Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways

FASEB Journal

Volumn 24, Issue 12, 2010, Pages 4722-4732

  Zhou, Ping ^a,b   Gross, Shimon ^a   Liu, Ji Hua ^c   Yu, Bo Yang ^c   Feng, Ling Ling ^d   Nolta, Jan ^a,b   Sharma, Vijay ^a   Piwnica Worms, David ^a   Qiu, Samuel X ^d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

^d SOUTH CHINA INSTITUTE OF BOTANY   (China)

Author keywords

Apoptosis; Bioluminescence imaging; Hepatocellular toxin; Herb products; TNF

Indexed keywords

CHALCONE DERIVATIVE; FLAVOKAWAIN B; GLUTATHIONE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; KAVA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CELL DEATH; CELL STRAIN HEPG2; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RHIZOME; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; FLAVONOIDS; GLUTATHIONE; HEP G2 CELLS; HUMANS; I-KAPPA B KINASE; KAVA; LIVER; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ATOMIC FORCE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; PLANT ROOTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

PIPER METHYSTICUM; PIPERACEAE;

EID: 78349302551     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-163311     Document Type: Article

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