Signaling networks in aging

Journal of Cell Science

Volumn 121, Issue 4, 2008, Pages 407-412

  Greer, Eric L ^a   Brunet, Anne ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYTOCHROME P450; GROWTH HORMONE RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN RECEPTOR; IRON SULFUR PROTEIN; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PREGNENOLONE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; RNA; SIRTUIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UBIQUINONE;

ADIPOSE TISSUE; AGING; ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR STRESS SIGNAL; DIET RESTRICTION; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; FOOD INTAKE; GENE MUTATION; HORMONE RESPONSE; LIFESPAN; LONGEVITY; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PLEIOTROPY; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; STEROIDOGENESIS; TELOMERE; TUMOR SUPPRESSOR GENE;

AGING; ANIMALS; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 40949149823     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.021519     Document Type: Article

References (102)

1. An, J. H. and Blackwell, T. K. (2003). SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17, 1882-1893.
2. Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M. et al. (2005). Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp. Gerontol. 40, 685-693.
3. Apfeld, J., O'Connor, G, McDonagh, T, DiStefano, P. S. and Curtis, R. (2004). The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18, 3004-3009.
4. Avery, L. (1993). The genetics of feeding in Caenorhabditis elegans. Genetics 133, 897-917.
5. Bauer, J. H., Poon, P. C, Glatt-Deeley, H., Abrams, J. M. and Helfand, S. L. (2005). Neuronal expression of p53 dommant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15, 2063-2068.
6. Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A, Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K. et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342.
7. Bishop, N. A. and Guarente, L. (2007). Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447, 545-549.
8. Bluher, M., Kahn, B. B. and Kahn, C. R. (2003). Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574.
9. Broue, F., Liere, P., Kenyon, C. and Baulieu, E. E. (2007). A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell 6, 87-94.
10. Brown-Borg, H. M., Borg, K. E., Meliska, C. J. and Bartke, A. (1996). Dwarf mice and the ageing process. Nature 384, 33.
11. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu. L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead trainscription factor. Cell 96, 857-868.
12. Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y. et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015.
13. Campisi, J. (2005). Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev. 126, 51-58.
14. Chen, D., Steele, A. D, Lindquist, S. and Guarente, L. (2005). Increase in activity during calorie restriction requires Sirtl. Science 310, 1641.
15. Chen, D., Pan, K. Z., Palter, J. E. and Kapahi, P. (2007). Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 6, 525-533.
16. Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J. and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
17. Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A. and Kopchick, J. J. (2003). Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144, 3799-3810.
18. Curran, S. P. and Ruvkun, G. (2007). Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 3, e56.
19. Curtis, R., O'Connor, G. and DiStefano, P. S. (2006). Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell 5, 119-126.
20. Daitoku H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T. and Fukamizu, A. (2004). Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl. Acad. Sci. USA 101, 10042-10047.
21. Dasgupta, B. and Milbrandt, J. (2007). Resveratrol stimulates AMP kmase activity in neurons. Proc. Natl. Acad. Sci. USA 104, 7217-7222.
22. De Sandre-Giovannoli, A., Bernard, R., Cau, P., Navarro, C., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Munnich, A., Le Merrer, M. et al. (2003). Lamin a truncation in Hutchinson-Gilford progeria. Science 300, 2055.
23. Dillin, A., Hsu, A. L., Arantes-Oliveira, N, Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J. and Kenyon, C. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-2401.
24. Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P. et al. (2003). Recurrent de novo point mutations in 1amin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293-298.
25. Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M. and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290.
26. Feng, J., Bussiere, F. and Hekimi, S. (2001). Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 1, 633-644.
27. Flurkey, K., Papaconstantinou, J., Miller, R. A. and Harrison, D. E. (2001). Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98, 6736-6741.
28. Frescas, D, Valenti, L. and Accili, D. (2005). Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 280, 20589-20595.
29. Friedman, D. B. and Johnson, T. E. (1988). A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86.
30. Garcia-Cao, I., Garcia-Cao, M., Martin-Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J. C., Blasco, M. A. and Serrano, M. (2002). "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235.
31. Gerisch, B., Weitzel, C., Kober-Eisermann, C., Rottiers, V. and Antebi, A. (2001). A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev. Cell 1, 841-851.
