Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis

Pathophysiology

Volumn 21, Issue 1, 2014, Pages 81-93

  Lu, Peng ^a   Sodhi, Chhinder P ^a,b   Hackam, David J ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Amniotic fluid; Endothelium; Epithelium; Intestinal inflammation; Necrotizing enterocolitis; Toll like receptor 4

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

AMNION FLUID; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; DISEASE SEVERITY; ENTERITIS; GASTROINTESTINAL DISEASE; GOBLET CELL; HEMATOPOIETIC CELL; HUMAN; INNATE IMMUNITY; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE INJURY; LACTOBACILLUS REUTERI; MICROCIRCULATION; MOLECULAR INTERACTION; NECROTIZING ENTEROCOLITIS; PATHOGENESIS; PREMATURITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

EID: 84896087245     PISSN: 09284680     EISSN: 1873149X     Source Type: Journal    
DOI: 10.1016/j.pathophys.2013.11.007     Document Type: Article

References (192)

1. Anderson K.V., Jurgens G., Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985, 42:779-789.
2. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996, 86:973-983.
3. Kawai T., Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 2011, 34:637-650.
4. Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
5. Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D., Hood L.E., Aderem A. The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:9577-9582.
6. Kawai T., Akira S. TLR signaling. Cell Death Differ. 2006, 13:816-825.
7. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 2010, 11:373-384.
8. Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004, 5:987-995.
9. Dai J., Liu B., Li Z. Regulatory T cells and Toll-like receptors: what is the missing link?. Int. Immunopharmacol. 2009, 9:528-533.
10. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
11. Miyake K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 2007, 19:3-10.
12. Blasius A.L., Beutler B. Intracellular Toll-like receptors. Immunity 2010, 32:305-315.
13. Uronen-Hansson H., Allen J., Osman M., Squires G., Klein N., Callard R.E. Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 2004, 111:173-178.
14. Neal M.D., Leaphart C., Levy R., Prince J., Billiar T.R., Watkins S., Li J., Cetin S., Ford H., Schreiber A., Hackam D.J. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J. Immunol. 2006, 176:3070-3079.
15. Dunzendorfer S., Lee H.K., Soldau K., Tobias P.S. Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. 2004, 18:1117-1119.
16. Hornef M.W., Frisan T., Vandewalle A., Normark S., Richter-Dahlfors A. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J. Exp. Med. 2002, 195:559-570.
17. Hornef M.W., Normark B.H., Vandewalle A., Normark S. Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells. J. Exp. Med. 2003, 198:1225-1235.
18. Latz E., Visintin A., Lien E., Fitzgerald K.A., Monks B.G., Kurt-Jones E.A., Golenbock D.T., Espevik T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the Toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 2002, 277:47834-47843.
19. Pifer R., Benson A., Sturge C.R., Yarovinsky F. UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J. Biol. Chem. 2011, 286:3307-3314.
20. Brinkmann M.M., Spooner E., Hoebe K., Beutler B., Ploegh H.L., Kim Y.M. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 2007, 177:265-275.
21. Piccinini A.M., Midwood K.S. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm. 2010, 2010.
22. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., Sugiyama M., Okabe M., Takeda K., Akira S. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science (New York, NY) 2003, 301:640-643.
23. O'Neill L.A., Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 2007, 7:353-364.
24. Takeda K., Akira S. TLR signaling pathways. Semin. Immunol. 2004, 16:3-9.
25. Barton G.M., Kagan J.C. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 2009, 9:535-542.
26. Takeda K., Akira S. Roles of Toll-like receptors in innate immune responses. Genes Cells 2001, 6:733-742.
27. Palsson-McDermott E.M., O'Neill L.A. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 2004, 113:153-162.
28. Hayashi F., Means T.K., Luster A.D. Toll-like receptors stimulate human neutrophil function. Blood 2003, 102:2660-2669.
29. Parker L.C., Whyte M.K., Dower S.K., Sabroe I. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J. Leukoc. Biol. 2005, 77:886-892.
30. Sanjuan M.A., Dillon C.P., Tait S.W., Moshiach S., Dorsey F., Connell S., Komatsu M., Tanaka K., Cleveland J.L., Withoff S., Green D.R. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007, 450:1253-1257.
31. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007, 449:819-826.
32. Blander J.M. Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation. Trends Immunol. 2007, 28:19-25.
33. West A.P., Brodsky I.E., Rahner C., Woo D.K., Erdjument-Bromage H., Tempst P., Walsh M.C., Choi Y., Shadel G.S., Ghosh S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 2011, 472:476-480.
34. Jin B., Sun T., Yu X.H., Yang Y.X., Yeo A.E. The effects of TLR activation on T-cell development and differentiation. Clin. Dev. Immunol. 2012, 2012:836485.
