Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells

British Journal of Pharmacology

Volumn 117, Issue 7, 1996, Pages 1507-1515

  Jenkins, A ^a   Franks, N P ^a   Lieb, W R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

5 HT3 receptor; 5 hydroxytryptamine; Alcohols; Barbiturates; Cutoff effect; General anaesthesia; Inhalational anaesthetics; N1E115; Neuroblastoma cells

Indexed keywords

ALCOHOL DERIVATIVE; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; BEMESETRON; BUTANOL; DECANOL; ENFLURANE; HALOTHANE; HEXANOL; INHALATION ANESTHETIC AGENT; ISOFLURANE; LAURYL ALCOHOL; METHOXYFLURANE; MYRISTYL ALCOHOL; OCTANOL; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; THIOPENTAL;

ANIMAL CELL; ARTICLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; GENERAL ANESTHESIA; MEMBRANE CURRENT; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; VOLTAGE CLAMP;

EID: 0029963818     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15314.x     Document Type: Article

References (47)

1. ALIFIMOFF, J.K., FIRESTONE, L.L. & MILLER, K.W. (1989). Anaesthetic potencies of primary alkanols: Implications for the molecular dimensions of the anaesthetic site. Br. J. Pharmacol., 96, 9-16.
2. AMANO, T., RICHELSON, E. & NIRENBERG, M. (1972). Neurotransmitter synthesis by neuroblastoma clones. Proc. Natl. Acad. Sci. U.S.A., 69, 258-263.
3. 3 receptor of N1E-115 neuroblastoma cells. Naunyn-Schmied Arch. Pharmacol., 347, 125-132.
4. BELL, G.H. (1973). Solubilities of normal aliphatic acids, alcohols and alkanes in water. Chem. Phys. Lipids, 10, 1-10.
5. 3 receptor. J. Neurochem., 64, 1401-1405.
6. CURRY, S., LIEB, W.R. & FRANKS, N.P. (1990). Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity. Biochemistry, 29, 4641-4652.
7. DE ARMENDI, A.J., TONNER, P.H., BUGGE, B. & MILLER, K.W. (1993). Barbiturate action is dependent on the conformational state of the acetylcholine receptor. Anesthesiology, 79, 1033-1041.
8. 3 receptors. Br. J. Pharmacol., 114, 1641-1651.
9. FRANKS, N.P. & LIEB, W.R. (1985). Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature, 316, 349-351.
10. FRANKS, N.P. & LIEB, W.R. (1991). Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science, 254, 427-430.
11. FRANKS, N.P. & LIEB, W.R. (1993). Selective actions of volatile general anaesthetics at molecular and cellular levels. Br. J. Anaesth., 71, 65-76.
12. FRANKS, N.P. & LIEB, W.R. (1994). Molecular and cellular mechanisms of general anaesthesia. Nature, 367, 607-614.
13. 3 receptor stably expressed in HEK 293 cells. Br. J. Pharmacol., 114, 1211-1221.
14. HAIGH, C.G., KAPLAN, L.A., DURHAM, J.M., DUPEYRON, J.P., HARMER, M. & KENNY, G.N.C. (1993). Nausea and vomiting after gynaecological surgery: A meta-analysis of factors affecting their incidence. Br. J. Anaesth., 71, 517-522.
15. A receptor. Br. J. Pharmacol., 112, 906-910.
16. HAMILL, O.P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F.J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflüg. Arch., 391, 85-100.
17. HARRISON, N.L., KUGLER, J.L., JONES, M.V., GREENBLATT, E.P. & PRITCHETT, D.B. (1993). Positive modulation of human γ-aminobutyric acid type A and glycine receptors by the inhalational anesthetic isoflurane. Mol. Pharmacol., 44, 628-632.
18. 3 receptor A subunit. Eur. J. Pharmacol., 245, 187-192.
19. HUSSY, N., LUKAS, W. & JONES, K.A. (1994). Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors. J. Physiol., 481, 311-323.
