Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 23, 2013, Pages 9451-9456

  Yazji, Ibrahim ^a,b   Sodhi, Chhinder P ^a,b   Lee, Elizabeth K ^a,b   Good, Misty ^a,b   Egan, Charlotte E ^a,b   Afrazi, Amin ^a,b   Neal, Matthew D ^a,b   Jia, Hongpeng ^a,b   Lin, Joyce ^a,b   Ma, Congrong ^a,b   Branca, Maria F ^a,b   Prindle, Thomas ^a,b   Richardson, Ward M ^b   Ozolek, John ^a,b   Billiar, Timothy R ^b   Binion, David G ^b   Gladwin, Mark T ^b   Hackam, David J ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Infant formula; Neonatal inflammation; Neonatal nutrition; Prematurity; Sepsis

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NITRITE; SILDENAFIL; SODIUM NITRATE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST MILK; CONTROLLED STUDY; ENZYME ACTIVITY; INTESTINE PERFUSION; MICROCIRCULATION; MOUSE; NECROTIZING ENTEROCOLITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SMALL INTESTINE;

INFANT FORMULA; NEONATAL INFLAMMATION; NEONATAL NUTRITION; PREMATURITY; SEPSIS;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ENTEROCOLITIS, NECROTIZING; INFANT FORMULA; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; MICROCIRCULATION; MICROSCOPY, CONFOCAL; MILK, HUMAN; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PIPERAZINES; PURINES; SIGNAL TRANSDUCTION; SULFONES; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 84878723744     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219997110     Document Type: Article

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