35. Pone E.J., Xu Z., White C.A., Zan H., Casali P. B cell TLRs and induction of immunoglobulin class-switch DNA recombination. Front. Biosci. 2012, 17:2594-2615.
36. Tsuboi N., Yoshikai Y., Matsuo S., Kikuchi T., Iwami K., Nagai Y., Takeuchi O., Akira S., Matsuguchi T. Roles of Toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J. Immunol. 2002, 169:2026-2033.
37. Wolfs T.G., Buurman W.A., van Schadewijk A., de Vries B., Daemen M.A., Hiemstra P.S., van't Veer C. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J. Immunol. 2002, 168:1286-1293.
38. Anders H.J., Banas B., Schlondorff D. Signaling danger: Toll-like receptors and their potential roles in kidney disease. J. Am. Soc. Nephrol. 2004, 15:854-867.
39. Gribar S.C., Richardson W.M., Sodhi C.P., Hackam D.J. No longer an innocent bystander: epithelial Toll-like receptor signaling in the development of mucosal inflammation. Mol. Med. (Cambridge, MA) 2008, 14:645-659.
40. Nitschke M., Wiehl S., Baer P.C., Kreft B. Bactericidal activity of renal tubular cells: the putative role of human beta-defensins. Exp. Nephrol. 2002, 10:332-337.
41. Lehmann J., Retz M., Harder J., Krams M., Kellner U., Hartmann J., Hohgrawe K., Raffenberg U., Gerber M., Loch T., Weichert-Jacobsen K., Stockle M. Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect. Dis. 2002, 2:20.
42. Patole P.S., Schubert S., Hildinger K., Khandoga S., Khandoga A., Segerer S., Henger A., Kretzler M., Werner M., Krombach F., Schlondorff D., Anders H.J. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int. 2005, 68:2582-2587.
43. Biragyn A., Ruffini P.A., Leifer C.A., Klyushnenkova E., Shakhov A., Chertov O., Shirakawa A.K., Farber J.M., Segal D.M., Oppenheim J.J., Kwak L.W. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science (New York, NY) 2002, 298:1025-1029.
44. Akcay A., Nguyen Q., Edelstein C.L. Mediators of inflammation in acute kidney injury. Mediators Inflamm. 2009, 2009:137072.
45. Chen J., John R., Richardson J.A., Shelton J.M., Zhou X.J., Wang Y., Wu Q.Q., Hartono J.R., Winterberg P.D., Lu C.Y. Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury. Kidney Int. 2011, 79:288-299.
46. Greene C.M., McElvaney N.G. Toll-like receptor expression and function in airway epithelial cells. Arch. Immunol. Ther. Exp. (Warsz) 2005, 53:418-427.
47. Guillot L., Le Goffic R., Bloch S., Escriou N., Akira S., Chignard M., Si-Tahar M. Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 2005, 280:5571-5580.
48. Sha Q., Truong-Tran A.Q., Plitt J.R., Beck L.A., Schleimer R.P. Activation of airway epithelial cells by Toll-like receptor agonists. Am. J. Respir. Cell Mol. Biol. 2004, 31:358-364.
49. Parilla N.W., Hughes V.S., Lierl K.M., Wong H.R., Page K. CpG DNA modulates interleukin 1beta-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells. Respir. Res. 2006, 7:84.
50. Greene C.M., Carroll T.P., Smith S.G., Taggart C.C., Devaney J., Griffin S., O'Neill S J., McElvaney N.G. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J. Immunol. 2005, 174:1638-1646.
51. Hertz C.J., Wu Q., Porter E.M., Zhang Y.J., Weismuller K.H., Godowski P.J., Ganz T., Randell S.H., Modlin R.L. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J. Immunol. 2003, 171:6820-6826.
52. Noulin N., Quesniaux V.F., Schnyder-Candrian S., Schnyder B., Maillet I., Robert T., Vargaftig B.B., Ryffel B., Couillin I. Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J. Immunol. 2005, 175:6861-6869.
53. Skerrett S.J., Liggitt H.D., Hajjar A.M., Ernst R.K., Miller S.I., Wilson C.B. Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 287:L143-L152.
54. Kovach M.A., Standiford T.J. Toll like receptors in diseases of the lung. Int. Immunopharmacol. 2011, 11:1399-1406.
55. Andonegui G., Zhou H., Bullard D., Kelly M.M., Mullaly S.C., McDonald B., Long E.M., Robbins S.M., Kubes P. Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J. Clin. Invest. 2009, 119:1921-1930.
56. Menden H., Tate E., Hogg N., Sampath V. LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-beta phosphorylation. Am. J. Physiol. Lung Cell Mol. Physiol. 2012, 304:L445-L455.
