Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 171-180

  Liu, Xiao Ling ^a   Tee, Hui Wearn ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Breast cancer resistance protein; Chalcones with basic functionalities; Inhibition of ABC transport proteins; P glycoprotein; Structure activity analysis

Indexed keywords

3 (2,4 DIMETHOXYPHENYL) 1 [4 (PIPERAZIN 1 YL)PHENYL]PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 (2,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; ACTIN; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; CALCEIN ACETOXYMETHYL ESTER; CHALCONE DERIVATIVE; CYCLOSPORIN A; DOXORUBICIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; MITOXANTRONE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG TUMOR LEVEL; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CELL LINE, TUMOR; CHALCONES; DRUG RESISTANCE, NEOPLASM; ELECTRONS; HUMANS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38049039819     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.006     Document Type: Article

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