Age to survive: DNA damage and aging

Trends in Genetics

Volumn 24, Issue 2, 2008, Pages 77-85

  Schumacher, Björn ^a   Garinis, George A ^a   Hoeijmakers, Jan H J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; SOMATOMEDIN;

AGING; BONE ATROPHY; CACHEXIA; CALORIC RESTRICTION; CELL LOSS; COCKAYNE SYNDROME; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE MUTATION; GENETIC ANALYSIS; HUMAN; ICHTHYOSIS; LIFESPAN; LONGEVITY; METAZOON; MOLECULAR EVOLUTION; MORTALITY; NEOPLASM; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROGERIA; PROTEIN FUNCTION; REGULATOR GENE; RETINA CELL; REVIEW; SIGNAL TRANSDUCTION; STRESS; TRICHOTHIODYSTROPHY; WERNER SYNDROME;

AGING; ANIMALS; COCKAYNE SYNDROME; DISEASE MODELS, ANIMAL; DNA DAMAGE; EVOLUTION, MOLECULAR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INVERTEBRATES; LONGEVITY; MICE; NEOPLASMS; PROGERIA; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

METAZOA;

EID: 38549106119     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2007.11.004     Document Type: Review

References (88)

1. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
2. Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249 (1990) 908-912
3. Guarente L., and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408 (2000) 255-262
4. Rea S.L., et al. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat. Genet. 37 (2005) 894-898
5. Partridge L., et al. Dietary restriction in Drosophila. Mech. Ageing Dev. 126 (2005) 938-950
6. Snell G.D. Dwarf, a new mendelian recessive character of the house mouse. Proc. Natl. Acad. Sci. U. S. A. 15 (1929) 733-734
7. Liang H., et al. Genetic mouse models of extended lifespan. Exp. Gerontol. 38 (2003) 1353-1364
8. Heiman M.L., et al. Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice. Endocrine 20 (2003) 149-154
9. Carter C.S., et al. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 18 (2002) 295-301
10. Zhou Y., et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13215-13220
11. Bonkowski M.S., et al. Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 562-567
12. Kurosu H., et al. Suppression of aging in mice by the hormone Klotho. Science 309 (2005) 1829-1833
13. Holzenberger M., et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
14. Bartke A., et al. Extending the lifespan of long-lived mice. Nature 414 (2001) 412
15. Kirkwood T.B. Understanding the odd science of aging. Cell 120 (2005) 437-447
16. Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
17. Ramirez C.L., et al. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell. Mol. Life Sci. 64 (2007) 155-170
18. Lombard D.B., et al. DNA repair, genome stability, and aging. Cell 120 (2005) 497-512
19. Mitchell J.R., et al. Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr. Opin. Cell Biol. 15 (2003) 232-240
20. Botta E., et al. Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. Hum. Mol. Genet. 11 (2002) 2919-2928
21. Vermeulen W., et al. A temperature-sensitive disorder in basal transcription and DNA repair in humans. Nat. Genet. 27 (2001) 299-303
22. Niedernhofer L.J., et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444 (2006) 1038-1043
23. Tian M., et al. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol. Cell. Biol. 24 (2004) 1200-1205
24. Gurtan A.M., and D'Andrea A.D. Dedicated to the core: understanding the Fanconi anemia complex. DNA Repair (Amst.) 5 (2006) 1119-1125
25. Niedernhofer L.J., et al. Fanconi anemia (cross)linked to DNA repair. Cell 123 (2005) 1191-1198
26. Shiloh Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31 (1997) 635-662
27. Caspari T. How to activate p53. Curr. Biol. 10 (2000) R315-R317
28. Difilippantonio S., et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat. Cell Biol. 7 (2005) 675-685
29. Meier U.T. Dissecting dyskeratosis. Nat. Genet. 33 (2003) 116-117
30. Marrone A., et al. Dyskeratosis congenita: telomerase, telomeres and anticipation. Curr. Opin. Genet. Dev. 15 (2005) 249-257
31. Lans H., and Hoeijmakers J.H. Cell biology: ageing nucleus gets out of shape. Nature 440 (2006) 32-34
32. Varela I., et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437 (2005) 564-568
33. Liu B., et al. Genomic instability in laminopathy-based premature aging. Nat. Med. 11 (2005) 780-785
34. Dolle M.E., et al. Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat. Genet. 17 (1997) 431-434
35. Sedelnikova O.A., et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6 (2004) 168-170
36. Kipling D., et al. What can progeroid syndromes tell us about human aging?. Science 305 (2004) 1426-1431
37. Kuro-o M., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51
38. Lebel M., and Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13097-13102
39. Blasco M.A., et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91 (1997) 25-34
40. Rudolph K.L., et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96 (1999) 701-712
41. van der Horst G.T., et al. Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. Cell 89 (1997) 425-435
