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Volumn 17, Issue 1, 2013, Pages 85-100

Direct and indirect gene regulation by a life-extending foxo protein in C. elegans: Roles for GATA factors and lipid gene regulators

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; LIPID; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR GATA;

EID: 84872143888     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.12.013     Document Type: Article
Times cited : (137)

References (65)
  • 1
    • 43049146145 scopus 로고    scopus 로고
    • Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans
    • F. Anokye-Danso, A. Anyanful, Y. Sakube, and H. Kagawa Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans J. Mol. Biol. 379 2008 201 211
    • (2008) J. Mol. Biol. , vol.379 , pp. 201-211
    • Anokye-Danso, F.1    Anyanful, A.2    Sakube, Y.3    Kagawa, H.4
  • 2
    • 0032538315 scopus 로고    scopus 로고
    • Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
    • DOI 10.1016/S0092-8674(00)81751-1
    • J. Apfeld, and C. Kenyon Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span Cell 95 1998 199 210 (Pubitemid 28473781)
    • (1998) Cell , vol.95 , Issue.2 , pp. 199-210
    • Apfeld, J.1    Kenyon, C.2
  • 3
  • 4
    • 0035019007 scopus 로고    scopus 로고
    • Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    • DOI 10.1007/s003350020002
    • W.H. Biggs 3rd, W.K. Cavenee, and K.C. Arden Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse Mamm. Genome 12 2001 416 425 (Pubitemid 32463734)
    • (2001) Mammalian Genome , vol.12 , Issue.6 , pp. 416-425
    • Biggs III, W.H.1    Cavenee, W.K.2    Arden, K.C.3
  • 5
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • DOI 10.1126/science.1078223
    • M. Blüher, B.B. Kahn, and C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574 (Pubitemid 36135156)
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 6
    • 47549100826 scopus 로고    scopus 로고
    • An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans
    • DOI 10.1016/j.cell.2008.05.044, PII S0092867408007071
    • Y.V. Budovskaya, K. Wu, L.K. Southworth, M. Jiang, P. Tedesco, T.E. Johnson, and S.K. Kim An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans Cell 134 2008 291 303 (Pubitemid 352010330)
    • (2008) Cell , vol.134 , Issue.2 , pp. 291-303
    • Budovskaya, Y.V.1    Wu, K.2    Southworth, L.K.3    Jiang, M.4    Tedesco, P.5    Johnson, T.E.6    Kim, S.K.7
  • 7
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • DOI 10.1126/science.1124646
    • E. Cohen, J. Bieschke, R.M. Perciavalle, J.W. Kelly, and A. Dillin Opposing activities protect against age-onset proteotoxicity Science 313 2006 1604 1610 (Pubitemid 44414028)
    • (2006) Science , vol.313 , Issue.5793 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 8
    • 67649491263 scopus 로고    scopus 로고
    • A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
    • S.P. Curran, X. Wu, C.G. Riedel, and G. Ruvkun A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants Nature 459 2009 1079 1084
    • (2009) Nature , vol.459 , pp. 1079-1084
    • Curran, S.P.1    Wu, X.2    Riedel, C.G.3    Ruvkun, G.4
  • 9
    • 0037174629 scopus 로고    scopus 로고
    • Timing requirements for insulin/IGF-1 signaling in C. elegans
    • DOI 10.1126/science.1074240
    • A. Dillin, D.K. Crawford, and C. Kenyon Timing requirements for insulin/IGF-1 signaling in C. elegans Science 298 2002 830 834 (Pubitemid 35231536)
    • (2002) Science , vol.298 , Issue.5594 , pp. 830-834
    • Dillin, A.1    Crawford, D.K.2    Kenyon, C.3
  • 10
    • 56849110390 scopus 로고    scopus 로고
    • The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans
    • DOI 10.1111/j.1474-9726.2008.00435.x
    • E.A. Evans, W.C. Chen, and M.W. Tan The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans Aging Cell 7 2008 879 893 (Pubitemid 352749441)
    • (2008) Aging Cell , vol.7 , Issue.6 , pp. 879-893
