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Volumn 17, Issue 19, 2011, Pages 6313-6321
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A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors
a
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Author keywords
[No Author keywords available]
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Indexed keywords
GROWTH DIFFERENTIATION FACTOR 15;
PROTEIN P53;
SERDEMETAN;
ADULT;
ADVANCED CANCER;
ALKALINE PHOSPHATASE BLOOD LEVEL;
ANEMIA;
AREA UNDER THE CURVE;
ARTICLE;
ASTHENIA;
BLOOD SAMPLING;
BLOOD TOXICITY;
BREAST CANCER;
CANCER MORTALITY;
CENTRAL NERVOUS SYSTEM METASTASIS;
COLORECTAL CANCER;
CONSTIPATION;
CONTROLLED STUDY;
CYTOKINE PRODUCTION;
DECREASED APPETITE;
DIARRHEA;
DOSE RESPONSE;
DRUG ABSORPTION;
DRUG BLOOD LEVEL;
DRUG DOSE ESCALATION;
DRUG ERUPTION;
DRUG HALF LIFE;
DRUG RESPONSE;
DRUG TOLERABILITY;
DRUG WITHDRAWAL;
DYSPNEA;
EPENDYMOMA;
FATIGUE;
FEMALE;
FEVER;
GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL;
HEART LEFT VENTRICLE EJECTION FRACTION;
HUMAN;
HUMAN TISSUE;
HYPERCALCEMIA;
HYPOCALCEMIA;
HYPOPHOSPHATEMIA;
INSOMNIA;
INTESTINE OBSTRUCTION;
KIDNEY CANCER;
LEUKOPENIA;
LIVER FUNCTION;
LUNG INFECTION;
LYMPHOCYTE COUNT;
LYMPHOCYTOPENIA;
MAJOR CLINICAL STUDY;
MALE;
MAXIMUM PLASMA CONCENTRATION;
MAXIMUM TOLERATED DOSE;
MELANOMA;
MULTIPLE CYCLE TREATMENT;
NAUSEA;
NEUTROPENIA;
ONCOCYTOMA;
OVARY CANCER;
PANCREAS CANCER;
PANCYTOPENIA;
PHASE 1 CLINICAL TRIAL;
PNEUMONIA;
PRIORITY JOURNAL;
PRURITUS;
QT PROLONGATION;
SARCOMA;
SIDE EFFECT;
SKIN BIOPSY;
SOLID TUMOR;
SPINAL CORD COMPRESSION;
STEADY STATE;
THROMBOCYTOPENIA;
TREMOR;
TUMOR BIOPSY;
VOMITING;
ADMINISTRATION, ORAL;
ANTINEOPLASTIC AGENTS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG ADMINISTRATION SCHEDULE;
FEMALE;
HUMANS;
MALE;
MAXIMUM TOLERATED DOSE;
MIDDLE AGED;
NEOPLASMS;
TRYPTAMINES;
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EID: 80053504901
PISSN: 10780432
EISSN: 15573265
Source Type: Journal
DOI: 10.1158/1078-0432.CCR-11-1101 Document Type: Article |
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Times cited : (54)
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References (9)
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