42. de Boer J., et al. Premature aging in mice deficient in DNA repair and transcription. Science 296 (2002) 1276-1279
43. van der Pluijm I., et al. Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5 (2006) e2
44. Harada Y.N., et al. Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene. Mol. Cell. Biol. 19 (1999) 2366-2372
45. Shiomi N., et al. Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol. Cell. Biol. 24 (2004) 3712-3719
46. Shiomi N., et al. Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg. DNA Repair (Amst.) 4 (2005) 351-357
47. Wong J.C., and Buchwald M. Disease model: fanconi anemia. Trends Mol. Med. 8 (2002) 139-142
48. Barlow C., et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86 (1996) 159-171
49. Chang S., et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat. Genet. 36 (2004) 877-882
50. Wong K.K., et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421 (2003) 643-648
51. Wright W.E., and Shay J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat. Med. 6 (2000) 849-851
52. Alekseev S., et al. Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation. Cancer Res. 65 (2005) 10298-10306
53. Vogel H., et al. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10770-10775
54. Burkle A. Poly(ADP-ribosyl)ation: a posttranslational protein modification linked with genome protection and mammalian longevity. Biogerontology 1 (2000) 41-46
55. van de Ven M., et al. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet. 2 (2006) e192
56. Mostoslavsky R., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 (2006) 315-329
57. Giordano R., et al. Somatopause reflects age-related changes in the neural control of GH/IGF-I axis. J. Endocrinol. Invest. 28 3 Suppl (2005) 94-98
58. Salmon A.B., et al. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am. J. Physiol. Endocrinol. Metab. 289 (2005) E23-E29
59. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol. 8 (2007) 703-713
60. Campisi J. Aging, tumor suppression and cancer: high wire-act!. Mech. Ageing Dev. 126 (2005) 51-58
61. Zhou B.B., and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature 408 (2000) 433-439
62. Holzenberger M. The role of insulin-like signalling in the regulation of ageing. Horm. Res. 62 (2004) 89-92
63. Larsson O., et al. Role of insulin-like growth factor 1 receptor signalling in cancer. Br. J. Cancer 96 Suppl (2007) R2-R6
64. Harris S.L., and Levine A.J. The p53 pathway: positive and negative feedback loops. Oncogene 24 (2005) 2899-2908
65. Hussain S.P., and Harris C.C. Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens. Mutat. Res. 462 (2000) 311-322
66. Maier B., et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18 (2004) 306-319
67. Tyner S.D., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
68. Garcia-Cao I., et al. Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21 (2002) 6225-6235
69. Matheu A., et al. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18 (2004) 2736-2746
70. Sharpless N.E., and DePinho R.A. The INK4A/ARF locus and its two gene products. Curr. Opin. Genet. Dev. 9 (1999) 22-30
71. Matheu A., et al. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448 (2007) 375-379
72. Kirkwood T. Ageing: too fast by mistake. Nature 444 (2006) 1015-1017
73. Bartke A. New findings in transgenic, gene knockout and mutant mice. Exp. Gerontol. 41 (2006) 1217-1219
74. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 (2005) 449-460
75. Medawar P.B. An Unsolved Problem of Biology (1952), Lewis, London
76. Kirkwood T.B., and Cremer T. Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum. Genet. 60 (1982) 101-121
77. Bartke A., and Brown-Borg H. Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63 (2004) 189-225
78. Harper J.M., et al. Does caloric restriction extend life in wild mice?. Aging Cell 5 (2006) 441-449
79. Chen J., et al. A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 62 (2007) 126-135
80. Lehmann A.R. DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie. 85 (2003) 1101-1111
81. Fitch M.E., et al. In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J. Biol. Chem. 278 (2003) 46906-46910
82. Laine J.P., and Egly J.M. When transcription and repair meet: a complex system. Trends Genet. 22 (2006) 430-436
83. Wijnhoven S.W., et al. Tissue specific mutagenic and carcinogenic responses in NER defective mouse models. Mutat. Res. 614 (2007) 77-94
84. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
85. Andressoo J.O., et al. An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell 10 (2006) 121-132
86. Jaspers N.G., et al. First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am. J. Hum. Genet. 80 (2007) 457-466
87. Kaneko H., and Kondo N. Clinical features of Bloom syndrome and function of the causative gene, BLM helicase. Expert Rev. Mol. Diagn. 4 (2004) 393-401
88. Kitao S., et al. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat. Genet. 22 (1999) 82-84