메뉴 건너뛰기




Volumn 304, Issue 1, 2013, Pages

The hepatic bile acid transporters ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis

Author keywords

Bile acids; Hepatic bile acid transport; Inflammatory cytokines; Multidrug resistance associated protein 2; Sodiumdependent taurocholate transporting polypeptide

Indexed keywords

BILE ACID; BILE SALT EXCRETORY PUMP PROTEIN; CARRIER PROTEIN; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; INTERLEUKIN 18; INTERLEUKIN 8; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 4; SODIUM DEPENDENT TAUROCHOLATE TRANSPORTING POLYPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84871881542     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00317.2012     Document Type: Article
Times cited : (21)

References (45)
  • 1
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: A novel mechanism of inflammation during obstructive cholestasis
    • Allen K, Jaeschke H, Copple BL. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178: 175-186, 2011.
    • (2011) Am J Pathol , vol.178 , pp. 175-186
    • Allen, K.1    Jaeschke, H.2    Copple, B.L.3
  • 2
    • 3042599451 scopus 로고    scopus 로고
    • Lipopolysaccharidemediated regulation of hepatic transporter mRNA levels in rats
    • Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharidemediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 32: 734-741, 2004.
    • (2004) Drug Metab Dispos , vol.32 , pp. 734-741
    • Cherrington, N.J.1    Slitt, A.L.2    Li, N.3    Klaassen, C.D.4
  • 4
    • 14844291348 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
    • Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem 280: 6960-6968, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 6960-6968
    • Dawson, P.A.1    Hubbert, M.2    Haywood, J.3    Craddock, A.L.4    Zerangue, N.5    Christian, W.V.6    Ballatori, N.7
  • 11
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • Green RM, Beier D, Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111: 193-198, 1996.
    • (1996) Gastroenterology , vol.111 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 14
    • 40749099697 scopus 로고    scopus 로고
    • Does abnormal bile acid metabolism contribute to NEC?
    • Halpern MD, Dvorak B. Does abnormal bile acid metabolism contribute to NEC? Semin Perinatol 32: 114-121, 2008.
    • (2008) Semin Perinatol , vol.32 , pp. 114-121
    • Halpern, M.D.1    Dvorak, B.2
  • 20
    • 0029099818 scopus 로고
    • Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver
    • Hardikar W, Ananthanarayanan M, Suchy FJ. Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J Biol Chem 270: 20841-20846, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 20841-20846
    • Hardikar, W.1    Ananthanarayanan, M.2    Suchy, F.J.3
  • 21
    • 0036786429 scopus 로고    scopus 로고
    • Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia
    • Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther 303: 273-281, 2002.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 273-281
    • Hartmann, G.1    Cheung, A.K.2    Piquette-Miller, M.3
  • 22
    • 0024373642 scopus 로고
    • Regulation of bile acid synthesis
    • III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat
    • Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J Lipid Res 30: 1161-1171, 1989.
    • (1989) J Lipid Res , vol.30 , pp. 1161-1171
    • Heuman, D.M.1    Hylemon, P.B.2    Vlahcevic, Z.R.3
  • 23
    • 2542565908 scopus 로고    scopus 로고
    • Method for hand-feeding mouse pups with nursing bottles
    • Hoshiba J. Method for hand-feeding mouse pups with nursing bottles. Contemp Top Lab Anim Sci 43: 50-53, 2004.
    • (2004) Contemp Top Lab Anim Sci , vol.43 , pp. 50-53
    • Hoshiba, J.1
  • 24
    • 0028248738 scopus 로고
    • Neonatal necrotizing enterocolitis, a disease of the immature intestinal mucosal barrier
    • Israel EJ. Neonatal necrotizing enterocolitis, a disease of the immature intestinal mucosal barrier. Acta Paediatr Suppl 396: 27-32, 1994.
    • (1994) Acta Paediatr Suppl , vol.396 , pp. 27-32
    • Israel, E.J.1
  • 25
    • 34948885729 scopus 로고    scopus 로고
    • Effect of cholesterol, cholic acid and cholestyramine administration on the intestinal mRNA expressions related to cholesterol and bile acid metabolism in the rat
    • Kamisako T, Ogawa H, Yamamoto K. Effect of cholesterol, cholic acid and cholestyramine administration on the intestinal mRNA expressions related to cholesterol and bile acid metabolism in the rat. J Gastroenterol Hepatol 22: 1832-1837, 2007.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1832-1837
    • Kamisako, T.1    Ogawa, H.2    Yamamoto, K.3
  • 26
    • 0034085159 scopus 로고    scopus 로고
    • Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis
    • Kawaguchi T, Sakisaka S, Mitsuyama K, Harada M, Koga H, Taniguchi E, Sasatomi K, Kimura R, Ueno T, Sawada N, Mori M, Sata M. Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis. Hepatology 31: 1285-1295, 2000.
    • (2000) Hepatology , vol.31 , pp. 1285-1295
