Seeking structural specificity: Direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics

Pharmacological Reviews

Volumn 66, Issue 2, 2014, Pages 396-412

  Howard, Rebecca J ^a   Trudell, James R ^b   Adron Harris, R ^c  

^a SKIDMORE COLLEGE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; ANESTHETIC AGENT; LIGAND; LIGAND GATED ION CHANNEL; PROTEIN BINDING;

ALCOHOL-RELATED DISORDERS; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALCOHOL-RELATED DISORDERS; ALCOHOLS; ANESTHETICS, GENERAL; ANIMALS; BEHAVIOR, ANIMAL; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGAND-GATED ION CHANNELS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84893695012     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.113.007468     Document Type: Review

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