    • Evans, E.A.1    Chen, W.C.2    Tan, M.-W.3
  • 11
    • 35848955910 scopus 로고    scopus 로고
    • Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans
    • M.L. Florez-McClure, L.A. Hohsfield, G. Fonte, M.T. Bealor, and C.D. Link Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans Autophagy 3 2007 569 580 (Pubitemid 350060053)
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 569-580
    • Florez-McClure, M.L.1    Hohsfield, L.A.2    Fonte, G.3    Bealor, M.T.4    Link, C.D.5
  • 12
    • 0032526161 scopus 로고    scopus 로고
    • The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine
    • DOI 10.1006/dbio.1998.8899
    • T. Fukushige, M.G. Hawkins, and J.D. McGhee The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine Dev. Biol. 198 1998 286 302 (Pubitemid 28304445)
    • (1998) Developmental Biology , vol.198 , Issue.2 , pp. 286-302
    • Fukushige, T.1    Hawkins, M.G.2    McGhee, J.D.3
  • 14
    • 0034661826 scopus 로고    scopus 로고
    • Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
    • DOI 10.1042/0264-6021:3490629
    • T. Furuyama, T. Nakazawa, I. Nakano, and N. Mori Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues Biochem. J. 349 2000 629 634 (Pubitemid 30465799)
    • (2000) Biochemical Journal , vol.349 , Issue.2 , pp. 629-634
    • Furuyama, T.1    Nakazawa, T.2    Nakano, I.3    Mori, N.4
  • 15
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
    • D. Garigan, A.L. Hsu, A.G. Fraser, R.S. Kamath, J. Ahringer, and C. Kenyon Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation Genetics 161 2002 1101 1112 (Pubitemid 34831435)
    • (2002) Genetics , vol.161 , Issue.3 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.-L.2    Fraser, A.G.3    Kamath, R.S.4    Abringet, J.5    Kenyon, C.6
  • 17
    • 3142749712 scopus 로고    scopus 로고
    • Long-lived Drosophila with over-expressed dFOXO in adult fat body
    • DOI 10.1126/science.1098219
    • M.E. Giannakou, M. Goss, M.A. Jünger, E. Hafen, S.J. Leevers, and L. Partridge Long-lived Drosophila with overexpressed dFOXO in adult fat body Science 305 2004 361 (Pubitemid 38938145)
    • (2004) Science , vol.305 , Issue.5682 , pp. 361
    • Giannakou, M.E.1    Goss, M.2    Junger, M.A.3    Hafen, E.4    Leevers, S.J.5    Partridge, L.6
  • 18
    • 0033561174 scopus 로고    scopus 로고
    • ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis
    • DOI 10.1006/dbio.1999.9202
    • J.S. Gilleard, Y. Shafi, J.D. Barry, and J.D. McGhee ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis Dev. Biol. 208 1999 265 280 (Pubitemid 29183989)
    • (1999) Developmental Biology , vol.208 , Issue.2 , pp. 265-280
    • Gilleard, J.S.1    Shafi, Y.2    Barry, J.D.3    McGhee, J.D.4
  • 21
    • 37249054901 scopus 로고    scopus 로고
    • Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1
    • DOI 10.1074/jbc.M704735200
    • M. Hatta, and L.A. Cirillo Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1 J. Biol. Chem. 282 2007 35583 35593 (Pubitemid 350277102)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.49 , pp. 35583-35593
    • Hatta, M.1    Cirillo, L.A.2
  • 22
    • 0035846604 scopus 로고    scopus 로고
    • Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • DOI 10.1016/S0960-9822(01)00594-2
    • S.T. Henderson, and T.E. Johnson daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans Curr. Biol. 11 2001 1975 1980 (Pubitemid 33146425)
    • (2001) Current Biology , vol.11 , Issue.24 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 24
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • DOI 10.1038/nature02549
    • D.S. Hwangbo, B. Gershman, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 2004 562 566 (Pubitemid 38737660)
    • (2004) Nature , vol.429 , Issue.6991 , pp. 562-566
    • Hwangbo, D.S.1    Garsham, B.2    Tu, M.-P.3    Palmer, M.4    Tatar, M.5
  • 25
    • 33847345896 scopus 로고    scopus 로고
    • Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs
    • DOI 10.1016/j.ydbio.2006.04.467, PII S0012160606007640
    • W.B. Iser, M.S. Gami, and C.A. Wolkow Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs Dev. Biol. 303 2007 434 447 (Pubitemid 46341272)
    • (2007) Developmental Biology , vol.303 , Issue.2 , pp. 434-447
    • Iser, W.B.1    Gami, M.S.2    Wolkow, C.A.3
  • 26
    • 79952434397 scopus 로고    scopus 로고
    • Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants
    • W.B. Iser, M.A. Wilson, W.H. Wood 3rd, K. Becker, and C.A. Wolkow Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants PLoS ONE 6 2011 e17369
    • (2011) PLoS ONE , vol.6 , pp. 17369
    • Iser, W.B.1    Wilson, M.A.2    Wood III, W.H.3    Becker, K.4    Wolkow, C.A.5
  • 28
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • DOI 10.1038/366461a0
    • C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464 (Pubitemid 24013878)
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 29
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • C.J. Kenyon The genetics of ageing Nature 464 2010 504 512
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 31
    • 12144264839 scopus 로고    scopus 로고
    • Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
    • S.T. Lamitina, and K. Strange Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress Am. J. Physiol. Cell Physiol. 288 2005 C467 C474
    • (2005) Am. J. Physiol. Cell Physiol. , vol.288
    • Lamitina, S.T.1    Strange, K.2
  • 32
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • DOI 10.1016/S0960-9822(01)00595-4
    • R.Y. Lee, J. Hench, and G. Ruvkun Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway Curr. Biol. 11 2001 1950 1957 (Pubitemid 33146421)
    • (2001) Current Biology , vol.11 , Issue.24 , pp. 1950-1957
    • Lee, R.Y.N.1    Hench, J.2    Ruvkun, G.3
  • 33
    • 70350365110 scopus 로고    scopus 로고
    • Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression
    • S.J. Lee, C.T. Murphy, and C. Kenyon Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression Cell Metab. 10 2009 379 391
    • (2009) Cell Metab. , vol.10 , pp. 379-391
    • Lee, S.J.1    Murphy, C.T.2    Kenyon, C.3
  • 34
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • DOI 10.1038/ng1056
    • S.S. Lee, R.Y. Lee, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity Nat. Genet. 33 2003 40 48 (Pubitemid 36068680)
    • (2003) Nature Genetics , vol.33 , Issue.1 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.N.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 35
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
    • DOI 10.1016/S0092-8674(03)00889-4
    • N. Libina, J.R. Berman, and C. Kenyon Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan Cell 115 2003 489 502 (Pubitemid 37456810)
    • (2003) Cell , vol.115 , Issue.4 , pp. 489-502
    • Libina, N.1    Berman, J.R.2    Kenyon, C.3
  • 36
    • 0030657540 scopus 로고    scopus 로고
    • Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • DOI 10.1126/science.278.5341.1319
    • K. Lin, J.B. Dorman, A. Rodan, and C. Kenyon daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans Science 278 1997 1319 1322 (Pubitemid 27495748)
    • (1997) Science , vol.278 , Issue.5341 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 37
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • DOI 10.1038/88850
    • K. Lin, H. Hsin, N. Libina, and C. Kenyon Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling Nat. Genet. 28 2001 139 145 (Pubitemid 32538058)
    • (2001) Nature Genetics , vol.28 , Issue.2 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 38
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • C.D. Link Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 92 1995 9368 9372
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 39
    • 0036608026 scopus 로고    scopus 로고
