IL-1 receptor-associated kinase M downregulates DSS-induced colitis

Inflammatory Bowel Diseases

Volumn 16, Issue 10, 2010, Pages 1778-1786

  Berglund, Martin ^a   Melgar, Silvia ^b,c   Kobayashi, Koichi S ^d   Flavell, Richard A ^f   Hörnquist, Elisabeth Hultgren ^e   Hultgren, Olof H ^a,f,g  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c GLAXOSMITHKLINE   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f ÖREBRO UNIVERSITY   (Sweden)

^g ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Colitis; IRAK M; Proinflammatory cytokines; TLR signaling

Indexed keywords

DEXTRAN SULFATE; DRINKING WATER; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; MESSENGER RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DOWN REGULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM;

ANIMALS; COLITIS; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMALE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 78649275419     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21287     Document Type: Article

References (51)

1. Cho JH,. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol. 2008; 8: 458-466.
2. Xavier RJ, Podolsky DK,. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007; 448: 427-434.
3. Baumgart DC, Carding SR,. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007; 369: 1627-1640.
4. Okayasu I, Hatakeyama S, Yamada M, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990; 98: 694-702.
5. Melgar S, Karlsson A, Michaelsson E,. Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. Am J Physiol Gastrointest Liver Physiol. 2005; 288: G1328-1338.
6. Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993; 69: 238-249.
7. Ni J, Chen SF, Hollander D,. Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut. 1996; 39: 234-241.
8. Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut. 2006; 55: 342-347.
9. Leung FW, Heng MC, Allen S, et al. Involvement of luminal bacteria, heat shock protein 60, macrophages and gammadelta T cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci. 2000; 45: 1472-1479.
10. Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology. 1994; 107: 1643-1652.
11. Kumar H, Kawai T, Akira S,. Toll-like receptors and innate immunity. Biochem Biophys Res Commun. 2009; 388: 621-625.
12. Carpenter S, O'Neill LA,. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signaling proteins. Biochem J. 2009; 422: 1-10.
13. Akira S, Takeda K,. Toll-like receptor signaling. Nat Rev Immunol. 2004; 4: 499-511.
14. O'Neill LA, Greene C,. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J Leukoc Biol. 1998; 63: 650-657.
15. Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997; 278: 1612-1615.
16. Keating SE, Maloney GM, Moran EM, et al. IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. J Biol Chem. 2007; 282: 33435-33443.
17. Janeway CA Jr, Medzhitov R,. Innate immune recognition. Annu Rev Immunol. 2002; 20: 197-216.
18. Cook DN, Pisetsky DS, Schwartz DA,. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004; 5: 975-979.
19. Cario E,. Therapeutic impact of Toll-like receptors on inflammatory bowel diseases: a multiple-edged sword. Inflamm Bowel Dis. 2008; 14: 411-421.
20. Liew FY, Xu D, Brint EK, et al. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol. 2005; 5: 446-458.
21. Wesche H, Gao X, Li X, et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999; 274: 19403-19410.
22. Kobayashi K, Hernandez LD, Galan JE, et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 2002; 110: 191-202.
23. Deng JC, Cheng G, Newstead MW, et al. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest. 2006; 116: 2532-2542.
24. Xie Q, Gan L, Wang J, et al. Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Mol Immunol. 2007; 44: 3453-3461.
25. Li H, Cuartas E, Cui W, et al. IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. J Exp Med. 2005; 201: 1169-1177.
26. Larsson AE, Melgar S, Rehnstrom E, et al. Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Inflamm Bowel Dis. 2006; 12: 478-485.
27. Melgar S, Karlsson L, Rehnstrom E, et al. Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease. Int Immunopharmacol. 2008; 8: 836-844.
28. Fritsch Fredin M, Elgbratt K, Svensson D, et al. Dextran sulfate sodium-induced colitis generates a transient thymic involutionâimpact on thymocyte subsets. Scand J Immunol. 2007; 65: 421-429.
29. Hultgren OH, Berglund M, Bjursten M, et al. Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice. World J Gastroenterol. 2006; 12: 621-624.
30. Berglund M, Thomas JA, Fredin MF, et al. Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cell Immunol. 2009; 259: 27-32.
31. Korn T, Bettelli E, Oukka M, et al. IL-17 and Th17 Cells. Annu Rev Immunol. 2009; 27: 485-517.
32. Vignali DA, Collison LW, Workman CJ,. How regulatory T cells work. Nat Rev Immunol. 2008; 8: 523-532.
33. Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001; 19: 683-765.
34. Siveke JT, Hamann A,. T helper 1 and T helper 2 cells respond differentially to chemokines. J Immunol. 1998; 160: 550-554.
35. Sasaki S, Ishida Y, Nishio N, et al. Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice. Inflammation. 2008; 31: 319-328.
36. Tarcic N, Ovadia H, Weiss DW, et al. Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids. J Neuroimmunol. 1998; 82: 40-46.
37. Melgar S, Bjursell M, Gerdin AK, et al. Mice with experimental colitis show an altered metabolism with decreased metabolic rate. Am J Physiol Gastrointest Liver Physiol. 2007; 292: G165-172.
38. Zhang YH, Takahashi K, Jiang GZ, et al. In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide. Infect Immun. 1993; 61: 5044-5048.
39. von Boehmer H, Teh HS, Kisielow P,. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today. 1989; 10: 57-61.
40. Berglund M, Thomas JA, Hornquist EH, et al. Toll-like receptor cross-hyporesponsiveness is functional in interleukin-1-receptor-associated kinase-1 (IRAK-1)-deficient macrophages: differential role played by IRAK-1 in regulation of tumour necrosis factor and interleukin-10 production. Scand J Immunol. 2008; 67: 473-479.
41. Ho IC, Tai TS, Pai SY,. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 2009; 9: 125-135.
42. Sawa Y, Oshitani N, Adachi K, et al. Comprehensive analysis of intestinal cytokine messenger RNA profile by real-time quantitative polymerase chain reaction in patients with inflammatory bowel disease. Int J Mol Med. 2003; 11: 175-179.
43. Stevceva L, Pavli P, Husband A, et al. Dextran sulphate sodium-induced colitis is ameliorated in interleukin 4 deficient mice. Genes Immun. 2001; 2: 309-316.
44. Eastaff-Leung N, Mabarrack N, Barbour A, et al. Foxp3(+) regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol. 2010; 30: 80-89.
45. Mueller A, Strange PG,. The chemokine receptor, CCR5. Int J Biochem Cell Biol. 2004; 36: 35-38.
46. Balaci L, Spada MC, Olla N, et al. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am J Hum Genet. 2007; 80: 1103-1114.
47. Escoll P, del Fresno C, Garcia L, et al. Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. Biochem Biophys Res Commun. 2003; 311: 465-472.
48. Eaden JA, Abrams KR, Mayberry JF,. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001; 48: 526-535.
49. Harada K, Isse K, Sato Y, et al. Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M. Liver Int. 2006; 26: 935-942.
50. Rosati O, Martin MU,. Identification and characterization of murine IRAK-M. Biochem Biophys Res Commun. 2002; 293: 1472-1477.
51. Oshima N, Ishihara S, Rumi MA, et al. A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol. 2010; 159: 185-198.