Apical sodium-dependent bile acid transporter upregulation is associated with necrotizing enterocolitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 3, 2010, Pages

  Halpern, Melissa D ^a   Weitkamp, Jörn Hendrik ^c   Mount Patrick, Sarah K ^a   Dobrenen, Holly J ^a   Khailova, Ludmila ^a   Correa, Hernan ^c   Dvorak, Bohuslav ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bile salt export pump; Epithelial transport; SC 435

Indexed keywords

APICAL SODIUM BILE ACID TRANSPORTER; BILE ACID; CARRIER PROTEIN; FARNESOID X RECEPTOR; GASTROINTESTINAL AGENT; MESSENGER RNA; SC 435; UNCLASSIFIED DRUG; 1 (4 (4 (3,3 DIBUTYL 7 (DIMETHYLAMINO) 2,3,4,5 TETRAHYDRO 4 HYDROXY 1,1 DIOXIDO 1 BENZOTHIEPIN 5 YL)PHENOXY)BUTYL) 4 AZA 1 AZONIABICYCLO(2.2.2)OCTANE; 1-(4-(4-(3,3-DIBUTYL-7-(DIMETHYLAMINO)-2,3,4,5-TETRAHYDRO-4-HYDROXY-1,1-DIOXIDO-1-BENZOTHIEPIN-5-YL)PHENOXY)BUTYL)-4-AZA-1-AZONIABICYCLO(2.2.2)OCTANE; AMINE OXIDE; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SODIUM BILE ACID COTRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TROPANE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION REGULATION; ILEUM; IMMUNOHISTOLOGY; INTESTINE CELL; INTESTINE SECRETION; KNOCKOUT MOUSE; MOUSE; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CYCLIC N-OXIDES; ENTEROCOLITIS, NECROTIZING; ENTEROCYTES; HUMANS; ILEUM; INFANT, NEWBORN; INFANT, PREMATURE; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SYMPORTERS; TROPANES; UP-REGULATION;

EID: 77957013173     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00242.2010     Document Type: Article

References (45)

