallagher, E. (2005). From JNK to pay dirt: Jun kinases, their biochemistry, hysiology and clinical importance. IUBMB Life 57, 283-295
-
(2005)
IUBMB Life
, vol.57
, pp. 283-295
-
-
Karin, M.1
Gallagher, E.2
-
72
-
-
62649089279
-
Insulin and JNK: Optimizing metabolic homeostasis and lifespan
-
Karpac, J. and Jasper, H. (2009). Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol. Metab. 20, 100-106
-
(2009)
Trends Endocrinol. Metab
, vol.20
, pp. 100-106
-
-
Karpac, J.1
Jasper, H.2
-
73
-
-
66149160390
-
JNK signaling in insulin- producing cells is required for adaptive responses to stress in Drosophila
-
Karpac, J., Hull-Thompson, J., Falleur, M. and Jasper, H. (2009). JNK signaling in insulin- producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8, 288-295
-
(2009)
Aging Cell
, vol.8
, pp. 288-295
-
-
Karpac, J.1
Hull-Thompson, J.2
Falleur, M.3
Jasper, H.4
-
74
-
-
79958181684
-
Dynamic coordination of innate immune ignaling and insulin signaling regulates systemic responses to localized DNA damage
-
Karpac, J., Younger, A. and Jasper, H. (2011). Dynamic coordination of innate immune ignaling and insulin signaling regulates systemic responses to localized DNA damage. Dev. Cell 20, 841-854
-
(2011)
Dev. Cell
, vol.20
, pp. 841-854
-
-
Karpac, J.1
Younger, A.2
Jasper, H.3
-
75
-
-
77952316009
-
Inflammatory bowel disease
-
Kaser, A., Zeissig, S. and Blumberg, R. S. (2010). Inflammatory bowel disease. Annu. Rev. Immunol. 28, 573-621
-
(2010)
Annu. Rev. Immunol
, vol.28
, pp. 573-621
-
-
Kaser, A.1
Zeissig, S.2
Blumberg, R.S.3
-
76
-
-
77950191067
-
Dietary restriction and aging
-
2009
-
Katewa, S. D. and Kapahi, P. (2010). Dietary restriction and aging, 2009. Aging Cell 9, 105-112
-
(2010)
Aging Cell
, vol.9
, pp. 105-112
-
-
Katewa, S.D.1
Kapahi, P.2
-
77
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
Kenyon, C. (2005). The plasticity of aging: insights from long-lived mutants. Cell 120, 449- 460
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
78
-
-
77950200010
-
The genetics of ageing
-
Kenyon, C. J. (2010). The genetics of ageing. Nature 464, 504-512
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
79
-
-
0027771804
-
A C. Elegans mutant that lives twice as long as wild type
-
Kenyon, C., Chang, J., Gensch, E., Rudner, A. and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
80
-
-
0033966768
-
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS- 1, and IRS-2
-
Kido, Y., Burks, D. J., Withers, D., Bruning, J. C., Kahn, C. R., White, M. F. and Accili, D. (2000). Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS- 1, and IRS-2. J. Clin. Invest. 105, 199-205
-
(2000)
J. Clin. Invest
, vol.105
, pp. 199-205
-
-
Kido, Y.1
Burks, D.J.2
Withers, D.3
Bruning, J.C.4
Kahn, C.R.5
White, M.F.6
Accili, D.7
-
81
-
-
0030813398
-
Daf-2, an insulin receptor- like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura, K. D., Tissenbaum, H. A., Liu, Y. and Ruvkun, G. (1997). daf-2, an insulin receptor- like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
82
-
-
0037974530
-
Insulin receptor knockout mice
-
Kitamura, T., Kahn, C. R. and Accili, D. (2003). Insulin receptor knockout mice. Annu. Rev. Physiol. 65, 313-332
-
(2003)
Annu. Rev. Physiol
, vol.65
, pp. 313-332
-
-
Kitamura, T.1
Kahn, C.R.2
Accili, D.3
-
83
