Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy

Journal of the American Chemical Society

Volumn 127, Issue 38, 2005, Pages 13220-13226

  D'Silva, Loyola ^a   Ozdowy, Przemyslaw ^a   Krajewski, Marcin ^a   Rothweiler, Ulli ^a   Singh, Mahavir ^a   Holak, Tad A ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPLEXATION; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRECIPITATION (CHEMICAL); RESONANCE; TUMORS;

CANCER THERAPY; DENATURATION; LIGANDS; TUMOR CELLS;

PROTEINS;

BORON DERIVATIVE; CARBON 13; CHALCONE; LIGAND; NITROGEN 15; NSC 279287; NUTLIN 3; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER THERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DISSOCIATION; ESCHERICHIA COLI; LIGAND BINDING; MOLECULAR WEIGHT; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PRECIPITATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION;

BORON COMPOUNDS; CARBON ISOTOPES; CELL LINE, TUMOR; CHALCONE; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN ISOTOPES; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 25444487775     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja052143x     Document Type: Article

References (44)

1. Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science 1996, 274, 1531.
2. Markus, M. A.; Nakayama, T.; Matsudaira, P.; Wagner, G. Protein Sci. 1994, 3, 70.
3. Kriwacki, R. W.; Hengst, L.; Tennant, L.; Reed, S. I.; Wright, P. E. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 11504.
4. Prestegard, J. H.; Valafar, H.; Glushka, J.; Tian, F. Biochemistry 2001, 40, 8677.
5. Dehner, A.; Furrer, J.; Richter, K.; Schuster, I.; Buchner, J.; Kessler, H. Chembiochem 2003, 4, 870.
6. Fernandez, C. O.; Hoyer, W.; Zweckstetter, M.; Jares-Erijman, E. A.; Subramaniam, V.; Griesinger, C.; Jovin, T. M. EMBO J. 2004, 23, 2039.
7. Seidel, R. D.; Amor, J. C.; Kahn, R. A.; Prestegard, J. H. Biochemistry 2004, 43, 15393.
8. Coles, M.; Heller, M.; Kessler, H. Drug Discovery Today 2003, 8, 803.
9. Pellacchia, M.; Sem, D. S.; Wüthrich, K. Nat. Rev. Drug Discovery 2002, 1, 211.
10. Stockman, B. J.; Dalvit, C. Prog. Nucl. Magn. Reson. Spectrosc. 2002, 41, 187.
11. Lepre, C. A.; Moore, J. M.; Peng, J. W. Chem. Rev. 2004, 104, 3641.
12. Reese, M. L.; Doetsche, V. J. Am. Chem. Soc. 2003, 125, 14250.
13. Fischer, P. M.; Lane, D. P. Trends Pharmacol. Sci. 2004, 25, 343.
14. Chene, P. Nat. Rev. Cancer 2003, 3, 102.
15. Klein, C.; Vassilev, L. T. Br. J. Cancer 2004, 9, 1415.
16. Chen, J.; Marechal, V.; Levine, A. J. Mol. Cell. Biol. 1993, 13, 4107.
17. Picksley, S. M.; Vojtesek, B.; Sparks, A.; Lane, D. P. Oncogens 1994, 9, 2523.
18. Bottger, V.; Bottger, A.; Howard, S. F.; Picksley, S. M.; Chene, P.; Garcia-Echeverria, C.; Hochkeppel, H. K.; Lane, D. P. Oncogene 1996, 13, 2141.
19. Bottger, A.; Bottger, V.; Sparks, A.; Liu, W. L.; Howard, S. F.; Lane, D. P. Curr. Biol. 1997, 7, 860.
20. Schon, O.; Friedler, A.; Bycroft, M.; Freund, S. M. V.; Fersht, A. R. J. Mol. Biol. 2002, 325, 491.
21. Schon, O.; Friedler, A.; Freund, S.; Fersht, A. R. J. Mol. Biol. 2004, 336, 197.
22. Vassilev, L. T.; Vu, B. T.; Graves, B.; Carvajal, D.; Podlaski, F.; Filipovic, Z.; Kong, N.; Kammlott, U.; Lukacs, C.; Klein, C.; Fotouhi, N.; Liu, E. A. Science 2004, 303, 844.
23. Grasberger, B. L.; et al. J. Med. Chem. 2005, 48, 909.
24. Wüthrich, K. Angew. Chem., Int. Ed. 2003, 42, 3340.
25. Rehm, T.; Huber, R.; Holak, T. A. Structure 2002, 10, 1613.
26. Riek, R.; Pervushin, K.; Wüthrich, K. Trends Biochem. Sci. 2000, 25, 462.
27. Kussie, P. H.; Gorina, S.; Marechal, V.; Elenbass, B.; Moreau, J.; Levine, A. J.; Pavletich, N. P. Science 1996, 274, 948.
28. Blommers, M. J. J.; Fendrich, G.; Garcia-Echeverria, C.; Chene, P. J. Am. Chem. Soc. 1997, 119, 3425.
29. Stoll, R.; et al. Biochemistry 2001, 40, 336.
30. Fry, D. C.; Emerson, S. D.; Palme, S.; Vu, B. T.; Liu, C. M.; Podlaski, F. J. Biomol. NMR 2004, 30, 163.
31. Dawson, R.; Mueller, L.; Dehner, A.; Klein, C.; Kessler, H.; Buchner, J. J. Mol. Biol. 2003, 332, 1131.
32. Galatin, P. S.; Abraham, D. J. J. Med. Chem. 2004, 47, 4163.
33. Kumar, S. K.; Hager, E.; Petit, C.; Gurulingappa, H.; Davidson, N. E.; Khan, S. R. J. Med. Chem. 2003, 46, 2813.
34. Dyson, H. J.; Wright, P. E. Nat. Rev. Mol. Cell Biol 2005, 6, 197.
35. Bell, S.; Klein, C.; Müller, L.; Hansen, S.; Buchner, J. J. Mol. Biol. 2002, 322, 917.
36. Ayed, A.; Mulder, F. A. A.; Yi, G. S.; Lu, Y.; Kay, L. E.; Arrowsmith, C. H. Nat. Struct. Biol. 2001, 8, 756.
37. Lee, H.; Mok, K. H.; Muhandiram, R.; Park, K. H.; Suk, J. E.; Kim, D. H.; Chang, J.; Sung, Y. C.; Choi, K. Y.; Man, K. H. J. Biol. Chem. 2000, 275, 29426.
38. Uesugi, M.; Verdine, G. L. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 14801.
39. Lee, J. O.; Russo, A. A.; Pavletich, N. P. Nature 1998, 391, 859.
40. Hu, Q. J.; Dyson, N.; Harlow, E. EMBO J. 1990, 9, 1147.
41. Huang, S.; Wang, N. P.; Tseng, B. Y.; Lee, W. H.; Lee, E. H. EMBO J. 1990, 9, 1815.
42. Kaelin, W. G., Jr.; Ewen, M. E.; Livingston, D. M. Mol. Cell. Biol. 1990, 10, 3761.
43. Senn, H.; Eugster, A.; Otting, G.; Suter, F.; Wüthrich, K. Eur. Biophys. J. 1987, 14, 301.
44. Mori, S.; Abeygunawardana, C.; Johnson, M. O.; van Zijl, P. C. J. Magn. Reson., Ser. B 1995, 108, 94.