Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2659-2665

  Dyrager, Christine ^a   Wickström, Malin ^b   Fridén Saxin, Maria ^a   Friberg, Annika ^a   Dahlén, Kristian ^a   Wallén, Erik A A ^a,c   Gullbo, Joachim ^b   Grøtli, Morten ^a   Luthman, Kristina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Chalcones; Cytotoxicity; Molecular modeling; Tubulin polymerization

Indexed keywords

1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 1 HYDROXY 5 PHENYLPENTA 1,4 DIEN 3 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 3 (4 DIETHYLAMINOPHENYL)PROP 2 EN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 3 [4 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 3 PHENYL PROP 2 EN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 5 (1 BENZYL 1H INDOL 3 YL)PENTA 2,4 DIEN 1 ONE; 1 (3 BROMO 5 CHLORO 2 HYDROXYPHENYL) 5 PHENYLPENTA 2,4 DIEN 1 ONE; 1 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 (4 DIETHYLAMINOPHENYL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; BETA TUBULIN; CHALCONE DERIVATIVE; DIENONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MOLECULAR INTERACTION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KETONES; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 79954418634     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.005     Document Type: Article

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