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops, G. J., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W., Coffer, P. J., Huang, T. T., Bos, J. L., Medema, R. H. and Burgering, B. M. (2002). Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
84
-
-
34047268684
-
The host defense of Drosophila melanogaster
-
Lemaitre, B. and Hoffmann, J. (2007). The host defense of Drosophila melanogaster. Annu. Rev. Immunol. 25, 697-743
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 697-743
-
-
Lemaitre, B.1
Hoffmann, J.2
-
85
-
-
36049044765
-
Drosophila and the genetics of the internal milieu
-
Leopold, P. and Perrimon, N. (2007). Drosophila and the genetics of the internal milieu. Nature 450, 186-188
-
(2007)
Nature
, vol.450
, pp. 186-188
-
-
Leopold, P.1
Perrimon, N.2
-
86
-
-
0037380570
-
Daf-28 encodes a C. Elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
-
Li, W., Kennedy, S. G. and Ruvkun, G. (2003). daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 17, 844-858
-
(2003)
Genes Dev
, vol.17
, pp. 844-858
-
-
Li, W.1
Kennedy, S.G.2
Ruvkun, G.3
-
87
-
-
34848924279
-
Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction
-
Libert, S., Chao, Y., Zwiener, J. and Pletcher, S. D. (2008). Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Mol. Immunol. 45, 810-817
-
(2008)
Mol. Immunol
, vol.45
, pp. 810-817
-
-
Libert, S.1
Chao, Y.2
Zwiener, J.3
Pletcher, S.D.4
-
88
-
-
0345447590
-
Tissue-specific activities of C. Elegans DAF-16 in the regulation of lifespan
-
Libina, N., Berman, J. R. and Kenyon, C. (2003). Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115, 489-502
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
89
-
-
54549104587
-
Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
-
Lin, G., Xu, N. and Xi, R. (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455, 1119-1123
-
(2008)
Nature
, vol.455
, pp. 1119-1123
-
-
Lin, G.1
Xu, N.2
Xi, R.3
-
90
-
-
79955513612
-
Manifestations and mechanisms of stem cell aging
-
Liu, L. and Rando, T. A. (2011). Manifestations and mechanisms of stem cell aging. J. Cell Biol. 193, 257-266
-
(2011)
J. Cell Biol
, vol.193
, pp. 257-266
-
-
Liu, L.1
Rando, T.A.2
-
91
-
-
77955608813
-
Evolutionary adaptations to dietary changes
-
Luca, F., Perry, G. H. and Di Rienzo, A. (2010). Evolutionary adaptations to dietary changes. Annu. Rev. Nutr. 30, 291-314s
-
(2010)
Annu. Rev. Nutr
, vol.30
, pp. 291-314
-
-
Luca, F.1
Perry, G.H.2
Di Rienzo, A.3
-
92
-
-
33846515971
-
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation
-
Luo, X., Puig, O., Hyun, J., Bohmann, D. and Jasper, H. (2007). Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J. 26, 380- 390
-
(2007)
EMBO J.
, vol.26
, pp. 380-390
-
-
Luo, X.1
Puig, O.2
Hyun, J.3
Bohmann, D.4
Jasper, H.5
-
93
-
-
50649099122
-
Aging and survival: The genetics of life span extension by dietary restriction
-
Mair, W. and Dillin, A. (2008). Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727-754
-
(2008)
Annu. Rev. Biochem
, vol.77
, pp. 727-754
-
-
Mair, W.1
Dillin, A.2
-
94
-
-
0037473115
-
An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer
-
Mamay, C. L., Mingo-Sion, A. M., Wolf, D. M., Molina, M. D. and Van Den Berg, C. L. (2003). An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. Oncogene 22, 602-614
-
(2003)
Oncogene
, vol.22
, pp. 602-614
-
-
Mamay, C.L.1
Mingo-Sion, A.M.2
Wolf, D.M.3
Molina, M.D.4
Van Den Berg, C.L.5
-
95
-
-
0038004740
-
Targeting JNK for therapeutic benefit: From junk to gold?
