New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 6, 2011, Pages 1895-1906

  Reddy, M Vijaya Bhaskar ^a   Shen, Yuh Chiang ^b   Yang, Jai Sing ^c   Hwang, Tsong Long ^d   Bastow, Kenneth F ^e   Qian, Keduo ^e   Lee, Kuo Hsiung ^c,e   Wu, Tian Shung ^a,c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^e University of North Carolina   (United States)

Author keywords

Apoptosis; Bichalcone analogs; Cytotoxicity; Nitric oxide production inhibition

Indexed keywords

1 (3 ((4 (4 ACETYLPHENYL)PIPERAZIN 1 YL)METHYL) 4 HYDROXYPHENYL 5 METHOXYPHENYL) 3 (PYRIDIN 3 YL)PROP 2 EN 1 ONE; 1 (3 ((4 (4 ACETYLPHENYL)PIPERAZIN 1 YL)METHYL) 4 HYDROXYPHENYL) 3 (1 METHYL 1H PYRROL 2 YL) PROP 2 EN 1 ONE; 1 (4 (4 (5 CINNAMOYL 2 HYDROXY 3 METHOXY BENZYL)PIPERAZIN 1 YL)PHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 (4 (4 (5 CINNAMOYL 2 HYDROXYBENZYL)PIPERAZINE 1 YL)PHENYL) 3 PHENYLPROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (1 METHYL 1H PYRROL 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (4 METHOXYPHENYL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (METHYLFURAN 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (PYRIDIN 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (PYRIDIN 3 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (3 METHYLTHIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (PYRIDIN 3 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (FURAN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (PYRIDIN 3 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 ((4 (4 (3 (PYRIDIN 3 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 METHOXY 5 ((4 (4 (3 (3 METHYL THIOPEN 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (3 METHYLTHIOPEN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 METHOXY 5 ((4 (4 (3 (4 METHOXYPHENYL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 METHOXY 5 ((4 (4 (3 (METHOXYPHENYL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 METHOXY 5 ((4 (4 (3 (PYRIDIN 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 1 (4 HYDROXY 3 METHOXY 5 ((4 (4 (3 (THIOPHEN 2 YL)ACRYLOYL) PHENYL)PIPERAZIN 1 YL)METHYL)PHENYL) 3 (THIOPEN 2 YL)PROP 2 EN 1 ONE; 1 [4 [4 (5 ACETYL 2 HYDROXYBENZYL)PIPERAZIN 1 YL] PHENYL]ETHANONE; 1 [4 [4 (5 ACETYL 3 METHOXYBENZYL)PIPERAZIN 1 YL] PHENYL]ETHANONE; 3 (2 CHLOROPHENYL) 1 (4 (4 (5 (3 (2 CHLOROPHENYL)ACRYLO) 2 HYDROXYBENZYL)PIPERAZINE 1 YL)PHENYL)PROP 2 EN 1 ONE; 3 (2 CHLOROPHENYL) 1 (4 (4 (5 (3 (2 CHLOROPHENYL)ACRYLOYL) 2 HYDROXY 3 METHOXYBENZYL)PIPERAZINE 1 YL)PHENYL)PROP 2 EN OL; 3 (2,4 DICHLOROPHENYL) 1 (4 (4 (5 (3 (2,4 DICHLOROPHENYL)ACRYLO) 2 HYDROXYBENZYL)PIPERAZINE 1 YL)PHENYL)PROP 2 EN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 5 YL) 1 (4 (4 (5 (3 (BENZO[D][1,3]DIOXOL 5 YL)ACRYLO) 2 HYDROXYBENZYL)PIPERAZINE 1 YL)PHENYL)PROP 2 EN 1 ONE; BICHALCONE DERIVATIVE; I KAPPA B KINASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROGLIA; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PYRIDINES; TRANSCRIPTION FACTOR RELA;

EID: 79952452624     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.004     Document Type: Article

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