메뉴 건너뛰기




Volumn 8, Issue 11, 2012, Pages

Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; TARGET OF RAPAMYCIN KINASE; TUBERIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84870700189     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003045     Document Type: Article
Times cited : (83)

References (75)
  • 1
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi DJ, Jamieson CH, Weissman IL, (2008) Stems cells and the pathways to aging and cancer. Cell 132: 681-696.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 2
    • 61849161599 scopus 로고    scopus 로고
    • Stem cells, their niches and the systemic environment: an aging network
    • Drummond-Barbosa D, (2008) Stem cells, their niches and the systemic environment: an aging network. Genetics 180: 1787-1797.
    • (2008) Genetics , vol.180 , pp. 1787-1797
    • Drummond-Barbosa, D.1
  • 3
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA, (2007) How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8: 703-713.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 4
    • 78649519914 scopus 로고    scopus 로고
    • Metabolic regulation of stem cell behavior and implications for aging
    • Jasper H, Jones DL, (2010) Metabolic regulation of stem cell behavior and implications for aging. Cell Metab 12: 561-565.
    • (2010) Cell Metab , vol.12 , pp. 561-565
    • Jasper, H.1    Jones, D.L.2
  • 5
    • 77954614220 scopus 로고    scopus 로고
    • Intestinal stem cell asymmetric division in the Drosophila posterior midgut
    • Hou SX, (2010) Intestinal stem cell asymmetric division in the Drosophila posterior midgut. J Cell Physiol 224: 581-584.
    • (2010) J Cell Physiol , vol.224 , pp. 581-584
    • Hou, S.X.1
  • 6
    • 58949101489 scopus 로고    scopus 로고
    • Intestinal stem cells in mammals and Drosophila
    • Casali A, Batlle E, (2009) Intestinal stem cells in mammals and Drosophila. Cell Stem Cell 4: 124-127.
    • (2009) Cell Stem Cell , vol.4 , pp. 124-127
    • Casali, A.1    Batlle, E.2
  • 7
    • 80755174406 scopus 로고    scopus 로고
    • Maintaining tissue homeostasis: dynamic control of somatic stem cell activity
    • Biteau B, Hochmuth CE, Jasper H, (2011) Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell 9: 402-411.
    • (2011) Cell Stem Cell , vol.9 , pp. 402-411
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 8
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli CA, Perrimon N, (2006) Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439: 475-479.
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 9
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein B, Spradling A, (2006) The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439: 470-474.
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 10
    • 33847168133 scopus 로고    scopus 로고
    • Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    • Ohlstein B, Spradling A, (2007) Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 315: 988-992.
    • (2007) Science , vol.315 , pp. 988-992
    • Ohlstein, B.1    Spradling, A.2
  • 11
    • 80052700259 scopus 로고    scopus 로고
    • Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
    • Perdigoto CN, Schweisguth F, Bardin AJ, (2011) Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 138: 4585-4595.
    • (2011) Development , vol.138 , pp. 4585-4595
    • Perdigoto, C.N.1    Schweisguth, F.2    Bardin, A.J.3
  • 13
    • 79955521176 scopus 로고    scopus 로고
    • EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
    • Xu N, Wang SQ, Tan D, Gao Y, Lin G, et al. (2011) EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev Biol 354: 31-43.
    • (2011) Dev Biol , vol.354 , pp. 31-43
    • Xu, N.1    Wang, S.Q.2    Tan, D.3    Gao, Y.4    Lin, G.5
  • 14
    • 77956507262 scopus 로고    scopus 로고
    • Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation
    • Staley BK, Irvine KD, (2010) Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr Biol 20: 1580-1587.
    • (2010) Curr Biol , vol.20 , pp. 1580-1587
    • Staley, B.K.1    Irvine, K.D.2
  • 15
    • 78650187792 scopus 로고    scopus 로고
    • The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
    • Shaw RL, Kohlmaier A, Polesello C, Veelken C, Edgar BA, et al. (2010) The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 137: 4147-4158.
    • (2010) Development , vol.137 , pp. 4147-4158
    • Shaw, R.L.1    Kohlmaier, A.2    Polesello, C.3    Veelken, C.4    Edgar, B.A.5
  • 16
    • 78650471357 scopus 로고    scopus 로고
    • Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    • Ren F, Wang B, Yue T, Yun EY, Ip YT, et al. (2010) Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A 107: 21064-21069.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21064-21069
    • Ren, F.1    Wang, B.2    Yue, T.3    Yun, E.Y.4    Ip, Y.T.5
  • 17
    • 78650202455 scopus 로고    scopus 로고
    • The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz P, Perez J, Perrimon N, (2010) The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 137: 4135-4145.