-
Manning, A. M. and Davis, R. J. (2003). Targeting JNK for therapeutic benefit: from junk to gold? Nat. Rev. Drug Discov. 2, 554-565
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 554-565
-
-
Manning, A.M.1
Davis, R.J.2
-
96
-
-
20444441548
-
Cancer: Inflammation by remote control
-
Mantovani, A. (2005). Cancer: inflammation by remote control. Nature 435, 752-753
-
(2005)
Nature
, vol.435
, pp. 752-753
-
-
Mantovani, A.1
-
97
-
-
58149231380
-
Cancer: Inflaming metastasis
-
Mantovani, A. (2009). Cancer: inflaming metastasis. Nature 457, 36-37
-
(2009)
Nature
, vol.457
, pp. 36-37
-
-
Mantovani, A.1
-
98
-
-
24144492761
-
All roads lead to Foxo
-
Matsumoto, M. and Accili, D. (2005). All roads lead to Foxo. Cell Metab. 1, 215-216
-
(2005)
Cell Metab
, vol.1
, pp. 215-216
-
-
Matsumoto, M.1
Accili, D.2
-
99
-
-
78650175195
-
Stem cell dynamics in response to nutrient availability
-
McLeod, C. J., Wang, L., Wong, C. and Jones, D. L. (2010). Stem cell dynamics in response to nutrient availability. Curr. Biol. 20, 2100-2105
-
(2010)
Curr. Biol
, vol.20
, pp. 2100-2105
-
-
McLeod, C.J.1
Wang, L.2
Wong, C.3
Jones, D.L.4
-
100
-
-
31444452338
-
Evidence that stem cells reside in the adult Drosophila midgut epithelium
-
Micchelli, C. A. and Perrimon, N. (2006). Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439, 475-479
-
(2006)
Nature
, vol.439
, pp. 475-479
-
-
Micchelli, C.A.1
Perrimon, N.2
-
101
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A. and Kahn, C. R. (2000). Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
102
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova, M. M., Vasquez, D. S., Ravnskjaer, K., Denechaud, P. D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M. and Shaw, R. J. (2011). Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145, 607-621
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
103
-
-
3042685022
-
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response
-
Mizuno, T., Hisamoto, N., Terada, T., Kondo, T., Adachi, M., Nishida, E., Kim, D. H., Ausubel, F. M. and Matsumoto, K. (2004). The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 23, 2226-2234
-
(2004)
EMBO J
, vol.23
, pp. 2226-2234
-
-
Mizuno, T.1
Hisamoto, N.2
Terada, T.3
Kondo, T.4
Adachi, M.5
Nishida, E.6
Kim, D.H.7
Ausubel, F.M.8
Matsumoto, K.9
-
104
-
-
50649085536
-
Toward a control theory analysis of aging
-
Murphy, M. P. and Partridge, L. (2008). Toward a control theory analysis of aging. Annu. Rev. Biochem. 77, 777-798
-
(2008)
Annu. Rev. Biochem
, vol.77
, pp. 777-798
-
-
Murphy, M.P.1
Partridge, L.2
-
105
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the ifespan of Caenorhabditis elegans
-
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H. and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the ifespan of Caenorhabditis elegans. Nature 424, 277-283
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
106
-
-
33845914051
-
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
-
Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W. et al. (2006). A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038-1043
-
(2006)
Nature
, vol.444
, pp. 1038-1043
-
-
Niedernhofer, L.J.1
Garinis, G.A.2
Raams, A.3
Lalai, A.S.4
Robinson, A.R.5
Appeldoorn, E.6
Odijk, H.7
Oostendorp, R.8
Ahmad, A.9
Van Leeuwen, W.10
-
107
-
-
52449112590
-
14-3-3 Epsilon antagonizes Foxo to control growth, apoptosis and longevity in Drosophila
-
Nielsen, M. D., Luo, X., Biteau, B., Syverson, K. and Jasper, H. (2008). 14-3-3 Epsilon antagonizes Foxo to control growth, apoptosis and longevity in Drosophila. Aging Cell 7, 688-699
-
(2008)
Aging Cell
, vol.7
, pp. 688-699
-
-
Nielsen, M.D.1
Luo, X.2
Biteau, B.3
Syverson, K.4
Jasper, H.5
-
108
-
-
76649145629
-
Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells
-
Niwa, T., Tsukamoto, T., Toyoda, T., Mori, A., Tanaka, H., Maekita, T., Ichinose, M., Tatematsu, M. and Ushijima, T. (2010). Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 70, 1430-1440
-
(2010)
Cancer Res
, vol.70
, pp. 1430-1440
-
-
Niwa, T.1
Tsukamoto, T.2
Toyoda, T.3
Mori, A.4
Tanaka, H.5
Maekita, T.6
Ichinose, M.7
Tatematsu, M.8
Ushijima, T.9
-
109
-
-
80155123827
-
Altered modes of stem cell division drive adaptive intestinal growth
-
O'Brien, L. E., Soliman, S. S., Li, X. and Bilder, D. (2011). Altered modes of stem cell division drive adaptive intestinal growth. Cell 147, 603-614
-
(2011)
Cell
, vol.147
, pp. 603-614
