Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

Journal of Inflammation (United Kingdom)

Volumn 9, Issue , 2012, Pages

  Boaru, Sorina Georgiana ^a   Borkham Kamphorst, Erawan ^a   Tihaa, Lidia ^a   Haas, Ute ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Animal models; Hepatic inflammation; Hepatic stellate cells; Hepatocytes; Inflammasome; Kupffer cells

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; INFLAMMASOME; LIPOPOLYSACCHARIDE; MESSENGER RNA; NLRC4 PROTEIN; NLRP1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HEPATITIS; IN VITRO STUDY; KUPFFER CELL; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALIA;

EID: 84870062861     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-9-49     Document Type: Article

References (42)

1. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β Martinon F, Burns K, Tschopp J, Mol Cell 2002 10 417 426 10.1016/S1097-2765(02)00599-3 12191486 (Pubitemid 35007355)
2. The inflammasomes: guardians of the body. Martinon F, Mayor A, Tschopp J, Annu Rev Immunol 2009 27 229 265 10.1146/annurev.immunol.021908.132715 19302040
3. How the noninflammasome NLRs function in the innate immune system. Ting JP, Duncan JA, Lei Y, Science 2010 327 286 290 10.1126/science.1184004 20075243
4. The inflammasomes. Schroder K, Tschopp J, Cell 2010 140 821 832 10.1016/j.cell.2010.01.040 20303873
5. Inflammasomes in health and disease. Strowig T, Henao-Mejia J, Elinav E, Flavell R, Nature 2012 481 278 286 10.1038/nature10759 22258606
6. Central roles of NLRs and inflammasomes in viral infection. Kanneganti TD, Nat Rev Immunol 2010 10 688 698 10.1038/nri2851 20847744
7. The inflammasome NLRs in immunity, inflammation, and associated diseases. Davis BK, Wen H, Ting JP, Annu Rev Immunol 2011 29 707 735 10.1146/annurev- immunol-031210-101405 21219188
8. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES, Nature 2009 458 509 513 10.1038/nature07710 19158676
9. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M, Proc Natl Acad Sci USA 2008 105 7803 7808 10.1073/pnas.0802726105 18511561 (Pubitemid 351872719)
10. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Kanneganti TD, Ozören N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G, Nature 2006 440 233 236 10.1038/nature04517 16407888 (Pubitemid 43372103)
11. The NLR gene family: a standard nomenclature. Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA, Immunity 2008 28 285 287 10.1016/j.immuni.2008.02.005 18341998 (Pubitemid 351350631)
12. Inflammasomes in intestinal inflammation and cancer. Chen GY, Núñez G, Gastroenterology 2011 141 1986 1999 10.1053/j.gastro.2011. 10.002 22005480
13. Inflammasome is a central player in the induction of obesity and insulin resistance. Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD, Proc Natl Acad Sci USA 2011 108 15324 15329 10.1073/pnas.1100255108 21876127
14. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA, Nature 2012 482 179 185 22297845
15. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G, Hepatology 2011 54 133 144 10.1002/hep.24341 21488066
16. Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver. Ganz M, Csak T, Nath B, Szabo G, World J Gastroenterol 2011 17 4772 4778 10.3748/wjg.v17.i43.4772 22147977
17. Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation. Menzel CL, Sun Q, Loughran PA, Pape HC, Billiar TR, Scott MJ, Mol Med 2011 17 1031 1038 21666957
18. Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice. Zhu P, Duan L, Chen J, Xiong A, Xu Q, Zhang H, Zheng F, Tan Z, Gong F, Fang M, Hum Gene Ther 2011 22 853 864 10.1089/hum.2010.145 21128730
19. Inflammasome-mediated regulation of hepatic stellate cells. Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ, Am J Physiol Gastrointest Liver Physiol 2009 296 1248 G1257 10.1152/ajpgi.90223.2008 19359429
20. The synthesis of proteoglycans in fat-storing cells of rat liver. Schäfer S, Zerbe O, Gressner AM, Hepatology 1987 7 680 687 10.1002/hep.1840070411 3111965 (Pubitemid 17130709)
21. Upregulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Fehrenbach H, Weiskirchen R, Kasper M, Gressner AM, Hepatology 2001 34 943 952 11679965 (Pubitemid 33032029)
22. Preparation of isolated rat liver cells. Seglen PO, Methods Cell Biol 1976 13 29 83 177845
23. Isolation of primary rat liver fibroblasts. Kruglov EA, Jain D, Dranoff JA, J Investig Med 2002 50 179 184 10.2310/6650.2002.33431 12033282 (Pubitemid 34522659)
24. Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signaling. Meurer SK, Tihaa L, Borkham-Kamphorst E, Weiskirchen R, Cell Signal 2011 23 683 699 10.1016/j.cellsig.2010.12.002 21146604
25. Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6. Greenwel P, Schwartz M, Rosas M, Peyrol S, Grimaud JA, Rojkind M, Lab Invest 1991 65 644 653 1753710
26. Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Greenwel P, Rubin J, Schwartz M, Hertzberg EL, Rojkind M, Lab Invest 1993 69 210 216 8394478 (Pubitemid 23262501)
27. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Borkham-Kamphorst E, Stoll D, Gressner AM, Weiskirchen R, Biochem Biophys Res Commun 2004 32 413 423 (Pubitemid 39055762)
28. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Kountouras J, Billing BH, Scheuer PJ, Br J Exp Pathol 1984 65 305 311 6743531 (Pubitemid 14085298)
29. Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats. Arias M, Sauer-Lehnen S, Treptau J, Janoschek N, Theuerkauf I, Buettner R, Gressner AM, Weiskirchen R, BMC Gastroenterol 2003 3 29 10.1186/1471-230X-3-29 14565855 (Pubitemid 38671514)
30. Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury. Liedtke C, Bangen JM, Freimuth J, Beraza N, Lambertz D, Cubero FJ, Hatting M, Karlmark KR, Streetz KL, Krombach GA, Tacke F, Gassler N, Riethmacher D, Trautwein C, Gastroenterology 2011 141 2176 2187 10.1053/j.gastro.2011.08.037 21878202
31. Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury. Borkham-Kamphorst E, Kovalenko E, van Roeyen CR, Gassler N, Bomble M, Ostendorf T, Floege J, Gressner AM, Weiskirchen R, Lab Invest 2008 88 1090 1100 10.1038/labinvest.2008.71 18663351
32. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA, Proc Natl Acad Sci USA 1994 91 3652 3656 10.1073/pnas.91.9.3652 8170963 (Pubitemid 24139489)
33. Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. Xu LL, Warren MK, Rose WL, Gong W, Wang JM, J Leukoc Biol 1996 60 365 371 8830793 (Pubitemid 26325618)
34. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. Fujitani Y, Nakajima K, Kojima H, Nakae K, Takeda T, Hirano T, Biochem Biophys Res Commun 1994 202 1181 1187 10.1006/bbrc.1994.2053 7519422 (Pubitemid 24259337)
35. Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Yoo JY, Huso DL, Nathans D, Desiderio S, Cell 2002 108 331 344 10.1016/S0092-8674(02)00636-0 11853668 (Pubitemid 34178398)
36. Signalling pathways in alcohol-induced liver inflammation. Mandrekar P, Szabo G, J Hepatol 2009 50 1258 1266 10.1016/j.jhep.2009.03.007 19398236
37. The TLR4/TRIF-mediated activation of NLRP3 inflammasome underlies endotoxin-induced liver injury in mice. Tsutsui H, Imamura M, Fujimoto J, Nakanishi K, Gastroenterol Res Pract 2010 2010 641865 20634907
38. Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation. Borkham-Kamphorst E, Drews F, Weiskirchen R, Liver Int 2011 31 656 665 10.1111/j.1478-3231.2011.02495.x 21457438
39. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. Tiegs G, Hentschel J, Wendel A, J Clin Invest 1992 90 196 203 10.1172/JCI115836 1634608
40. Increased sensitivity to endotoxemia in the bile duct-ligated cirrhotic rat. Harry D, Anand R, Holt S, Davies S, Marley R, Fernando B, Goodier D, Moore K, Hepatology 1999 30 1198 1205 10.1002/hep.510300515 10534341 (Pubitemid 29510858)
41. Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice. Pritchard MT, Cohen JI, Roychowdhury S, Pratt BT, Nagy LE, J Hepatol 2010 53 655 662 10.1016/j.jhep.2010.04.017 20615570
42. Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice. Bruck R, Aeed H, Brazovsky E, Noor T, Hershkoviz R, Liver Int 2005 25 613 621 10.1111/j.1478-3231.2005.01050.x 15910499 (Pubitemid 40861911)