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Volumn 14, Issue 2, 2014, Pages 181-200

Molecular targeted approaches to cancer therapy and prevention using chalcones

Author keywords

Bioactive dietary compounds; Chalcones; Chemoprevention; Molecular targets

Indexed keywords

ANDROGEN RECEPTOR; BETA CATENIN; CHALCONE; DEATH RECEPTOR; ESTROGEN RECEPTOR; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; ISOLIQUIRITIGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEASOME; PROTEIN MDM2; PROTEIN P53; STAT3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TUBULIN; WNT PROTEIN; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE;

EID: 84896325215     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/1568009614666140122160515     Document Type: Review
Times cited : (112)

References (136)
  • 1
    • 79956360137 scopus 로고    scopus 로고
    • Dietary chalcones with chemopreventive and chemotherapeutic potential
    • Orlikova, B.; Tasdemir, D.; Golais, F.; Dicato, M.; Diederich, M. Dietary chalcones with chemopreventive and chemotherapeutic potential. Genes Nutr. 2011, 6, 125-147.
    • (2011) Genes Nutr. , vol.6 , pp. 125-147
    • Orlikova, B.1    Tasdemir, D.2    Golais, F.3    Dicato, M.4    Diederich, M.5
  • 2
    • 79952104482 scopus 로고    scopus 로고
    • The role of chalcones in suppression of NF-κB-mediated inflammation and cancer
    • Yadav, V. R.; Prasad, S.; Sung, B.; Aggarwal, B. B. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. Int. Immunopharmacol. 2011, 11, 295-309.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 295-309
    • Yadav, V.R.1    Prasad, S.2    Sung, B.3    Aggarwal, B.B.4
  • 4
    • 84870165075 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of chalcone derivatives (mini review)
    • Bukhari, S. N.; Jasamai, M.; Jantan, I. Synthesis and biological evaluation of chalcone derivatives (mini review). Mini Rev. Med. Chem. 2012, 12, 1394-1403.
    • (2012) Mini Rev. Med. Chem. , vol.12 , pp. 1394-1403
    • Bukhari, S.N.1    Jasamai, M.2    Jantan, I.3
  • 5
    • 84879799563 scopus 로고    scopus 로고
    • Understanding, recognizing, and managing toxicities of targeted anticancer therapies
    • Dy, G. K.; Adjei, A. A. Understanding, recognizing, and managing toxicities of targeted anticancer therapies. CA Cancer J. Clin. 2013, 63, 249-279.
    • (2013) CA Cancer J. Clin. , vol.63 , pp. 249-279
    • Dy, G.K.1    Adjei, A.A.2
  • 9
    • 0037784028 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of novel boronicchalcone derivatives as antitumor agents
    • Kumar, S. K.; Hager, E.; Pettit, C.; Gurulingappa, H.; Davidson, N. E.; Khan, S. R. Design, synthesis, and evaluation of novel boronicchalcone derivatives as antitumor agents. J. Med. Chem. 2003 46, 2813-2825.
    • (2003) J. Med. Chem. , vol.46 , pp. 2813-2825
    • Kumar, S.K.1    Hager, E.2    Pettit, C.3    Gurulingappa, H.4    Davidson, N.E.5    Khan, S.R.6
  • 11
    • 18844373926 scopus 로고    scopus 로고
    • Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells
    • Hsu, Y. L.; Kuo, P. L.; Lin, C. C. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. Life Sci. 2005, 77, 279-292.
    • (2005) Life Sci. , vol.77 , pp. 279-292
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 12
    • 33745276531 scopus 로고    scopus 로고
    • A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome
    • Achanta, G.; Modzelewska, A.; Feng, L.; Khan, S. R.; Huang, P. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol. Pharmacol. 2006, 70, 426-433.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 426-433
    • Achanta, G.1    Modzelewska, A.2    Feng, L.3    Khan, S.R.4    Huang, P.5
  • 13
    • 35748977117 scopus 로고    scopus 로고
    • Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination
    • Chen, Z.; Knutson, E.; Wang, S.; Martinez, L. A.; Albrecht, T. Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. Biol. Chem. 2007, 282, 29284-29295.
    • (2007) Biol. Chem. , vol.282 , pp. 29284-29295
    • Chen, Z.1    Knutson, E.2    Wang, S.3    Martinez, L.A.4    Albrecht, T.5
  • 14
    • 35448941897 scopus 로고    scopus 로고
    • Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo
    • Sasayama, T.; Tanaka, K.; Mizukawa, K.; Kawamura A.; Kondoh, T.; Hosoda, K.; Kohmura, E. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. J. Neurooncol. 2007, 85, 123-132.
    • (2007) J. Neurooncol. , vol.85 , pp. 123-132
    • Sasayama, T.1    Tanaka, K.2    Mizukawa, K.3    Kawamura, A.4    Kondoh, T.5    Hosoda, K.6    Kohmura, E.7
  • 15
    • 25444487775 scopus 로고    scopus 로고
    • Monitoring the effects of antagonists on proteinprotein interactions with NMR spectroscopy
    • D'Silva, L.; Ozdowy, P.; Krajewski, M.; Rothweiler, U.; Singh, M.; Holak, T. A. Monitoring the effects of antagonists on proteinprotein interactions with NMR spectroscopy. J. Am. Chem. Soc. 2005, 127, 13220-13226.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 13220-13226
    • D'Silva, L.1    Ozdowy, P.2    Krajewski, M.3    Rothweiler, U.4    Singh, M.5    Holak, T.A.6
  • 16
    • 47249090909 scopus 로고    scopus 로고
    • Hydroxysafflor yellow A upregulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia
    • Lian, Z. Q.; Zhao, D. L.; Zhu, H. B. Hydroxysafflor yellow A upregulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia. Yao Xue Xue Bao 2008, 43, 484-489.
    • (2008) Yao Xue Xue Bao , vol.43 , pp. 484-489
    • Lian, Z.Q.1    Zhao, D.L.2    Zhu, H.B.3
  • 18
    • 84867012134 scopus 로고    scopus 로고
    • A new chalcone derivative (E)-3-(4-methoxyphenyl)-2-methyl-1-(3, 4, 5-trimethoxyphenyl) prop-2-en-1-one suppresses prostate cancer involving p53-mediated cell cycle arrests and apoptosis
    • Zhang, Y.; Srinivasan, B.; Xing, C.; Lü, J. A new chalcone derivative (E)-3-(4-methoxyphenyl)-2-methyl-1-(3, 4, 5-trimethoxyphenyl) prop-2-en-1-one suppresses prostate cancer involving p53-mediated cell cycle arrests and apoptosis. Anticancer Res. 2012, 32, 3689-3698.
