Cytotoxic 2′,5′-dihydroxychalcones with unexpected antiangiogenic activity

European Journal of Medicinal Chemistry

Volumn 38, Issue 2, 2003, Pages 179-187

  Nam, Nguyen Hai ^a   Kim, Yong ^a   You, Young Jae ^a   Hong, Dong Ho ^a   Kim, Hwan Mook ^b   Ahn, Byung Zun ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

2 ,5 Dihydroxychalcone; Antiangiogenic activity; Antitumor activity; Cytotoxicity

Indexed keywords

1 (2,5 DIHYDROXYPHENYL) 3 (2 FLUOROPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2 NAPHTHYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2,3 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2,3,4 TRIMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2,3,4,5,6 PENTAFLUOROPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (3,4 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (4 DIMETHYLAMINOPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (4 METHOXYPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (4 PHENYLPHENYL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (INDOL 3 YL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (PYRIDIN 3 YL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 (QUINOLIN 2 YL) 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 3 PHENYL 2 PROPEN 1 ONE; 1 (2,5 DIHYDROXYPHENYL) 5 PHENYL 2,4 DIENEPENTAN 1 ONE; 2 CHLORO 2',5' DIHYDROXYCHALCONE; 2',5' DIHYDROXYCHALCONE; 3 (2,5 DIFLUOROPHENYL) 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (3 CHLOROPHENYL) 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (4 BROMOPHENYL) 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (4 CHLOROPHENYL) 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 [(2 BROMO 5 METHOXY)PHENYL] 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 [(5 BROMO 2 HYDROXY)PHENYL] 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; 3 [(5 BROMO 2 METHOXY)PHENYL] 1 (2,5 DIHYDROXYPHENYL) 2 PROPEN 1 ONE; ANGIOGENESIS INHIBITOR; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CHALCONE; DRUG DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LUNG CARCINOMA; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; TUMOR CELL LINE; UMBILICAL VEIN; ANIMAL; CELL CULTURE; CELL STRAIN HCT116; CHEMISTRY; COLON TUMOR; COMPARATIVE STUDY; DRUG EFFECT; IC 50; LEWIS CARCINOMA; MELANOMA; MOUSE; SQUAMOUS CELL CARCINOMA; VASCULAR ENDOTHELIUM;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, LEWIS LUNG; CARCINOMA, SQUAMOUS CELL; CHALCONE; COLONIC NEOPLASMS; ENDOTHELIUM, VASCULAR; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MELANOMA; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037294729     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01443-5     Document Type: Article

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