Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7711-7722

  Ducki, Sylvie ^a,b,c,d   Mackenzie, Grant ^c   Greedy, Ben ^e   Armitage, Simon ^e   Chabert, Jérémie Fournier Dit ^c,d   Bennett, Elizabeth ^c   Nettles, Jim ^f   Snyder, James P ^f   Lawrence, Nicholas J ^a,e  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SALFORD   (United Kingdom)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^f EMORY UNIVERSITY   (United States)

Author keywords

Anticancer; Antivascular; Chalcone; Colchicine; Combretastatin; Docking; Podophyllotoxin; Tubulin

Indexed keywords

CHALCONE DERIVATIVE; COLCHICINE DERIVATIVE; COMBRETASTATIN A4; PODOPHYLLOTOXIN; TUBULIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ALGORITHMS; BIBENZYLS; BINDING SITES; CELL LINE; CHALCONES; COLCHICINE; DRUG DISCOVERY; HUMANS; HYDROCARBONS, CYCLIC; MICROTUBULES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 72049105856     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.044     Document Type: Article

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