Butein suppresses constitutive and inducible signal transducer and activator of transcription (stat) 3 activation and stat3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1

Molecular Pharmacology

Volumn 75, Issue 3, 2009, Pages 525-533

  Pandey, Manoj K ^a   Bokyung, Sung ^a   Kwang, Seok Ahn ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; BUTEIN; CHALCONE; CYCLIN D1; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; STAT3 PROTEIN; THALIDOMIDE; VANADIC ACID; ANGIOGENESIS MODULATOR; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; PTPN6 PROTEIN, HUMAN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DELETION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TUMOR CELL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYME INDUCTION; GENETICS; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANGIOGENESIS MODULATING AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DOWN-REGULATION; ENZYME INDUCTION; HUMANS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 62149113324     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.052548     Document Type: Article

References (36)

1. Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunmimakkara AB, Sung B, and Ichikawa H (2006) Targeting signal-transducer-and-activator-of- transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann NY Acad Sci 1091:151-169.
2. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shisbodia S, and Aggarwal BB (2007) Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemo-resistance through down-regulation of STAT3 and nuclear factor-kappa B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109:2293-2302.
3. Bowman T. Garcia R, Turkson J, and Jove R (2000) STATs in oncogenesis. Oncogene 19:2474-2488.
4. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernández-Luna JL, Nuñez G, et al. (1999) Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10:105-115.
5. Cavo M (2006) Proteasome inhibitor bortezomib for the treatment of multiple myeloma. Leukemia 20:1341-1352.
6. Chim CS, Fung TK, Cheung WC, Liang R, and Kwong YL (2004) SOCS1 and SHP1 hypermetbylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood 103:4630-4635.
7. Danial NN, Pernis A, and Rothman PB (1995) Jak-STAT signaling induced by the v-abl oncogene. Science 269:1875-1877.
8. Digicaylioglu M and Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature412:641-647.
9. + anaplastic large-cell lymphoma. Blood 108:2796-2803.
10. Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409:349-354.
11. Iwashita K, Kobori M, Yamaki K, and Tsushida T (2000) Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem 64:1813-1820.
12. Jain N, Zhang T, Kee WH, Li W, and Cao X (1999) Protein kinase Cδ associates with and phospborylates Stat3 in an interleukin-6-dependent manner. J Biol Chem 274:24392-24400.
13. Jang HS, Kook SH, Son YO, Kim JG, Jeon YM, Jang YS, Choi KC, Kim J, Han SK, Lee KY, et al. (2005) Flavonoids purified from Rhus vemiciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta 1726:309-316.
14. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, and Tanaka H (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83-85.
15. Kim NY, Pae HO, Ob GS, Kang TH, Kim YC, Rhew HY, and Chung HT (2001) Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol Toxicol 88:261-266.
16. Lee JC, Lee KY, Kim J, Na CS, Jung NC, Chung GH, and Jang YS (2004) Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol 42:1383-1388.
17. Lee SH, Seo GS, Kim HS, Woo SW, Ko G, and Sohn DH (2006) 2',4',6'-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway. Biochem Pharmacol 72:1322-1333.
18. Li Z, Xu M, Xing S, Ho WT, Ishii T, Li Q, Fu X, and Zhao ZJ (2007) Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J Biol Chem 282:3428-3432.
19. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, et al. (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379:645-648.
20. Nelson KL, Rogers JA, Bowman TL, Jove R, and Smithgall TE (1998) Activation of STAT3 by the c-Fes protein-tyrosine kinase. J Biol Chem 273:7072-7077.
21. Nilsson K, Bennich H, Johansson SG, and Pontén J (1970) Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin Exp Immunol 7:477-489.
22. Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R, and Yu H (2002) Roles of activated Src and Stat3 signaling in melanomatumor cell growth. Oncogene 21:7001-7010.
23. Oka T, Ouchida M, Koyama M, Ogama Y, Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, et al. (2002) Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res 62:63B0-6394.
24. Otero DC, Poli V, David M, and Rickert RC (2006) Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol 177:6593-6597.
25. Pandey MK, Sandur SK, Sung B, Sethi G, Kunmimakkara AB, and Aggarwal BB (2007) Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-KB and NF- KB-regulated gene expression through direct inhibition of IKBα kinase β on cysteine 179 residue. J Biol Chem 282:17340-17350.
26. Shuai K, Stark GR, Kerr IM, and Darnell JE Jr (1993) A single phosphotyrosine residue of Stat91 required for gene activation by mterferon-gamma. Science 261: 1744-1746.
27. Simonian PL, Grillot DA, and Nuñez G (1997) Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood 90:1208-1216.
28. Tu Y, Renner S, Xu F, Fleishman A, Taylor J, Weisz J, Vescio R, Rettig M, Berenson J, Krajewski S, et al. (1998) BCL-X expression in multiple myeloma: possible indicator of chemo-resistance. Cancer Res 58(2):256-262.
29. Wang Y, Chan FL, Chen S, and Leung LK (2005) The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aro-matase. Life Sci 77:39-51.
30. Willett WC (1994) Diet and health: what should we eat? Science 264:532-537.
31. Woetmann A, Nielsen M, Christensen ST, Brockdorff J, Kaltoft K, Engel AM, Skov S, Brender C, Geisler C, Svejgaard A, et al. (1999) Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3. Proc Natl Acad Sci USA 96:10620-10625.
32. Wu C, Sun M, Liu L, and Zhou GW (2003) The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene 306:1-12.
33. Yit CC and Das NP (1994) Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett 82:65-72.
34. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, and Jove R (1995) Enhanced DNA-binding activity of a Stat.3-related protein in cells transformed by the Src oncoprotein. Science 269:81-83.
35. Yu Z, Zhang W, and Kone BC (2002) Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 367:97-105.
36. Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski JJ, Medveczky P, and Jove R (2000) Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jakl kinase activity. J Biol Chem 275:24935-24944.