Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7698-7710

  Ducki, Sylvie ^a,b,c,d   Rennison, David ^a,b   Woo, Meiko ^a,b   Kendall, Alexander ^a,b   Chabert, Jérémie Fournier Dit ^c,d   McGown, Alan T ^b,c   Lawrence, Nicholas J ^a,e  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SALFORD   (United Kingdom)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Anticancer; Antivascular; Chalcone; Colchicine; Combretastatin; SD400; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; CHALCONE DERIVATIVE; COLCHICINE; COMBRETASTATIN A4; SD 400; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ARTICLE; BINDING COMPETITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL SHAPE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY;

ANTINEOPLASTIC AGENTS; BIBENZYLS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; K562 CELLS; MICROTUBULES; NEOVASCULARIZATION, PHYSIOLOGIC; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 72049087235     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.039     Document Type: Article

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