Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gβγ modulation

Journal of Biological Chemistry

Volumn 285, Issue 39, 2010, Pages 30203-30213

  Yevenes, Gonzalo E ^a,d   Moraga Cid, Gustavo ^a   Avila, Ariel ^a   Guzmán, Leonardo ^a   Figueroa, Maximiliano ^b   Peoples, Robert W ^c   Aguayo, Luis G ^a  

^a Department of Physiology   (Chile)

^b UNIVERSITY OF CONCEPCIÓN   (Chile)

^c MARQUETTE UNIVERSITY   (United States)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; IONS; LIGANDS; MODULATION;

ALLOSTERIC MODULATION; BINDING POCKETS; CONFORMATIONAL CHANGE; ETHANOL CONCENTRATIONS; EXTRACELLULAR RESIDUES; GLYCINE RECEPTOR; ION CHANNEL; ION-CHANNEL GATING; ISOFORMS; MOLECULAR BASIS; PROTEIN STRUCTURES; SELECTIVE MUTATION; TRANSMEMBRANES;

ETHANOL;

ALCOHOL; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR ALPHA2; GLYCINE RECEPTOR BETA; GLYCINE RECEPTOR GAMMA; UNCLASSIFIED DRUG; CENTRAL DEPRESSANT AGENT; GLRA2 PROTEIN, HUMAN; GLRB PROTEIN, HUMAN;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM;

ALLOSTERIC REGULATION; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HUMANS; RECEPTORS, GLYCINE;

EID: 77956911877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.134676     Document Type: Article

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