-
-
O'Brien, L.E.1
Soliman, S.S.2
Li, X.3
Bilder, D.4
-
110
-
-
84872166765
-
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
-
Odegaard, J. I. and Chawla, A. (2013). Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 339, 172-177
-
(2013)
Science
, vol.339
, pp. 172-177
-
-
Odegaard, J.I.1
Chawla, A.2
-
111
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh, S. W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R. J. and Tissenbaum, H. A. (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102, 4494-4499
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Svrzikapa, N.3
Jiang, F.4
Davis, R.J.5
Tissenbaum, H.A.6
-
112
-
-
31444444485
-
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
-
Ohlstein, B. and Spradling, A. (2006). The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439, 470-474
-
(2006)
Nature
, vol.439
, pp. 470-474
-
-
Ohlstein, B.1
Spradling, A.2
-
113
-
-
33847168133
-
Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
-
Ohlstein, B. and Spradling, A. (2007). Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 315, 988-992
-
(2007)
Science
, vol.315
, pp. 988-992
-
-
Ohlstein, B.1
Spradling, A.2
-
114
-
-
71649090271
-
A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
-
Okamoto, N., Yamanaka, N., Yagi, Y., Nishida, Y., Kataoka, H., O'Connor, M. B. and Mizoguchi, A. (2009). A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila. Dev. Cell 17, 885-891
-
(2009)
Dev. Cell
, vol.17
, pp. 885-891
-
-
Okamoto, N.1
Yamanaka, N.2
Yagi, Y.3
Nishida, Y.4
Kataoka, H.5
O'Connor, M.B.6
Mizoguchi, A.7
-
115
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H. and Hotamisligil, G. S. (2004). Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457- 461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
116
-
-
68149169938
-
Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans
-
Panowski, S. H. and Dillin, A. (2009). Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol. Metab. 20, 259-264
-
(2009)
Trends Endocrinol. Metab
, vol.20
, pp. 259-264
-
-
Panowski, S.H.1
Dillin, A.2
-
117
-
-
0031864164
-
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
-
Parkes, T. L., Elia, A. J., Dickinson, D., Hilliker, A. J., Phillips, J. P. and Boulianne, G. L. (1998). Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat. Genet. 19, 171-174
-
(1998)
Nat. Genet
, vol.19
, pp. 171-174
-
-
Parkes, T.L.1
Elia, A.J.2
Dickinson, D.3
Hilliker, A.J.4
Phillips, J.P.5
Boulianne, G.L.6
-
118
-
-
77950251400
-
A human gut microbial gene catalogue established by metagenomic sequencing
-
Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., Yamada, T. et al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65
-
(2012)
Nature
, vol.464
, pp. 59-65
-
-
Qin, J.1
Li, R.2
Raes, J.3
Arumugam, M.4
Burgdorf, K.S.5
Manichanh, C.6
Nielsen, T.7
Pons, N.8
Levenez, F.9
Yamada, T.10
-
119
-
-
33646567128
-
From gut homeostasis to cancer
-
Radtke, F., Clevers, H. and Riccio, O. (2006). From gut homeostasis to cancer. Curr. Mol. Med. 6, 275-289
-
(2006)
Curr. Mol. Med
, vol.6
, pp. 275-289
-
-
Radtke, F.1
Clevers, H.2
Riccio, O.3
-
120
-
-
84866978180
-
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
-
Rajan, A. and Perrimon, N. (2012). Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell 151, 123-137
-
(2012)
Cell
, vol.151
, pp. 123-137
-
-
Rajan, A.1
Perrimon, N.2
-
121
-
-
84856090875
-
Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock
-
Rando, T. A. and Chang, H. Y. (2012). Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 148, 46-57
-
(2012)
Cell
, vol.148
, pp. 46-57
-
-
Rando, T.A.1
Chang, H.Y.2
-
122
-
-
80455143200
-
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
-
Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jr, Jones, D. L. and Walker, D. W. (2011). Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 14, 623-634
-
(2011)
Cell Metab
, vol.14
, pp. 623-634
-
-
Rera, M.1
Bahadorani, S.2
Cho, J.3
Koehler, C.L.4
Ulgherait, M.5
Hur, J.H.6
Ansari, W.S.7
Lo, T.8
Jones, Jr.D.L.9
Walker, D.W.10
-
123
-
-
84871830937
-
Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
-
Rera, M., Clark, R. I. and Walker, D. W. (2012). Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc. Natl. Acad. Sci. USA 109, 21528-21533
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 21528-21533
-
-
Rera, M.1
Clark, R.I.2
Walker, D.W.3
-
124
-
-
84875902181
-
Organ-specific mediation of lifespan extension: More than a gut feeling?
