Chalcone derivatives inhibit glutathione S-transferase P1-1 activity: Insights into the interaction mode of α, β-unsaturated carbonyl compounds

Chemical Biology and Drug Design

Volumn 73, Issue 5, 2009, Pages 511-514

  Wang, Jian ^a   Wang, Shaojie ^a   Song, Dandan ^a   Zhao, Dongmei ^a   Sha, Yu ^a   Jiang, Yuting ^a   Jing, Yongkui ^b   Cheng, Maosheng ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

, unsaturated carbonyl compounds; Chalcone derivatives; Chemotherapy resistance; Glutathione S transferase P1 1; Molecular field; Molecular modeling; Phase II detoxification enzyme

Indexed keywords

ACROLEIN; CARBONYL DERIVATIVE; CHALCONE DERIVATIVE; CINNAMALDEHYDE; CROTONALDEHYDE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE P1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SUBSTITUTION REACTION; THREE DIMENSIONAL IMAGING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MODELS, MOLECULAR;

EID: 64249171525     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00807.x     Document Type: Article

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