    • Making worm guts: The gene regulatory network of the Caenorhabditis elegans endoderm
    • DOI 10.1006/dbio.2002.0655
    • M.F. Maduro, and J.H. Rothman Making worm guts: the gene regulatory network of the Caenorhabditis elegans endoderm Dev. Biol. 246 2002 68 85 (Pubitemid 34625976)
    • (2002) Developmental Biology , vol.246 , Issue.1 , pp. 68-85
    • Maduro, M.F.1    Rothman, J.H.2
  • 41
    • 84858341125 scopus 로고    scopus 로고
    • New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals
    • M. McCormick, K. Chen, P. Ramaswamy, and C. Kenyon New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals Aging Cell 11 2012 192 202
    • (2012) Aging Cell , vol.11 , pp. 192-202
    • McCormick, M.1    Chen, K.2    Ramaswamy, P.3    Kenyon, C.4
  • 42
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • J. McElwee, K. Bubb, and J.H. Thomas Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16 Aging Cell 2 2003 111 121
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 45
    • 37649022616 scopus 로고    scopus 로고
    • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    • C.T. Murphy, S.J. Lee, and C. Kenyon Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 104 2007 19046 19050
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19046-19050
    • Murphy, C.T.1    Lee, S.J.2    Kenyon, C.3
  • 47
    • 0030659557 scopus 로고    scopus 로고
    • The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • DOI 10.1038/40194
    • S. Ogg, S. Paradis, S. Gottlieb, G.I. Patterson, L. Lee, H.A. Tissenbaum, and G. Ruvkun The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999 (Pubitemid 27485694)
    • (1997) Nature , vol.389 , Issue.6654 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 48
    • 31744438846 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • DOI 10.1038/ng1723, PII NG1723
    • S.W. Oh, A. Mukhopadhyay, B.L. Dixit, T. Raha, M.R. Green, and H.A. Tissenbaum Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation Nat. Genet. 38 2006 251 257 (Pubitemid 43177243)
    • (2006) Nature Genetics , vol.38 , Issue.2 , pp. 251-257
    • Seung, W.O.1    Mukhopadhyay, A.2    Dixit, B.L.3    Raha, T.4    Green, M.R.5    Tissenbaum, H.A.6
  • 49
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • DOI 10.1038/nature05837, PII NATURE05837
    • S.H. Panowski, S. Wolff, H. Aguilaniu, J. Durieux, and A. Dillin PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans Nature 447 2007 550 555 (Pubitemid 46868041)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 50
    • 0028046675 scopus 로고
    • Cloning and characterization of seven human forkhead proteins: Binding site specificity and DNA bending
    • S. Pierrou, M. Hellqvist, L. Samuelsson, S. Enerbäck, and P. Carlsson Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending EMBO J. 13 1994 5002 5012 (Pubitemid 24319383)
    • (1994) EMBO Journal , vol.13 , Issue.20 , pp. 5002-5012
    • Pierrou, S.1    Hellqvist, M.2    Samuelsson, L.3    Enerback, S.4    Carlsson, P.5
  • 51
    • 0024576633 scopus 로고
    • GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression
    • M. Plumb, J. Frampton, H. Wainwright, M. Walker, K. Macleod, G. Goodwin, and P. Harrison GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression Nucleic Acids Res. 17 1989 73 92 (Pubitemid 19030019)
    • (1989) Nucleic Acids Research , vol.17 , Issue.1 , pp. 73-92
    • Plumb, M.1    Frampton, J.2    Wainwright, H.3    Walker, M.4    MacLeod, K.5    Goodwin, G.6    Harrison, P.7
  • 52
    • 84859230772 scopus 로고    scopus 로고
    • The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex
    • S.D. Postnikoff, M.E. Malo, B. Wong, and T.A. Harkness The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex PLoS Genet. 8 2012 e1002583
    • (2012) PLoS Genet. , vol.8 , pp. 1002583
    • Postnikoff, S.D.1    Malo, M.E.2    Wong, B.3    Harkness, T.A.4
  • 54
    • 84872122062 scopus 로고    scopus 로고