    • (2012) Anticancer Res. , vol.32 , pp. 3689-3698
    • Zhang, Y.1    Srinivasan, B.2    Xing, C.3    Lü, J.4
  • 19
    • 77956179034 scopus 로고    scopus 로고
    • Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production
    • Kim, T. H.; Seo, W. D.; Ryu, H. W.; Seo, H. R.; Jin, Y. B.; Lee, M.; Ji, Y. H.; Park, K. H.; Lee, Y. S. Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production. Chem. Biol. Interact. 2010, 188, 111-118.
    • (2010) Chem. Biol. Interact. , vol.188 , pp. 111-118
    • Kim, T.H.1    Seo, W.D.2    Ryu, H.W.3    Seo, H.R.4    Jin, Y.B.5    Lee, M.6    Ji, Y.H.7    Park, K.H.8    Lee, Y.S.9
  • 20
    • 61749083799 scopus 로고    scopus 로고
    • Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53
    • Tang, Y.; Simoneau, A. R.; Xie, J.; Shahandeh, B.; Zi, X. Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53. Cancer Prev. Res. (Phila Pa) 2008, 1, 439-51.
    • (2008) Cancer Prev. Res. (Phila Pa) , vol.1 , pp. 439-451
    • Tang, Y.1    Simoneau, A.R.2    Xie, J.3    Shahandeh, B.4    Zi, X.5
  • 21
    • 84890522483 scopus 로고    scopus 로고
    • KAVA chalcone, Flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model
    • Liu, Z.; Xu, X.; Li, X.; Liu, S.; Simoneau, A. R.; He, F.; Wu, X. R.; Zi, X. KAVA chalcone, Flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model. Cancer Prev. Res. (Phila) 2013, 6, 1365-1375.
    • (2013) Cancer Prev. Res. (Phila) , vol.6 , pp. 1365-1375
    • Liu, Z.1    Xu, X.2    Li, X.3    Liu, S.4    Simoneau, A.R.5    He, F.6    Wu, X.R.7    Zi, X.8
  • 22
    • 56649106665 scopus 로고    scopus 로고
    • A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells
    • Kahyo, T.; Ichikawa, S.; Hatanaka, T.; Yamada, M. K.; Setou, M. A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J. Pharmacol. Sci. 2008, 108, 364-371.
    • (2008) J. Pharmacol. Sci. , vol.108 , pp. 364-371
    • Kahyo, T.1    Ichikawa, S.2    Hatanaka, T.3    Yamada, M.K.4    Setou, M.5
  • 23
    • 0024820010 scopus 로고
    • Interaction of tubulin and cellular microtubules with the new antitumor drug MDL 27048. A powerful and reversible microtubule inhibitor
    • Peyrot, V.; Leynadier, D.; Sarrazin, M.; Briand, C.; Rodriquez, A.; Nieto, J. M.; Andreu, J. M. Interaction of tubulin and cellular microtubules with the new antitumor drug MDL 27048. A powerful and reversible microtubule inhibitor. J. Biol. Chem. 1989, 264, 21296-21301.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21296-21301
    • Peyrot, V.1    Leynadier, D.2    Sarrazin, M.3    Briand, C.4    Rodriquez, A.5    Nieto, J.M.6    Andreu, J.M.7
  • 25
  • 26
    • 72049087235 scopus 로고    scopus 로고
    • Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity
    • Ducki, S.; Rennison, D.; Woo, M.; Kendall, A.; Chabert, J. F.; McGown, A. T.; Lawrence, N. J. Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity. Bioorg. Med. Chem. 2009, 17, 7698-7710.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 7698-7710
    • Ducki, S.1    Rennison, D.2    Woo, M.3    Kendall, A.4    Chabert, J.F.5    McGown, A.T.6    Lawrence, N.J.7
  • 28
    • 0030846513 scopus 로고    scopus 로고
    • Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: Type II estrogen binding sites and tubulin
    • ter Haar, E.; Hamel, E.; Balachandran, R.; Day, B. W. Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin. Anticancer Res. 1997, 17, 1861-1869.
    • (1997) Anticancer Res. , vol.17 , pp. 1861-1869
    • ter Haar, E.1    Hamel, E.2    Balachandran, R.3    Day, B.W.4
  • 29
    • 77957017657 scopus 로고    scopus 로고
    • Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: A comparative study of uptake, cell cycle and damage to cellular compartments
    • Zoldakova, M.; Kornyei, Z.; Brown, A.; Biersack, B.; Madarasz, E.; Schobert, R. Effects of a combretastatin A4 analogous chalcone and its Pt-complex on cancer cells: A comparative study of uptake, cell cycle and damage to cellular compartments. Biochem. Pharmacol. 2010, 80, 1487-1496.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1487-1496
    • Zoldakova, M.1    Kornyei, Z.2    Brown, A.3    Biersack, B.4    Madarasz, E.5    Schobert, R.6
  • 30
    • 77649231931 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents
    • Tu, H. Y.; Huang, A. M.; Hour, T. C.; Yang, S. C.; Pu, Y. S.; Lin, C. N. Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents. Bioorg. Med. Chem. 2010 18, 2089-2098.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 2089-2098
    • Tu, H.Y.1    Huang, A.M.2    Hour, T.C.3    Yang, S.C.4    Pu, Y.S.5    Lin, C.N.6
  • 34
    • 84872676363 scopus 로고    scopus 로고
    • (E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization
    • Vitorović-Todorović, M. D.; Erić-Nikolić, A.; Kolundžija, B.; Hamel, E.; Ristić, S.; Juranić, I. O.; Drakulić, B. J. (E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: design, antiproliferative activity and inhibition of tubulin polymerization. Eur. J. Med. Chem. 2013, 62, 40.
    • (2013) Eur. J. Med. Chem. , vol.62 , pp. 40
    • Vitorović-Todorović, M.D.1    Erić-Nikolić, A.2    Kolundžija, B.3    Hamel, E.4    Ristić, S.5    Juranić, I.O.6    Drakulić, B.J.7
  • 35
    • 60549086471 scopus 로고    scopus 로고
    • Pt(II) complexes of a combretastatin A-4 analogous chalcone: Effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression
    • Schobert, R.; Biersack, B.; Dietrich, A.; Knauer, S.; Zoldakova, M.; Fruehauf, A.; Mueller, T. Pt(II) complexes of a combretastatin A-4 analogous chalcone: effects of conjugation on cytotoxicity, tumor specificity, and long-term tumor growth suppression. J. Med. Chem. 2009, 52, 241-246.
