Synthesis and biological evaluation of 2′,5′-dimethoxychalcone derivatives as microtubule-targeted anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2089-2098

  Tu, Huang Yao ^a   Huang, A Mei ^a   Hour, Tzyh Chyuan ^a   Yang, Shyh Chyun ^a   Pu, Yeong Shiau ^b   Lin, Chun Nan ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAITUNG UNIVERSITY   (Taiwan)

Author keywords

Anti mitotic; Anticancer; Chalcone; Claisen Schmidt condensation; Microtubule; Paclitaxel; Synthesis; Tubulin polymerization

Indexed keywords

2',5' DIMETHOXYCHALCONE DERIVATIVE; 4 (2 METHYLETHYL)CARBAMOYL 2',5' DIMETHOXYCHALCONE; 4 TETRAHYDROPYRROLYLCARBAMOYL 2',5' DIMETHOXYCHALCONE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CISPLATIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE REGULATION; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; MICROTUBULE; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROTUBULES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 77649231931     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.012     Document Type: Article

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