    • (2010) Development , vol.137 , pp. 4135-4145
    • Karpowicz, P.1    Perez, J.2    Perrimon, N.3
  • 18
    • 58049218983 scopus 로고    scopus 로고
    • Tissue damage-induced intestinal stem cell division in Drosophila
    • Amcheslavsky A, Jiang J, Ip YT, (2009) Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4: 49-61.
    • (2009) Cell Stem Cell , vol.4 , pp. 49-61
    • Amcheslavsky, A.1    Jiang, J.2    Ip, Y.T.3
  • 19
    • 73949145172 scopus 로고    scopus 로고
    • Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
    • Apidianakis Y, Pitsouli C, Perrimon N, Rahme L, (2009) Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A 106: 20883-20888.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20883-20888
    • Apidianakis, Y.1    Pitsouli, C.2    Perrimon, N.3    Rahme, L.4
  • 20
    • 73549097743 scopus 로고    scopus 로고
    • JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    • Beebe K, Lee WC, Micchelli CA, (2010) JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol 338: 28-37.
    • (2010) Dev Biol , vol.338 , pp. 28-37
    • Beebe, K.1    Lee, W.C.2    Micchelli, C.A.3
  • 21
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • Biteau B, Hochmuth CE, Jasper H, (2008) JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3: 442-455.
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 22
    • 79955133184 scopus 로고    scopus 로고
    • EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
    • Biteau B, Jasper H, (2011) EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138: 1045-1055.
    • (2011) Development , vol.138 , pp. 1045-1055
    • Biteau, B.1    Jasper, H.2
  • 23
    • 78449240115 scopus 로고    scopus 로고
    • Lifespan extension by preserving proliferative homeostasis in Drosophila
    • doi: 10.1371/journal.pgen.1001159
    • Biteau B, Karpac J, Supoyo S, DeGennaro M, Lehmann R, et al. (2010) Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet 6: e1001159 doi:10.1371/journal.pgen.1001159.
    • (2010) PLoS Genet , vol.6
    • Biteau, B.1    Karpac, J.2    Supoyo, S.3    DeGennaro, M.4    Lehmann, R.5
  • 24
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • Buchon N, Broderick NA, Chakrabarti S, Lemaitre B, (2009) Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 23: 2333-2344.
    • (2009) Genes Dev , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 25
    • 78650397479 scopus 로고    scopus 로고
    • Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
    • Buchon N, Broderick NA, Kuraishi T, Lemaitre B, (2010) Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 8: 152.
    • (2010) BMC Biol , vol.8 , pp. 152
    • Buchon, N.1    Broderick, N.A.2    Kuraishi, T.3    Lemaitre, B.4
  • 26
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation
    • Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B, (2009) Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 5: 200-211.
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 27
    • 78650977190 scopus 로고    scopus 로고
    • EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
    • Jiang H, Grenley MO, Bravo MJ, Blumhagen RZ, Edgar BA, (2011) EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8: 84-95.
    • (2011) Cell Stem Cell , vol.8 , pp. 84-95
    • Jiang, H.1    Grenley, M.O.2    Bravo, M.J.3    Blumhagen, R.Z.4    Edgar, B.A.5
  • 28
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, et al. (2009) Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137: 1343-1355.
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5
  • 29
    • 69549113488 scopus 로고    scopus 로고
    • Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
    • Lee WC, Beebe K, Sudmeier L, Micchelli CA, (2009) Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 136: 2255-2264.
    • (2009) Development , vol.136 , pp. 2255-2264
    • Lee, W.C.1    Beebe, K.2    Sudmeier, L.3    Micchelli, C.A.4
  • 30
    • 54549104587 scopus 로고    scopus 로고
    • Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
    • Lin G, Xu N, Xi R, (2008) Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455: 1119-1123.
    • (2008) Nature , vol.455 , pp. 1119-1123
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 31
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • Hochmuth CE, Biteau B, Bohmann D, Jasper H, (2011) Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 8: 1-12.
    • (2011) Cell Stem Cell , vol.8 , pp. 1-12
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 32
    • 43449097534 scopus 로고    scopus 로고
    • Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
    • Choi NH, Kim JG, Yang DJ, Kim YS, Yoo MA, (2008) Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 7: 318-334.