    • A bioinformatic overview of condition-specific FOXO3 gene regulatory networks in mammals
    • Cold Spring Harbor Laboratory
    • E.E. Santo, Z. Xuan, and M.Q. Zhang A bioinformatic overview of condition-specific FOXO3 gene regulatory networks in mammals Meeting on Molecular Genetics of Aging 2006 Cold Spring Harbor Laboratory 160
    • (2006) Meeting on Molecular Genetics of Aging , pp. 160
    • Santo, E.E.1    Xuan, Z.2    Zhang, M.Q.3
  • 57
    • 84864622015 scopus 로고    scopus 로고
    • Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways
    • D.E. Shore, C.E. Carr, and G. Ruvkun Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways PLoS Genet. 8 2012 e1002792
    • (2012) PLoS Genet. , vol.8 , pp. 1002792
    • Shore, D.E.1    Carr, C.E.2    Ruvkun, G.3
  • 58
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • DOI 10.1126/science.1142179
    • A. Taguchi, L.M. Wartschow, and M.F. White Brain IRS2 signaling coordinates life span and nutrient homeostasis Science 317 2007 369 372 (Pubitemid 47106376)
    • (2007) Science , vol.317 , Issue.5836 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 59
    • 40149104005 scopus 로고    scopus 로고
    • The Mediator subunit MDT-15 confers metabolic adaptation to ingested material
    • S. Taubert, M. Hansen, M.R. Van Gilst, S.B. Cooper, and K.R. Yamamoto The Mediator subunit MDT-15 confers metabolic adaptation to ingested material PLoS Genet. 4 2008 e1000021
    • (2008) PLoS Genet. , vol.4 , pp. 1000021
    • Taubert, S.1    Hansen, M.2    Van Gilst, M.R.3    Cooper, S.B.4    Yamamoto, K.R.5
  • 60
    • 33745178477 scopus 로고    scopus 로고
    • A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans
    • S. Taubert, M.R. Van Gilst, M. Hansen, and K.R. Yamamoto A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans Genes Dev. 20 2006 1137 1149
    • (2006) Genes Dev. , vol.20 , pp. 1137-1149
    • Taubert, S.1    Van Gilst, M.R.2    Hansen, M.3    Yamamoto, K.R.4
  • 61
    • 84856228489 scopus 로고    scopus 로고
    • Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans
    • T. Tonsaker, R.M. Pratt, and J.D. McGhee Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans Mech. Ageing Dev. 133 2012 50 53
    • (2012) Mech. Ageing Dev. , vol.133 , pp. 50-53
    • Tonsaker, T.1    Pratt, R.M.2    McGhee, J.D.3
  • 62
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • DOI 10.1126/science.1068712
    • H. Tran, A. Brunet, J.M. Grenier, S.R. Datta, A.J. Fornace Jr., P.S. DiStefano, L.W. Chiang, and M.E. Greenberg DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein Science 296 2002 530 534 (Pubitemid 34408672)
    • (2002) Science , vol.296 , Issue.5567 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3    Datta, S.R.4    Fornace Jr., A.J.5    DiStefano, P.S.6    Chiang, L.W.7    Greenberg, M.E.8
  • 63
    • 0041507039 scopus 로고    scopus 로고
    • Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
    • G.A. Walker, and G.J. Lithgow Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals Aging Cell 2 2003 131 139
    • (2003) Aging Cell , vol.2 , pp. 131-139
    • Walker, G.A.1    Lithgow, G.J.2
  • 64
    • 55849101681 scopus 로고    scopus 로고
    • Fat metabolism links germline stem cells and longevity in C. elegans
    • M.C. Wang, E.J. O'Rourke, and G. Ruvkun Fat metabolism links germline stem cells and longevity in C. elegans Science 322 2008 957 960
    • (2008) Science , vol.322 , pp. 957-960
    • Wang, M.C.1    O'Rourke, E.J.2    Ruvkun, G.3
  • 65
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. elegans life-span by insulinlike signaling in the nervous system
    • C.A. Wolkow, K.D. Kimura, M.S. Lee, and G. Ruvkun Regulation of C. elegans life-span by insulinlike signaling in the nervous system Science 290 2000 147 150
    • (2000) Science , vol.290 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.S.3    Ruvkun, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.