1. Armand M, Hamosh M, Mehta NR, Angelus PA, Philpott JR, Henderson TR, Dwyer NK, Lairon D, Hamosh P. Effect of human milk or formula on gastric function and fat digestion in the premature infant. Pediatr Res 40: 429-437, 1996.
2. Arrese M, Trauner M, Sacchiero RJ, Crossman MW, Shneider BL. Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology 28: 1081-1087, 1998.
3. Balistreri WF, Heubi JE, Suchy FJ. Immaturity of the enterohepatic circulation in early life: factors predisposing to "physiologic" maldigestion and cholestasis. J Pediatr Gastroenterol Nutr 2: 346-354, 1983.
4. Ballance WA, Dahms BB, Shenker N, Kliegman RM. Pathology of neonatal necrotizing enterocolitis: a ten-year experience. J Pediatr 117: S6-S13, 1990.
5. Barlow B, Santulli TV, Heird WC, Pitt J, Blanc WA, Schullinger JN. An experimental study of acute neonatal enterocolitis - the importance of breast milk. J Pediatr Surg 9: 587-595, 1974.
6. -/- mice by SC-435. J Lipid Res 44: 1614-1621, 2003.
7. Caplan MS, Jilling T. New concepts in necrotizing enterocolitis. Curr Opin Pediatr 13: 111-115, 2001.
8. Caplan MS, MacKendrick W. Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention. Pediatr Pathol 13: 357-369, 1993.
9. Chen F, Ma L, Dawson PA, Sinal CJ, Sehayek E, Gonzalez FJ, Breslow J, Ananthanarayanan M, Shneider BL. Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 278: 19909-19916, 2003.
10. Dvorak B, Halpern MD, Holubec H, Dvorakova K, Dominguez JA, Williams CS, Meza YG, Kozakova H, McCuskey RS. Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr Res 53: 426-433, 2003.
11. Dvorak B, Halpern MD, Holubec H, Williams CS, McWilliam DL, Dominguez JA, Stepankova R, Payne CM, McCuskey RS. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 282: G156-G164, 2002.
12. Dvorak B, Kolinska J, McWilliam DL, Williams CS, Higdon T, Zakostelecka M, Koldovsky O. The expression of epidermal growth factor and transforming growth factor-α mRNA in the small intestine of suckling rats: organ culture study. FEBS Lett 435: 119-124, 1998.
13. Figge A, Lammert F, Paigen B, Henkel A, Matern S, Korstanje R, Shneider BL, Chen F, Stoltenberg E, Spatz K, Hoda F, Cohen DE, Green RM. Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem 279: 2790-2799, 2004.
14. Halpern MD, Dominguez JA, Dvorakova K, Holubec H, Williams CS, Meza YG, Ruth MC, Dvorak B. Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor. J Pediatr Gastroenterol Nutr 36: 126-133, 2003.
15. Halpern MD, Holubec H, Dominguez JA, Meza YG, Williams CS, Ruth MC, McCuskey RS, Dvorak B. Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 284: G695-G702, 2003.
16. Halpern MD, Holubec H, Dominguez JA, Williams CS, Meza YG, McWilliam DL, Payne CM, McCuskey RS, Besselsen DG, Dvorak B. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Pediatr Res 51: 733-739, 2002.
17. Halpern MD, Holubec H, Saunders TA, Dvorak K, Clark JA, Doelle SM, Ballatori N, Dvorak B. Bile acids induce ileal damage during experimental necrotizing enterocolitis. Gastroenterology 130: 359-372, 2006.
18. Halpern MD, Khailova L, Molla-Hosseini D, Arganbright K, Reynolds C, Yajima M, Hoshiba J, Dvorak B. Decreased development of necrotizing enterocolitis in IL-18-deficient mice. Am J Physiol Gastrointest Liver Physiol 294: G20-G26, 2008.
19. Hammons JL, Jordan WE, Stewart RL, Taulbee JD, Berg RW. Age and diet effects on fecal bile acids in infants. J Pediatr Gastroenterol Nutr 7: 30-38, 1988.
20. Hamosh M. Digestion in the newborn. Clin Perinatol 23: 191-209, 1996.
21. Hamosh M. Digestion in the premature infant: the effects of human milk. Semin Perinatol 18: 485-494, 1994.
22. Hamosh M, Iverson SJ, Kirk CL, Hamosh P. Milk lipids and neonatal fat digestion: relationship between fatty acid composition, endogenous and exogenous digestive enzymes and digestion of milk fat. World Rev Nutr Diet 75: 86-91, 1994.
23. Henkel A, Wei Z, Cohen DE, Green RM. Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones. Mamm Genome 16: 903-908, 2005.
24. Heubi JE, Balistreri WF, Suchy FJ. Bile salt metabolism in the first year of life. J Lab Clin Med 100: 127-136, 1982.
25. Hoshiba J. Method for hand-feeding mouse pups with nursing bottles. Contemp Top Lab Anim Sci 43: 50-53, 2004.
26. Hwang ST, Henning SJ. Ontogenic regulation of components of ileal bile acid absorption. Exp Biol Med (Maywood) 226: 674-680, 2001.
27. Israel EJ. Neonatal necrotizing enterocolitis, a disease of the immature intestinal mucosal barrier. Acta Paediatr Suppl 396: 27-32, 1994.
28. Jackson GD, Dai Y, Sewell WA. Bile mediates intestinal pathology in endotoxemia in rats. Infect Immun 68: 4714-4719, 2000.
29. Kafetzis DA, Skevaki C, Costalos C. Neonatal necrotizing enterocolitis: an overview. Curr Opin Infect Dis 16: 349-355, 2003.
30. Kliegman RM, Fanaroff AA. Neonatal necrotizing enterocolitis: a nine-year experience. II. Outcome assessment. Am J Dis Child 135: 608-611, 1981.
31. Li H, Xu G, Shang Q, Pan L, Shefer S, Batta AK, Bollineni J, Tint GS, Keller BT, Salen G. Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7-hydroxylase. Metabolism 53: 927-932, 2004.
32. Lien EL. The role of fatty acid composition and positional distribution in fat absorption in infants. J Pediatr 125: S62-S68, 1994.
33. Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet 336: 1519-1523, 1990.
34. Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B. Identification of a nuclear receptor for bile acids. Science 284: 1362-1365, 1999.
35. Neimark E, Chen F, Li X, Shneider BL. Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. Hepatology 40: 149-156, 2004.
36. Neu J. Necrotizing enterocolitis: the search for a unifying pathogenic theory leading to prevention. Pediatr Clin North Am 43: 409-432, 1996.
37. Schanler RJ, Shulman RJ, Lau C. Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 103: 1150-1157, 1999.
38. Shneider BL, Setchell KD, Crossman MW. Fetal and neonatal expression of the apical sodium-dependent bile acid transporter in the rat ileum and kidney. Pediatr Res 42: 189-194, 1997.
39. Stravitz RT, Sanyal AJ, Pandak WM, Vlahcevic ZR, Beets JW, Dawson PA. Induction of sodium-dependent bile acid transporter messenger RNA, protein, and activity in rat ileum by cholic acid. Gastroenterology 113: 1599-1608, 1997.
40. Suchy FJ, Balistreri WF. Uptake of taurocholate by hepatocytes isolated from developing rats. Pediatr Res 16: 282-285, 1982.
41. Suchy FJ, Balistreri WF, Heubi JE, Searcy JE, Levin RS. Physiologic cholestasis: elevation of the primary serum bile acid concentrations in normal infants. Gastroenterology 80: 1037-1041, 1981.
42. Suchy FJ, Courchene SM, Balistreri WF. Ontogeny of hepatic bile acid conjugation in the rat. Pediatr Res 19: 97-101, 1985.
43. Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Phillips JB, Wright LL. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr 119: 630-638, 1991.
44. Weimer J. The Economic Benefits of Breastfeeding: A Review and Analysis. Washington, DC: Food and Rural Economics Division, Economic Research Service, US Department of Agriculture, 2001.
45. + cells in artificially reared mouse pups. Biosci Biotechnol Biochem 71: 2420-2427, 2007.