    • (2009) J. Med. Chem. , vol.52 , pp. 241-246
    • Schobert, R.1    Biersack, B.2    Dietrich, A.3    Knauer, S.4    Zoldakova, M.5    Fruehauf, A.6    Mueller, T.7
  • 36
    • 79954418171 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents
    • Ruan, B. F.; Lu, X.; Tang, J. F.; Wei, Y.; Wang, X. L.; Zhang, Y. B.; Wang, L. S.; Zhu, H. L. Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. Bioorg. Med. Chem. 2011, 19, 2688-2695.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2688-2695
    • Ruan, B.F.1    Lu, X.2    Tang, J.F.3    Wei, Y.4    Wang, X.L.5    Zhang, Y.B.6    Wang, L.S.7    Zhu, H.L.8
  • 38
    • 79954418634 scopus 로고    scopus 로고
    • Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents
    • Dyrager, C.; Wickström, M.; Fridén-Saxin, M.; Friberg, A.; Dahlén, K.; Wallén, E. A.; Gullbo, J.; Grøtli, M.; Luthman, K. Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents. Bioorg. Med. Chem. 2011, 19, 2659-2665.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 2659-2665
    • Dyrager, C.1    Wickström, M.2    Fridén-Saxin, M.3    Friberg, A.4    Dahlén, K.5    Wallén, E.A.6    Gullbo, J.7    Grøtli, M.8    Luthman, K.9
  • 40
    • 53049083867 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor action and resistance in cancer
    • McConkey, D. J.; Zhu, K. Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist. Updat. 2008, 12, 164-179.
    • (2008) Drug Resist. Updat. , vol.12 , pp. 164-179
    • McConkey, D.J.1    Zhu, K.2
  • 41
    • 78751659623 scopus 로고    scopus 로고
    • β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells
    • Bazzaro, M.; Anchoori, R. K.; Mudiam, M. K.; Issaenko, O.; Kumar, S.; Karanam, B.; Lin, Z., Isaksson Vogel, R.; Gavioli, R.; Destro, F.; Ferretti, V.; Roden, R. B.; Khan, S. R., β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells. J. Med. Chem. 2011, 54, 449-56.
    • (2011) J. Med. Chem. , vol.54 , pp. 449-456
    • Bazzaro, M.1    Anchoori, R.K.2    Mudiam, M.K.3    Issaenko, O.4    Kumar, S.5    Karanam, B.6    Lin, Z.7    Isaksson Vogel, R.8    Gavioli, R.9    Destro, F.10    Ferretti, V.11    Roden, R.B.12    Khan, S.R.13
  • 43
    • 84860755914 scopus 로고    scopus 로고
    • Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
    • Issaenko, O. A.; Amerik, A. Y. Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes. Cell Cycle 2012, 11, 1804-1817.
    • (2012) Cell Cycle , vol.11 , pp. 1804-1817
    • Issaenko, O.A.1    Amerik, A.Y.2
  • 44
    • 84864610628 scopus 로고    scopus 로고
    • Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line
    • Eskander, R. N.; Randall, L. M.; Sakai, T.; Guo, Y.; Hoang, B.; Zi, X. Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. J. Obstet. Gynaecol. Res. 2012, 38, 1086-1094.
    • (2012) J. Obstet. Gynaecol. Res. , vol.38 , pp. 1086-1094
    • Eskander, R.N.1    Randall, L.M.2    Sakai, T.3    Guo, Y.4    Hoang, B.5    Zi, X.6
  • 45
    • 84878700728 scopus 로고    scopus 로고
    • Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
    • Ji, T.; Lin, C.; Krill, L. S.; Eskander, R.; Guo, Y.; Zi, X.; Hoang, B. H. Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis. Mol. Cancer 2013 12, 55.
    • (2013) Mol. Cancer , vol.12 , pp. 55
    • Ji, T.1    Lin, C.2    Krill, L.S.3    Eskander, R.4    Guo, Y.5    Zi, X.6    Hoang, B.H.7
  • 46
    • 4143140833 scopus 로고    scopus 로고
    • Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
    • Hsieh, T. C.; Guo, J.; Kunicki, J.; Lee, M. Y.; Darzynkiewicz, Z.; Wu, J. M. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem. Biophys. Res. Commun. 2004, 322, 263-270.
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 263-270
    • Hsieh, T.C.1    Guo, J.2    Kunicki, J.3    Lee, M.Y.4    Darzynkiewicz, Z.5    Wu, J.M.6
  • 47
    • 64949183401 scopus 로고    scopus 로고
    • Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin
    • Lee, Y. M.; Lim, D. Y.; Choi, H. J.; Jung, J. I.; Chung, W. Y.; Park, J. H. Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. J. Med. Food 2009, 12, 8-14.
    • (2009) J. Med. Food , vol.12 , pp. 8-14
    • Lee, Y.M.1    Lim, D.Y.2    Choi, H.J.3    Jung, J.I.4    Chung, W.Y.5    Park, J.H.6
  • 48
    • 62749157517 scopus 로고    scopus 로고
    • Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition
    • Park, I.; Park, K. K.; Park, J. H.; Chung, W. Y. Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. Cancer Lett. 2009, 277, 174-181.
    • (2009) Cancer Lett. , vol.277 , pp. 174-181
    • Park, I.1    Park, K.K.2    Park, J.H.3    Chung, W.Y.4
  • 50
    • 1842577637 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin
    • Ii, T.; Satomi, Y.; Katoh, D.; Shimada, J.; Baba, M.; Okuyama, T.; Nishino, H.; Kitamura, N. Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. Cancer Lett. 2004, 207, 27-35.
    • (2004) Cancer Lett. , vol.207 , pp. 27-35
    • Ii, T.1    Satomi, Y.2    Katoh, D.3    Shimada, J.4    Baba, M.5    Okuyama, T.6    Nishino, H.7    Kitamura, N.8
  • 51
    • 84878869508 scopus 로고    scopus 로고
    • Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation
    • Park, S.; Gwak, J.; Han, S. J.; Oh, S. Cardamonin Suppresses the Proliferation of Colon Cancer Cells by Promoting β-Catenin Degradation. Biol. Phar. Bull. 2013, 6, 1040-1044.
