Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

Nature Medicine

Volumn 12, Issue 6, 2006, Pages 650-656

  Netea, Mihai G ^a,b   Joosten, Leo A B ^c   Lewis, Eli ^b   Jensen, Dalan R ^d   Voshol, Peter J ^e   Kullberg, Bart Jan ^a   Tack, Cees J ^a   Van Krieken, Han ^a   Kim, Soo Hyun ^c   Stalenhoef, Anton F ^a   Van De Loo, Fons A ^c   Verschueren, Ineke ^a   Pulawa, Leslie ^d   Akira, Shizuo ^f   Eckel, Robert H ^d   Dinarello, Charles A ^b   Van Den Berg, Wim ^c   Van Der Meer, Jos W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF COLORADO   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CUCURBITACIN GLYCOSIDE; GLUCOSE; INSULIN; INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 18 RECEPTOR; RECOMBINANT INTERLEUKIN 18; RECOMBINANT LEPTIN; STAT3 PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPHAGIA; INHIBITION KINETICS; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; LIPID STORAGE; LIVER FUNCTION; LIVER LEVEL; MOLECULAR DYNAMICS; MOUSE; MUSCLE LEVEL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TISSUE LEVEL; TRANSGENIC MOUSE; TREATMENT OUTCOME;

ANIMALS; BODY WEIGHT; EATING; ENERGY METABOLISM; GLUCONEOGENESIS; GLUCOSE; GLYCOPROTEINS; HOMEOSTASIS; HYPERPHAGIA; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OBESITY; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-18; RECOMBINANT PROTEINS; STAT3 TRANSCRIPTION FACTOR;

EID: 33745009509     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1415     Document Type: Article

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