-
Rera, M., Azizi, M. J. and Walker, D. W. (2013). Organ-specific mediation of lifespan extension: more than a gut feeling? Ageing Res. Rev. 12, 436-444
-
(2013)
Ageing Res. Rev
, vol.12
, pp. 436-444
-
-
Rera, M.1
Azizi, M.J.2
Walker, D.W.3
-
125
-
-
77953373468
-
Ionizing radiation and aging: Rejuvenating an old idea
-
Richardson, R. B. (2009). Ionizing radiation and aging: rejuvenating an old idea. Aging 1, 887-902
-
(2009)
Aging
, vol.1
, pp. 887-902
-
-
Richardson, R.B.1
-
126
-
-
33645888693
-
Nutrition and aging: Changes in the regulation of energy metabolism with aging
-
Roberts, S. B. and Rosenberg, I. (2006). Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol. Rev. 86, 651-667
-
(2006)
Physiol. Rev
, vol.86
, pp. 651-667
-
-
Roberts, S.B.1
Rosenberg, I.2
-
128
-
-
77956185248
-
CJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
-
Sabio, G. and Davis, R. J. (2010). cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem. Sci. 35, 490-496
-
(2010)
Trends Biochem. Sci
, vol.35
, pp. 490-496
-
-
Sabio, G.1
Davis, R.J.2
-
129
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K. and Davis, R. J. (2008). A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539-1543
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
130
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel, A. R. and Kahn, C. R. (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
131
-
-
84857861919
-
Mechanisms for insulin resistance: Common threads and missing links
-
Samuel, V. T. and Shulman, G. I. (2012). Mechanisms for insulin resistance: common threads and missing links. Cell 148, 852-871
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
132
-
-
33745294013
-
The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
-
Schoenborn, V., Heid, I. M., Vollmert, C., Lingenhel, A., Adams, T. D., Hopkins, P. N., Illig, ., Zimmermann, R., Zechner, R., Hunt, S. C. et al. (2006). The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 55, 1270-1275
-
(2006)
Diabetes
, vol.55
, pp. 1270-1275
-
-
Schoenborn, V.1
Heid, I.M.2
Vollmert, C.3
Lingenhel, A.4
Adams, T.D.5
Hopkins, P.N.6
Illig, T.7
Zimmermann, R.8
Zechner, R.9
Hunt, S.C.10
-
133
-
-
73149120015
-
Transcription-blocking DNA damage in aging: A mechanism for hormesis
-
Schumacher, B. (2009). Transcription-blocking DNA damage in aging: a mechanism for hormesis. Bioessays 31, 1347-1356
-
(2009)
Bioessays
, vol.31
, pp. 1347-1356
-
-
Schumacher, B.1
-
134
-
-
38549106119
-
Age to survive: DNA damage and aging
-
Schumacher, B., Garinis, G. A. and Hoeijmakers, J. H. (2008). Age to survive: DNA damage and aging. Trends Genet. 24, 77-85
-
(2008)
Trends Genet
, vol.24
, pp. 77-85
-
-
Schumacher, B.1
Garinis, G.A.2
Hoeijmakers, J.H.3
-
135
-
-
0033636780
-
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
-
Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S. and Goldstein, . L. (2000). Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86
-
(2000)
Mol. Cell
, vol.6
, pp. 77-86
-
-
Shimomura, I.1
Matsuda, M.2
Hammer, R.E.3
Bashmakov, Y.4
Brown, M.S.5
Goldstein, L.6
-
136
-
-
84855422546
-
Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro
-
Sieber, M. H. and Thummel, C. S. (2012). Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Cell Metab. 15, 122-127
-
(2012)
Cell Metab
, vol.15
, pp. 122-127
-
-
Sieber, M.H.1
Thummel, C.S.2
-
137
-
-
71649107200
-
A Drosophila insulin-like peptide promotes growth during nonfeeding states
-
Slaidina, M., Delanoue, R., Gronke, S., Partridge, L. and Léopold, P. (2009). A Drosophila insulin-like peptide promotes growth during nonfeeding states. Dev. Cell 17, 874-884
