Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents

ChemMedChem

Volumn 5, Issue 11, 2010, Pages 1937-1947

  Kamal, Ahmed ^a   Dastagiri, D ^a   Ramaiah, M Janaki ^a   Reddy, J Surendranadha ^a   Bharathi, E Vijaya ^a   Srinivas, Chatla ^a   Pushpavalli, S N C V L ^a   Pal, Dhananjaya ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

antitumor agents; apoptosis; cancer; cyclins CDKs; imidazo 2,1 b thiazoles; NF B

Indexed keywords

3 [6 (2 THIENYL) IMIDAZO[2,1 B][1,3]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) 2 PROPEN 1 ONE; 3 [6 (3,4 DIMETHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 FLUOROPHENYL) 2 METHYLIMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 FLUOROPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PRO 2 EN 1 ONE; 3 [6 (4 FLUOROPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (BENZO[D] [1,3]DIOXOL 5 YL) PROP 2 EN 1 ONE; 3 [6 (4 FLUOROPHENYL) IMIDAZO[2,1 B]THIAZOL 5YL] 1 (3,4 DIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) 2 METHYLIMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZO 5YL] 1 (3,5 DIFLUOROPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (1H PYRROL 2 YL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4 DIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (BENZO[D] [1,3]DIOXOL 5 YL) PROP 2 EN 1 ONE; 3 [6 (4 METHOXYPHENYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (THIEN 2 YL) PROP 2 EN 1 ONE; 3 [6 (THIEN 2 YL) 2 METHYLIMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (TRIFLUOROMETHYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4 DIMETHOXYPHENYL) PROP 2 EN 1 ONE; 3 [6 (TRIFLUOROMETHYL) IMIDAZO[2,1 B]THIAZOL 5 YL] 1 (3,4,5 TRIMETHOXYPHENYL) PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 9; CHALCONE DERIVATIVE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN E; DOXORUBICIN; IMIDAZOTHIAZOLE GUANYLHYDRAZONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P21; PROTEIN P27; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN MCF 7; CELL VIABILITY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CHALCONE; CYCLIN-DEPENDENT KINASES; CYCLINS; FEMALE; HUMANS; IMIDAZOLES; NF-KAPPA B; THIAZOLES;

EID: 78349282280     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000346     Document Type: Article

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