57. Cario E., Brown D., McKee M., Lynch-Devaney K., Gerken G., Podolsky D.K. Commensal-associated molecular patterns induce selective Toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am. J. Pathol. 2002, 160:165-173.
58. Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 2000, 68:7010-7017.
59. Gewirtz A.T., Navas T.A., Lyons S., Godowski P.J., Madara J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 2001, 167:1882-1885.
60. Gopal R., Birdsell D., Monroy F.P. Regulation of Toll-like receptors in intestinal epithelial cells by stress and Toxoplasma gondii infection. Parasite Immunol. 2008, 30:563-576.
61. Ogawa H., Rafiee P., Heidemann J., Fisher P.J., Johnson N.A., Otterson M.F., Kalyanaraman B., Pritchard K.A., Binion D.G. Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J. Immunol. 2003, 170:5956-5964.
62. Maaser C., Heidemann J., von Eiff C., Lugering A., Spahn T.W., Binion D.G., Domschke W., Lugering N., Kucharzik T. Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J. Immunol. 2004, 172:5056-5062.
63. Otte J.M., Rosenberg I.M., Podolsky D.K. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003, 124:1866-1878.
64. Burke J.P., Cunningham M.F., Watson R.W., Docherty N.G., Coffey J.C., O'Connell P.R. Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts. Br. J. Surg. 2010, 97:1126-1134.
65. Afrazi A., Sodhi C.P., Richardson W., Neal M., Good M., Siggers R., Hackam D.J. New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond. Pediatr. Res. 2011, 69:183-188.
66. Sodhi C.P., Neal M.D., Siggers R., Sho S., Ma C., Branca M.F., Prindle T., Russo A.M., Afrazi A., Good M., Brower-Sinning R., Firek B., Morowitz M.J., Ozolek J.A., Gittes G.K., Billiar T.R., Hackam D.J. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology 2012, 143:708-718. e701-e705.
67. Abreu M.T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat. Rev. Immunol. 2010, 10:131-144.
68. Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat. Rev. Immunol. 2008, 8:411-420.
69. Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132:1359-1374.
70. Gibson D.L., Montero M., Ropeleski M.J., Bergstrom K.S., Ma C., Ghosh S., Merkens H., Huang J., Mansson L.E., Sham H.P., McNagny K.M., Vallance B.A. Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling. Gastroenterology 2010, 139:1277-1288.
71. Vijay-Kumar M., Wu H., Aitken J., Kolachala V.L., Neish A.S., Sitaraman S.V., Gewirtz A.T. Activation of Toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm. Bowel Dis. 2007, 13:856-864.
72. Vijay-Kumar M., Sanders C.J., Taylor R.T., Kumar A., Aitken J.D., Sitaraman S.V., Neish A.S., Uematsu S., Akira S., Williams I.R., Gewirtz A.T. Deletion of TLR5 results in spontaneous colitis in mice. J. Clin. Invest. 2007, 117:3909-3921.
73. Rhee S.H., Im E., Riegler M., Kokkotou E., O'Brien M., Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:13610-13615.
74. Lee J., Mo J.H., Katakura K., Alkalay I., Rucker A.N., Liu Y.T., Lee H.K., Shen C., Cojocaru G., Shenouda S., Kagnoff M., Eckmann L., Ben-Neriah Y., Raz E. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 2006, 8:1327-1336.
75. Gribar S.C., Sodhi C.P., Richardson W.M., Anand R.J., Gittes G.K., Branca M.F., Jakub A., Shi X.H., Shah S., Ozolek J.A., Hackam D.J. Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J. Immunol. 2009, 182:636-646.
76. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
77. Fukata M., Michelsen K.S., Eri R., Thomas L.S., Hu B., Lukasek K., Nast C.C., Lechago J., Xu R., Naiki Y., Soliman A., Arditi M., Abreu M.T. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am. J. Physiol. 2005, 288:G1055-G1065.
78. Szebeni B., Veres G., Dezsofi A., Rusai K., Vannay A., Mraz M., Majorova E., Arato A. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin. Exp. Immunol. 2008, 151:34-41.
79. Siggers R.H., Hackam D.J. The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases. Cell. Mol. Life Sci. 2011, 68:3623-3634.
80. Rakoff-Nahoum S., Hao L., Medzhitov R. Role of Toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006, 25:319-329.
81. Shah J.A., Vary J.C., Chau T.T., Bang N.D., Yen N.T., Farrar J.J., Dunstan S.J., Hawn T.R. Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. J. Immunol. 2012, 189:1737-1746.
82. Wald D., Qin J., Zhao Z., Qian Y., Naramura M., Tian L., Towne J., Sims J.E., Stark G.R., Li X. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 2003, 4:920-927.