-
(2009)
Dev. Cell
, vol.17
, pp. 874-884
-
-
Slaidina, M.1
Delanoue, R.2
Gronke, S.3
Partridge, L.4
Léopold, P.5
-
138
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J. L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M. et al. (2007). JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 6, 386-397
-
(2007)
Cell Metab
, vol.6
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
-
139
-
-
79953044605
-
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
-
Sousa-Nunes, R., Yee, L. L. and Gould, A. P. (2011). Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature 471, 508-512
-
(2011)
Nature
, vol.471
, pp. 508-512
-
-
Sousa-Nunes, R.1
Yee, L.L.2
Gould, A.P.3
-
140
-
-
2342548187
-
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span
-
Sun, J., Molitor, J. and Tower, J. (2004). Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech. Ageing Dev. 125, 341-349
-
(2004)
Mech. Ageing Dev
, vol.125
, pp. 341-349
-
-
Sun, J.1
Molitor, J.2
Tower, J.3
-
141
-
-
22944479314
-
JNK antagonizes Akt- mediated survival signals by phosphorylating 14-3-3
-
Sunayama, J., Tsuruta, F., Masuyama, N. and Gotoh, Y. (2005). JNK antagonizes Akt- mediated survival signals by phosphorylating 14-3-3. J. Cell Biol. 170, 295-304
-
(2005)
J. Cell Biol
, vol.170
, pp. 295-304
-
-
Sunayama, J.1
Tsuruta, F.2
Masuyama, N.3
Gotoh, Y.4
-
142
-
-
78649513976
-
Diabetes and insulin in regulation of brain cholesterol metabolism
-
Suzuki, R., Lee, K., Jing, E., Biddinger, S. B., McDonald, J. G., Montine, T. J., Craft, S. and Kahn, C. R. (2010). Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 12, 567-579
-
(2010)
Cell Metab
, vol.12
, pp. 567-579
-
-
Suzuki, R.1
Lee, K.2
Jing, E.3
Biddinger, S.B.4
McDonald, J.G.5
Montine, T.J.6
Craft, S.7
Kahn, C.R.8
-
143
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
Taguchi, A., Wartschow, L. M. and White, M. F. (2007). Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
144
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar, M., Kopelman, A., Epstein, D., Tu, M. P., Yin, C. M. and Garofalo, R. S. (2001). A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
145
-
-
0037470501
-
The endocrine regulation of aging by insulin- like signals
-
Tatar, M., Bartke, A. and Antebi, A. (2003). The endocrine regulation of aging by insulin- like signals. Science 299, 1346-1351
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
147
-
-
72449195397
-
Molecular mechanisms of metabolic regulation by insulin in Drosophila
-
Teleman, A. A. (2010). Molecular mechanisms of metabolic regulation by insulin in Drosophila. Biochem. J. 425, 13-26
-
(2010)
Biochem. J
, vol.425
, pp. 13-26
-
-
Teleman, A.A.1
-
148
-
-
0036007110
-
Model organisms as a guide to mammalian aging
-
Tissenbaum, H. A. and Guarente, L. (2002). Model organisms as a guide to mammalian aging. Dev. Cell 2, 9-19
-
(2002)
Dev. Cell
, vol.2
, pp. 9-19
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
149
-
-
58349117867
-
Endocrine regulation of aging and reproduction in Drosophila
-
Toivonen, J. M. and Partridge, L. (2009). Endocrine regulation of aging and reproduction in Drosophila. Mol. Cell. Endocrinol. 299, 39-50
-
(2009)
Mol. Cell. Endocrinol
, vol.299
, pp. 39-50
-
-
Toivonen, J.M.1
Partridge, L.2
-
150
-
-
79954633863
-
Heat shock proteins and Drosophila aging
-
Tower, J. (2011). Heat shock proteins and Drosophila aging. Exp. Gerontol. 46, 355- 362
-
(2011)
Exp. Gerontol
, vol.46
, pp. 355-362
-
-
Tower, J.1
-
151
-
-