20. 3 receptors in clonal cell lines studied by patch-clamp techniques. Br. J. Pharmacol., 97, 27-40.
21. 3 receptor-mediated ion current in NCB-20 neuroblastoma cells. Neurosci. Lett., 122, 57-60.
22. 3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol. Pharmacol., 40, 263-270.
23. 3 receptor-mediated ion current in nodose ganglion neurons from the adult rat. J. Pharmacol. Exp. Ther., 265, 771-776.
24. 3RA receptors expressed in a mammalian cell line. Neuropharmacology, 33, 1567-1572.
25. 3 receptors expressed in Xenopus laevis oocytes. J. Pharmacol. Exp. Ther., 271, 898-905.
26. MCKENZIE, D., FRANKS, N.P. & LIEB, W.R. (1995). Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. Br. J. Pharmacol., 115, 275-282.
27. 3 receptor, a serotonin-gated ion channel. Science, 254, 432-437.
28. MILLER, K.W., FIRESTONE, L.L., ALIFIMOFF, J.K. & STREICHER, P. (1989). Nonanesthetic alcohols dissolve in synaptic membranes without perturbing their lipids. Proc. Natl. Acad. Sci. U.S.A., 86, 1084-1087.
29. 3 receptor: Heterogeneity in distribution and function among species. Mol. Pharmacol., 48, 407-416.
30. MOSS, G.W.J., FRANKS, N.P. & LIEB, W.R. (1991). Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase. Proc. Natl. Acad. Sci. U.S.A., 88, 134-138.
31. NAKAHIRO, M., YEH, J.Z., BRUNNER, E. & NARAHASHI, T. (1989). General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons. FASEB J., 3, 1850-1854.
32. 3 receptor-mediated electrical response in cultured mouse neuroblastoma cells. Neuropharmacology, 27, 301-307.
33. ORTELLS, M.O. & LUNT, G.G. (1995). Evolutionary history of the ligand-gated ion-channel super-family of receptors. Trends Neurosci., 18, 121-127.
34. PARKER, I., GUNDERSEN, C.B. & MILEDI, R. (1986). Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes. J. Neurosci., 6, 2290-2297.
35. 3 receptor-induced currents in N1E-115 neuroblastoma cells. Eur. J. Pharmacol., 151, 491-495.
36. 3 receptor-mediated currents in rabbit nodose ganglion neurones. Br. J. Pharmacol., 103, 1623-1625.
37. 3 receptors. Trends Pharmacol. Sci., 13, 391-397.
38. POCOCK, G. & RICHARDS, C.D. (1987). The action of pentobarbitone on stimulus-secretion coupling in adrenal chromaffin cells. Br. J. Pharmacol., 90, 71-80.
39. RABEY, P.G. & SMITH, G. (1992). Anaesthetic factors contributing to postoperative nausea and vomiting. Br. J. Anaesth., 69 (Suppl. 1), 40S-45S.
40. RAVENTÓS, J. (1956). The action of Fluothane - a new volatile anaesthetic. Br. J. Pharmacol. Chemother., 11, 394-410.
41. ROPERT, N. & GUY, N. (1991). Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. J. Physiol., 441, 121-136.
42. 19F NMR spectroscopy. J. Pharmac. Biomed. Anal., 10, 1-7.
43. UNWIN, N. (1993). Neurotransmitter action: Opening of ligand-gated ion channels. Neuron, 10 (Suppl.), 31-41.
44. WAKAMORI, M., IKEMOTO, Y. & AKAIKE, N. (1991). Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat. J. Neurophysiol., 66, 2014-2021.
45. WATCHA, M.F. & WHITE, P.F. (1992). Postoperative nausea and vomiting: Its etiology, treatment, and prevention. Anesthesiology, 77, 162-184.
46. 3 receptor gene and functional expression of two splice variants. Mol. Brain Res., 26, 233-241.
47. WOOD, S.C., FORMAN, S.A. & MILLER, K.W. (1991). Short chain and long chain alkanols have different sites of action on nicotonic acetylcholine receptor channels from Torpedo. Mol. Pharmacol., 39, 332-338.