32. Gerisch, B, Rottiers, V., Li, D., Motola, D. L., Cummins, C. L., Lehrach, H, Maagelsdorf, D. J. and Antebi, A. (2007). A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104, 5014-5019.
33. Giannakou, M. E., Goss, M., Junger, M. A., Hafen, E., Leevers, S. J. and Partridge, L. (2004). Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305, 361.
34. Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M. et al. (2005). Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122, 221-233.
35. Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D, Gygi, S. P. and Brunet, A. (2007a). An AMPK-FOX0 pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 17, 1646-1656.
36. Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P. and Brunet, A. (2007b). The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 282, 30107-30119.
37. Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G. and Lee, S. S. (2005). A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19, 1544-1555.
38. Hansen, M, Hsu, A. L., Dillin, A. and Kenyon, C. (2005). New genes tied to endocrine, metabolic, and dietary regulation of lifespan ftom a Caenorhabditis elegans genornic RNAi screen. PLoS Genet. 1, 119-128.
39. Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S. J. and Kenyon, C. (2007). Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110.
40. Henderson, S. T., Bonafe, M. and Johnson, T. E. (2006). daf-16 protects the nematode Caenorhabditis elegans during food deprivation. J. Gerontol. A Biol. Sci. Med. Sci. 61, 444-460.
41. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geloen, A., Even, P. C., Cervera, P. and Le Bouc, Y. (2003). IGF- 1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
42. Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M. and Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562-566.
43. Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N. et al. (2007). alpha-Klotho as a regulator of calcium homeostasis. Science 316, 1615-1618.
44. Ingram, D. K., Anson, R. M., de Cabo, R, Mamczarz, J., Zhu, M., Mattison, J., Lane, M. A. and Roth, G. S. (2004). Development of calorie restriction mimetics as a prolongevity strategy. Ann. N. Y. Acad. Sci. 1019, 412-423.
45. Inoki, K., Zhu, T. and Guan, K. L. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
46. Jia, K., Albert, P. S. and Riddle, D. L. (2002). DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129, 221-231.
47. Jia, K., Chen, D. and Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897-3906.
48. Kaeberlein, M., McVey, M. and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580.
49. Kaeberlein, M, Kirkland, K. T., Fields, S. and Kennedy, B. K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2, E296.
50. Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. and Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890.
51. Kennedy, B. K., Austriaco, N. R., Jr, Zhang, J. and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-496.
52. Kenyon, C., Chang, J, Gensch, E., Rudner, A. and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
53. Kimura, K. D., Tissenbaum, H. A., Liu, Y. and Ruvkun, G. (1997). daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
54. Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L. and Burgering, B. M. (1999). Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634.
55. Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E. et al. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390, 45-51.
56. Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H. et al. (2005). Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833.
57. Lakowski, B. and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-1013.
58. Lakowski, B. and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 95, 13091-13096.
59. Lee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J. and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33, 40-48.
60. Lehtinen, M. K., Yuan, Z., Boag, P. R., Yang, Y., Villen, J., Becker, E. B., DiBacco, S., de la Iglesia, N., Gygi, S., Blackwell, T. K. et al. (2006). A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987-1001.
61. Lin, K., Dorman, J. B., Rodan, A. and Kenyon, C. (1997). daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.
62. Lin, S. J., Defossez, P. A. and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128.
63. Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R. and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-348.
64. Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E. and Hekimi, S. (2005). Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19, 2424-2434.
65. Lombard, D. B., Chun, K. F., Mostoslavsky, R., Franco, S., Gostissa, M. and Alt, F. W. (2005). DNA repair, genome stability, and aging. Cell 120, 497-512.
66. Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M. and Scrable, H. (2004). Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306-319.
67. Matheu, A., Pantoja, C., Efeyan, A., Criado, L. M., Martin-Caballero, J., Flores, J. M., Klatt, P. and Serrano, M. (2004). Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18, 2736-2746.
68. Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Vina, J., Blasco, M. A. and Serrano, M. (2007). Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448, 375-379.
69. Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L. and Pelicci, P. G. (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313.
70. Morris, J. Z., Tissenbaum, H. A. and Ruvkun, G. (1996). A phosphatidylinositol-3-OH kinase family member regulating longevity and (hapause in Caenorhabditis elegans. Nature 382, 536-539.
71. Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M. et al. (2006). Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
72. Motta, M. C., Divecha, N, Lemieux, M, Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M. and Guarente, L. (2004). Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563.
73. Navarro, C. L., Can, P. and Levy, N. (2006). Molecular bases of progeroid syndromes. Hum. Mol. Genet. 15 Spec. No 2, R151-R161.
74. Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A. and Ruvkan, G. (1997). The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999.
75. Oh, S. W., Mukhopadhyay, A, Svrzikapa, N., Jiang, F., Davis, R. J. and Tissenbaum, H. A. (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102, 4494-4499.
76. Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J. and Kapahi, P. (2007). Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6, 111-119.
77. Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J. and Dillin, A. (2007). PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447, 550-555.
78. Pinton, P., Rimessi, A., Marchi, S, Orsini, F., Migliaccio, E., Giorgio, M., Contursi, C., Minucci, S., Mantovani, F., Wieckowski, M. R. et al. (2007). Protein kinase C beta and prolyl Isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 315, 659-663.
79. Rogina, B. and Helfand, S. L. (2004). Sir2 mediates longevity in tile fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101, 15998-16003.
80. Rose, G., Dato, S, Altomare, K., Bellizi, D., Garasto, S., Greco, V., Pamarino, G., Feraco, E., Mari, V., Barbi, C. et al. (2003). Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp. Gerontol. 38, 1065-1070.
81. Roth, G. S., Lane, M. A., Ingram, D. K., Mattison, J. A., Elahi, D., Tobin, J. D., Muller, D. and Metter, E. J. (2002). Biomarkers of caloric restriction may predict longevity in humans. Science 297, 811.
82. Rudolph, K. L., Chang, S., Lee, H. W., Blasco, M., Gottlieb, G. J., Greider, C. and DePinho, R. A. (1999). Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701-712.
83. Shaw, W. M., Luo, S., Landis, J., Ashraf, J. and Murphy, C. T. (2007). The C. elegans TGF-beta dauer Pathway regulates longevity via insulin signaling. Curr. Biol. 17, 1635-1645.
84. Shiraki-Iida, T., Aizawa, H, Matsumura, Y., Sekine, S., Iida, A., Anazawa, H., Nagai, R., Kuro-o. M. and Nabeshima, Y. (1998). Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 424, 6-10.
85. Syntichaki, P., Troulinaki, K. and Tavernarakis, N. (2007). eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445, 922-926.
86. Taguchi, A., Wartschow, L. M. and White, M. F. (2007). Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-372.
87. Tatar, M., Kopelman, A., Epstein, D., Tu, M. P., Yin, C. M. and Garofalo, R. S. (2001). A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110.
88. Tissenbaum, H. A. and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230.
89. Tyner, S. D., Venkatachalam, S, Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C. et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53.
90. Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S. and Yamashita, T. (2006). Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770-774.
91. Van Der Horst, A., Tertoolen, L. G., De Vries-Smits, L. M., Frye, R. A, Medema, R. H. and Burgering, B. M. (2004). FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J. Biol. Chem. 279, 28873-28879.
92. Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L. and Muller, F. (2003). Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426, 620.
93. Viswanathan, M., Kim, S. K., Berdichevsky, A. and Guarente, L. (2005). A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9, 605-615.
94. Wallace, D. C. (2005). A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359-407.
95. Wang, M. C., Bohmann, D. and Jasper, H. (2003). JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5, 811-816.
96. Wang, M. C., Bohmann, D. and Jasper, H. (2005). JNK extends life span and limit growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125.
97. Wang, Y. and Tissenbaum, H. A. (2006). Overlapping and distinct functions for a Caenorbabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 127, 48-56.
98. Wolf, E., Kahnt, E., Ehrlein, J., Hermanns, W., Brem, G. and Wanke, R. (1993). Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mech. Ageing Dev. 68, 71-87.
99. Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M. and Sinclair, D. (2004). Sirtuin activators munic caloric restriction and delay ageing in metazoans. Nature 430, 686-689.
100. Yan, L., Vatner, D. E., O'Connor, J, P., Ivessa, A., Ge, H., Chen, W., Hirotani, S., Ishikawa, Y., Sadoshima, J. and Vatner, S. F. (2007). Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130, 247-258.
101. Yang, Y., Hou, H., Haller, E. M., Nicosia, S. V. and Bai, W. (2005). Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 24, 1021-1032.
102. Zang, M., Xu, S., Maitland-Toolan, K. A, Zuccollo. A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J. and Cohen, R. A. (2006). Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55, 2180-2191.