83. Qin J., Qian Y., Yao J., Grace C., Li X. SIGIRR inhibits interleukin-1 receptor- and Toll-like receptor 4-mediated signaling through different mechanisms. J. Biol. Chem. 2005, 280:25233-25241.
84. Kobayashi K., Hernandez L.D., Galan J.E., Janeway C.A., Medzhitov R., Flavell R.A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 2002, 110:191-202.
85. Dubuquoy L., Jansson E.A., Deeb S., Rakotobe S., Karoui M., Colombel J.F., Auwerx J., Pettersson S., Desreumaux P. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 2003, 124:1265-1276.
86. Appel S., Mirakaj V., Bringmann A., Weck M.M., Grunebach F., Brossart P. PPAR-gamma agonists inhibit Toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. Blood 2005, 106:3888-3894.
87. Gon Y., Asai Y., Hashimoto S., Mizumura K., Jibiki I., Machino T., Ra C., Horie T. A20 inhibits Toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 2004, 31:330-336.
88. Burns K., Clatworthy J., Martin L., Martinon F., Plumpton C., Maschera B., Lewis A., Ray K., Tschopp J., Volpe F. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat. Cell Biol. 2000, 2:346-351.
89. Zhang G., Ghosh S. Negative regulation of Toll-like receptor-mediated signaling by Tollip. J. Biol. Chem. 2002, 277:7059-7065.
90. Capelluto D.G. Tollip: a multitasking protein in innate immunity and protein trafficking. Microbes Infect./Institut Pasteur 2012, 14:140-147.
91. Oshima N., Ishihara S., Rumi M.A., Aziz M.M., Mishima Y., Kadota C., Moriyama I., Ishimura N., Amano Y., Kinoshita Y. A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 2010, 159:185-198.
92. Steenholdt C., Andresen L., Pedersen G., Hansen A., Brynskov J. Expression and function of Toll-like receptor 8 and Tollip in colonic epithelial cells from patients with inflammatory bowel disease. Scand. J. Gastroenterol. 2009, 44:195-204.
93. Kadota C., Ishihara S., Aziz M.M., Rumi M.A., Oshima N., Mishima Y., Moriyama I., Yuki T., Amano Y., Kinoshita Y. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 2010, 162:348-361.
94. Garlanda C., Riva F., Polentarutti N., Buracchi C., Sironi M., De Bortoli M., Muzio M., Bergottini R., Scanziani E., Vecchi A., Hirsch E., Mantovani A. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:3522-3526.
95. Xiao H., Gulen M.F., Qin J., Yao J., Bulek K., Kish D., Altuntas C.Z., Wald D., Ma C., Zhou H., Tuohy V.K., Fairchild R.L., de la Motte C., Cua D., Vallance B.A., Li X. The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immunity 2007, 26:461-475.
96. Berglund M., Melgar S., Kobayashi K.S., Flavell R.A., Hornquist E.H., Hultgren O.H. IL-1 receptor-associated kinase M downregulates DSS-induced colitis. Inflamm. Bowel Dis. 2010, 16:1778-1786.
97. Eun C.S., Han D.S., Lee S.H., Paik C.H., Chung Y.W., Lee J., Hahm J.S. Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: effect on Toll-like receptor pathway. Dig. Dis. Sci. 2006, 51:693-697.
98. Lee E.G., Boone D.L., Chai S., Libby S.L., Chien M., Lodolce J.P., Ma A. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (New York, NY) 2000, 289:2350-2354.
99. Vereecke L., Sze M., Mc Guire C., Rogiers B., Chu Y., Schmidt-Supprian M., Pasparakis M., Beyaert R., van Loo G. Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J. Exp. Med. 2010, 207:1513-1523.
100. Schmid M., Fellermann K., Fritz P., Wiedow O., Stange E.F., Wehkamp J. Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J. Leukoc. Biol. 2007, 81:907-915.
101. Reardon C., Lechmann M., Brustle A., Gareau M.G., Shuman N., Philpott D., Ziegler S.F., Mak T.W. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity 2011, 35:223-235.
102. Neu J., Walker W.A. Necrotizing enterocolitis. N. Engl. J. Med. 2011, 364:255-264.
103. Berman L., Moss R.L. Necrotizing enterocolitis: an update. Semin. Fetal Neonatal Med. 2011, 16:145-150.
104. Hsueh W., Caplan M.S., Qu X.W., Tan X.D., De Plaen I.G., Gonzalez-Crussi F. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr. Dev. Pathol. 2003, 6:6-23.
105. Hackam D.J., Upperman J.S., Grishin A., Ford H.R. Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin. Pediatr. Surg. 2005, 14:49-57.
