Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 1, 2010, Pages 39-45

  Chau, Peipei ^a   Höifödt Lidö, Helga ^a   Löf, Elin ^a   Söderpalm, Bo ^a,b   Ericson, Mia ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acamprosate; Ethanol Intake; Glycine Receptor; Microinjection; Strychnine

Indexed keywords

ACAMPROSATE; ALCOHOL; GLYCINE RECEPTOR; RINGER SOLUTION; SODIUM CHLORIDE; STRYCHNINE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; MICROINJECTION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

ALCOHOL DRINKING; ANIMALS; DOPAMINE; ETHANOL; MALE; MICROINJECTIONS; NUCLEUS ACCUMBENS; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; TAURINE;

ANIMALIA; RATTUS; STRYCHNOS TOXIFERA;

EID: 74049159098     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.01063.x     Document Type: Article

References (36)

1. Blomqvist O, Ericson M, Engel JA, Söderpalm B (1997) Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. Eur J Pharmacol 334 : 149 156.
2. Boismare F, Daoust M, Moore N, Saligaut C, Lhuintre JP, Chretien P, Durlach J (1984) A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacol Biochem Behav 21 : 787 789.
3. Cowen MS, Adams C, Kraehenbuehl T, Vengeliene V, Lawrence AJ (2005) The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system. Addict Biol 10 : 233 242.
4. Czachowski CL, Legg BH, Samson HH (2001) Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 25 : 344 350.
5. Ericson M, Blomqvist O, Engel JA, Söderpalm B (1998) Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine. Eur J Pharmacol 358 : 189 196.
6. Ericson M, Löf E, Stomberg R, Chau P, Söderpalm B (2008) Nicotinic acetylcholine receptors in the anterior, but not posterior, ventral tegmental area mediate ethanol-induced elevation of accumbal dopamine levels. J Pharmacol Exp Ther 326 : 76 82.
7. Ericson M, Molander A, Löf E, Engel JA, Söderpalm B (2003) Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. Eur J Pharmacol 467 : 85 93.
8. Ericson M, Molander A, Stomberg R, Söderpalm B (2006) Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine. Eur J Neurosci 23 : 3225 3229.
9. Heyser CJ, Schulteis G, Durbin P, Koob GF (1998) Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18 : 125 133.
10. Hölter SM, Landgraf R, Zieglgänsberger W, Spanagel R (1997) Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcohol Clin Exp Res 21 : 862 868.
11. Hussy N, Deleuze C, Pantaloni A, Desarménien MG, Moos F (1997) Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation. J Physiol 502 : 609 621.
12. Ikemoto S (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56 : 27 78.
13. Koob GF, Nestler EJ (1997) The neurobiology of drug addiction. J Neuropsychiatry Clin Neurosci 9 : 482 497.
14. Korpi ER (1994) Role of GABAA receptors in the actions of alcohol and in alcoholism: recent advances. Alcohol Alcohol 29 : 115 129.
15. Le Magnen J, Tran G, Durlach J, Martin C (1987) Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4 : 97 102.
16. Lidö HH, Stomberg R, Fagerberg A, Ericson M, Söderpalm B (2009) The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcohol Clin Exp Res 33 : 1151 1157.
17. Littleton J (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90 : 1179 1188.
18. Löf E, Ericson M, Stomberg R, Söderpalm B (2007) Characterization of ethanol-induced dopamine elevation in the rat nucleus accumbens. Eur J Pharmacol 555 : 148 155.
19. Maksay G (1998) Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands. Neuropharmacology 37 : 1633 1641.
20. Mason BJ (2005) Acamprosate in the treatment of alcohol dependence. Expert Opin Pharmacother 6 : 2103 2115.
21. Molander A, Lidö HH, Löf E, Ericson M, Söderpalm B (2007) The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol 42 : 11 18.
22. Molander A, Löf E, Stomberg R, Ericson M, Söderpalm B (2005) Involvement of accumbal glycine receptors in the regulation of voluntary ethanol intake in the rat. Alcohol Clin Exp Res 29 : 38 45.
23. Molander A, Söderpalm B (2005a) Glycine receptors regulate dopamine release in the rat nucleus accumbens. Alcohol Clin Exp Res 29 : 17 26.
24. Molander A, Söderpalm B (2005b) Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcohol Clin Exp Res 29 : 27 37.
25. Nadal R, Chappell AM, Samson HH (1998) Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration. Alcohol Clin Exp Res 22 : 1190 1198.
26. Olive MF, Nannini MA, Ou CJ, Koenig HN, Hodge CW (2002) Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release. Eur J Pharmacol 437 : 55 61.
27. Paille FM, Guelfi JD, Perkins AC, Royer RJ, Steru L, Parot P (1995) Double-blind randomized multicenter trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol 30 : 239 247.
28. Palma E, Fucile S, Barabino B, Miledi R, Eusebi F (1999) Strychnine activates neuronal alpha7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains. Proc Natl Acad Sci U S A 96 : 13421 13426.
29. Paxinos G, Watson C (2007) The Rat Brain in Stereotaxic Coordinates. Academic Press Inc., London, UK.
30. Shirasaki T, Klee MR, Nakaye T, Akaike N (1991) Differential blockade of bicuculline and strychnine on GABA- and glycine-induced responses in dissociated rat hippocampal pyramidal cells. Brain Res 561 : 77 83.
31. Söderpalm B, Löf E, Ericson M (2009) Mechanistic studies of ethanol′s interaction with the mesolimbic dopamine reward system. Pharmacopsychiatry 42 (Suppl. 1 87 94.
32. Spanagel R, Hölter SM, Allingham K, Landgraf R, Zieglgänsberger W (1996) Acamprosate and alcohol: I Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305 : 39 44. (Pubitemid 26195983)
33. Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U (2005) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11 : 35 42.
34. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22 : 521 527.
35. Terenius L (1998) Rational treatment of addiction. Curr Opin Chem Biol 2 : 541 547.
36. Xu TL (1999) Gamma-aminobutyric acid-induced responses in acutely dissociated neurons from the rat sacral dorsal commissural nucleus. J Auton Nerv Syst 75 : 156 163.