Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 48, 2009, Pages 20388-20393

  Iyer, Shankar S ^a   Pulskens, Wilco P ^b   Sadler, Jeffrey J ^a   Butter, Loes M ^b   Teske, Gwendoline J ^b   Ulland, Tyler K ^a   Eisenbarth, Stephanie C ^c   Florquin, Sandrine ^b   Flavell, Richard A ^c   Leemans, Jaklien C ^b   Sutterwala, Fayyaz S ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caspase 1; Interleukin 1 ; Necrosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; INTERLEUKIN 1BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL DAMAGE; CELL DEATH; CELL HYPOXIA; CONTROLLED STUDY; CYTOKINE RELEASE; IN VIVO STUDY; INFLAMMATION; KIDNEY DYSFUNCTION; KIDNEY ISCHEMIA; KIDNEY TUBULE NECROSIS; MITOCHONDRION; MORTALITY; MOUSE; NONHUMAN; PERITONEUM; PRIORITY JOURNAL; TISSUE INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX PROTEINS; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NECROSIS;

ANIMALIA;

EID: 73949118676     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908698106     Document Type: Article

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