Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12556-12564

  Shan, Qiang ^b   Haddrill, Justine L ^b   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHLORINE COMPOUNDS; MUTAGENESIS;

SIGNAL TRANSDUCTION;

BIOCHEMISTRY;

ANTHELMINTIC AGENT; CHLORIDE CHANNEL; GLYCINE RECEPTOR; IVERMECTIN; PICROTOXIN; RECOMBINANT RECEPTOR; STRYCHNINE; ZINC; GLYCINE; ION CHANNEL; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; MEMBRANE CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; AMINO ACID SUBSTITUTION; ANIMAL; CAENORHABDITIS ELEGANS; CELL LINE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; COMPARATIVE STUDY; DIMERIZATION; DRUG EFFECT; DRUG POTENTIATION; KIDNEY; METABOLISM; PATCH CLAMP; PHYSIOLOGY;

STRYCHNOS TOXIFERA;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CELL LINE; CHLORIDE CHANNELS; DIMERIZATION; GLYCINE; HUMANS; ION CHANNEL GATING; ION CHANNELS; IVERMECTIN; KIDNEY; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; STRYCHNINE;

EID: 0035918183     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011264200     Document Type: Article

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