106. Leaphart C.L., Cavallo J., Gribar S.C., Cetin S., Li J., Branca M.F., Dubowski T.D., Sodhi C.P., Hackam D.J. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J. Immunol. 2007, 179:4808-4820.
107. Blakely M.L., Lally K.P., McDonald S., Brown R.L., Barnhart D.C., Ricketts R.R., Thompson W.R., Scherer L.R., Klein M.D., Letton R.W., Chwals W.J., Touloukian R.J., Kurkchubasche A.G., Skinner M.A., Moss R.L., Hilfiker M.L. Postoperative outcomes of extremely low birth-weight infants with necrotizing enterocolitis or isolated intestinal perforation: a prospective cohort study by the NICHD Neonatal Research Network. Ann. Surg. 2005, 241:984-989. discussion 989-994.
108. Hintz S.R., Kendrick D.E., Stoll B.J., Vohr B.R., Fanaroff A.A., Donovan E.F., Poole W.K., Blakely M.L., Wright L., Higgins R. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics 2005, 115:696-703.
109. Lainwala S., Perritt R., Poole K., Vohr B. Neurodevelopmental and growth outcomes of extremely low birth weight infants who are transferred from neonatal intensive care units to level I or II nurseries. Pediatrics 2007, 119:e1079-e1087.
110. Guner Y.S., Franklin A.L., Chokshi N.K., Castle S.L., Pontarelli E., Wang J., Wang L., Prasadarao N.V., Upperman J.S., Grishin A.V., Ford H.R. P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab. Investig.: J. Technical Methods Pathol. 2011, 91:1668-1679.
111. Gregory K.E., Deforge C.E., Natale K.M., Phillips M., Van Marter L.J. Necrotizing enterocolitis in the premature infant: neonatal nursing assessment, disease pathogenesis, and clinical presentation. Adv. Neonatal Care 2011, 11:155-164. quiz 165-156.
112. Claud E.C., Walker W.A. Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis. FASEB J. 2001, 15:1398-1403.
113. Hackam D.J., Good M., Sodhi C.P. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin. Pediatr. Surg. 2013, 22:76-82.
114. Lin P.W., Stoll B.J. Necrotising enterocolitis. Lancet 2006, 368:1271-1283.
115. Blakey J.L., Lubitz L., Campbell N.T., Gillam G.L., Bishop R.F., Barnes G.L. Enteric colonization in sporadic neonatal necrotizing enterocolitis. J. Pediatr. Gastroenterol. Nutr. 1985, 4:591-595.
116. Hentges D.J. The anaerobic microflora of the human body. Clin. Infect. Dis. 1993, 16(Suppl. 4):S175-S180.
117. Wang Y., Hoenig J.D., Malin K.J., Qamar S., Petrof E.O., Sun J., Antonopoulos D.A., Chang E.B., Claud E.C. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J. 2009, 3:944-954.
118. Coates E.W., Karlowicz M.G., Croitoru D.P., Buescher E.S. Distinctive distribution of pathogens associated with peritonitis in neonates with focal intestinal perforation compared with necrotizing enterocolitis. Pediatrics 2005, 116:e241-e246.
119. Bury R.G., Tudehope D. Enteral antibiotics for preventing necrotizing enterocolitis in low birthweight or preterm infants. Cochrane Database Syst. Rev. (Online) 2001, CD000405.
120. Krediet T.G., van Lelyveld N., Vijlbrief D.C., Brouwers H.A., Kramer W.L., Fleer A., Gerards L.J. Microbiological factors associated with neonatal necrotizing enterocolitis: protective effect of early antibiotic treatment. Acta Paediatr. 2003, 92:1180-1182.
121. Cetin S., Ford H.R., Sysko L.R., Agarwal C., Wang J., Neal M.D., Baty C., Apodaca G., Hackam D.J. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. J. Biol. Chem. 2004, 279:24592-24600.
122. Cario E., Rosenberg I.M., Brandwein S.L., Beck P.L., Reinecker H.C., Podolsky D.K. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J. Immunol. 2000, 164:966-972.
123. Otte J.M., Cario E., Podolsky D.K. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 2004, 126:1054-1070.
124. Nanthakumar N., Meng D., Goldstein A.M., Zhu W., Lu L., Uauy R., Llanos A., Claud E.C., Walker W.A. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS ONE 2011, 6:e17776.
125. Fusunyan R.D., Nanthakumar N.N., Baldeon M.E., Walker W.A. Evidence for an innate immune response in the immature human intestine: Toll-like receptors on fetal enterocytes. Pediatr. Res. 2001, 49:589-593.
126. Neal M.D., Sodhi C.P., Dyer M., Craig B.T., Good M., Jia H., Yazji I., Afrazi A., Richardson W.M., Beer-Stolz D., Ma C., Prindle T., Grant Z., Branca M.F., Ozolek J., Hackam D.J. A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis. J. Immunol. 2007, 190:3541-3551.