    • Kawaguchi, T.1    Sakisaka, S.2    Mitsuyama, K.3    Harada, M.4    Koga, H.5    Taniguchi, E.6    Sasatomi, K.7    Kimura, R.8    Ueno, T.9    Sawada, N.10    Mori, M.11    Sata, M.12
  • 27
    • 38749136631 scopus 로고    scopus 로고
    • Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    • Le Vee M, Gripon P, Stieger B, Fardel O. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 36: 217-222, 2008.
    • (2008) Drug Metab Dispos , vol.36 , pp. 217-222
    • Le Vee, M.1    Gripon, P.2    Stieger, B.3    Fardel, O.4
  • 28
    • 33745529832 scopus 로고    scopus 로고
    • Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells
    • Li T, Jahan A, Chiang JY. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 43: 1202-1210, 2006.
    • (2006) Hepatology , vol.43 , pp. 1202-1210
    • Li, T.1    Jahan, A.2    Chiang, J.Y.3
  • 29
    • 41349089776 scopus 로고    scopus 로고
    • Stellaard F. Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics
    • Liu Y, Havinga R, FRVDL, Boverhof R, Sauer PJ, Kuipers F, Stellaard F. Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics. Pediatr Res 63: 375-381, 2008.
    • (2008) Pediatr Res , vol.63 , pp. 375-381
    • Liu, Y.1    Havinga, R.2
  • 30
    • 82655183571 scopus 로고    scopus 로고
    • Active transport of bile acids decreases mucin 2 in neonatal ileum: Implications for development of necrotizing enterocolitis
    • Martin NA, Mount Patrick SK, Estrada TE, Frisk HA, Rogan DT, Dvorak B, Halpern MD. Active transport of bile acids decreases mucin 2 in neonatal ileum: implications for development of necrotizing enterocolitis. PLoS One 6: e27191, 2011.
    • (2011) PLoS One , vol.6
    • Martin, N.A.1    Mount, P.S.K.2    Estrada, T.E.3    Frisk, H.A.4    Rogan, D.T.5    Dvorak, B.6    Halpern, M.D.7
  • 35
    • 44649128491 scopus 로고    scopus 로고
    • Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion
    • Ogura J, Kobayashi M, Itagaki S, Hirano T, Iseki K. Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion. Life Sci 82: 1242-1248, 2008.
    • (2008) Life Sci , vol.82 , pp. 1242-1248
    • Ogura, J.1    Kobayashi, M.2    Itagaki, S.3    Hirano, T.4    Iseki, K.5
  • 36
    • 33846933119 scopus 로고    scopus 로고
    • Prevention of necrotizing enterocolitis in preterm infants: A 20-year experience
    • Pietz J, Achanti B, Lilien L, Stepka EC, Mehta SK. Prevention of necrotizing enterocolitis in preterm infants: a 20-year experience. Pediatrics 119: e164-e170, 2007.
    • (2007) Pediatrics , vol.119
    • Pietz, J.1    Achanti, B.2    Lilien, L.3    Stepka, E.C.4    Mehta, S.K.5
  • 38
    • 0028800562 scopus 로고
    • Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter
    • Shneider BL, Dawson PA, Christie DM, Hardikar W, Wong MH, Suchy FJ. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J Clin Invest 95: 745-754, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 745-754
    • Shneider, B.L.1    Dawson, P.A.2    Christie, D.M.3    Hardikar, W.4    Wong, M.H.5    Suchy, F.J.6
  • 41
    • 0023338067 scopus 로고
    • Determinants of bile formation during development: Ontogeny of hepatic bile acid metabolism and transport
    • Suchy FJ, Bucuvalas JC, Novak DA. Determinants of bile formation during development: ontogeny of hepatic bile acid metabolism and transport. Semin Liver Dis 7: 77-84, 1987.
    • (1987) Semin Liver Dis , vol.7 , pp. 77-84
    • Suchy, F.J.1    Bucuvalas, J.C.2    Novak, D.A.3
  • 42
    • 0036924065 scopus 로고    scopus 로고
    • Hepatobiliary transport of bile acids and organic anions
    • Takikawa H. Hepatobiliary transport of bile acids and organic anions. J Hepatobiliary Pancreat Surg 9: 443-447, 2002.
    • (2002) J Hepatobiliary Pancreat Surg , vol.9 , pp. 443-447
    • Takikawa, H.1
  • 43
    • 0037313267 scopus 로고    scopus 로고
    • Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2
    • Tomer G, Ananthanarayanan M, Weymann A, Balasubramanian N, Suchy FJ. Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2. Pediatr Res 53: 288-294, 2003.
    • (2003) Pediatr Res , vol.53 , pp. 288-294
    • Tomer, G.1    Ananthanarayanan, M.2    Weymann, A.3    Balasubramanian, N.4    Suchy, F.J.5
  • 44
    • 0015592211 scopus 로고
    • Bile-salt metabolism in the newborn
    • Measurement of pool size and synthesis by stable isotope technic
    • Watkins JB, Ingall D, Szczepanik P, Klein PD, Lester R. Bile-salt metabolism in the newborn. Measurement of pool size and synthesis by stable isotope technic. N Engl J Med 288: 431-434, 1973.
    • (1973) N Engl J Med , vol.288 , pp. 431-434
    • Watkins, J.B.1    Ingall, D.2    Szczepanik, P.3    Klein, P.D.4    Lester, R.5
  • 45
    • 84871904314 scopus 로고    scopus 로고
    • Diminishing thymic size and delayed appearance of splenic CD4+ and CD8+ cells in artificially reared mouse pups
    • In press
    • Yajima M, Hoshiba J, Terahara M, Yajima T. Diminishing thymic size and delayed appearance of splenic CD4+ and CD8+ cells in artificially reared mouse pups. Biosci Biotechnol Biochem In press.
    • Biosci Biotechnol Biochem
    • Yajima, M.1    Hoshiba, J.2    Terahara, M.3    Yajima, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.