    • (2008) Aging Cell , vol.7 , pp. 318-334
    • Choi, N.H.1    Kim, J.G.2    Yang, D.J.3    Kim, Y.S.4    Yoo, M.A.5
  • 33
    • 80155123827 scopus 로고    scopus 로고
    • Altered modes of stem cell division drive adaptive intestinal growth
    • O'Brien LE, Soliman SS, Li X, Bilder D, (2011) Altered modes of stem cell division drive adaptive intestinal growth. Cell 147: 603-614.
    • (2011) Cell , vol.147 , pp. 603-614
    • O'Brien, L.E.1    Soliman, S.S.2    Li, X.3    Bilder, D.4
  • 34
    • 81755187019 scopus 로고    scopus 로고
    • Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway
    • Choi NH, Lucchetta E, Ohlstein B, (2011) Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway. Proc Natl Acad Sci U S A 108: 18702-18707.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18702-18707
    • Choi, N.H.1    Lucchetta, E.2    Ohlstein, B.3
  • 35
    • 59649094753 scopus 로고    scopus 로고
    • Insulin/TOR signaling in growth and homeostasis: a view from the fly world
    • Grewal SS, (2009) Insulin/TOR signaling in growth and homeostasis: a view from the fly world. Int J Biochem Cell Biol 41: 1006-1010.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1006-1010
    • Grewal, S.S.1
  • 36
    • 0036007420 scopus 로고    scopus 로고
    • Control of growth and organ size in Drosophila
    • Johnston LA, Gallant P, (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64.
    • (2002) Bioessays , vol.24 , pp. 54-64
    • Johnston, L.A.1    Gallant, P.2
  • 37
    • 16544383044 scopus 로고    scopus 로고
    • The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb
    • discussion 154-149, 265-148
    • Nobukini T, Thomas G, (2004) The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Found Symp 262: 148-154; discussion 154-149, 265-148.
    • (2004) Novartis Found Symp , vol.262 , pp. 148-154
    • Nobukini, T.1    Thomas, G.2
  • 38
    • 73349138892 scopus 로고    scopus 로고
    • Regulation of tissue growth through nutrient sensing
    • Hietakangas V, Cohen SM, (2009) Regulation of tissue growth through nutrient sensing. Annu Rev Genet 43: 389-410.
    • (2009) Annu Rev Genet , vol.43 , pp. 389-410
    • Hietakangas, V.1    Cohen, S.M.2
  • 39
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    • Britton JS, Lockwood WK, Li L, Cohen SM, Edgar BA, (2002) Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell 2: 239-249.
    • (2002) Dev Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 40
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
    • Huang J, Manning BD, (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412: 179-190.
    • (2008) Biochem J , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 41
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 42
    • 67650917394 scopus 로고    scopus 로고
    • Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth
    • doi: 10.1371/journal.pone.0006305
    • Schleich S, Teleman AA, (2009) Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. PLoS ONE 4: e6305 doi:10.1371/journal.pone.0006305.
    • (2009) PLoS ONE , vol.4
    • Schleich, S.1    Teleman, A.A.2
  • 43
    • 5444233787 scopus 로고    scopus 로고
    • Tsc2 is not a critical target of Akt during normal Drosophila development
    • Dong J, Pan D, (2004) Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev 18: 2479-2484.
    • (2004) Genes Dev , vol.18 , pp. 2479-2484
    • Dong, J.1    Pan, D.2
  • 44
    • 41649117158 scopus 로고    scopus 로고
    • WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase
    • Hu J, Zacharek S, He YJ, Lee H, Shumway S, et al. (2008) WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev 22: 866-871.
    • (2008) Genes Dev , vol.22 , pp. 866-871
    • Hu, J.1    Zacharek, S.2    He, Y.J.3    Lee, H.4    Shumway, S.5
  • 45
    • 63149136365 scopus 로고    scopus 로고
    • Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment
    • Inoki K, Guan KL, (2009) Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet 18: R94-100.
    • (2009) Hum Mol Genet , vol.18 , pp. 94-100
    • Inoki, K.1    Guan, K.L.2
  • 46
    • 77954945936 scopus 로고    scopus 로고
    • mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells
    • Easley CAt, Ben-Yehudah A, Redinger CJ, Oliver SL, Varum ST, et al. (2010) mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram 12: 263-273.