127. Lotz M., Gutle D., Walther S., Menard S., Bogdan C., Hornef M.W. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J. Exp. Med. 2006, 203:973-984.
128. Jilling T., Simon D., Lu J., Meng F.J., Li D., Schy R., Thomson R.B., Soliman A., Arditi M., Caplan M.S. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J. Immunol. 2006, 177:3273-3282.
129. Chan K.L., Wong K.F., Luk J.M. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications. World J. Gastroenterol. 2009, 15:4745-4752.
130. Liu Y., Zhu L., Fatheree N.Y., Liu X., Pacheco S.E., Tatevian N., Rhoads J.M. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am. J. Physiol. 2009, 297:G442-G450.
131. Lu J., Jilling T., Li D., Caplan M.S. Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Pediatr. Res. 2007, 61:427-432.
132. Zamora R., Grishin A., Wong C., Boyle P., Wang J., Hackam D., Upperman J.S., Tracey K.J., Ford H.R. High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Am. J. Physiol. 2005, 289:G643-G652.
133. Caplan M.S., Simon D., Jilling T. The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. Semin. Pediatr. Surg. 2005, 14:145-151.
134. Mollen K.P., Gribar S.C., Anand R.J., Kaczorowski D.J., Kohler J.W., Branca M.F., Dubowski T.D., Sodhi C.P., Hackam D.J. Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis. J. Pediatr. Surg. 2008, 43:1175-1181.
135. Sodhi C.P., Shi X.H., Richardson W.M., Grant Z.S., Shapiro R.A., Prindle T., Branca M., Russo A., Gribar S.C., Ma C., Hackam D.J. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Gastroenterology 2010, 138:185-196.
136. Soliman A., Michelsen K.S., Karahashi H., Lu J., Meng F.J., Qu X., Crother T.R., Rabizadeh S., Chen S., Caplan M.S., Arditi M., Jilling T. Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS ONE 2010, 5:e15044.
137. Lu J., Pierce M., Franklin A., Jilling T., Stafforini D.M., Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr. Res. 2010, 68:225-230.
138. Neal M.D., Sodhi C.P., Jia H., Dyer M., Egan C.E., Yazji I., Good M., Afrazi A., Marino R., Slagle D., Ma C., Branca M.F., Prindle T., Grant Z., Ozolek J., Hackam D.J. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J. Biol. Chem. 2012, 287:37296-37308.
139. Dai S., Sodhi C., Cetin S., Richardson W., Branca M., Neal M.D., Prindle T., Ma C., Shapiro R.A., Li B., Wang J.H., Hackam D.J. Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness. J. Biol. Chem. 2010, 285:4995-5002.
140. Yu J., Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008, 27(Suppl. 1):S71-S83.
141. Wu B., Qiu W., Wang P., Yu H., Cheng T., Zambetti G.P., Zhang L., Yu J. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut 2007, 56:645-654.
142. Qureshi F.G., Leaphart C., Cetin S., Li J., Grishin A., Watkins S., Ford H.R., Hackam D.J. Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Gastroenterology 2005, 128:1012-1022.
143. Mammen J.M., Matthews J.B. Mucosal repair in the gastrointestinal tract. Crit. Care Med. 2003, 31:S532-S537.
144. Hackam D.J., Ford H.R. Cellular, biochemical, and clinical aspects of wound healing. Surg. Infect. 2002, 3(Suppl. 1):S23-S35.
145. Ibrahim A., Mbodji K., Hassan A., Aziz M., Boukhettala N., Coeffier M., Savoye G., Dechelotte P., Marion-Letellier R. Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium. Clin. Nutr. (Edinburgh, Scotland) 2011, 30:678-687.
146. Yazji I., Sodhi C.P., Lee E.K., Good M., Egan C.E., Afrazi A., Neal M.D., Jia H., Lin J., Ma C., Branca M.F., Prindle T., Richardson W.M., Ozolek J., Billiar T.R., Binion D.G., Gladwin M.T., Hackam D.J. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc. Natl. Acad. Sci. U.S.A. 2013, 110(June (23)):9451-9456.
147. Halpern M.D., Dvorak B. Does abnormal bile acid metabolism contribute to NEC?. Semin. Perinatol. 2008, 32:114-121.
148. Martin N.A., Mount Patrick S.K., Estrada T.E., Frisk H.A., Rogan D.T., Dvorak B., Halpern M.D. Active transport of bile acids decreases mucin 2 in neonatal ileum: implications for development of necrotizing enterocolitis. PLoS ONE 2011, 6:e27191.
