Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1630-1637

  Navarini, Andréia Lilian Formento ^a   Chiaradia, Louise Domeneghini ^a   Mascarello, Alessandra ^a   Fritzen, Márcio ^a   Nunes, Ricardo José ^a   Yunes, Rosendo Augusto ^a   Creczynski Pasa, Tânia Beatriz ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Antitumoral; Apoptosis; ATP; GSH; Hydroxychalcones; Melanoma

Indexed keywords

1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (2 CARBOXYPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (2 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (2,6 IMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (4 BUTHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (4 METHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 3' BROMO 4',6' DIMETHOXYPHENYL) 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 4',6' DIMETHOXYPHENYL) 3 (1 NAPHTYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 4',6' DIMETHOXYPHENYL) 3 (3 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXY 4',6' DIMETHOXYPHENYL) 3 (3 NITROPHENYL) 2 PROPEN 1 ONE; 1 (2' HYDROXYPHENYL) 3 (1 NAPHTYL) 2 PROPEN 1 ONE; 1 (2' HYDROXYPHENYL) 3 (2 NAPHTYL) 2 PROPEN 1 ONE; 1 (3' HYDROXYPHENYL) 3 (1 NAPHTYL) 2 PROPEN 1 ONE; 1 (3' METHOXY 4' HYDROXYPHENYL) 3 (2 NAPHTYL) 2 PROPEN 1 ONE; ACETOPHENONE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ALDEHYDE; CHALCONE DERIVATIVE; GLUTATHIONE; UNCLASSIFIED DRUG;

ALKALINITY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HYDROXYLATION; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; POLYMERIZATION; PROTEIN DEPLETION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHALCONE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLUTATHIONE; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA; MICE; MITOCHONDRIA; SPECTROPHOTOMETRY, INFRARED;

EID: 61349139307     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.009     Document Type: Article

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