    • (2010) Cell Reprogram , vol.12 , pp. 263-273
    • Easley, C.A.1    Ben-Yehudah, A.2    Redinger, C.J.3    Oliver, S.L.4    Varum, S.T.5
  • 48
    • 23644444460 scopus 로고    scopus 로고
    • Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila
    • LaFever L, Drummond-Barbosa D, (2005) Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 309: 1071-1073.
    • (2005) Science , vol.309 , pp. 1071-1073
    • LaFever, L.1    Drummond-Barbosa, D.2
  • 49
    • 77953299671 scopus 로고    scopus 로고
    • Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary
    • LaFever L, Feoktistov A, Hsu HJ, Drummond-Barbosa D, (2010) Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137: 2117-2126.
    • (2010) Development , vol.137 , pp. 2117-2126
    • LaFever, L.1    Feoktistov, A.2    Hsu, H.J.3    Drummond-Barbosa, D.4
  • 50
    • 77955762208 scopus 로고    scopus 로고
    • TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation
    • Sun P, Quan Z, Zhang B, Wu T, Xi R, (2010) TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development 137: 2461-2469.
    • (2010) Development , vol.137 , pp. 2461-2469
    • Sun, P.1    Quan, Z.2    Zhang, B.3    Wu, T.4    Xi, R.5
  • 51
    • 59049103731 scopus 로고    scopus 로고
    • Insulin levels control female germline stem cell maintenance via the niche in Drosophila
    • Hsu HJ, Drummond-Barbosa D, (2009) Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proc Natl Acad Sci U S A 106: 1117-1121.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1117-1121
    • Hsu, H.J.1    Drummond-Barbosa, D.2
  • 52
    • 78650175195 scopus 로고    scopus 로고
    • Stem cell dynamics in response to nutrient availability
    • McLeod CJ, Wang L, Wong C, Jones DL, (2010) Stem cell dynamics in response to nutrient availability. Curr Biol 20: 2100-2105.
    • (2010) Curr Biol , vol.20 , pp. 2100-2105
    • McLeod, C.J.1    Wang, L.2    Wong, C.3    Jones, D.L.4
  • 53
    • 79958207849 scopus 로고    scopus 로고
    • Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
    • Amcheslavsky A, Ito N, Jiang J, Ip YT, (2011) Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J Cell Biol 193: 695-710.
    • (2011) J Cell Biol , vol.193 , pp. 695-710
    • Amcheslavsky, A.1    Ito, N.2    Jiang, J.3    Ip, Y.T.4
  • 54
    • 0035341376 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
    • Lee T, Luo L, (2001) Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci 24: 251-254.
    • (2001) Trends Neurosci , vol.24 , pp. 251-254
    • Lee, T.1    Luo, L.2
  • 55
    • 24944498730 scopus 로고    scopus 로고
    • Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
    • Wu Q, Zhang Y, Xu J, Shen P, (2005) Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc Natl Acad Sci U S A 102: 13289-13294.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13289-13294
    • Wu, Q.1    Zhang, Y.2    Xu, J.3    Shen, P.4
  • 56
    • 0033603208 scopus 로고    scopus 로고
    • Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    • Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, et al. (1999) Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97: 865-875.
    • (1999) Cell , vol.97 , pp. 865-875
    • Bohni, R.1    Riesgo-Escovar, J.2    Oldham, S.3    Brogiolo, W.4    Stocker, H.5
  • 57
    • 0030060198 scopus 로고    scopus 로고
    • The Drosophila insulin receptor is required for normal growth
    • Chen C, Jack J, Garofalo RS, (1996) The Drosophila insulin receptor is required for normal growth. Endocrinology 137: 846-856.
    • (1996) Endocrinology , vol.137 , pp. 846-856
    • Chen, C.1    Jack, J.2    Garofalo, R.S.3
  • 58
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK, (2001) The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355.
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hariharan, I.K.5
  • 59
    • 0033582748 scopus 로고    scopus 로고
    • gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito N, Rubin GM, (1999) gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96: 529-539.
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 60
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E, (2000) Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14: 2689-2694.
    • (2000) Genes Dev , vol.14 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 61
    • 5344224052 scopus 로고    scopus 로고
    • Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila
    • Bateman JM, McNeill H, (2004) Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila. Cell 119: 87-96.
    • (2004) Cell , vol.119 , pp. 87-96
    • Bateman, J.M.1    McNeill, H.2
  • 63
    • 74249099740 scopus 로고    scopus 로고
    • A transient niche regulates the specification of Drosophila intestinal stem cells
    • Mathur D, Bost A, Driver I, Ohlstein B, (2010) A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327: 210-213.