    • (2013) Biol. Phar. Bull. , vol.6 , pp. 1040-1044
    • Park, S.1    Gwak, J.2    Han, S.J.3    Oh, S.4
  • 52
    • 68149160590 scopus 로고    scopus 로고
    • Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells
    • Hsu, Y. L.; Chia, C. C.; Chen, P.J.; Huang, S. E.; Huang, S. C.; Kuo, P. L. Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. Mol. Nutr. Food Res. 2009, 53, 826-835.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 826-835
    • Hsu, Y.L.1    Chia, C.C.2    Chen, P.J.3    Huang, S.E.4    Huang, S.C.5    Kuo, P.L.6
  • 53
    • 36649009387 scopus 로고    scopus 로고
    • Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in human bladder cancer cells
    • Shen, K. H.; Chang, J. K.; Hsu, Y. L.; Kuo, P. L. Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in human bladder cancer cells. Basic Clin. Pharmacol. Toxicol. 2007, 101, 254-261.
    • (2007) Basic Clin. Pharmacol. Toxicol. , vol.101 , pp. 254-261
    • Shen, K.H.1    Chang, J.K.2    Hsu, Y.L.3    Kuo, P.L.4
  • 54
    • 33745601961 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgenindependent human prostate cancer cells PC3 and DU145
    • Yun, J. M.; Kweon, M. H.; Kwon, H.; Hwang, J. K.; Mukhtar, H. Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgenindependent human prostate cancer cells PC3 and DU145. Carcinogenesis 2006, 27, 1454-1464.
    • (2006) Carcinogenesis , vol.27 , pp. 1454-1464
    • Yun, J.M.1    Kweon, M.H.2    Kwon, H.3    Hwang, J.K.4    Mukhtar, H.5
  • 56
    • 35448941897 scopus 로고    scopus 로고
    • Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo
    • Sasayama, T.; Tanaka, K.; Mizukawa, K.; Kawamura, A.; Kondoh, T.; Hosoda, K.; Kohmura, E. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. J. Neurooncol. 2007, 85, 123-132.
    • (2007) J. Neurooncol. , vol.85 , pp. 123-132
    • Sasayama, T.1    Tanaka, K.2    Mizukawa, K.3    Kawamura, A.4    Kondoh, T.5    Hosoda, K.6    Kohmura, E.7
  • 61
    • 77954942475 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: Its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signalregulated kinase
    • Sun, Z. J.; Chen, G.; Zhang, W.; Hu, X.; Huang, C. F.; Wang, Y. F.; Jia, J.; Zhao, Y. F. Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signalregulated kinase. J. Pharmacol. Exp. Ther. 2010, 334, 500-512.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 500-512
    • Sun, Z.J.1    Chen, G.2    Zhang, W.3    Hu, X.4    Huang, C.F.5    Wang, Y.F.6    Jia, J.7    Zhao, Y.F.8
  • 63
    • 17144400791 scopus 로고    scopus 로고
    • Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
    • Zi, X.; Simoneau, A. R. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res.2005, 65, 3479-3486.
    • (2005) Cancer Res , vol.65 , pp. 3479-3486
    • Zi, X.1    Simoneau, A.R.2
  • 64
    • 77956113476 scopus 로고    scopus 로고
    • Flavokawain B, a kava chalcone, induces apoptosis via upregulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
    • Tang, Y.; Li, X.; Liu, Z.; Simoneau, A. R.; Xie, J.; Zi, X. Flavokawain B, a kava chalcone, induces apoptosis via upregulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int. J. Cancer 2010, 127, 1758-1768.
    • (2010) Int. J. Cancer , vol.127 , pp. 1758-1768
    • Tang, Y.1    Li, X.2    Liu, Z.3    Simoneau, A.R.4    Xie, J.5    Zi, X.6
  • 65
    • 52649126205 scopus 로고    scopus 로고
    • Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL)
    • Kim, N. Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch. Pharm. Res. 2008, 31, 1179-1186.
    • (2008) Arch. Pharm. Res. , vol.31 , pp. 1179-1186
    • Kim, N.1
  • 66
    • 69249108878 scopus 로고    scopus 로고
    • Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis
    • Ohtsuki, T.; Kikuchi, H.; Koyano, T.; Kowithayakorn, T.; Sakai, T.; Ishibashi, M. Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis. Bioorg. Med. Chem. 2009, 17, 6748-6754.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 6748-6754
    • Ohtsuki, T.1    Kikuchi, H.2    Koyano, T.3    Kowithayakorn, T.4    Sakai, T.5    Ishibashi, M.6
  • 67
    • 67349188370 scopus 로고    scopus 로고
    • Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells
    • Yoshida, T.; Horinaka, M.; Takara, M.; Tsuchihashi, M.; Mukai, N.; Wakada, M.; Sakai, T. Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ. Health Prev. Med. 2008, 13, 281-287.
    • (2008) Environ. Health Prev. Med. , vol.13 , pp. 281-287
    • Yoshida, T.1    Horinaka, M.2    Takara, M.3    Tsuchihashi, M.4    Mukai, N.5    Wakada, M.6    Sakai, T.7
  • 70
    • 77956116309 scopus 로고    scopus 로고
    • Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells
    • Szliszka, E.; Czuba, Z. P.; Mazur, B.; Paradysz, A.; Krol, W. Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells. Molecules 2010, 15, 5336-5353.
    • (2010) Molecules , vol.15 , pp. 5336-5353
    • Szliszka, E.1    Czuba, Z.P.2    Mazur, B.3    Paradysz, A.4    Krol, W.5
  • 73
    • 84858032579 scopus 로고    scopus 로고
    • Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death
    • Robinson, M. W.; Overmeyer, J. H.; Young, A. M.; Erhardt, P. W.; Maltese, W. A. Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death. J. Med. Chem. 2012, 55, 1940-1956.
    • (2012) J. Med. Chem. , vol.55 , pp. 1940-1956
    • Robinson, M.W.1    Overmeyer, J.H.2    Young, A.M.3    Erhardt, P.W.4    Maltese, W.A.5
  • 74
    • 70949087763 scopus 로고    scopus 로고
    • Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities
    • Srinivasan, B.; Johnson, T. E.; Lad, R.; Xing, C. Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. J. Med. Chem. 2009, 52, 7228-7235.
