Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABAA receptors

Journal of Neurochemistry

Volumn 96, Issue 3, 2006, Pages 885-892

  Jung, Sangwook ^a,b   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

aminobutyric acid type A; Alcohol; Conformational changes; Oocyte; Substituted cysteine accessibility method; Two electrode voltage clamp

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; HEXANOL; HEXYLMETHANETHIOSULFONATE; MEMBRANE PROTEIN; PROTEIN TM2; PROTEIN TM3; RECEPTOR SUBUNIT; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE MUTATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ETHANOL; GAMMA-AMINOBUTYRIC ACID; HEXANOLS; LARVA; MEMBRANE POTENTIALS; MESYLATES; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 33645099659     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03617.x     Document Type: Article

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