Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2688-2695

  Ruan, Ban Feng ^a   Lu, Xiang ^a   Tang, Jian Feng ^a   Wei, Yao ^a   Wang, Xiao Liang ^a   Zhang, Yan Bin ^a   Wang, Li Sheng ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b GUANGXI UNIVERSITY   (China)

Author keywords

Antiproliferative activity; Antitubulin polymerization; Chalcone; Molecular docking; Resveratrol

Indexed keywords

1 (3 BROMOPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (3 CHLOROPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (3,4 DICHLOROPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 BROMOPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 BUTOXYPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 [(1,1' BIPHENYL) 4 YL] 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 1 [4 (DIETHYLAMINO)PHENYL] 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL]PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (2,4 DIMETHYLPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (3 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (3,4 DIMETHYLPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (4 ETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (4 MORPHOLINOPHENYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (4 TOLYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 (O TOLYL)PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 [4 (DODECYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 [4 (HEXYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 [4 (PENTAN 2 YLOXY)PHENYL]PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 [4 (TRIFLUOROMETHYL)PHENYL]PROP 2 EN 1 ONE; 3 [2,4 DIMETHOXY 6 (4 METHOXYSTYRYL)PHENYL] 1 PHENYLPROP 2 EN 1 ONE; CHALCONE; COLCHICINE; RESVERATROL; TUBULIN; TUBULIN MODULATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MELANOMA CELL; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN;

BINDING SITES; CELL LINE, TUMOR; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PROTEIN BINDING; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 79954418171     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.001     Document Type: Article

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