Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 22, 2013, Pages 7018-7024

  Shin, Soon Young ^a   Yoon, Hyuk ^a   Hwang, Doseok ^a   Ahn, Seunghyun ^b   Kim, Dong Wook ^c   Koh, Dongsoo ^b   Lee, Young Han ^a   Lim, Yoongho ^a  

^a Konkuk University   (South Korea)

^b Dongduk Women's University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Aurora kinase; Benzochalcone; Clonogenicity; Colorectal cancer; Flavonoid; In silico docking

Indexed keywords

1 [1 (4 CHLOROPHENYL) 5 (2,3,4 TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [1 (4 CHLOROPHENYL) 5 (2,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [1 (4 CHLOROPHENYL) 5 (2,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [1 (4 CHLOROPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [5 (2,3 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [5 (2,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [5 (3,5 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 1 [5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2,3 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2,3,4 TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (2,4,6 TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (3,5 DIMETHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; 2 [5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL]NAPHTHALEN 2 OL; ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL STRAIN HCT116; CELL SURVIVAL; CHEMICAL MODIFICATION; CLONOGENIC ASSAY; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AURORA KINASE; BENZOCHALCONE; CLONOGENICITY; COLORECTAL CANCER; FLAVONOID; IN SILICO DOCKING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AURORA KINASES; BINDING SITES; CHALCONES; COLORECTAL NEOPLASMS; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES;

EID: 84885841523     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.09.014     Document Type: Article

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