149. Forstermann U., Sessa W.C. Nitric oxide synthases: regulation and function. Eur. Heart J. 2012, 33:829-837. 837a-837d.
150. Marletta M.A. Nitric oxide synthase structure and mechanism. J. Biol. Chem. 1993, 268:12231-12234.
151. Kloner R.A. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am. J. Cardiol. 2005, 96:42M-46M.
152. Jornot L., Mirault M.E., Junod A.F. Differential expression of hsp70 stress proteins in human endothelial cells exposed to heat shock and hydrogen peroxide. Am. J. Respir. Cell Mol. Biol. 1991, 5:265-275.
153. Madamanchi N.R., Li S., Patterson C., Runge M.S. Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway. Arterioscler. Thromb. Vasc. Biol. 2001, 21:321-326.
154. Muramatsu T., Tada H., Kobayashi N., Yamji M., Shirai T., Ohnishi T. Induction of the 72-kD heat shock protein in organ-cultured normal human skin. J. Invest. Dermatol. 1992, 98:786-790.
155. Melkonyan H.S., Ushakova T.E., Umansky S.R. Hsp70 gene expression in mouse lung cells upon chronic gamma-irradiation. Int. J. Radiat. Biol. 1995, 68:277-280.
156. Liu R.Y., Corry P.M., Lee Y.J. Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells. J. Cell Sci. 1994, 107(Pt 8):2209-2214.
157. Afrazi A., Sodhi C.P., Good M., Jia H., Siggers R., Yazji I., Ma C., Neal M.D., Prindle T., Grant Z.S., Branca M.F., Ozolek J., Chang E.B., Hackam D.J. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J. Immunol. 2012, 188:4543-4557.
158. Hu S., Ciancio M.J., Lahav M., Fujiya M., Lichtenstein L., Anant S., Musch M.W., Chang E.B. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology 2007, 133:1893-1904.
159. Paimela T., Hyttinen J.M., Viiri J., Ryhanen T., Karjalainen R.O., Salminen A., Kaarniranta K. Celastrol regulates innate immunity response via NF-kappaB and Hsp70 in human retinal pigment epithelial cells. Pharmacol. Res. 2011, 64:501-508.
160. Kalmar B., Greensmith L. Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects. Cell. Mol. Biol. Lett. 2009, 14:319-335.
161. Wischmeyer P.E., Musch M.W., Madonna M.B., Thisted R., Chang E.B. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am. J. Physiol. 1997, 272:G879-G884.
162. Kessel A., Toubi E., Pavlotzky E., Mogilner J., Coran A.G., Lurie M., Karry R., Sukhotnik I. Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat. Clin. Exp. Immunol. 2008, 151:341-347.
163. Akisu M., Baka M., Huseyinov A., Kultursay N. The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. Ann. Nutr. Metab. 2003, 47:262-266.
164. Sevastiadou S., Malamitsi-Puchner A., Costalos C., Skouroliakou M., Briana D.D., Antsaklis A., Roma-Giannikou E. The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates. J. Matern. Fetal Neonatal Med. 2011, 24:1294-1300.
165. Halpern M.D., Holubec H., Saunders T.A., Dvorak K., Clark J.A., Doelle S.M., Ballatori N., Dvorak B. Bile acids induce ileal damage during experimental necrotizing enterocolitis. Gastroenterology 2006, 130:359-372.
166. Halpern M.D., Weitkamp J.H., Mount Patrick S.K., Dobrenen H.J., Khailova L., Correa H., Dvorak B. Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis. Am. J. Physiol. 2010, 299:G623-G631.
167. Cherrington N.J., Estrada T.E., Frisk H.A., Canet M.J., Hardwick R.N., Dvorak B., Lux K., Halpern M.D. The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis. Am. J. Physiol. 2012, 304:G48-G56.
168. Milano J., McKay J., Dagenais C., Foster-Brown L., Pognan F., Gadient R., Jacobs R.T., Zacco A., Greenberg B., Ciaccio P.J. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol. Sci. 2004, 82:341-358.
169. Wu Y., Zhu X., Li N., Chen T., Yang M., Yao M., Liu X., Jin B., Wang X., Cao X. CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination. J. Immunol. 2011, 187:4881-4889.
170. Franchi L., Warner N., Viani K., Nunez G. Function of Nod-like receptors in microbial recognition and host defense. Immunol. Rev. 2009, 227:106-128.
171. Richardson W.M., Sodhi C.P., Russo A., Siggers R.H., Afrazi A., Gribar S.C., Neal M.D., Dai S., Prindle T., Branca M., Ma C., Ozolek J., Hackam D.J. Nucleotide-binding oligomerization domain-2 inhibits Toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology 2010, 139:904-917. 917 e901-906.
172. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000, 102:33-42.
173. Mulvihill S.J., Stone M.M., Debas H.T., Fonkalsrud E.W. The role of amniotic fluid in fetal nutrition. J. Pediatr. Surg. 1985, 20:668-672.
174. Scott S.M., Buenaflor G.G., Orth D.N. Immunoreactive human epidermal growth factor concentrations in amniotic fluid, umbilical artery and vein serum, and placenta in full-term and preterm infants. Biol. Neonate 1989, 56:246-251.
175. Barka T., van der Noen H., Gresik E.W., Kerenyi T. Immunoreactive epidermal growth factor in human amniotic fluid. Mount Sinai J. Med. (NY) 1978, 45:679-684.
176. Good M., Siggers R.H., Sodhi C.P., Afrazi A., Alkhudari F., Egan C.E., Neal M.D., Yazji I., Jia H., Lin J., Branca M.F., Ma C., Prindle T., Grant Z., Shah S., Slagle D., Paredes J., Ozolek J., Gittes G.K., Hackam D.J. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:11330-11335.
177. Siggers J.L., Ostergaard M.V., Siggers R.H., Skovgaard K., Molbak L., Thymann T., Schmidt M., Moller H.K., Purup S., Fink L.N., Frokiaer H., Boye M., Sangild P.T., Bering S.B. Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates. Am. J. Physiol. 2013, 304(May (10)):G864-G875.
178. Dubuquoy L., Rousseaux C., Thuru X., Peyrin-Biroulet L., Romano O., Chavatte P., Chamaillard M., Desreumaux P. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 2006, 55:1341-1349.
179. Fort M.M., Mozaffarian A., Stover A.G., Correia Jda S., Johnson D.A., Crane R.T., Ulevitch R.J., Persing D.H., Bielefeldt-Ohmann H., Probst P., Jeffery E., Fling S.P., Hershberg R.M. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J. Immunol. 2005, 174:6416-6423.
180. Barochia A., Solomon S., Cui X., Natanson C., Eichacker P.Q. Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opin. Drug Metab. Toxicol. 2011, 7:479-494.
181. Neal M.D., Jia H., Eyer B., Good M., Guerriero C.J., Sodhi C.P., Afrazi A., Prindle T., Ma C., Branca M., Ozolek J., Brodsky J.L., Wipf P., Hackam D.J. Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors. PLoS ONE 2013, 8:e65779.
182. Kosloske A.M. Breast milk decreases the risk of neonatal necrotizing enterocolitis. Adv. Nutr. Res. 2001, 10:123-137.
183. Meinzen-Derr J., Poindexter B., Wrage L., Morrow A.L., Stoll B., Donovan E.F. Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death. J. Perinatol. 2009, 29:57-62.
184. Quigley M.A., Henderson G., Anthony M.Y., McGuire W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst. Rev. (Online) 2007, CD002971.
185. Hunter C.J., Williams M., Petrosyan M., Guner Y., Mittal R., Mock D., Upperman J.S., Ford H.R., Prasadarao N.V. Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect. Immun. 2009, 77:1031-1043.
186. Khailova L., Dvorak K., Arganbright K.M., Halpern M.D., Kinouchi T., Yajima M., Dvorak B. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Am. J. Physiol. 2009, 297:G940-G949.
187. Khailova L., Mount Patrick S.K., Arganbright K.M., Halpern M.D., Kinouchi T., Dvorak B. Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis. Am. J. Physiol. 2010, 299:G1118-G1127.
188. Liu Y., Fatheree N.Y., Mangalat N., Rhoads J.M. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine. Am. J. Physiol. 2012, 302:G608-G617.
189. Deshpande G., Rao S., Patole S., Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010, 125:921-930.
190. Caplan M., Frost B. Myth: necrotizing enterocolitis: probiotics will end the disease, and surgical intervention improves the outcome. Semin. Fetal Neonatal Med. 2011, 16:264-268.
191. Hunter C., Dimaguila M.A., Gal P., Wimmer J.E., Ransom J.L., Carlos R.Q., Smith M., Davanzo C.C. Effect of routine probiotic, Lactobacillus reuteri DSM 17938, use on rates of necrotizing enterocolitis in neonates with birthweight<1000grams: a sequential analysis. BMC Pediatr. 2012, 12:142.
192. Rojas M.A., Lozano J.M., Rojas M.X., Rodriguez V.A., Rondon M.A., Bastidas J.A., Perez L.A., Rojas C., Ovalle O., Garcia-Harker J.E., Tamayo M.E., Ruiz G.C., Ballesteros A., Archila M.M., Arevalo M. Prophylactic probiotics to prevent death and nosocomial infection in preterm infants. Pediatrics 2012, 130:e1113-e1120.