    • (2009) J. Med. Chem. , vol.52 , pp. 7228-7235
    • Srinivasan, B.1    Johnson, T.E.2    Lad, R.3    Xing, C.4
  • 75
    • 33847633373 scopus 로고    scopus 로고
    • Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile
    • Liu, Y. C.; Hsieh, C. W.; Wu, C. C.; Wung, B. S. Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. Life Sci. 2007, 80, 1420-1430.
    • (2007) Life Sci. , vol.80 , pp. 1420-1430
    • Liu, Y.C.1    Hsieh, C.W.2    Wu, C.C.3    Wung, B.S.4
  • 76
    • 84884687097 scopus 로고    scopus 로고
    • Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity
    • Gan, F. F.; Kaminska, K. K.; Yang, H.; Liew, C. Y.; Leow, P. C.; So, C. L.; Tu, L. N.; Roy, A.; Yap, C. W.; Kang, T. S.; Chui, W. K.; Chew, E. H. Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity. Antioxid. Redox. Signal. 2013, 19, 1149-1165.
    • (2013) Antioxid. Redox. Signal. , vol.19 , pp. 1149-1165
    • Gan, F.F.1    Kaminska, K.K.2    Yang, H.3    Liew, C.Y.4    Leow, P.C.5    So, C.L.6    Tu, L.N.7    Roy, A.8    Yap, C.W.9    Kang, T.S.10    Chui, W.K.11    Chew, E.H.12
  • 77
    • 84864413623 scopus 로고    scopus 로고
    • A SAR study on a series of synthetic lipophilic chalcones as inhibitor of transcription factor NF-κB
    • Venkateswararao, E.; Sharma, V. K.; Lee, K. C.; Sharma, N.; Park, S. H.; Kim, Y.; Jung, S. H. A SAR study on a series of synthetic lipophilic chalcones as inhibitor of transcription factor NF-κB. Eur. J. Med. Chem. 2012, 54, 379-386.
    • (2012) Eur. J. Med. Chem. , vol.54 , pp. 379-386
    • Venkateswararao, E.1    Sharma, V.K.2    Lee, K.C.3    Sharma, N.4    Park, S.H.5    Kim, Y.6    Jung, S.H.7
  • 78
    • 34547125342 scopus 로고    scopus 로고
    • Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaB alpha kinase beta on cysteine 179 residue
    • Pandey, M. K.; Sandur, S. K.; Sung, B.; Sethi, G.; Kunnumakkara, A. B.; Aggarwal, B. B. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaB alpha kinase beta on cysteine 179 residue. J. Biol. Chem. 2007, 282, 17340-17350.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17340-17350
    • Pandey, M.K.1    Sandur, S.K.2    Sung, B.3    Sethi, G.4    Kunnumakkara, A.B.5    Aggarwal, B.B.6
  • 79
    • 44449141072 scopus 로고    scopus 로고
    • A novel anticancer effect of butein: Inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells
    • Zhang, L.; Chen, W.; Li, X. A novel anticancer effect of butein: inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells. FEBS Lett. 2008, 582, 1821-1828.
    • (2008) FEBS Lett. , vol.582 , pp. 1821-1828
    • Zhang, L.1    Chen, W.2    Li, X.3
  • 80
    • 34047236705 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells
    • Kumar, S.; Sharma, A.; Madan, B.; Singhal, V.; Ghosh, B. Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. Biochem. Pharmacol. 2007, 73, 1602-1612.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1602-1612
    • Kumar, S.1    Sharma, A.2    Madan, B.3    Singhal, V.4    Ghosh, B.5
  • 81
    • 61949193344 scopus 로고    scopus 로고
    • Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells
    • Harikumar, K. B.; Kunnumakkara, A. B.; Ahn, K. S.; Anand, P.; Krishnan, S.; Guha, S.; Aggarwal, B. B. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009, 113, 2003-2013.
    • (2009) Blood , vol.113 , pp. 2003-2013
    • Harikumar, K.B.1    Kunnumakkara, A.B.2    Ahn, K.S.3    Anand, P.4    Krishnan, S.5    Guha, S.6    Aggarwal, B.B.7
  • 82
    • 51849097711 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids
    • Lorenzo, P.; Alvarez, R.; Ortiz, M. A.; Alvarez, S.; Piedrafita, F. J.; de Lera, A. R. Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. J. Med. Chem. 2008, 51, 5431-5440.
    • (2008) J. Med. Chem. , vol.51 , pp. 5431-5440
    • Lorenzo, P.1    Alvarez, R.2    Ortiz, M.A.3    Alvarez, S.4    Piedrafita, F.J.5    de Lera, A.R.6
  • 83
    • 78349302551 scopus 로고    scopus 로고
    • Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-{kappa}B and MAPK signaling pathways
    • Zhou, P.; Gross, S.; Liu, J. H.; Yu, B. Y.; Feng, L. L.; Nolta, J.; Sharma, V.; Piwnica-Worms, D.; Qiu, S. X. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-{kappa}B and MAPK signaling pathways. FASEB J. 2010, 24, 4722-4732.
    • (2010) FASEB J. , vol.24 , pp. 4722-4732
    • Zhou, P.1    Gross, S.2    Liu, J.H.3    Yu, B.Y.4    Feng, L.L.5    Nolta, J.6    Sharma, V.7    Piwnica-Worms, D.8    Qiu, S.X.9
  • 84
    • 33644821070 scopus 로고    scopus 로고
    • Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives
    • Folmer, F.; Blasius, R.; Morceau, F.; Tabudravu, J.; Dicato, M.; Jaspars, M.; Diederich, M. Inhibition of TNFalpha-induced activation of nuclear factor kappaB by kava (Piper methysticum) derivatives. Biochem. Pharmacol. 2006, 71, 1206-1218.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1206-1218
    • Folmer, F.1    Blasius, R.2    Morceau, F.3    Tabudravu, J.4    Dicato, M.5    Jaspars, M.6    Diederich, M.7
  • 85
    • 80051549637 scopus 로고    scopus 로고
    • The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition
    • Orlikova, B.; Tasdemir, D.; Golais, F.; Dicato, M.; Diederich, M. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem. Pharmacol. 2011, 82, 620-631.