34547602916
-
Loss-of- unction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo, D. M., Carvalho-Filho, M. A., Carvalheira, J. B., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A. et al. (2007). Loss-of- unction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986-1998
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.3
Prada, P.O.4
Hirabara, S.M.5
Schenka, A.A.6
Araújo, E.P.7
Vassallo, J.8
Curi, R.9
Velloso, L.A.10
-
152
-
-
2442429306
-
JNK promotes Bax translocation to mitochondria hrough phosphorylation of 14-3-3 proteins
-
Tsuruta, F., Sunayama, J., Mori, Y., Hattori, S., Shimizu, S., Tsujimoto, Y., Yoshioka, K., Masuyama, N. and Gotoh, Y. (2004). JNK promotes Bax translocation to mitochondria hrough phosphorylation of 14-3-3 proteins. EMBO J. 23, 1889-1899
-
(2004)
EMBO J
, vol.23
, pp. 1889-1899
-
-
Tsuruta, F.1
Sunayama, J.2
Mori, Y.3
Hattori, S.4
Shimizu, S.5
Tsujimoto, Y.6
Yoshioka, K.7
Masuyama, N.8
Gotoh, Y.9
-
153
-
-
67650299380
-
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
-
Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S. and Jobin, C. (2009). Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS ONE 4, e6026
-
(2009)
PLoS ONE
, vol.4
-
-
Uronis, J.M.1
Mühlbauer, M.2
Herfarth, H.H.3
Rubinas, T.C.4
Jones, G.S.5
Jobin, C.6
-
154
-
-
33846030099
-
Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome
-
van der Pluijm, I., Garinis, G. A., Brandt, R. M., Gorgels, T. G., Wijnhoven, S. W., Diderich, K. E., de Wit, J., Mitchell, J. R., van Oostrom, C., Beems, R. et al. (2007). Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5, e2
-
(2007)
PLoS Biol
, vol.5
-
-
Van Der Pluijm, I.1
Garinis, G.A.2
Brandt, R.M.3
Gorgels, T.G.4
Wijnhoven, S.W.5
Diderich, K.E.6
De Wit, J.7
Mitchell, J.R.8
Van Oostrom, C.9
Beems, R.10
-
155
-
-
39149139982
-
DFOXO regulates transcription of a Drosophila acid lipase
-
Vihervaara, T. and Puig, O. (2008). dFOXO regulates transcription of a Drosophila acid lipase. J. Mol. Biol. 376, 1215-1223
-
(2008)
J. Mol. Biol
, vol.376
, pp. 1215-1223
-
-
Vihervaara, T.1
Puig, O.2
-
156
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A., Miklossy, J., Dina, C., Hani, E. H. et al. (2000). The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat. Genet. 24, 291- 295
-
(2000)
Nat. Genet
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
Mooser, V.4
Steinmann, M.5
Widmann, C.6
Maillard, A.7
Miklossy, J.8
Dina, C.9
Hani, E.H.10
-
157
-
-
0242362732
-
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
-
Wang, M. C., Bohmann, D. and Jasper, H. (2003). JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5, 811-816
-
(2003)
Dev. Cell
, vol.5
, pp. 811-816
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
158
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang, M. C., Bohmann, D. and Jasper, H. (2005). JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115- 125
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
159
-
-
79955802436
-
A hormonedependentmodule regulating energy balance
-
Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M. M., Shaw, R. J., Yates, J. R., III, Fischer, W. H., Thomas, J. B. and Montminy, M. (2011). A hormonedependentmodule regulating energy balance. Cell 145, 596-606
-
(2011)
Cell
, vol.145
, pp. 596-606
-
-
Wang, B.1
Moya, N.2
Niessen, S.3
Hoover, H.4
Mihaylova, M.M.5
Shaw, R.J.6
Yates III, J.R.7
Fische, W.H.8
Thomas, J.B.9
Montminy, M.10
-
160
-
-
9644278037
-
Insulin regulation of heart function in aging fruit flies
-
