Engagement of NOD2 has a dual effect on proIL-1β mRNA transcription and secretion of bioactive IL-1β

European Journal of Immunology

Volumn 38, Issue 1, 2008, Pages 184-191

  Ferwerda, Gerben ^a   Kramer, Matthijs ^b   de Jong, Dirk ^a   Piccini, Alessandra ^d   Joosten, Leo A ^a   DevesaGiner, Isabel ^a   Girardin, Stephen E ^c   Adema, Gosse J ^b   van der Meer, Jos W M ^a   Kullberg, Bart Jan ^a   Rubartelli, Anna ^d   Netea, Mihai G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Cytokines; Gene expression; Immune regulation; Monocytes; TLR

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; MESSENGER RNA; MURAMYL DIPEPTIDE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; HOMOZYGOSITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; BLOTTING, WESTERN; CASPASE 1; CROHN DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-1BETA; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38349081519     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737103     Document Type: Article

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