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 620-631
    • Orlikova, B.1    Tasdemir, D.2    Golais, F.3    Dicato, M.4    Diederich, M.5
  • 86
    • 33645218036 scopus 로고    scopus 로고
    • Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis
    • Hsu, Y. L.; Kuo, P. L.; Tzeng, W. S.; Lin, C. C. Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis. Food Chem. Toxicol. 2006, 44, 704-713.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 704-713
    • Hsu, Y.L.1    Kuo, P.L.2    Tzeng, W.S.3    Lin, C.C.4
  • 87
    • 79251646629 scopus 로고    scopus 로고
    • Stercurensin inhibits nuclear factor-κB-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation
    • Kim, Y. J.; Kim, H. C.; Ko, H.; Amor, E. C.; Lee, J. W.; Yang, H. O. Stercurensin inhibits nuclear factor-κB-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation. J. Cell Biochem. 2011, 112, 548-558.
    • (2011) J. Cell Biochem. , vol.112 , pp. 548-558
    • Kim, Y.J.1    Kim, H.C.2    Ko, H.3    Amor, E.C.4    Lee, J.W.5    Yang, H.O.6
  • 88
    • 79952452624 scopus 로고    scopus 로고
    • New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis
    • Reddy, M. V.; Shen, Y. C.; Yang, J. S.; Hwang, T. L.; Bastow, K. F.; Qian, K.; Lee, K. H.; Wu, T. S. New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis. Bioorg. Med. Chem. 2011, 19, 1895-1906.
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 1895-1906
    • Reddy, M.V.1    Shen, Y.C.2    Yang, J.S.3    Hwang, T.L.4    Bastow, K.F.5    Qian, K.6    Lee, K.H.7    Wu, T.S.8
  • 90
    • 77952239232 scopus 로고    scopus 로고
    • Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants
    • Zhou, J.; Geng, G.; Wu, J. H. Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants. Invest. New Drug 2010 28, 291-298.
    • (2010) Invest. New Drug , vol.28 , pp. 291-298
    • Zhou, J.1    Geng, G.2    Wu, J.H.3
  • 93
    • 0027520072 scopus 로고
    • Inhibitory effects of 3'-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis
    • Satomi, Y. Inhibitory effects of 3'-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis. Int. J. Cancer 1993, 55, 506-514.
    • (1993) Int. J. Cancer , vol.55 , pp. 506-514
    • Satomi, Y.1
  • 94
    • 17444362645 scopus 로고    scopus 로고
    • The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase
    • Wang, Y.; Chan, F. L.; Chen, S.; Leung, L. K. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci. 2005, 77, 39-51.
    • (2005) Life Sci. , vol.77 , pp. 39-51
    • Wang, Y.1    Chan, F.L.2    Chen, S.3    Leung, L.K.4
  • 95
    • 58749093583 scopus 로고    scopus 로고
    • Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase
    • Ye, L.; Gho, W. M.; Chan, F. L.; Chen, S.; Leung, L. K. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. Int. J. Cancer 2009, 124, 1028-1036.
    • (2009) Int. J. Cancer , vol.124 , pp. 1028-1036
    • Ye, L.1    Gho, W.M.2    Chan, F.L.3    Chen, S.4    Leung, L.K.5
  • 99
    • 0032497591 scopus 로고    scopus 로고
    • Halogenated chalcones with high-affinity binding to P-glycoprotein: Potential modulators of multidrug resistance
    • Bois, F.; Beney, C.; Boumendjel, A.; Mariotte, A. M.; Conseil, G.; Di Pietro, A. Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance. J. Med. Chem. 1998, 41, 4161-4164.
    • (1998) J. Med. Chem. , vol.41 , pp. 4161-4164
    • Bois, F.1    Beney, C.2    Boumendjel, A.3    Mariotte, A.M.4    Conseil, G.5    Di Pietro, A.6
  • 100
    • 0033384470 scopus 로고    scopus 로고
    • Synthesis and biological activity of 4-alkoxy chalcones: Potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance
    • Bois, F.; Boumendjel, A.; Mariotte, A. M.; Conseil, G.; Di Petro, A. Synthesis and biological activity of 4-alkoxy chalcones: potential hydrophobic modulators of P-glycoprotein-mediated multidrug resistance. Bioorg. Med. Chem. 1999, 7, 2691-2695.
    • (1999) Bioorg. Med. Chem. , vol.7 , pp. 2691-2695
    • Bois, F.1    Boumendjel, A.2    Mariotte, A.M.3    Conseil, G.4    Di Petro, A.5
  • 102
    • 38049039819 scopus 로고    scopus 로고
    • Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein
    • Liu, X. L.; Tee, H. W.; Go, M. L. Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein. Bioorg. Med. Chem. 2008, 16, 171-180.
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 171-180
    • Liu, X.L.1    Tee, H.W.2    Go, M.L.3
  • 103
    • 48849104955 scopus 로고    scopus 로고
    • Modulation of breast cancer resistance protein (BCRP/ABCG2) by non-basic chalcone analogues
    • Han, Y.; Riwanto, M.; Go, M. L.; Ee, P. L. Modulation of breast cancer resistance protein (BCRP/ABCG2) by non-basic chalcone analogues. Eur. J. Pharm. Sci. 2008, 35, 30-41.
    • (2008) Eur. J. Pharm. Sci. , vol.35 , pp. 30-41
    • Han, Y.1    Riwanto, M.2    Go, M.L.3    Ee, P.L.4
  • 104
    • 22244459203 scopus 로고    scopus 로고
    • In vitro and in vivo reversal of cancer cell multidrug resistance by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone
    • Qian, F.; Ye, C. L.; Wei, D. Z.; Lu, Y. H.; Yang, S. L. In vitro and in vivo reversal of cancer cell multidrug resistance by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone. J. Chemother. 2005, 17, 309-314.
    • (2005) J. Chemother. , vol.17 , pp. 309-314
    • Qian, F.1    Ye, C.L.2    Wei, D.Z.3    Lu, Y.H.4    Yang, S.L.5
  • 106
    • 84862796284 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of bifendatechalcone hybrids as a new class of potential P-glycoprotein inhibitors
    • Gu, X.; Ren, Z.; Tang, X.; Peng, H.; Ma, Y.; Lai, Y.; Peng, S.; Zhang, Y. Synthesis and biological evaluation of bifendatechalcone hybrids as a new class of potential P-glycoprotein inhibitors. Bioorg. Med. Chem. 2012, 20, 2540-2548.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 2540-2548
    • Gu, X.1    Ren, Z.2    Tang, X.3    Peng, H.4    Ma, Y.5    Lai, Y.6    Peng, S.7    Zhang, Y.8
  • 107
    • 64249171525 scopus 로고    scopus 로고
    • Chalcone derivatives inhibit glutathione Stransferase P1-1 activity: Insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds
    • Wang, J.; Wang, S.; Song, D.; Zhao, D.; Sha, Y.; Jiang, Y.; Jing, Y.; Cheng, M. Chalcone derivatives inhibit glutathione Stransferase P1-1 activity: insights into the interaction mode of alpha, beta-unsaturated carbonyl compounds. Chem. Biol. Drug Des. 2009, 73, 511-514.
