Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 1, 2005, Pages 338-345

  Stevens, Renna ^c   Rüsch, Dirk ^b   Solt, Ken ^a   Raines, Douglas E ^a   Davies, Paul A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL MARBURG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; BUTANOL; CHLOROFORM; CYSTEINE; HALIDE; HALOTHANE; HEXANOL; INHALATION ANESTHETIC AGENT; ION CHANNEL; ISOFLURANE; LIGAND; OCTANOL; RECEPTOR SUBUNIT; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; SEROTONIN 3B RECEPTOR; SEVOFLURANE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; ELECTRODE; EVOKED RESPONSE; EXPERIMENT; FEMALE; INHIBITION KINETICS; MODULATION; MOLECULAR WEIGHT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS;

ALCOHOLS; ALGORITHMS; ANESTHETICS, INHALATION; ANIMALS; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, SEROTONIN, 5-HT3; RNA, MESSENGER; XENOPUS LAEVIS;

EID: 23044495814     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.085076     Document Type: Article

References (39)

1. Alhaider AA, Lei SZ, and Wilcox GL (1991) Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J Neurosci 11:1881-1888.
2. Alifimoff JK, Firestone LL, and Miller KW (1989) Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site. Br J Pharmacol 96:9-16.
3. Apfel CC, Kranke P, Katz MH, Goepfert C, Papenfuss T, Rauch S, Heineck R, Greim CA, and Roewer N (2002) Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth 88:659-668.
4. Campagna JA, Miller KW, and Forman SA (2003) Mechanisms of actions of inhaled anesthetics. N Engl J Med 348:2110-2124.
5. Comet MA, Sevoz-Couche C, Hanoun N, Hamon M, and Laguzzi R (2004) 5-HT-mediated inhibition of cardiovagal baroreceptor reflex response during defense reaction in the rat. Am J Physiol 287:H1641-H1649.
6. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, and Kirkness EF (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature (Lond) 397:359-363.
7. Davies PA, Wang W, Hales TG, and Kirkness EF (2003) A novel class of ligand-gated ion channel is activated by Zn2+. J Biol Chem 278:712-717.
8. Deady JE, Koblin DD, Eger EI 2nd, Heavner JE, and D'Aoust B (1981) Anesthetic potencies and the unitary theory of narcosis. Anesth Analg 60:380-384.
9. Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, et al. (1999) The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem 274:30799-30810.
10. Eger EI 2nd, Laster MJ, Gregory GA, Katoh T, and Sonner JM (2003) Women appear to have the same minimum alveolar concentration as men: a retrospective study. Anesthesiology 99:1059-1061.
11. Férézou I, Cauli B, Hill EL, Rossier J, Hamel E, and Lambolez B (2002) 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. J Neurosci 22:7389-7397.
12. Hornby PJ (2001) Central neurocircuitry associated with emesis. Am J Med 111 (Suppl 8A):106S-112S.
13. Huang J, Spier AD, and Pickel VM (2004) 5-HT3A receptor subunits in the rat medial nucleus of the solitary tract: subcellular distribution and relation to the serotonin transporter. Brain Res 1028:156-169.
14. Jenkins A, Franks NP, and Lieb WR (1996) Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br J Pharmacol 117:1507-1515.
15. A receptor. J Neurosci 21:RC136.
16. Koshizaki M, Kawamata M, Shimada SG, Saito Y, and Collins JG (2003) 5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons. Anesth Analg 96:1027-1031, table of contents.
17. Koyama S, Matsumoto N, Kubo C, and Akaike N (2000) Presynaptic 5-HT3 receptormediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons. J Physiol 529:373-383.
18. Lopreato GF, Banerjee P, and Mihic SJ (2003) Amino acids in transmembrane domain two influence anesthetic enhancement of serotonin-3A receptor function. Brain Res Mol Brain Res 118:45-51.
19. Machu TK and Harris RA (1994) Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Ther 271:898-905.
20. McMahon LL and Kauer JA (1997) Hippocampal interneurons are excited via serotonin-gated ion channels. J Neurophysiol 78:2493-2502.
21. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, et al. (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature (Lond) 389:385-389.
22. Miller KW, Paton WD, Smith RA, and Smith EB (1973) The pressure reversal of general anesthesia and the critical volume hypothesis. Mol Pharmacol 9:131-143.
23. Monk SA, Desai K, Brady CA, Williams JM, Lin L, Princivalle A, Hope AG, and Barnes NM (2001) Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus. Neuropharmacology 41:1013-1016.
24. Morales M, McCollum N, and Kirkness EF (2001) 5-HT(3)-receptor subunits A and B are co-expressed in neurons of the dorsal root ganglion. J Comp Neurol 438: 163-172.
25. Morales M and Wang SD (2002) Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 22:6732-6741.
26. Niesler B, Frank B, Kapeller J, and Rappold GA (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310:101-111.
27. Nosjean A, Compoint C, Buisseret-Delmas C, Orer HS, Merahi N, Puizillout JJ, and Laguzzi R (1990) Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat. Neurosci Lett 114:22-26.
28. Puig MV, Santana N, Celada P, Mengod G, and Artigas F (2004) In vivo excitation of GABA interneurons in the medial prefrontal cortex through 5-HT3 receptors. Cereb Cortex 14:1365-1375.
29. Reeves DC and Lummis SC (2002) The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (Review). Mol Membr Biol 19:11-26.
30. Stevens R, Rusch D, Davies PA, and Raines DE (2005) Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors. Anesth Analg, in press.
31. Stewart A, Davies PA, Kirkness EF, Safa P, and Hales TG (2003) Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells. Neuropharmacology 44:214-223.
32. Strum DP and Eger EI 2nd (1987) Partition coefficients for sevoflurane in human blood, saline and olive oil. Anesth Analg 66:654-656.
33. Suzuki T, Koyama H, Sugimoto M, Uchida I, and Mashimo T (2002) The diverse actions of volatile and gaseous anesthetics on human-cloned 5-hydroxytryptamine3 receptors expressed in Xenopus oocytes. Anesthesiology 96:699-704.
34. Tanimoto T, Takeda M, Nishikawa T, and Matsumoto S (2004) The role of 5-hydroxytryptamine3 receptors in the vagal afferent activation-induced inhibition of the first cervical dorsal horn spinal neurons projected from tooth pulp in the rat. J Pharmacol Exp Ther 311:803-810.
35. Wadhwa A, Durrani J, Sengupta P, Doufas AG, and Sessler DI (2003) Women have the same desflurane minimum alveolar concentration as men: a prospective study. Anesthesiology 99:1062-1065.
36. Wang Y, Ramage AG, and Jordan D (1998) Presynaptic 5-HT3 receptors evoke an excitatory response in dorsal vagal preganglionic neurones in anaesthetized rats. J Physiol 509:683-694.
37. Wood SC, Forman SA, and Miller KW (1991) Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo. Mol Pharmacol 39:332-338.
38. Zhou FM and Hablitz JJ (1999) Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J Neurophysiol 82:2989-2999.
39. Zhou Q and Lovinger DM (1996) Pharmacologic characteristics of potentiation of 5-HT3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells. J Pharmacol Exp Ther 278:732-740.