Wessells, R. J., Fitzgerald, E., Cypser, J. R., Tatar, M. and Bodmer, R. (2004). Insulin regulation of heart function in aging fruit flies. Nat. Genet. 36, 1275-1281
-
(2004)
Nat. Genet
, vol.36
, pp. 1275-1281
-
-
Wessells, R.J.1
Fitzgerald, E.2
Cypser, J.R.3
Tatar, M.4
Bodmer, R.5
-
162
-
-
38449093926
-
The MAP kinase JNK-1 of Caenorhabditis elegans: Location, activation, and influences over temperature- dependent insulin-like signaling, stress responses, and fitness
-
Wolf, M., Nunes, F., Henkel, A., Heinick, A. and Paul, R. J. (2008). The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature- dependent insulin-like signaling, stress responses, and fitness. J. Cell. Physiol. 214, 721- 729
-
(2008)
J. Cell. Physiol
, vol.214
, pp. 721-729
-
-
Wolf, M.1
Nunes, F.2
Henkel, A.3
Heinick, A.4
Paul, R.J.5
-
163
-
-
0034613164
-
Regulation of C. Elegans life-span by insulinlike signaling in the nervous system
-
Wolkow, C. A., Kimura, K. D., Lee, M. S. and Ruvkun, G. (2000). Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290, 147- 150
-
(2000)
Science
, vol.290
, pp. 147-150
-
-
Wolkow, C.A.1
Kimura, K.D.2
Lee, M.S.3
Ruvkun, G.4
-
164
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier, R. J. and Podolsky, D. K. (2007). Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
165
-
-
84857473501
-
Insulin signaling regulates fatty acid catabolism at the level of CoA activation
-
Xu, X., Gopalacharyulu, P., Seppänen-Laakso, T., Ruskeepää, A. L., Aye, C. C., Carson, B. P., Mora, S., Orešič, M. and Teleman, A. A. (2012). Insulin signaling regulates fatty acid catabolism at the level of CoA activation. PLoS Genet. 8, e1002478
-
(2012)
PLoS Genet
, vol.8
-
-
Xu, X.1
Gopalacharyulu, P.2
Seppänen-Laakso, T.3
Ruskeepää, A.L.4
Aye, C.C.5
Carson, B.P.6
Mora, S.7
Orešič, M.8
Teleman, A.A.9
-
166
-
-
34547942526
-
Liver-specific knockdown of JNK1 up- regulates proliferator-activated receptor γ coactivator 1β and increases plasma triglyceride despite reduced glucose and insulin levels in dietinduced obese mice
-
Yang, R., Wilcox, D. M., Haasch, D. L., Jung, P. M., Nguyen, P. T., Voorbach, M. J., Doktor, S., Brodjian, S., Bush, E. N., Lin, E. et al. (2007). Liver-specific knockdown of JNK1 up- regulates proliferator-activated receptor γ coactivator 1β and increases plasma triglyceride despite reduced glucose and insulin levels in dietinduced obese mice. J. Biol. Chem. 282, 22765-22774
-
(2007)
J. Biol. Chem
, vol.282
, pp. 22765-22774
-
-
Yang, R.1
Wilcox, D.M.2
Haasch, D.L.3
Jung, P.M.4
Nguyen, P.T.5
Voorbach, M.J.6
Doktor, S.7
Brodjian, S.8
Bush, E.N.9
Lin, E.10
-
167
-
-
0032487857
-
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
-
Yin, M. J., Yamamoto, Y. and Gaynor, R. B. (1998). The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396, 77-80
-
(1998)
Nature
, vol.396
, pp. 77-80
-
-
Yin, M.J.1
Yamamoto, Y.2
Gaynor, R.B.3
-
168
-
-
14744301343
-
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
Yoshida, K., Yamaguchi, T., Natsume, T., Kufe, D. and Miki, Y. (2005). JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol. 7, 278-285
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 278-285
-
-
Yoshida, K.1
Yamaguchi, T.2
Natsume, T.3
Kufe, D.4
Miki, Y.5
-
169
-
-
84872143888
-
Direct and indirect gene regulation by a life-extending FOXO protein in C. Elegans: Roles for GATA factors and lipid gene regulators
-
Zhang, P., Judy, M., Lee, S. J. and Kenyon, C. (2013). Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab. 17, 85-100
-
(2013)
Cell Metab
, vol.17
, pp. 85-100
-
-
Zhang, P.1
Judy, M.2
Lee, S.J.3
Kenyon, C.4
|