    • (2009) Chem. Biol. Drug Des. , vol.73 , pp. 511-514
    • Wang, J.1    Wang, S.2    Song, D.3    Zhao, D.4    Sha, Y.5    Jiang, Y.6    Jing, Y.7    Cheng, M.8
  • 108
    • 84892441231 scopus 로고    scopus 로고
    • Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway
    • Wu, K. C.; McDonald, P. R.; Liu, J.; Klaassen, C. D. Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway. Planta. Med. 2014, 80 (1), 97-104.
    • (2014) Planta. Med. , vol.80 , Issue.1 , pp. 97-104
    • Wu, K.C.1    McDonald, P.R.2    Liu, J.3    Klaassen, C.D.4
  • 109
    • 33645814383 scopus 로고    scopus 로고
    • Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets
    • Albini, A.; Dell'Eva, R.; Vene, R.; Ferrari, N.; Buhler, D. R.; Noonan, D. M.; Fassina, G. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J. 2006, 20, 527-529.
    • (2006) FASEB J. , vol.20 , pp. 527-529
    • Albini, A.1    Dell'Eva, R.2    Vene, R.3    Ferrari, N.4    Buhler, D.R.5    Noonan, D.M.6    Fassina, G.7
  • 110
  • 111
    • 33646440301 scopus 로고    scopus 로고
    • Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone
    • Lee, Y. S.; Lim, S. S.; Shin, K. H.; Kim, Y. S.; Ohuchi, K.; Jung, S. H. Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone. Biol. Pharm. Bull. 2006, 29, 1028-1031.
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 1028-1031
    • Lee, Y.S.1    Lim, S.S.2    Shin, K.H.3    Kim, Y.S.4    Ohuchi, K.5    Jung, S.H.6
  • 112
    • 0037294729 scopus 로고    scopus 로고
    • Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity
    • Nam, N. H.; Kim, Y.; You, Y. J.; Hong, D. H.; Kim, H. M.; Ahn, B. Z. Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity. Eur. J. Med. Chem. 2003, 38, 179-187.
    • (2003) Eur. J. Med. Chem. , vol.38 , pp. 179-187
    • Nam, N.H.1    Kim, Y.2    You, Y.J.3    Hong, D.H.4    Kim, H.M.5    Ahn, B.Z.6
  • 115
    • 0033862764 scopus 로고    scopus 로고
    • 2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha-and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells
    • Madan, B.; Batra, S.; Ghosh, B. 2'-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha-and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. Mol. Pharmacol. 2000, 58, 526-534.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 526-534
    • Madan, B.1    Batra, S.2    Ghosh, B.3
  • 116
    • 35648974809 scopus 로고    scopus 로고
    • AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
    • Dell'Eva, R.; Ambrosini, C.; Vannini, N.; Piaggio, G.; Albini, A.; Ferrari, N. AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies. Cancer 2007, 110, 2007-2011.
    • (2007) Cancer , vol.110 , pp. 2007-2011
    • Dell'Eva, R.1    Ambrosini, C.2    Vannini, N.3    Piaggio, G.4    Albini, A.5    Ferrari, N.6
  • 117
    • 17844405853 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a component from Chinese herbal medicine
    • Zhu, X. F.; Xie, B. F.; Zhou, J. M.; Feng, G. K.; Liu, Z. C.; Wei, X. Y.; Zhang, F. X.; Liu, M. F.; Zeng, Y. X. Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a component from Chinese herbal medicine. Mol. Pharmacol. 2005, 67, 1444-1450.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1444-1450
    • Zhu, X.F.1    Xie, B.F.2    Zhou, J.M.3    Feng, G.K.4    Liu, Z.C.5    Wei, X.Y.6    Zhang, F.X.7    Liu, M.F.8    Zeng, Y.X.9
  • 118
    • 84855691371 scopus 로고    scopus 로고
    • Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase
    • Rizvi, S. U.; Siddiqui, H. L.; Nisar, M.; Khan, N.; Khan, I. Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase. Bioorg. Med. Chem. Lett. 2012, 22, 942-944.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 942-944
    • Rizvi, S.U.1    Siddiqui, H.L.2    Nisar, M.3    Khan, N.4    Khan, I.5
  • 120
    • 62149113324 scopus 로고    scopus 로고
    • Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1
    • Pandey, M. K.; Sung, B.; Ahn, K. S.; Aggarwal, B. B. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol. Pharmacol. 2009, 75, 525-533.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 525-533
    • Pandey, M.K.1    Sung, B.2    Ahn, K.S.3    Aggarwal, B.B.4
  • 121
    • 80051679046 scopus 로고    scopus 로고
    • Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice
    • Takahashi, A.; Yamamoto, N.; Murakami, A. Cardamonin suppresses nitric oxide production via blocking the IFN-γ/STAT pathway in endotoxin-challenged peritoneal macrophages of ICR mice. Life Sci. 2011, 89, 337-342.
    • (2011) Life Sci. , vol.89 , pp. 337-342
    • Takahashi, A.1    Yamamoto, N.2    Murakami, A.3
  • 122
    • 66149119356 scopus 로고    scopus 로고
    • ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells
    • Li, D. D.; Wu, X. Q.; Tang, J.; Wei, X. Y.; Zhu, X. F. ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells. Cancer Biol. Ther. 2009, 8, 739-743.
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 739-743
    • Li, D.D.1    Wu, X.Q.2    Tang, J.3    Wei, X.Y.4    Zhu, X.F.5
  • 124
    • 27544496133 scopus 로고    scopus 로고
    • Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgenindependent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness
    • Zi, X.; Guo, Y.; Simoneau, A. R.; Hope, C.; Xie, J.; Holcombe, R. F.; Hoang, B. H. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgenindependent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 2005, 65, 9762-9770.
