Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth

International Journal of Cancer

Volumn 127, Issue 8, 2010, Pages 1758-1768

  Tang, Yaxiong ^a   Li, Xuesen ^a   Liu, Zhongbo ^a   Simoneau, Anne R ^a   Xie, Jun ^a,c   Zi, Xiaolin ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHENGDU INSTITUTE OF BIOLOGY   (China)

Author keywords

apoptosis; Bim; hormone refractory prostate cancer; natural; products

Indexed keywords

ANDROGEN RECEPTOR; BIM PROTEIN; CASPASE; CHALCONE DERIVATIVE; DEATH RECEPTOR 5; FLAVOKAWAIN A; FLAVOKAWAIN B; FLAVOKAWAIN C; PUMA PROTEIN; SHORT HAIRPIN RNA; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; AR PROTEIN, HUMAN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; FLAVONOID; MEMBRANE PROTEIN; MESSENGER RNA; ONCOPROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; STROMA CELL; TREATMENT FAILURE; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CELL PROLIFERATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOPRECIPITATION; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; HUMANS; IMMUNOPRECIPITATION; MALE; MEMBRANE PROTEINS; MICE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANDROGEN; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 77956113476     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25210     Document Type: Article

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