    • (2010) Science , vol.327 , pp. 210-213
    • Mathur, D.1    Bost, A.2    Driver, I.3    Ohlstein, B.4
  • 64
    • 78651499087 scopus 로고    scopus 로고
    • Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila
    • Zeng X, Chauhan C, Hou SX, (2010) Characterization of midgut stem cell- and enteroblast-specific Gal4 lines in drosophila. Genesis 48: 607-611.
    • (2010) Genesis , vol.48 , pp. 607-611
    • Zeng, X.1    Chauhan, C.2    Hou, S.X.3
  • 65
    • 60549101198 scopus 로고    scopus 로고
    • Direct response to Notch activation: signaling crosstalk and incoherent logic
    • Krejci A, Bernard F, Housden BE, Collins S, Bray SJ, (2009) Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci Signal 2: ra1.
    • (2009) Sci Signal , vol.2
    • Krejci, A.1    Bernard, F.2    Housden, B.E.3    Collins, S.4    Bray, S.J.5
  • 66
    • 0025277746 scopus 로고
    • Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
    • Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, et al. (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61: 523-534.
    • (1990) Cell , vol.61 , pp. 523-534
    • Fehon, R.G.1    Kooh, P.J.2    Rebay, I.3    Regan, C.L.4    Xu, T.5
  • 67
    • 0031716573 scopus 로고    scopus 로고
    • Use of FLP/FRT system to study Drosophila development
    • Theodosiou NA, Xu T, (1998) Use of FLP/FRT system to study Drosophila development. Methods 14: 355-365.
    • (1998) Methods , vol.14 , pp. 355-365
    • Theodosiou, N.A.1    Xu, T.2
  • 68
    • 79954632599 scopus 로고    scopus 로고
    • Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
    • Katewa SD, Kapahi P, (2010) Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol 46: 382-390.
    • (2010) Exp Gerontol , vol.46 , pp. 382-390
    • Katewa, S.D.1    Kapahi, P.2
  • 69
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma J, Meng Y, Kwiatkowski DJ, Chen X, Peng H, et al. (2010) Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 120: 103-114.
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3    Chen, X.4    Peng, H.5
  • 70
    • 74949090816 scopus 로고    scopus 로고
    • The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
    • Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, et al. (2010) The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest 120: 93-102.
    • (2010) J Clin Invest , vol.120 , pp. 93-102
    • Karbowniczek, M.1    Zitserman, D.2    Khabibullin, D.3    Hartman, T.4    Yu, J.5
  • 71
    • 77749321234 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways
    • Wang Z, Li Y, Banerjee S, Kong D, Ahmad A, et al. (2010) Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem 109: 726-736.
    • (2010) J Cell Biochem , vol.109 , pp. 726-736
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Kong, D.4    Ahmad, A.5
  • 72
    • 77950292495 scopus 로고    scopus 로고
    • Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model
    • Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, et al. (2010) Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res 70: 2476-2484.
    • (2010) Cancer Res , vol.70 , pp. 2476-2484
    • Efferson, C.L.1    Winkelmann, C.T.2    Ware, C.3    Sullivan, T.4    Giampaoli, S.5
  • 73
    • 74949110559 scopus 로고    scopus 로고
    • New roles for Notch in tuberous sclerosis
    • Pear WS, (2010) New roles for Notch in tuberous sclerosis. J Clin Invest 120: 84-87.
    • (2010) J Clin Invest , vol.120 , pp. 84-87
    • Pear, W.S.1
  • 74
    • 0032054380 scopus 로고    scopus 로고
    • The function of hairy-related bHLH repressor proteins in cell fate decisions
    • Fisher A, Caudy M, (1998) The function of hairy-related bHLH repressor proteins in cell fate decisions. Bioessays 20: 298-306.
    • (1998) Bioessays , vol.20 , pp. 298-306
    • Fisher, A.1    Caudy, M.2
  • 75
    • 34848918150 scopus 로고    scopus 로고
    • Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function
    • Lecuyer E, Yoshida H, Parthasarathy N, Alm C, Babak T, et al. (2007) Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell 131: 174-187.
    • (2007) Cell , vol.131 , pp. 174-187
    • Lecuyer, E.1    Yoshida, H.2    Parthasarathy, N.3    Alm, C.4    Babak, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.