    • (2005) Cancer Res. , vol.65 , pp. 9762-9770
    • Zi, X.1    Guo, Y.2    Simoneau, A.R.3    Hope, C.4    Xie, J.5    Holcombe, R.F.6    Hoang, B.H.7
  • 126
    • 77956368965 scopus 로고    scopus 로고
    • Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways
    • Sun, Y. W.; Huang, W. J.; Hsiao, C. J.; Chen, Y. C.; Lu, P. H.; Guh, J. H. Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways. Prostate 2010, 70, 1295-1306.
    • (2010) Prostate , vol.70 , pp. 1295-1306
    • Sun, Y.W.1    Huang, W.J.2    Hsiao, C.J.3    Chen, Y.C.4    Lu, P.H.5    Guh, J.H.6
  • 127
    • 84876694421 scopus 로고    scopus 로고
    • Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway
    • Niu, P.; Zhang, Y.; Shi, D.; Chen, Y.; Deng, J. Cardamonin ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway. Planta Med. 2013, 79, 452-458.
    • (2013) Planta Med. , vol.79 , pp. 452-458
    • Niu, P.1    Zhang, Y.2    Shi, D.3    Chen, Y.4    Deng, J.5
  • 128
    • 84856747785 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells
    • Chen, G.; Hu, X.; Zhang, W.; Xu, N.; Wang, F. Q.; Jia, J.; Zhang, W. F.; Sun, Z. J.; Zhao, Y. F. Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. Apoptosis 2012, 17, 90-101.
    • (2012) Apoptosis , vol.17 , pp. 90-101
    • Chen, G.1    Hu, X.2    Zhang, W.3    Xu, N.4    Wang, F.Q.5    Jia, J.6    Zhang, W.F.7    Sun, Z.J.8    Zhao, Y.F.9
  • 129
    • 77956179034 scopus 로고    scopus 로고
    • Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production
    • Kim, T. H.; Seo, W. D.; Ryu, H. W.; Seo, H. R.; Jin, Y. B.; Lee, M.; Ji, Y. H.; Park, K. H.; Lee, Y. S. Anti-tumor effects by a synthetic chalcone compound is mediated by c-Myc-mediated reactive oxygen species production. Chem. Biol. Interact. 2010, 188, 111-118.
    • (2010) Chem. Biol. Interact. , vol.188 , pp. 111-118
    • Kim, T.H.1    Seo, W.D.2    Ryu, H.W.3    Seo, H.R.4    Jin, Y.B.5    Lee, M.6    Ji, Y.H.7    Park, K.H.8    Lee, Y.S.9
  • 131
    • 84862820174 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel (E)-α-benzylsulfonyl chalcone derivatives as potential BRAF inhibitors
    • Li, Q. S.; Li, C. Y.; Lu, X.; Zhang, H.; Zhu, H. L. Design, synthesis and biological evaluation of novel (E)-α-benzylsulfonyl chalcone derivatives as potential BRAF inhibitors. Eur. J. Med. Chem. 2012, 50, 288-295.
    • (2012) Eur. J. Med. Chem. , vol.50 , pp. 288-295
    • Li, Q.S.1    Li, C.Y.2    Lu, X.3    Zhang, H.4    Zhu, H.L.5
  • 132
    • 84885841523 scopus 로고    scopus 로고
    • Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases
    • Shin, S. Y.; Yoon, H.; Hwang, D.; Ahn, S.; Kim, D. W.; Koh, D.; Lee, Y. H.; Lim, Y. Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases. Bioorg. Med. Chem. 2013, 21, 7018-24.
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 7018-7024
    • Shin, S.Y.1    Yoon, H.2    Hwang, D.3    Ahn, S.4    Kim, D.W.5    Koh, D.6    Lee, Y.H.7    Lim, Y.8
  • 133
    • 67650658743 scopus 로고    scopus 로고
    • Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers
    • Yang, Z.; Yang, J.; Jia, Y.; Tian, Y.; Wen, A. Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers. J. Ethnopharmacol. 2009, 124, 635-638.
    • (2009) J. Ethnopharmacol , vol.124 , pp. 635-638
    • Yang, Z.1    Yang, J.2    Jia, Y.3    Tian, Y.4    Wen, A.5
  • 134
    • 33748148704 scopus 로고    scopus 로고
    • Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A
    • Weber, T. M.; Ceilley, R. I.; Buerger, A.; Kolbe, L.; Trookman, N. S.; Rizer, R. L.; Schoelermann, A. Skin tolerance, efficacy, and quality of life of patients with red facial skin using a skin care regimen containing Licochalcone A. J. Cosmet. Dermatol. 2006, 5, 227-232.
    • (2006) J. Cosmet. Dermatol. , vol.5 , pp. 227-232
    • Weber, T.M.1    Ceilley, R.I.2    Buerger, A.3    Kolbe, L.4    Trookman, N.S.5    Rizer, R.L.6    Schoelermann, A.7
  • 135
    • 77951579512 scopus 로고    scopus 로고
    • Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: A randomized controlled comparative trial with cimetidine, an H2-receptor antagonist
    • Higuchi, K.; Watanabe, T.; Tanigawa, T.; Tominaga, K.; Fujiwara, Y.; Arakawa, T. Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist. J. Gastroenterol. Hepatol. 2010, 25 (Suppl 1), S155-S160.
    • (2010) J. Gastroenterol. Hepatol. , vol.25 , Issue.SUPPL. 1
    • Higuchi, K.1    Watanabe, T.2    Tanigawa, T.3    Tominaga, K.4    Fujiwara, Y.5    Arakawa, T.6
  • 136
    • 84884143583 scopus 로고    scopus 로고
    • Randomized, double-blind, split-side, comparison study of moisturizer containing licochalcone A and 1% hydrocortisone in the treatment of childhood atopic dermatitis
    • Wananukul, S.; Chatproedprai, S.; Chunharas, A.; Limpongsanuruk, W.; Singalavanija, S.; Nitiyarom, R.; Wisuthsarewong, W. Randomized, double-blind, split-side, comparison study of moisturizer containing licochalcone A and 1% hydrocortisone in the treatment of childhood atopic dermatitis. J. Med. Assoc. Thai. 2013, 96, 1135-1142.
    • (2013) J. Med. Assoc. Thai. , vol.96 , pp. 1135-1142
    • Wananukul, S.1    Chatproedprai, S.2    Chunharas, A.3    Limpongsanuruk, W.4    Singalavanija, S.5    Nitiyarom, R.6    Wisuthsarewong, W.7


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